Regulated exocytosis is mediated by a cascade of reactions that harness the basic membrane fusion machinery consisting of v-SNAREs on secretory vesicles and t-SNAREs on the plasma membrane. Both lipids and proteins form together regulatory networks that control distinct steps of the fusion process, culminating in sub-millisecond Ca²⁺-triggered exocytosis.

We use in vitro assays (reconstituted liposomes containing purified proteins and defined lipids) to dissect distinct steps such as vesicle tethering, docking, fusion pore formation and opening at the mechanistic level. Biochemical/biophysical methods such as dynamic light scattering, microscale thermophoresis, biolayer interferometry, FRET, crosslinking and mass spectrometry reveal interacting interfaces and their dynamics. In collaboration with other research groups, we gain structural insights by cryo-electron microscopy and x-ray crystallography and decipher physiological/pathophysiological functions of selected components in living neurons, employing electrophysiology.

Application requirements

We are looking for a highly motivated scientist, who shows both independence and team spirit. You should be interested in protein biochemistry, membrane biology, and be willing to become familiar with cutting edge technology and to gain teaching experience. The position will available in January 2026.

Please send your curriculum vitae, a brief letter of motivation, and the names of references to the adress below.


For further information please contact:
 

Thomas Söllner Office +49 6221545342  [thomas.soellner@bzh.uni-heidelberg.de]