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Peroxisomal Biogenesis

Groupleader: Wilhelm Just

Brodde A, Teigler A, Brugger B, Lehmann WD, Wieland F, Berger J, Just WW. Impaired neurotransmission in ether lipid-deficient nerve terminals.
Hum Mol Genet. 2012 Jun 15;21(12):2713-24

Bottelbergs A, Verheijden S, Van Veldhoven PP, Just W, Devos R, Baes M. Peroxisome deficiency but not the defect in ether lipid synthesis causes activation of the innate immune system and axonal loss in the central nervous system.
J Neuroinflammation. 2012 Mar 29;9:61, 1742-62.

Just W. FOCUS ON…metastasis suppressors.
FEBS Lett. 2011; 585(20):3147. 

Kou J, Kovacs GG, Höftberger R, Kulik W, Brodde A, Forss-Petter S, Hönigschnabl S, Gleiss A, Brügger B, Wanders R, Just W, Budka H, Jungwirth S, Fischer P, Berger J. 4. Peroxisomal alterations in Alzheimer's disease.
Acta Neuropathol. 2011; 122(3):271-83.

Just W. Focus on…LKB1/AMPK signaling.
FEBS Lett. 2011; 585(7):943

Grunau S, Lay D, Mindthoff S, Platta HW, Girzalsky W, Just WW, Erdmann R. The phosphoinositide 3-kinase Vps34p is required for pexophagy in Saccharomyces cerevisiae.
Biochem J. 2011; 434(1):161-70.

Schollenberger L, Gronemeyer T, Huber CM, Lay D, Wiese S, Meyer HE, Warscheid B, Saffrich R, Peränen J, Gorgas K, Just WW. RhoA regulates peroxisome association to microtubules and the actin cytoskeleton.
PLoS One 2010; 5(11):e13886.

Komljenovic D, Sandhoff R, Teigler A, Heid H, Just WW, Gorgas K. Disruption of blood-testis barrier dynamics in ether-lipid-deficient mice.
Cell Tissue Res. 2009; 337(2):281-99.

Teigler A, Komljenovic D, Draguhn A, Gorgas K, Just WW. Defects in myelination, paranode organization and Purkinje cell innervation in the ether lipid-deficient mouse cerebellum.
Hum Mol Genet. 2009; 18(11):1897-908.

Wiese S, Gronemeyer T, Ofman R, Kunze M, Grou CP, Almeida JA, Eisenacher M, Stephan C, Hayen H, Schollenberger L, Korosec T, Waterham HR, Schliebs W, Erdmann R, Berger J, Meyer HE, Just W, Azevedo JE, Wanders RJ, Warscheid B. Proteomics characterization of mouse kidney peroxisomes by tandem mass spectrometry and protein correlation profiling.
Mol Cell Proteomics 2007, 6(12):2045-57.

Jeynov B, Lay D, Schmidt F, Tahirovic S, Just WW. Phosphoinositide synthesis and degradation in isolated rat liver peroxisomes.
FEBS Lett. 2006, 580(25):5917-24.

Gorgas K, Teigler A, Komljenovic D, Just WW. The ether lipid-deficient mouse: tracking down plasmalogen functions.
Biochim Biophys Acta. 2006, 1763(12):1511-26.

Lay D, Gorgas K, Just WW. Peroxisome biogenesis: where Arf and coatomer might be involved.
Biochim Biophys Acta. 2006, 1763(12):1678-87.

Lay D, Grosshans BL, Heid H, Gorgas K, Just WW. Binding and functions of ADP-ribosylation factor on mammalian and yeast peroxisomes.
J Biol Chem. 2005, 280(41):34489-99.

Liu D, Nagan N, Just WW, Rodemer C, Thai TP, Zoeller RA. Role of dihydroxyacetonephosphate acyltransferase in the biosynthesis of plasmalogens and nonether glycerolipids.
J Lipid Res. 2005, 46(4):727-35.

Rodemer C, Thai TP, Brügger B, Kaercher T, Werner H, Nave KA, Wieland F, Gorgas K, Just W. Inactivation of ether lipid biosynthesis causes male infertility, defects in eye development and optic nerve hypoplasia in mice.
Hum Mol Genet. 2003, 12(15):1881-95.

Rodemer C, Thai TP, Brügger B, Gorgas K, Just W. Targeted disruption of ether lipid synthesis in mice.
Peroxisomal disorders and regulation of genes. (F. Roels, M. Baes, S. De Bie edts.)
Kluwer academic/Plenum Publishers 2003, 355-368.

T.P.Thai, C.Rodemer, A.Jauch, A.Hunziker, A.Moser, K.Gorgas and W.W.Just (2001). Impaired membrane traffic in defective ether lipid biosynthesis. Hum.Mol.Gen 10(2),127-136

M. Anton, M. Passreiter, D. Lay, T.P. Thai, K. Gorgas and W.W. Just (2000). ARF- and coatomer-mediated peroxisomal vesiculation. Cell Biochem. Biophys. 32, Spring: 27-36

C.M. Huber, R. Saffrich, K. Gorgas and W.W. Just (2000). Organelle motility regulated by the cell´s environment. Dissection of signaling pathways regulating movements of peroxisomes. Protoplasma, in press.

B. Pause, R. Saffrich, A. Hunziker, W. Ansorge and W.W. Just (2000) Targeting of the 22 kDa integral peroxisomal membrane protein. FEBS-Lett. 471, 23-28.

P.T. Thai, C. Rodemer, J. Worsch, A. Hunziker, K. Gorgas and W.W. Just (1999). Synthesis of plasmalogens in eye lens epithelial cells. FEBS-Lett. 456, 263-268.

C.M. Huber, R. Saffrich, W. Ansorge and W.W. Just (1999). Receptor-mediated regulation of peroxisomal motility in CHO and endothelial cells. EMBO J. 18, 5476-5485.

J. Biermann, W.W. Just, R.J. Wanders and H. Van Den Bosch (1999). Alkyl-dihydroxyacetone phosphate synthase and dihydroxyacetone phosphate acyltransferase form a protein complex in peroxisomes. Eur J Biochem. 261(2), 492-9

M. Passreiter, M. Anton, D. Lay, R. Frank, C. Harter, F.T. Wieland, K. Gorgas and W.W. Just (1998). Peroxisome biogenesis: involvement of ARF and coatomer. J. Cell Biol. 141, 373-383.

B. Pause, P. Diestelkötter, H. Heid and W.W. Just (1997). Cytosolic factors mediate protein insertion into the peroxisomal membrane. FEBS-Lett. 414, 95-98.

C.M. Huber, R. Saffrich, M. Anton, M. Paßreiter, W. Ansorge, K. Gorgas and W.W. Just (1997). A heterotrimeric G protein-phospholipase A2 signaling cascade is involved in the regulation of peroxisomal motility in CHO cells. J. Cell Sci. 110, 2955-2968.

P.T. Thai, H. Heid, H-R. Rackwitz, A. Hunziker, K. Gorgas and W.W. Just (1997). Ether lipid biosynthesis: isolation and molecular characterization of human dihydroxyacetonephosphate acyltransferase. FEBS-Lett. 420, 205-211.

W.W. Just and P. Diestelkötter (1996). Protein insertion into the peroxisomal membrane. Ann. N.Y. Acad. Sci. 804, 60-75.

S. Rapp, R. Saffrich, M. Anton, U. Jäkle, W. Ansorge, K. Gorgas and W.W. Just (1996). Microtubule-based peroxisome movement. J. Cell Sci. 109, 837-849.

P. Diestelkötter and W.W. Just (1993). In vitro insertion of the 22-kD peroxisomal membrane protein into isolated rat liver peroxisomes. J. Cell Biol. 123, 1717-1725.

S. Rapp, U. Soto and W.W. Just (1993). Import of firefly luciferase into peroxisomes of permeabilized Chinese hamster ovary cells: a model system to study peroxisomal protein import in vitro. Exp. Cell Res. 205, 59-65.

K.Kaldi,P. Diestelkotter,G. Stenbeck,S. Auerbach,U. Jakle,H.J. Magert,F.T. Wieland and W.W. Just (1993). Membrane topology of the 22 kDa integral peroxisomal membrane protein. FEBS Lett. 315(3), 217-22

P. Heinemann and W.W. Just (1992). Peroxisomal protein import. In vivo evidence for a novel translocation competent compartment. FEBS-Lett. 300, 179-182.