powered by multiNETT - Internet-Systementwicklung
HEIDELBERG UNIVERSITY

Carmen Ruiz de Almodóvar 
Molecular and Cellular Mechanisms of the Neurovascular link

Groupleader: Carmen Ruiz de Almodóvar

2017

Chen S, Tisch N, Kegel M, Yerbes R, Hermann R, Hudalla H, Zuliani C, Gülcüler GS, Zwadlo K, von Engelhardt J, Ruiz de Almodóvar C, Martin-Villalba A. CNS Macrophages Control Neurovascular Development via CD95L. Cell Rep. 2017 May 16;19(7):1378-1393

Himmels P, Paredes I, Adler H, Karakatsani A, Luck R, Marti HH, Ermakova O, Rempel E, Stoeckli ET & Ruiz de Almodovar C. Motor neurons control blood vessel patterning in the developing spinal cord. Nat Commun. 2017 Mar 6;8:14583.

Hänggi K, Vasilikos L, Freire Valls A, Yerbes R, Knop J, Spilgies L, Rieck K, Misra T, Bertin J, Gough PJ, Schmidt T, Ruiz de Almodovar C & Wong WW. RIPK1/RIPK3 promotes vascular permeability to allow tumor cell extravasation independent of its necroptotic function. Cell Death Dis. 2017 Feb 2;8(2):e2588.

2016
Schmitz R, Freire Valls A, Yerbes R, von Richter S, Kahlert C, Loges S, Weitz J, Schneider M, Ruiz de Almodovar C, Ulrigh A, Schmidt T. TAM receptors Tyro3 and Mer as novel targets in colorectal cancer. Oncotarget. 2016. Aug 30;7(35):56355-56370. doi: 10.18632/oncotarget.10889.

Lange C, Storkebaum E, Ruiz de Almodovar C, Dewerchin M & Carmeliet P. Vascular endothelial growth factor: a neurovascular target in neurological diseases. Nat Rev Neurol. 2016 Jul 1. doi: 10.1038/nrneurol.2016.88

Segura I, Lange C, Knevels E, Moskalyuk A, Pulizzi R, Eelen G, Chaze T, Tudor C, Boulegue C, Holt M, Daelemans D, Matondo M, Ghesquière B, Giugliano M, Ruiz de Almodovar C, Dewerchin M & Carmeliet P. The Oxygen Sensor PHD2 Controls Dendritic Spines and Synapses via Modification of Filamin A. Cell Rep. 2016 Mar 22;14(11):2653-67.

2015
Savant S, La Porta S, Budnik A, Busch K, Hu J, Tisch N, Korn C, Valls AF,
Benest AV, Terhardt D, Qu X, Adams RH, Baldwin HS, Ruiz de Almodóvar C, Rodewald
HR, Augustin HG. The Orphan Receptor Tie1 Controls Angiogenesis and Vascular
Remodeling by Differentially Regulating Tie2 in Tip and Stalk Cells. Cell Rep.
2015 Sep 22;12(11):1761-73.

Farias VA, O'Valle F, Lerma BA, Ruiz de Almodóvar C, López-Peñalver JJ, Nieto
A, Santos A, Fernández BI, Guerra-Librero A, Ruiz-Ruiz MC, Guirado D, Schmidt T,
Oliver FJ, Ruiz de Almodóvar JM. Human mesenchymal stem cells enhance the
systemic effects of radiotherapy. Oncotarget. 2015 Oct 13;6(31):31164-80.

Hacke M, Björkholm P, Hellwig A, Himmels P, de Almodóvar CR, Brügger B,
Wieland F, Ernst AM. Inhibition of Ebola virus glycoprotein-mediated cytotoxicity
by targeting its transmembrane domain and cholesterol. Nat Commun. 2015 Jul
9;6:7688.

Kessler T, Sahm F, Blaes J, Osswald M, Rübmann P, Milford D, Urban S, Jestaedt L, Heiland S, Bendszus M, Hertenstein A, Pfenning PN, Ruiz de Almodóvar C, Wick A, Winkler F, von Deimling A, Platten M, Wick W, Weiler M. Glioma cell VEGFR-2 confers resistance to chemotherapeutic and antiangiogenic treatments in PTEN-deficient glioblastoma. Oncotarget. 2015 Oct 13;6(31):31050-68.

2013
Lelli A, Gervais A, Colin C, Chéret C, Ruiz de Almodovar C, Carmeliet P, Krause KH, Boillée S, Mallat M.The NADPH oxidase Nox2 regulates VEGFR1/CSF-1R-mediated microglial chemotaxis and promotes early postnatal infiltration of phagocytes in the subventricular zone of the mouse cerebral cortex. Glia. 2013 Sep;61(9):1542-55.

Bono F, De Smet F, Herbert C, De Bock K, Georgiadou M, Fons P, Tjwa M, Alcouffe C, Ny A, Bianciotto M, Jonckx B, Murakami M, Lanahan AA, Michielsen C, Sibrac D, Dol-Gleizes F, Mazzone M, Zacchigna S, Herault JP, Fischer C, Rigon P, Ruiz de Almodovar C, Claes F, Blanc I, Poesen K, Zhang J, Segura I, Gueguen G, Bordes MF, Lambrechts D, Broussy R, van de Wouwer M, Michaux C, Shimada T, Jean I, Blacher S, Noel A, Motte P, Rom E, Rakic JM, Katsuma S, Schaeffer P, Yayon A, Van Schepdael A, Schwalbe H, Gervasio FL, Carmeliet G, Rozensky J, Dewerchin M, Simons M, Christopoulos A, Herbert JM, Carmeliet P. Inhibition of Tumor Angiogenesis and Growth by a Small-Molecule Multi-FGF Receptor Blocker with Allosteric Properties. Cancer Cell. 2013 Apr 15;23(4):477-488.

Carmeliet, P, Ruiz de Almodovar, C. VEGF ligands and receptors: implications in neurodevelopment and neurodegeneration. Cell Mol Life Sci. 2013 Mar 12.

Snuderl M*, Batista A*, Kirkpatrick ND*, Ruiz de Almodovar C*, Riedemann L, Walsh EC, Anolik R, Huang Y, Martin JD, Kamoun W, Knevels E, Schmidt T, Farrar CT, Vakoc BJ, Mohan N, Chung E, Roberge S, Peterson T, Bais C, Zhelyazkova BH, Yip S, Hasselblatt M, Rossig C, Niemeyer E, Ferrara N, Klagsbrun M, Duda DG, Fukumura D, Xu L, Carmeliet P, Jain RK. Targeting placental growth factor/neuropilin 1 pathway inhibits growth and spread of medulloblastoma. Cell, 2013 Feb 28;152(5):1065-76. (*These authors contributed equally)

2011
Meissirel, C*, Ruiz de Almodovar, C*, Knevels, E*, Coulon, C, Chounlamountri, N, Segura, I, de Rossi, P, Vinckier, S, Anthonis, K, Deléglise, B, de Mol, M, Ali, C, Dassonville, K, Loyens, E, Honnorat, J, Michotte, Y, Rogemond, V, Smolders, I, Voets, T, Vivien, D, Vanden Berghe, P, Van Den Bosch, L, Robberecht, W, Chédotal, A, Oliviero, S, Dewerchin, M, Schmucker, D, Thomasset, N, Salin, PA, & Carmeliet, P. VEGF modulates NMDA receptor activity via a Src-family-kinase-dependent cross-talk. Proc Natl Acad Sci U S A. 2011 Aug 16;108(33):13782-7. (*These authors contributed equally)

Ruiz de Almodovar, C*, Fabre, P*, Knevels, E, Coulon, C, Segura, I, Haddick, PCG, Aerts, L, Delattin, N, Strasser, G, Oh, WJ, Lange, C, Vinckier, S, Haigh, JJ, Fouquet, C, Henderson, C, Gu C, Alitalo K, Castellani V, Tessier-Lavigne M, Chedotal A, Charron F* and Carmeliet P*. VEGF mediates commissural axon chemoattraction through its receptor Flk1. Neuron 2011, June 9 (70):966-78. (*These authors contributed equally)

2010
Storkebaum, E*, Ruiz de Almodovar, C*, Meens, M, Zacchigna, S, Mazzone, M, Vanhoutte, G, Vinckier, S, Poesen, K, Lambrechts, D, Janssen, G, Fazzi, GE, Schiffers, PM, Rohrer, H, Van der Linden, A, DeMey, J. & Carmeliet, P. Impaired autonomic regulation of resistance arteries in mice with low vascular endothelial growth factor or upon vascular endothelial growth factor trap delivery. Circulation 2010, Jul 20;122(3):273-81. (*These authors contributed equally)

Geudens, I, Herpers, R, Hermans, K, Segura, I, Ruiz de Almodovar, C, Bussmann, J, De Smet, F, Vandevelde, W, Hogan, BM, Siekmann, A, Claes, F, Moore, J, Pistocchi, AS, Loges, S, Mazzone, M, Mariggi, MG, Bruyère, F, Cotelli, F, Kerjaschki, D, Noël, A, Foidart, J, Gerhardt, H., Ny, A., Langenberg, T., Lawson, N., Duckers, HJ., Schulte-Merker, S., Carmeliet, P. and Dewerchin, M. Role of Dll4/Notch in the formation and wiring of the lypmphatic network in zebrafish. Arterioscler Thromb Vasc Biol. 2010, Sep 30(9):1605-702.

Ruiz de Almodovar, C*, Coulon, C*, Knevels, E, Salin, PA, Chounlamountri, N, Poesen, K, Hermans, K, Lambrechts, D, Van Geyte, K, Dhondt, J, Dresselaers, T, Renaud, J, Aragones, J, Zacchigna, S, Geudens, I, Gall, D, Stroobants, S, Mutin, M, Dassonville, K, Storkebaum, E, Jordan, BJ, Eriksson, U, Moons, L, D’Hooge, R, Haigh, JJ, Belin, MF, Schiffmann, S, Van Hecke, P, Gallez, B, Chedotal, A, Honnorat, J, Thomasset, N, Carmeliet, P, and Meissirel, C. Matrix-binding VEGF isoforms guide granule cell migration in the cerebellum via VEGF receptor Flk1. J. Neurosci 2010, Nov 10; 30(45): 15052-66. (*These authors contributed equally)

Pierreux, CE, Cordi, S, Hick, AC, Ruiz de Almodovar, C, Courtoy, PJ, Carmeliet, P & Lemaigre, FP. An epithelial-endothelial crostalk regulates differentiation in developing pancreas. Dev Biol 2010, Nov 1; 347(1): 216-27.

2009
Ruiz de Almodovar, C, Lambrechts, D, Mazzone, M & Carmeliet, P. Role and theraputical potential of VEGF in the nervous system. Physiol Rev 2009, Apr; 89(2): 607-48.

Mazzone, M, Dettori, D, Leite de Oliveira, R, Loges, S, Schmidt, T, Jonckx, B, Tian, YM, Lanahan, AA, Pollard, P, Ruiz de Almodovar, C, De Smet, F, Vinckier, S, Aragones, J, Luttun, A, Wyns, S, Jordan, B, Pisacane, A, Gallez, B, Lampugnani, MG, Dejana, E, Simons, M, Ratcliffe, P, Maxwell, P. & Carmeliet, P.  Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization. Cell 2009, Mar 6, 136(5):839-51.

Segura, I, De Smet, F, Hohensinner, PJ, Ruiz de Almodovar, C. & Carmeliet, P. The neurovascular link in health and disease: an update. Trends Mol Med. 2009, Oct; 15(10):439-51.

2008
Zacchigna, S*, Ruiz de Almodovar, C* & Carmeliet, P.  Similarities between angiogenesis and neural development: what small animal models can tell us. Curr Top Dev Biol 2008, 80:1-55. (*These authors contributed equally)

Ruiz de Almodovar, C*, Zacchigna, S* & Carmeliet, P. Angiogenesis in the central nervous system. Book chapter in the book titled: Angiogenesis: an integrative approach from science to medicine. Edited by Figg and Folkman, Springer 2008, 489-504. (*These authors contributed equally)

2007
Mazzone, M, Ruiz de Almodovar, C, Carmeliet, P. Buiding in resistance to cell death. Nat Genet 2007. Nov; 39(11):1308-1309.

Ruiz de Almodovar, C*, Ny, A* & Carmeliet, P. General concepts of angiogenesis and vasculogenesis. Book chapter for the book titled “Retinal vascular disease”. Edited by Joussen, Gardner Kirchhof & Ryan. Springer 2007, 38-65. (*These authors contributed equally)

Zacchigna, S, Ruiz de Almodovar, C, Lafuste, P & Carmeliet, P. Vascular and Neural development, intersecting parallelisms and crossroads. Book chapter for the book titled: Therapeutic Neovascularization-Quo Vadis?. Edited by Deindl and Kupatt. Springer 2007, 159-191.

Ruiz de Almodovar, C*, Zacchigna, S*, Autiero, M & Carmeliet, P. Guidance of Vascular and Neuronal Network Formation. Book chapter for the book titled “Tumor angiogenesis: Mechanisms and Cancer therapy”. Edited by Marmé, Fusenig and Norbert. Springer 2007: 47-65. (*These authors contributed equally)

2006
Ruiz de Almodovar, C, Luttun, A & Carmeliet, P. An SDF-1 trap for myeloid cells stimulates angiogenesis. Cell 2006, 124, 18-21.

Chittenden, TW, Claes, F, Lanahan, AA, Autiero, M, Palac, RT, Tkachenko, EV, Elfenbein, A, Ruiz de Almodovar, C, Dedkov, E, Tomanek, R, Li, W, Westmore, M, Singh, J, Horowitz, A, Mulligan-Kehoe, MJ, Moodie, KL, Zhuang, ZW, Carmeliet, P & Simons, M. Selective regulation of arterial branching morphogenesis by synectin. Dev Cell, 2006. Jun;10(6):783-95.

Schenider, M, Ny, A, Ruiz de Almodovar, C & Carmeliet P.A new mouse model to study acquired lymphedema. PLoS Med, 2006. Jul; 3(7):e264.

Haigh, JJ, Ruiz de Almodovar, C, Schneider, M & Carmeliet, P. Non-angiogenic functions of VEGF. Book chapter for the book titled “Angiogenesis: From Basic Science to Clinical Aspects”. Edited by N. Ferrara. CRC Taylor & Francis 2006, 133-155.

2004
Ruiz de Almodovar, C, Ruiz-Ruiz, C, Rodriguez, A, Ortiz-Ferron, G, Redondo, J. M. & Lopez-Rivas, A. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) decoy receptor TRAIL-R3 is up-regulated by p53 in breast tumor cells through a mechanism involving an intronic p53-binding site, J Biol Chem, 2004. 279, 4093-101.

Ruiz-Ruiz, C, Ruiz de Almodovar, C, Rodriguez, A, Ortiz-Ferron, G, Redondo, J. M. & Lopez-Rivas, A.  The up-regulation of human caspase-8 by interferon-gamma in breast tumor cells requires the induction and action of the transcription factor interferon regulatory factor-1, J Biol Chem, 2004. 279, 19712-20.

Ruiz de Almodovar, C, Lopez-Rivas, A & Ruiz-Ruiz, C.  Interferon-gamma and TRAIL in human breast tumor cells, Vitam Horm, 2004. 67, 291-318.

Ruiz de Almodovar, C, Lopez-Rivas, A, Redondo, J. M. & Rodriguez, A. Transcriptional regulation of the TRAIL-R3 gene, Vitam Horm, 2004. 67, 51-63.

2003
Munoz-Pinedo, C, Ruiz-Ruiz, C, Ruiz de Almodovar, C, Palacios, C & Lopez-Rivas, A. Inhibition of glucose metabolism sensitizes tumor cells to death receptor-triggered apoptosis through enhancement of death-inducing signaling complex formation and apical procaspase-8 processing, J Biol Chem, 2003. 278, 12759-68.

2002
Ruiz de Almodovar, C, Lopez-Rivas, A, Redondo, J. M. & Rodriguez, A. Transcription initiation sites and promoter structure of the human TRAIL-R3 gene, FEBS Lett, 2002. 531, 304-8.

Munoz-Pinedo, C*, Ruiz de Almodovar, C* & Ruiz-Ruiz, C*. Death on the beach: a rosy forecast for the 21st century, Cell Death Differ, 2002. 9, 1026-9. (*These authors contributed equally)

2001
Ruiz de Almodovar, C, Ruiz-Ruiz, C, Munoz-Pinedo, C, Robledo, G & Lopez-Rivas, A. The differential sensitivity of Bcl-2-overexpressing human breast tumor cells to TRAIL or doxorubicin-induced apoptosis is dependent on Bcl-2 protein levels, Oncogene, 2001. 20, 7128-33.
  
Informationen