Work in the research group Moser von Filseck focuses on the molecular mechanism of membrane remodelling. Cellular membranes need to be remodelled (deformed, cut, fused) in order to maintain cellular and organellar integrity. We want to reconstitute the ESCRT-III membrane-remodelling machinery to study the structure and dynamics of its assembly and to understand how proteins and lipids interact on the molecular scale.
We are seeking a researcher with (or near completion of) a PhD degree in life sciences for a fully funded (E13 100 %) position available for a
Postdoctoral researcher in structural biology of membrane remodelling
As soon as possible.
The postdoctoral researcher will reconstitute ESCRT-III assemblies and their membrane-remodelling activity in vitro
from recombinant purified proteins and artificial lipid membranes and use cryogenic electron microscopy (cryo-EM) and tomography (cryo-ET) to characterise the interplay of proteins and membranes during this activity on the atomic level. To this end, we have access to high-end electron microscopy instrumentation (HDCryoNet
) and data processing infrastructure.
Pfitzner A, Moser von Filseck J and Roux A “Principles of membrane remodeling by dynamic ESCRT-III polymers” Trends Cell Biol
31(10), 856-868 (2021). https://doi.org/10.1016/j.tcb.2021.04.005 [Review]
Moser von Filseck J, Barberi L, Talledge N, Johnson I, Frost A, Lenz M and Roux A “Anisotropic ESCRT-III architecture governs helical membrane tube formation” Nat Commun 11, 1516 (2020). https://doi.org/10.1038/s41467-020-15327-4
Motivated and self-driven, with a PhD in life sciences or computation, interest in membrane biology, biochemistry and structural biology. The ideal candidate would come with a strong background in structural biology, especially cryogenic electron microscopy (cryo-EM), tomography (cryo-ET) and data processing including subtomogram averaging.
Please send your CV, letter of motivation and contacts of 2-3 references to email@example.com