Kinetochore and Chromosome Segregation / ESI MS Service
Groupleader: Johannes Lechner
The kinetochore is a specialized chromosomal structure that facilitates chromosome attachment and movement along spindle microtubules during chromosome segregation. Furthermore, the kinetochore communicates the actual state of its interaction with the spindle to a cell cycle regulating machinery. It is the first member of a signaling cascade that inhibits sister chromatid separation (the beginning of anaphase) if chromosomes lack a stable bi-polar spindle attachment. A defect in this checkpoint function has been correlated to human cancers.
My group analyses the protein composition and structure of the S. cerevisiae kinetochore by mass spectroscopy and the function of individual kinetochore proteins applying cell and molecular biological methods.
Download BZH Report Lechner 2008-2010