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Martin Koš 
Ribosomal RNA processing and modification

Groupleader: Martin Koš

ResearcherID E-2534-2011

Gnanasundram,S.V., Kos-Braun,I.C. and Koš,M. (2019). Two molecules of Has1 RNA helicase
function simultaneously in the biogenesis of small and large ribosomal.
(under revision in Nucl Acids Res)

Albert, B., Kos-Braun, I.C., Henras, A.K., Dez, C., Rueda, M.P., Zhang, X., Gadal, O., Kos, M., and Shore, D. (2019). A ribosome assembly stress response regulates transcription to maintain proteome homeostasis. eLife 2019;8:e45002 doi: 10.7554/eLife.45002

Kos-Braun,I.C. and Koš,M. (2017). Post-transcriptional regulation of ribosome biogenesis in yeast. Microbial Cell 4(5): 179-181. doi: 10.15698/mic2017.05.575 (invited microreview)

Kos-Braun,I.C., Jung,I. and Koš,M. (2017). Tor1 and CK2 kinases control a switch between alternative ribosome biogenesis pathways in a growth dependent manner. PLoS Biol 15(3):e2000245. doi:10.1371/journal.pbio.2000245.

Heissenberger,C., Dimitrijevic,N., Gonskikh,Y., Linder,A., Grillari-Voglauer,R., Koš,M., Polacek,N., Grillari,J. and Schosserer,M. (2017). NSUN5 methylates ribosomal RNA and modulates ribosome function in human cells. Experimental Gerontology 94:115-116.

Kornprobst,M., Turk,M., Kellner,N., Cheng,J., Flemming,D., Koš-Braun,I.C., Koš,M., Thoms,M., Berninghausen,O., Beckmann,R., Hurt,E., 2016. Architecture of the 90S Pre-ribosome: A Structural View on the Birth of the Eukaryotic Ribosome. Cell 166, 380–393.

Theile,D. and Koš,M. (2016). Structural and functional evaluation of interaction between mammalian ribosomal RNA with platinum-containing antineoplastic drugs. Toxicology Letters 242, 47-52.

Boon,K.-L., Pearson,M.D. and Koš,M. (2015). Self-association of Trimethylguanosine Synthase Tgs1 is required for efficient snRNA/snoRNA trimethylation and pre-rRNA processing. Sci Rep 5, 11282.

Gnanasundram,S.V. and Koš,M. (2015). Fast protein depletion system utilizing tetracycline repressible promoter and N-end rule in yeast. Mol Biol Cell 26, 762-8.

Schosserer,M., Minois,N., Angerer,T.B., Amring,M., Dellago,H, Harreither,E., Calle-Perez,A., Pircher,A., Gerstl,M.P., Pfeifenberger,S., Brandl,C., Sonntagbauer,M., Kriegner,A., Linder,A., Weinhäusel,A., Mohr,T., Steiger,M., Mattanovich,D., Rinnerthaler,M., Karl,T., Sharma,S., Entian,K.-D., Koš,M., Breitenbach,M., Wilson,I.B.H., Polacek,N., Grillari-Voglauer,R., Breitenbach-Koller,L. and Grillari,J. (2015). Methylation of ribosomal RNA by Nsun5 is a conserved mechanism modulating organismal life span. Nat Commun 6, 6158.

Bock,T., Chen,W.-H., Ori,A., Malik,N., Silva-Martin,N., Huerta-Cepas,J., Powell,S., Kastritis,P., Smyshlyaev,G., Vonkova,I., Kirkpatrick,J., Doerks,T.,  Nesme,L., Bassler,J., Koš,M., Hurt,E., Carlomagno,T., Gavin,A.-C., Barabás,O., Mueller,C., van Noort,V., Beck,M. and Bork,P. (2014). An integrated approach for genome annotation of the eukaryotic thermophile Chaetomium thermophilum. Nucl Acids Res 42, 13525-33.

Gigova A, Duggimpudi S, Pollex T, Schaefer M, Koš M. (2014). A cluster of methylations in the domain IV of 25S rRNA is required for ribosome stability. RNA 20, 1632-44.

Alexander, R.D., Barrass, J.D., Dichtl,B., Koš,M., Obtulowicz,T., Robert,M.-C., Koper,M., Karkusiewicz,I., Mariconti,L., Tollervey,D., Dichtl,B., Kufel,J., Bertrand,E. and Beggs,J.D. (2010). RiboSys, a high-resolution, quantitative approach to measure the in vivo kinetics of pre-mRNA splicing and 3’-end processing in Saccharomyces cerevisiae. RNA 16, 2570-80.

Boon,K.-L. and Koš,M. (2010). Deletion of Swm2p selectively impairs trimethylation of snRNAs by Trimethylguanosine synthase (Tgs1p). FEBS Lett. 584, 3299-3304.

Koš,M. and Tollervey,D. (2010). Yeast Pre-rRNA Processing and Modification Occur Cotranscriptionally. Mol. Cell 37, 809-820.

Bohnsack, M.T., Koš,M. and Tollervey,D. (2008). Quantitative analysis of snoRNA association with pre-ribosomes and release of snR30 by Rok1 helicase. EMBO Rep. 9, 1230-1236.

Ciocchetta,F., Hillston,J., Koš,M. and Tollervey,D. (2007). Modelling yeast pre-rRNA processing. In the Proceedings of Computational Methods in Systems Biology (CMSB), 2007. To appear in LNBI, Springer.

Belaya,K., Tollervey,D., and Koš,M. (2006). FLIPing heterokaryons to analyse nucleo-cytoplasmic shuttling of yeast proteins. RNA 12, 921-30.

Koš,M. and Tollervey,D. (2005). The Putative RNA Helicase Dbp4p Is Required for Release of the U14 snoRNA from Preribosomes in Saccharomyces cerevisiae. Mol. Cell 20, 53-64.

Metivier,R., Penot,G., Carmouche,R.P., Hubner,M.R., Reid,G., Denger,S., Manu,D., Brand,H., Koš,M., Benes,V. and others (2004). Transcriptional complexes engaged by apo-estrogen receptor-alpha isoforms have divergent outcomes. EMBO J. 23, 3653-3666.

Metivier,R., Penot,G., Hubner,M.R., Reid,G., Brand,H., Koš,M., and Gannon,F. (2003). Estrogen receptor-alpha directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter. Cell 115, 751-763.

Metivier,R., Stark,A., Flouriot,G., Hubner,M.R., Brand,H., Penot,G., Manu,D., Denger,S., Reid,G., Koš,M. and others (2002). A dynamic structural model for estrogen receptor-alpha activation by ligands, emphasizing the role of interactions between distant A and E domains. Mol. Cell 10, 1019-1032.

Reid,G., Denger,S., Koš,M., and Gannon,F. (2002). Human estrogen receptor-alpha: regulation by synthesis, modification and degradation. Cell Mol. Life Sci. 59, 821-831.

Koš,M., Denger,S., Reid,G., and Gannon,F. (2002). Upstream open reading frames regulate the translation of the multiple mRNA variants of the estrogen receptor alpha. J. Biol. Chem. 277, 37131-37138.

Koš,M., Denger,S., Reid,G., Korach,K.S., and Gannon,F. (2002). Down but not out? A novel protein isoform of the estrogen receptor alpha is expressed in the estrogen receptor alpha knockout mouse. J. Mol. Endocrinol. 29, 281-286.

Brand,H., Koš,M., Denger,S., Flouriot,G., Gromoll,J., Gannon,F., and Reid,G. (2002). A Novel Promoter Is Involved in the Expression of Estrogen Receptor alpha in Human Testis and Epididymis. Endocrinology 143, 3397-3404.

Koš,M., Reid,G., Denger,S., and Gannon,F. (2001). Minireview: genomic organization of the human ERalpha gene promoter region. Mol. Endocrinol. 15, 2057-2063.

Denger,S., Reid,G., Brand,H., Koš,M., and Gannon,F. (2001). Tissue-specific expression of human ERalpha and ERbeta in the male. Mol. Cell Endocrinol. 178, 155-160.

Denger,S., Reid,G., Koš,M., Flouriot,G., Parsch,D., Brand,H., Korach,K.S., Sonntag-Buck,V., and Gannon,F. (2001). ERalpha gene expression in human primary osteoblasts: evidence for the expression of two receptor proteins. Mol. Endocrinol. 15, 2064-2077.

Koš,M., O'Brien,S., Flouriot,G. and Gannon,F. (2000). Tissue-specific expression of multiple mRNA variants of the mouse estrogen receptor alpha gene. FEBS Lett. 477,15-20.

Flouriot,G., Brand,H., Denger,S., Metivier,R., Koš,M., Reid,G., Sonntag-Buck,V., and Gannon,F. (2000). Identification of a new isoform of the human estrogen receptor-alpha (hER-alpha) that is encoded by distinct transcripts and that is able to repress hER-alpha activation function 1. EMBO J. 19, 4688-4700.

Kučerová,D., Šloncová,E., Tuháčková,Z., Uhlířová,M., Koš,M., and Sovová,V. (1999). Changes of E-cadherin and beta-catenin levels during induced differentiation of colorectal carcinoma cells. Int. J. Mol. Med. 4, 541-544