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Johannes Lechner 
Kinetochore and Chromosome Segregation / ESI MS Service

Groupleader: Johannes Lechner

Ebert AD, Laußmann M, Wegehingel S, Kaderali L, Erfle H, Reichert J, Lechner J, Beer HD, Pepperkok R, Nickel W. Tec-kinase-mediated phosphorylation of fibroblast growth factor 2 is essential for unconventional secretion.
Traffic 2010; 11(6):813-26.

Ortiz J, Funk C, Schäfer A, Lechner J. Stu1 inversely regulates kinetochore capture and spindle stability.
Genes Dev. 2009; 23(23):2778-91.

Kemmler S, Stach M, Knapp M, Ortiz J, Pfannstiel J, Ruppert T, Lechner J. Mimicking Ndc80 phosphorylation triggers spindle assembly checkpoint signalling.
EMBO J. 2009; 28(8):1099-110.

Maekawa H, Priest C, Lechner J, Pereira G, Schiebel E. The yeast centrosome translates the positional information of the anaphase spindle into a cell cycle signal.
J Cell Biol. 2007, 179(3):423-36.

Sohn K, Schwenk J, Urban C, Lechner J, Schweikert M, Rupp S. Getting in touch with Candida albicans: the cell wall of a fungal pathogen.
Curr Drug Targets. 2006, 7(4):505-512.

Grosshans BL, Grötsch H, Mukhopadhyay D, Fernández IM, Pfannstiel J, Idrissi FZ, Lechner J, Riezman H, Geli MI. TEDS site phosphorylation of the yeast myosins I is required for ligand-induced but not for constitutive endocytosis of the G protein-coupled receptor Ste2p.
J Biol Chem. 2006, 281(16):11104-14.

Kerres A, Vietmeier-Decker C, Ortiz J, Karig I, Beuter C, Hegemann J, Lechner J, Fleig U. The fission yeast kinetochore component Spc7 associates with the EB1 family member Mal3 and is required for kinetochore-spindle association.
Mol Biol Cell. 2004, 15(12):5255-67.

Rodriguez-Navarro S, Fischer T, Luo MJ, Antunez O, Brettschneider S, Lechner J, Perez-Ortin JE, Reed R, Hurt E. Sus1, a functional component of the SAGA histone acetylase complex and the nuclear pore-associated mRNA export machinery.
Cell. 2004, 116(1):75-86.

Seelenmeyer C, Wegehingel S, Lechner J, Nickel W. The cancer antigen CA125 represents a novel counter receptor for galectin-1.
J Cell Sci. 2003, 116(Pt 7):1305-18.

Milkereit P, Strauss D, Bassler J, Gadal O, Kühn H, Schütz S, Gas N, Lechner J, Hurt E, Tschochner H. A Noc complex specifically involved in the formation and nuclear export of ribosomal 40 S subunits.
J Biol Chem. 2003, 278(6):4072-81.

Scharfenberger M, Ortiz J, Grau N, Janke C, Schiebel E, Lechner J. Nsl1p is essential for the establishment of bipolarity and the localization of the Dam-Duo complex.
EMBO J. 2003, 22(24):6584-97.

Fischer T, Sträßer K, Rácz A, Rodriguez-Navarro S, Oppizzi M, Ihrig P, Lechner J, Hurt E. The mRNA export machinery requires the novel Sac3p-Thp1p complex to dock at the nucleoplasmic entrance of the nuclear pores.
Embo J .2002, 21(21): 5843-5852.

Janke C, Ortíz J, Tanaka TU, Lechner J, Schiebel E. Four new subunits of the Dam1-Duo1 complex reveal novel functions in sister kinetochore biorientation. EMBO J. 2002, 21(1-2):181-93.

Stemmann O, Neidig A, Köcher T, Wilm M, Lechner J. Hsp90 enables Ctf13p/Skp1p to nucleate the budding yeast kinetochore.
Biochemistry 2002, 99(13):8585-90.

Janke, C., Ortiz, J., Lechner, J., Shevchenko, A., Shevchenko, A., Magiera, M.M., Schramm, C., and Schiebel, E. 2001. The budding yeast proteins Spc24p and Spc25p interact with Ndc80p and Nuf2p at the kinetochore and are important for kinetochore clustering and checkpoint control.
The EMBO J. 20, 777-791

Bassler J, Grandi P, Gadal O, et al. Identification of a 60S preribosomal particle that is closely linked to nuclear export. Mol Cell 2001; 8:517-29.

Gommel DU, Memon AR, Heiss A, et al. Recruitment to Golgi membranes of ADP-ribosylation factor 1 is mediated by the cytoplasmic domain of p23. Embo J 2001; 20:6751-60.

Hemmerich P, Stoyan T, Wieland G, Koch M, Lechner J, Diekmann S. Interaction of yeast kinetochore proteins with centromere- protein/transcription factor cbf1 [In Process Citation]. Proc Natl Acad Sci U S A 2000; 97:12583-8.

Ortiz J, Lechner J. The budding yeast kinetochore: less simple than expected. Protoplasma 2000; 211:12-19.

Ortiz J, Stemmann O, Rank S, Lechner J. A putative protein complex consisting of Ctf19, Mcm21, and Okp1 represents a missing link in the budding yeast kinetochore. Genes Dev 1999; 13:1140-55.

Pietrasanta LI, Thrower D, Hsieh W, et al. Probing the Saccharomyces cerevisiae centromeric DNA (CEN DNA)-binding factor 3 (CBF3) kinetochore complex by using atomic force microscopy. Proc Natl Acad Sci U S A 1999; 96:3757-62.

Stoyan T, Eck R, Lechner J, Hemmerich P, Kunkel W, Diekmann S. Cloning of a centromere binding factor 3d (CBF3D) gene from Candida glabrata. Yeast 1999; 15:793-8.

Lechner J, Ortiz J. The Saccharomyces cerevisiae kinetochore. FEBS Lett 1996; 389:70-4.

Stemmann O, Lechner J. The Saccharomyces cerevisiae kinetochore contains a cyclin-CDK complexing homologue, as identified by in vitro reconstitution. Embo J 1996; 15:3611-20.

Lechner J. A zinc finger protein, essential for chromosome segregation, constitutes a putative DNA binding subunit of the Saccharomyces cerevisiae kinetochore complex, Cbf3. Embo J 1994; 13:5203-11.

Jiang W, Lechner J, Carbon J. Isolation and characterization of a gene (CBF2) specifying a protein component of the budding yeast kinetochore. J Cell Biol 1993; 121:513-9.

Lechner J, Wieland F. Analysis of bacterial glycoproteins. Methods Mol Biol 1993; 14:119-29.

Lechner J, Carbon J. A 240 kd multisubunit protein complex, CBF3, is a major component of the budding yeast centromere. Cell 1991; 64:717-25.

Lechner J, Wieland F. Structure and biosynthesis of prokaryotic glycoproteins. Annu Rev Biochem 1989; 58:173-94.

Lechner J, Sumper M. The primary structure of a procaryotic glycoprotein. Cloning and sequencing of the cell surface glycoprotein gene of halobacteria. J Biol Chem 1987; 262:9724-9.

Wieland F, Lechner J, Sumper M. Iduronic acid is a constituent of sulfated dolichyl phosphate oligosaccharides in halobacteria. FEBS Lett. 1986; 195:77-81.

Wieland F, Lechner J, Sumper M. Sulfated Dolicholphosphate Oligosaccharides are Transiently Methylated during Biosynthesis of Halobacterial Glycoproteins. System. Appl. Microbiol. 1986; 7:286-392.

Lechner J, Wieland F, Sumper M. Biosynthesis of sulfated saccharides N-glycosidically linked to the protein via glucose. Purification and identification of sulfated dolichyl monophosphoryl tetrasaccharides from halobacteria. J Biol Chem 1985; 260:860-6.

Lechner J, Wieland F, Sumper M. Transient methylation of dolichyl oligosaccharides is an obligatory step in halobacterial sulfated glycoprotein biosynthesis. J Biol Chem 1985; 260:8984-9.

Wieland F, Lechner J, Sumper M. The Cell Wall Glycoprotein of Halobacteria: Structural, Functional and Biosynthetiv Aspects. Zentralbl. Bacteriol. Mikrobiol. Hyg. 1982; 1 Abt. Orig. C 3,:161-170.

Wieland F, Lechner J, Bernhardt G, Sumper M. Sulfation of a repetitive saccharide in halobacterial cell wall glycoprotein. FEBS Lett 1981; 132:319-323.