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Julien Béthune 
Posttranscriptional regulation of mRNA expression and localization

Groupleader: Julien Béthune

Schopp, I.M., Amaya Ramirez, C.C., Debeljak, J., Kreibich, E., Skribbe, M., Wild, K., and Béthune, J. (2017). Split-BioID a conditional proteomics approach to monitor the composition of spatiotemporally defined protein complexes. Nat Commun 8, 15690.


Béthune, J*, Artus-Revel, CG, and Filipowicz, W* (2012). Kinetic analysis reveals successive steps leading to miRNA-mediated silencing in mammalian cells. EMBO Rep. 13(8), 716-723.
→ Highlighted by E. Izaurralde in EMBO Rep. 13(8), 662-663 (2012)
→ Research highlight in Nature Chem Biol 8, 679 (2012)


Beck, R, Sun, Z, Adolf, F, Rutz, C, Bassler, J, Wild, K, Sinning, I, Hurt, E, Brugger, B, Béthune, J*, and Wieland, F* (2008). Membrane curvature induced by Arf1-GTP is essential for vesicle formation. Proc Natl Acad Sci U S A 105, 11731-11736.
→ Highlighted by the Faculty of 1000 (F1000.com/1119165)

Langer, JD, Roth, CM, Béthune, J, Stoops, EH, Brugger, B, Herten, DP, and Wieland, FT* (2008). A conformational change in the alpha-subunit of coatomer induced by ligand binding to gamma-COP revealed by single-pair FRET. Traffic 9, 597-607.


Sun, Z, Anderl, F, Frohlich, K, Zhao, L, Hanke, S, Brugger, B, Wieland, F*, and Béthune, J* (2007). Multiple and stepwise interactions between coatomer and ADP-ribosylation factor-1 (Arf1)-GTP. Traffic 8, 582-593.

Langer, JD, Stoops, EH, Béthune, J, and Wieland, FT* (2007). Conformational changes of coat proteins during vesicle formation. FEBS Lett 581, 2083-2088.


Béthune, J*, Kol, M, Hoffmann, J, Reckmann, I, Brugger, B, and Wieland, F* (2006). Coatomer, the coat protein of COPI transport vesicles, discriminates endoplasmic reticulum residents from p24 proteins. Mol Cell Biol 26, 8011-8021.

Béthune, J*, Wieland, F, and Moelleken, J (2006). COPI-mediated transport. J Membr Biol 211, 65-79.

* corresponding author