The Meinecke Lab at the Biochemistry Center of Heidelberg University invites applications for a fully funded PhD position to investigate the molecular mechanisms of mitochondrial membrane organization and lipid transfer.
Join a dynamic research environment in Heidelberg at one of Europe’s leading life science hubs and work at the interface of membrane biology, structural biology, and biophysics.
 
Project Overview
Mitochondria are highly dynamic organelles whose function depends on the precise organization of their membranes. The inner mitochondrial membrane is shaped by protein complexes such as MICOS (Mitochondrial Contact Site and Cristae Organizing System), while lipid transfer processes—mediated by conserved proteins such as Ups1/PRELID—maintain membrane composition and function.
 
This project aims to uncover how membrane architecture, lipid transport, and protein function are mechanistically integrated.
You will investigate:

• The structure and mechanism of the MICOS complex
• Lipid transfer pathways mediated by Ups/PRELID proteins
• The interplay between membrane lipid composition and protein activity

 
The project combines a multidisciplinary approach including:

• Protein biochemistry and molecular biology
• In vitro reconstitution and in vivo analysis
• Lipidomics and advanced fluorescence microscopy
• Structural biology (cryo-EM and cryo-electron tomography)

 
Your Profile
We are looking for a motivated and curious candidate with a strong interest in fundamental biological questions.
 
You should have:

• A Master’s degree (or be close to completion) in biochemistry, biophysics, molecular biology, or a related field
• A solid background in at least one of the following: biochemistry, cell biology, structural biology, or biophysics
• Interest in membrane biology and mitochondrial function
• Experience in molecular biology, protein biochemistry, cell culture, or microscopy (advantageous, but not required)
• Strong communication skills in English and a collaborative mindset

 
Research Environment
We offer a supportive, inclusive, and collaborative lab culture with a strong emphasis on open communication and scientific exchange.
 
The lab is embedded in the Heidelberg research ecosystem, one of Europe’s premier centers for biomedical research, providing:

• Access to state-of-the-art core facilities
• A highly interdisciplinary and international environment
• Extensive training and networking opportunities

 
What We Offer

• A fully funded PhD position within the Collaborative Research Center SFB 1638
• Training in cutting-edge methods including cryo-EM and membrane reconstitution
• Opportunities for international collaborations and conference participation
• Integration into a structured graduate program in Heidelberg

 
Start date: as soon as possible
 
How to Apply
Please submit your application as a single PDF including:

• A motivation letter (including research interests)
• Contact details of two referees

 
Send your application to: michael.meinecke@bzh.uni-heidelberg.de