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Molecular insight into the network of Drosophila cytoplasmic piRNA pathway proteins through a combination of systematic interaction screening and structural prediction. bioRxiv. doi: https://doi.org/10.1101/2024.05.31.596839
Salgania, H.K., Metz, J., Lingren, E., Bleischwitz, C., Hauser, D., Oliveras Máté, K., Bollack, D., Lahr, F.,Garbelyanski, A., Jeske, M. (2024)Recurrent innovation of protein-protein interactions in the Drosophila piRNA pathway. bioRxiv. doi: https://doi.org/10.1101/2024.10.05.616775
Riedelbauch, S., Masser, S., Fasching, S., Lin, S., Salgania, H.K., Aarup, M., Ebert, A., Jeske, M., Levine, M.T., Stelzl, U., Andersen, P. (2024)ReLo is a simple and rapid colocalization assay to identify and characterize direct protein–protein interactions. Nat Commun. 15(1):2875
Salgania, H.K., Metz, J., Jeske, M. (2024)H/ACA snoRNP guides ribosomal RNA subdomain folding in a satellite particle before joining the core 90S pre-ribosome
BioRxiv. 09.05.611419; doi: https://doi.org/10.1101/2024.09.05.611419 (2024).
Paulina Fischer, Matthias Thoms, Benjamin Lau, Timo Denk, Maria Kuvshinova, Otto Berninghausen, Dirk Flemming, Ed Hurt, Roland Beckmann (2024)Nuclear and cytosolic fractions of SOX2 synergize as transcriptional and translational co-regulators of cell fate
Cell Reports 43,14807 (2024).
Thorsten Schaefer, Nitish Mittal, Hui Wang, Meric Ataman, Silvia Candido, Jonas Lötscher, Sergiy Velychko, Lionel Tintignac, Thomas Bock, Anastasiya Börsch, Jochen Baßler, Tata Nageswara Rao, Jakub Zmajkovic, Francis Jacob, Alain Dumlin, Christoph Schürch, Alexander Schmidt, Radek C. Skoda, Christoph Hess, Hans R. Schöler, Holm Zaehres, Ed Hurt, Mihaela Zavolan and Claudia Lengerke (2024)Reprograming of the ubiquitin ligase Ubr1 by intrinsically disordered Roq1 through cooperating multifunctional motifs. bioRxiv. 2024 (abstract)
Peters N*, Kanngießer S*, Pajonk O, Salazar Claros R, Mogk A, Schuck S. (2024)SnapShot: Eukaryotic Ribosome Biogenesis II
Cell 187, February 29th, doi.org/10.1016/j.cell.2024.01.043 (2024)
Ed Hurt, Janet Iwasa and Roland Beckmann (2024)Structural and mechanistic insights into activation of the human RNA ligase RTCB by Archease. Nat Commun. 15:2378. DOI: 10.1038/s41467-024-46568-2
Gerber JL, Morales Guzmán SI, Worf L, Hubbe P, Kopp J, Peschek J (2024)Structure of fungal tRNA ligase with RNA reveals conserved substrate binding principles. bioRxiv.
DOI: https://doi.org/10.1101/2024.06.06.59771
Köhler S, Kopp J & Peschek J (2024)Thermophilie und Strukturbiologie - Hochauflösende Strukturanalysen von eukaryontischen Zell-Maschinen
BioSpektrum 06.24, 663-666 (2024).
Nikola Kellner and Ed Hurt (2024)RNA binding proteins Smaug and Cup induce CCR4-NOT-dependent deadenylation of the nanos mRNA in a reconstituted system. Nucleic Acids Research, 51 (8), 3950–3970.
Pekovic, F., Rammelt, C., Kubíková, J., Metz, J., Jeske, M., Wahle, E. (2023)Structural basis for binding of Smaug to the GPCR Smoothened and to the germline inducer Oskar. bioRxiv. doi: https://doi.org/10.1101/2023.02.19.529116
Kubíková, J., Ubartaitė, G., Metz, J., Jeske, M. (2023)Structural basis for binding of Drosophila Smaug to the GPCR Smoothened and to the germline inducer Oskar. Proceedings of the National Academy of Sciences 120: e2304385120.
Kubíková, J., Ubartaitė, G., Metz, J., Jeske, M. (2023)Adaptation to glucose starvation is associated with molecular reorganization of the circadian clock in Neurospora crassa. Elife. 2023; PMC9831608. doi:10.7554/eLife.79765.
Szőke, A., Sárkány, O., Schermann, G., Kapuy, O., Diernfellner, A. C. R., Brunner, M., Gyöngyösi, N. and Káldi, K. (2023)Antisense Transcription of the Neurospora Frequency Gene Is Rhythmically Regulated by CSP-1 Repressor but Dispensable for Clock Function. J Biol Rhythms. 2023; doi:10.1177/07487304231153914.
Cemel, I. A., Diernfellner, A. C. R. and Brunner, M. (2023)Concurrent remodelling of nucleolar 60S subunit precursors by the Rea1 ATPase and Spb4 RNA helicase
Elife, doi.org/10.7554/eLife.84877 (2023).
Valentin Mitterer, Matthias Thoms, Robert Buschauer, Ed Hurt and Roland Beckmann (2023)DEAD-box RNA helicases act as nucleotide exchange factors for casein kinase 2, Sci Signal 16: eabp8923. doi: doi.org/10.1126/scisignal.abp8923.
Fatti, E., Hirth, A., Švorinić, A., Günther, M., Cruciat, C.M., Stier, G., Acebron, S.P., Papageorgiou, D., Sinning, I., Krijgsveld, J., Höfer , T. & Niehrs, C. (2023)Identification and characterization of sugar regulated promotors in Chaetomium thermophilum
BMC Biotechnology, doi.org/10.1186/s12896-023-00791-9 (2023).
Sven Reislöhner, Geza Schermann, Max Kilian, Daniela S. Munoz, Christian Zimmerli, Nikola Kellner, Jochen Baßler, Michael Brunner and Ed Hurt (2023)Mechanism of 5S RNP recruitment and helicase-surveilled rRNA maturation during pre-60S biogenesis.
EMBO Reports, e56910; doi 10.15252/embr.202356910 (2023).
Benjamin Lau, Zixuan Huang, Nikola Kellner, Shuangshuang Niu, Otto Berninghausen, Roland Beckmann, Ed Hurt and Jingdong Cheng (2023)Mechanistic insights into RNA surveillance by the canonical poly(A) polymerase Pla1 of the MTREC complex, Nat Commun. 14: 772. doi: doi.org/10.1038/s41467-023-36402-6.
Soni, K., Sivadas, A., Horváth, A., Dobrev, N., Hayashi, R., Kiss, L., Simon, B., Wild, K. & Sinning*, I, Fischer*, T. (2023)Methionine aminopeptidase 2 and its autoproteolysis product have different binding sites on the ribosome, bioRxiv doi:https://doi.org/10.1101/2023.04.06. 535065.
Klein, M.A., Wild, K., Kisonaite, M. & Sinning, I. (2023)New motifs in Ndc1 mediating interaction with the Nup84 complex and nuclear membranes
J. Cell Biol., doi 10.1083/jcb.202210059 (2023).
Ingo Amm, Marion Weberruss, Andrea Hellwig, Johannes Schwarz, MariannaTatarek-Nassol, Christian Lüchtenborg, Martina Kallas, Britta Brügger, Ed Hurt and Wolfram Antonin (2023)Quantification of Dolichyl Phosphates Using Phosphate Methylation and Reverse-Phase Liquid Chromatography-High Resolution Mass Spectrometry.
Anal Chem. 2023 Feb 14;95(6):3210-3217. doi: 10.1021/acs.analchem.2c03623. Epub 2023 Jan 30. PMID: 36716239
Kale D, Kikul F, Phapale P, Beedgen L, Thiel C, Brügger B. (2023)Rixosome Structure Enables Coordination of 5S RNP Rotation with ITS2 pre-RNA Processing During Ribosome Formation
EMBO Reports, e57984 (2023).
Matthias Thoms, Benjamin Lau, Jingdong Cheng, Lisa Fromm, Timo Denk, Nikola Kellner, Dirk Flemming, Paulina Fischer, Laurent Falquet, Otto Berninghausen, Roland Beckmann and Ed Hurt (2023)SnapShot: Eukaryotic Ribosome Biogenesis I
Cell 186, 2282-2283 (2023).
Ed Hurt, Jingdong Chen, Jochen Bassler, Janet Iwasa and Roland Beckmann (2023)Structural inventory of cotranslational protein folding by the eukaryotic RAC complex, Structural inventory of cotranslational protein folding by the eukaryotic RAC complex, Nat. Struct. Mol. Biol. Apr 20. doi: doi.org/10.1038/s41594-023-00973-1 (online ahead of print).
Kišonaitė, M., Wild, K., Lapouge, K., Valentín Gesé, G., Kellner, N., Hurt, E. & Sinning, I. (2023)Structure of nascent 5S RNPs at the crossroad between ribosome assembly and MDM2-p53 pathways.
Nat. Struct. Mol. Biol. 30, 1119-1131 doi.org/10.1038/s41594-023-01006-7 (2023).
Nestor Miguel Castillo Duque de Estrada, Matthias Thoms, Dirk Flemming, Henrik M. Hammaren, Robert Buschauer, Michael Ameismeier, Jochen Baßler, Martin Beck, Roland Beckmann and Ed Hurt (2023)The RNA helicase Dbp10 coordinates assembly factor association with PTC formation during ribosome biogenesis
Nucl. Acid Res., doi.org/10.1093/nar/gkad1206 (2023).
Valentin Mitterer, Hussein Hamze, Natalia Kunowska, Ulrich Stelzl, Anthony Henras and Ed Hurt (2023)Transcription activator WCC recruits deacetylase HDA3 to control transcription dynamics and bursting in Neurospora. Sci Adv. 2023; PMC10313174. doi:10.1126/sciadv.adh0721.
Oehler, M., Geisser, L., Diernfellner, A. C. R. and Brunner, M. (2023)Trim-Away degrades lysine-less substrates without requiring ligase autoubiquitination, Nat. Commun. 14: 2160. doi: doi.org/10.1038/s41467-023-37504-x.
Kiss, L., Rhinesmith, T., Dickson, C.F., Weidenhausen, J., Smyly, S., Luptak, J., Yang, J.C., Maslen, S.L., Sinning, I., Neuhaus, D., Clift, D. & James, L.C. (2023)ReLo: a simple colocalization assay to identify and characterize physical protein-protein interactions. bioRxiv. doi: https://doi.org/10.1101/2022.03.04.482790
Salgania, H.K., Metz, J., and Jeske, M. (2022)RNA binding proteins Smaug and Cup induce CCR4-NOT-dependent deadenylation of the nanos mRNA in a reconstituted system. bioRxiv. doi:https://doi.org/10.1101/2022.05.11.491288
Pekovic, F., Rammelt, C., Kubíková, J., Metz, J., Jeske, M., Wahle, E. (2022)A homologous recombination system to generate epitope-tagged target genes in Chaetomium thermophilum. Int. J. Mol. Sci., 23, 3198, doi.org/10.3390/ijms23063198.
Nikola Kellner, Sabine Griesel and Ed Hurt (2022)A Role for Liquid-Ordered Plasma Membrane Nanodomains Coordinating the Unconventional Secretory Pathway of Fibroblast Growth Factor 2? Front Cell Dev Biol. 2022 Apr 1;10:864257.
doi: 10.3389/fcell.2022.864257. eCollection 2022.
Lolicato, F., Nickel, W. (2022)Antibacterial peptide CyclomarinA creates toxicity by deregulating the Mycobacterium tuberculosis ClpC1-ClpP1P2 protease. J. Biol. Chem. 298:102202. doi: https://doi.org/10.1016/j.jbc.2022.102202.
Taylor, G., Frommherz, Y., Katikaridis, P., Layer, D., Sinning, I., Carroni, M., Weber-Ban, E. & Mogk, A. (2022)Applikationsgestützte Lernarrangements in der medizinischen Lehre. HINT Bd. 3, 141–166. https://doi.org/10.11588/hint.2022.1.92856
Demirel, E. (2022)Biochemically validated structural model of the 15-subunit intraflagellar transport complex IFT-B. The EMBO journal, 41(24), e112440. https://doi.org/10.15252/embj.2022112440
Petriman, N. A., Loureiro-López, M., Taschner, M., Zacharia, N. K., Georgieva, M. M., Boegholm, N., Wang, J., Mourão, A., Russell, R. B., Andersen, J. S., & Lorentzen, E. (2022)Casein kinase 1 and disordered clock proteins form functionally equivalent, phospho-based circadian modules in fungi and mammals. Proc Natl Acad Sci U S A. 2022; PMC8892514. doi:10.1073/pnas.2118286119.
Marzoll, D., Serrano, F. E., Shostak, A., Schunke, C., Diernfellner, A. C. R. and Brunner, M. (2022)Cholesterol promotes clustering of PI(4,5)P2 driving unconventional secretion of FGF2.
J Cell Biol. 2022 Nov 7;221(11):e202106123. doi: 10.1083/jcb.202106123. Epub 2022 Sep 29. PMID: 36173379
Lolicato F, Saleppico R, Griffo A, Meyer A, Scollo F, Pokrandt B, Müller HM, Ewers H, Hähl H, Fleury JB, Seemann R, Hof M, Brügger B, Jacobs K, Vattulainen I, Nickel W. (2022)Cms1 coordinates stepwise local 90S pre-ribosome assembly with timely snR83 release. Cell Reports 41 (8), 111684.10.1016/j.celrep.2022.111684.
Benjamin Lau, Olga Beine-Golovchuk, Markus Kornprobst, Jingdong Cheng, Dieter Kressler, Beáta Jády, Tamás Kiss, Roland Beckmann, and Ed Hurt (2022)Cryo-EM insights into tail-anchored membrane protein biogenesis in eukaryotes, Curr. Opin. Struct. Biol. 75: 102428. doi: https://doi.org/10.1016/j.sbi.2022.102428.
Sinning, I. and McDowell, M.A. (2022)Data-driven modelling captures dynamics of the circadian clock of Neurospora crassa. PLoS Comput Biol. 2022; PMC9397904. doi:10.1371/journal.pcbi.1010331.
Singh, A., Li, C., Diernfellner, A. C. R., Höfer, T. and Brunner, M. (2022)Dual nature of the nucleolus. Genes and Develop. 36, 765–769.
Alan Tartakoff, Patrick DiMario, Ed Hurt, Brian McStay, Vikram Panse and David Tollervey (2022)Emergence of the primordial pre-60S from the 90S pre-ribosome. Cell Reports 39, doi.org/10.1016/j.celrep.2022.110640.
Ismail S, Flemming D, Thoms D, Gomes-Filho J, Randau L, Beckmann R, Hurt E (2022)Eukaryotic tRNA splicing - one goal, two strategies, many players. Biological chemistry, 403(8-9), 765–778. https://doi.org/10.1515/hsz-2021-0402
Gerber, J. L., Köhler, S., & Peschek, J (2022)Extended N-Terminal Acetyltransferase Naa50 in Filamentous Fungi Adds to Naa50 Diversity. Int J Mol Sci. 2022 Sep 16;23(18):10805. doi: doi.org/10.3390/ijms231810805. PMID: 36142717; PMCID: PMC9500918.
Weidenhausen J, Kopp J, Ruger-Herreros C, Stein F, Haberkant P, Lapouge K, Sinning I (2022)Glypican-1 drives unconventional secretion of Fibroblast Growth Factor 2. Elife. 2022 Mar 29;11:e75545. doi: 10.7554/eLife.75545. Online ahead of print.
Sparn, C., Dimou, E., Meyer, A., Saleppico, R., Wegehingel, S., Gerstner, M., Klaus, S., Ewers, H. & Nickel, W. (2022)Heilpflanzen: natürlich – sicher – wirksam? Skeptiker, 35(1), 4–15.
Schling, P. (2022)High-resolution structures of a thermophilic eukaryotic 80S ribosome reveal atomistic details of translocation, Nat Comms. 13: 476. https://doi.org/10.1038/s41467-022-27967-9..
Kišonaitė, M., Wild, K., Lapouge, K., Ruppert, T. & Sinning, I. (2022)How circadian clocks keep time: the discovery of slowness. FEBS Lett. 2022; doi:10.1002/1873-3468.14432.
Partch, C. and Brunner, M. (2022)HYPK promotes the activity of the Nα-acetyltransferase A complex to determine proteostasis of nonAc-X2/N-degron-containing proteins, Sci. Adv. 8:eabn6153. doi: https://doi.org/10.1126/sciadv.abn6153.
Miklánková, P., Linster, E., Boyer, J.B., Weidenhausen, J., Mueller, J., Armbruster, L., Lapouge, K., De La Torre, C., Bienvenut, W., Sticht, C., Mann, M., Meinnel, T., Sinning, I., Giglione, C., Hell, R. & Wirtz, M. (2022)In vitro structural maturation of the primordial pre-40S coupled with U3 snoRNA release and central pseudoknot formation. Nucl. Acid Res. 50, 11916-11923.
Cheng J, La Venuta G, Lau B, Beckmann R, Hurt E (2022)Introducing the Lipidomics Minimal Reporting Checklist.
Nat Metab. 2022 Sep;4(9):1086-1088. doi: 10.1038/s42255-022-00628-3. PMID: 35934691
McDonald JG, Ejsing CS, Kopczynski D, Holčapek M, Aoki J, Arita M, Arita M, Baker ES, Bertrand-Michel J, Bowden JA, Brügger B, Ellis SR, Fedorova M, Griffiths WJ, Han X, Hartler J, Hoffmann N, Koelmel JP, Köfeler HC, Mitchell TW, O'Donnell VB, Saigusa D, Schwudke D, Shevchenko A, Ulmer CZ, Wenk MR, Witting M, Wolrab D, Xia Y, Ahrends R, Liebisch G, Ekroos K. (2022)Membranumbau durch ESCRT-III-Proteine BIOspektrum 28 363-365 (2022). https://doi.org/10.1007/s12268-022-1774-x
Moser von Filseck, J (2022)Neurospora casein kinase 1a recruits the circadian clock protein FRQ via the C-terminal lobe of its kinase domain. FEBS Lett. 2022; doi:10.1002/1873-3468.14435.
Marzoll, D., Serrano, F. E., Diernfellner, A. C. R. and Brunner, M. (2022)Never-homozygous genetic variants in healthy populations are potential recessive disease candidates. npj Genom. Med. 7, 54. https://doi.org/10.1038/s41525-022-00322-z.
Schmenger, T., Diwan, G. D., Singh, G., Apic, G., & Russell, R. B. (2022)PRECOGx: exploring GPCR signaling mechanisms with deep protein representations. Nucleic acids research, 50(W1), W598–W610. https://doi.org/10.1093/nar/gkac426
Matic, M., Singh, G., Carli, F., De Oliveira Rosa, N., Miglionico, P., Magni, L., Gutkind, J. S., Russell, R. B., Inoue, A., & Raimondi, F (2022)Regulation of mitochondrial proteostasis by the proton gradient. EMBO Journal https://www.embopress.org/doi/full/10.15252/embj.2021110476
Patron M., Tarasenko D., Nolte H., Kroczek L., Ghosh M., Ohba Y., Lasarzewski Y, Alsadat Ahmadi Z., Cabrera-Orefice A., Eyiama A, Kellermann T., Rugarli EI. , Brandt U., Meinecke M., Langer T (2022)Reticulon-like REEP4 at the inner nuclear membrane promotes nuclear pore complex formation. J Cell Biol; 221 (2): e202101049. doi: https://doi.org/10.1083/jcb.20210104
Golchoubian, B., Brunner, A., Bragulat-Teixidor, H., Neuner, A., Akarlar, B.A., Ozlu, N. & Schlaitz, A.L. (2022)The C-terminal tail of ribosomal protein Rps15 is engaged in cytoplasmic pre-40S maturation. RNA Biol. 19, 560-574.
Rössler I, Weigl S, Fernández-Fernández J, Martín-Villanueva S, Strauss D , Hurt E, de la Cruz J, Pertschy B (2022)The human signal peptidase complex acts as a quality control enzyme for membrane proteins. Science. 2022 Dec 2;378(6623):996-1000. doi: 10.1126/science.abo5672. Epub 2022 Dec 1. PMID: 36454823.
Zanotti A, Coelho JPL, Kaylani D, Singh G, Tauber M, Hitzenberger M, Avci D, Zacharias M, Russell RB, Lemberg MK, Feige MJ (2022)The inner nuclear membrane protein Lem2 coordinates RNA degradation at the nuclear periphery. Nat Struct Mol Biol. 2022 Sep;29(9):910-921. doi: 10.1038/s41594-022-00831-6. Epub 2022 Sep 19. PMID: 36123402; PMCID: PMC9507967.
Caballero, L.M., Capella, M., Barrales, R.R., Dobrev, N., van Emden, T., Fischer-Burkart, S., Kinugasa, Y., Hirano, Y., Sinning, I., Fischer, T., Hiraoka, Y. & Braun, S. (2022)The nucleoplasmic phase of pre-40S formation prior to nuclear export. Nucl. Acid Res. 50, 11924-11937.
Cheng J, Lau B, Thoms M, Ameismeier M, Berninghausen O, Hurt E, Beckmann R. (2022)The S-palmitoylome and DHHC-PAT interactome of Drosophila melanogaster S2R+ cells indicate a high degree of conservation to mammalian palmitoylomes. PloS one, 17(8), e0261543. https://doi.org/10.1371/journal.pone.0261543
Porcellato, E., González-Sánchez, J. C., Ahlmann-Eltze, C., Elsakka, M. A., Shapira, I., Fritsch, J., Navarro, J. A., Anders, S., Russell, R. B., Wieland, F. T., & Metzendorf, C. (2022)Transformation of Chaetomium thermophilum and affinity-purification of native thermostable protein complexes. Methods in Mol. Biol. 2502, 35-50.
Nikola Kellner and Ed Hurt (2022)Unconventional secretion mediated by direct protein self-translocation across the plasma membranes of mammalian cells, Trends Biochem Sci. 2022 Apr 27;S0968-0004(22)00086-X.
doi: 10.1016/j.tibs.2022.04.001. Online ahead of print.
Sparn, C., Meyer, A., Saleppico, R., Nickel, W.
(2022)Unconventional secretion mediated by direct protein self-translocation across the plasma membranes of mammalian cells. Trends Biochem Sci. 2022 Apr 27;S0968-0004(22)00086-X.
doi: 10.1016/j.tibs.2022.04.001. Online ahead of print.
Sparn, C., Meyer, A., Saleppico, R., Nickel, W. (2022)Molekulare Funktionen von Keimbahn-spezifischen Proteinen. BIOspektrum. 27, 101.
Jeske, M. (2021)Molecular functions of germline proteins. EU Research. SPR21, 18.
Jeske, M. (2021)Mechanismen des nicht konventionellen RNA-Spleißens. BIOspektrum 27(3): 233–236
Peschek, J. (2021)A short perinuclear amphipathic α-helix in Apq12 promotes nuclear pore complex biogenesis. Open biology, 11(11), 210250. https://doi.org/10.1098/rsob.210250
Zhang, W., Khan, A., Vitale, J., Neuner, A., Rink, K., Lüchtenborg, C., Brügger, B., Söllner, T. H., & Schiebel, E. (2021)CaM Kinase II-δ Is Required for Diabetic Hyperglycemia and Retinopathy but Not Nephropathy. Diabetes; 70 (2): 616–626. doi: https://doi.org/10.2337/db19-0659
Chen, J., Fleming, T., Katz, S., Dewenter, M., Hofmann, K., Saadatmand, A., Kronlage, M., Werner, M.P., Pokrandt, B., Schreiter, F., Lin, J., Katz, D., Morgenstern, J., Elwakiel, A., Sinn, P., Gröne, H.J., Hammes, H.P., Nawroth, P.P., Isermann, B., Sticht, C., Brügger, B., Katus, H.A., Hagenmueller, M. & Backs, J. (2021)Catalyzing the Understanding of Enzyme Kinetics: A Consistent Application of Constructive Alignment and Its Evaluation. 7, 7–28. https://doi.org/10.11588/hint.2021.1.84505
Béthune, J. (2021)Cellular cholesterol and how to find it. Biochim Biophys Acta Mol Cell Biol Lipids. 1866(9):158989. https://doi.org/10.1016/j.bbalip.2021.158989
Schoop, V., Martello, A., Eden, E.R., & Höglinger, D. (2021)Convergent use of phosphatidic acid for hepatitis C virus and SARS-CoV-2 replication organelle formation. Nat Commun 12, 7276. https://doi.org/10.1038/s41467-021-27511-1
Tabata, K., Prasad, V., Paul, D., Lee, J.Y., Pham, M.T., Twu, W.I., Neufeldt, C.J., Cortese, M., Cerikan, B., Stahl, Y., Joecks, S., Tran, C.S., Lüchtenborg, C., V'kovski, P., Hörmann, K., Müller, A.C., Zitzmann, C., Haselmann, U., Beneke, J., Kaderali, L., Erfle, H., Thiel, V., Lohmann, V., Superti-Furga, G., Brügger, B. & Bartenschlager, R. (2021)Cooperativity of membrane-protein and protein–protein interactions control membrane remodeling by epsin 1 and affects clathrin-mediated endocytosis. Cell. Mol. Life Sci. 78, 2355–2370. https://doi.org/10.1007/s00018-020-03647-z. PDF.
Kroppen, B., Teske, N., Yambire, K., Denkert, N., Mukherjee, I., Tarasenko, D., Jaipura, G., Zweckstetter, M., Milosevic, I., Steinem, C. & Meinecke, M. (2021)ENTH domain-dependent membrane remodelling. ENTH domain-dependent membrane remodelling. Soft matter, 17(2), 233–24. https://doi.org/10.1039/C9SM02437A
Steinem C. & Meinecke M. (2021)Global Transcriptome Characterization and Assembly of the Thermophilic Ascomycete Chaetomium thermophilum. Genes (Basel). 2021; PMC8535861. doi:10.3390/genes12101549.
Singh, A., Schermann, G., Reislöhner, S., Kellner, N., Hurt, E. and Brunner, M. (2021)Gluten Sensitivity (1st ed.). Springer. https://doi.org/10.1007/978-3-658-32657-9
Harter, C. (2021)Ice2 promotes ER membrane biogenesis in yeast by inhibiting the conserved lipin phosphatase complex. EMBO Journal. (abstract)
Papagiannidis D, Bircham PW, Lüchtenborg C, Pajonk O, Ruffini G, Brügger B, Schuck S (2021)Identification of cis-acting determinants mediating the unconventional secretion of tau. Sci Rep 11, 12946. https://doi.org/10.1038/s41598-021-92433-3
Katsinelos, T., McEwan, W.A., Jahn, T.R. & Nickel, W. (2021)Imbalances in the eye lens proteome are linked to cataract formation. Nat Struct Mol Biol. 2021 Feb;28(2):143-151. doi: 10.1038/s41594-020-00543-9. Epub 2021 Jan 11. PMID: 33432246
Schmid PWN, Lim NCH, Peters C, Back KC, Bourgeois B, Pirolt F, Richter B, Peschek J, Puk O, Amarie OV, Dalke C, Haslbeck M, Weinkauf S, Madl T, Graw J, Buchner J (2021)Inositol triphosphate-triggered calcium release blocks lipid exchange at endoplasmic reticulum-Golgi contact sites. Nat Commun 12, 2673. https://doi.org/10.1038/s41467-021-22882-x
Malek, M., Wawrzyniak, A.M., Koch, P., Lüchtenborg, C., Hessenberger, M., Sachsenheimer, T., Jang, W., Brügger, B. & Haucke, V. (2021)Mechnetor: a web server for exploring protein mechanism and the functional context of genetic variants. Nucleic Acids Res. 2021 Jul 2;49(W1):W366-W374. doi: 10.1093/nar/gkab399. PMID: 34076240
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C. Reinhard, C. Harter, M. Bremser, B. Brügger, K. Sohn. B. Helms, and F. Wieland (1999)Receptor-mediated regulation of peroxisomal motility in CHO and endothelial cells. EMBO J. 18, 5476-5485.
C.M. Huber, R. Saffrich, W. Ansorge and W.W. Just (1999)Synthesis of alternative substrates for trypanothione reductase and thioredoxin reductase: an inexpensive microtiter colorimetric assay for inhibitor screening. Anal. Biochem. 268:1–8.
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P.T. Thai, C. Rodemer, J. Worsch, A. Hunziker, K. Gorgas and W.W. Just (1999)Synthesis of polyamine derivatives for the preparation of affinity chromatography columns for the search of new Trypanosoma cruzi targets. Bioorg. Med. Chem. Lett. 9:1567–72.
Davioud-Charvet E, Berecibar A, Girault S, Landry V, Drobecq H, Sergheraert C. (1999)The cytochrome bc1 complex from Rhodovulum sulfidophilum is a dimer with six quinones per monomer and an additional 6-kDa component, Eur. J. Biochem. 259: 709-718.
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Katahira, J., K. Sträßer, A. Podtelejnikov, M. Mann, J. U. Jung, and E. C. Hurt (1999)The TIM17.23 preprotein translocase of mitochondria: composition and function in protein transport into the matrix. Embo j. 1999; PMC1171444. doi:10.1093/emboj/18.13.3667.
Moro, F., Sirrenberg, C., Schneider, H. C., Neupert, W. and Brunner, M. (1999)Three v-SNAREs and two t-SNAREs, present in a pentameric cis-SNARE complex on isolated vacuoles, are essential for homotypic fusion. J. Cell Biol. 145; 1435-42.
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Endres, M., Neupert, W. and Brunner, M. (1999)tRNA aminoacylation - a visa to leave the nucleus. Curr. Biol. 9:R238 - R241.
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S. Siniossoglou, H. Santos-Rosa, J. Rappsilber, M. Mann and E. Hurt (1998)A putative heterotrimeric G protein inhibits the fusion of COPI-coated vesicles. Segregation of heterotrimeric G proteins from COPI-coated vesicles. J Biol Chem. 273(24):15203-8.
Helms JB, Helms-Brons D, Brügger B, Gkantiragas I, Eberle H, Nickel W, Nürnberg B, Gerdes HH, Wieland FT. (1998)A single binding site for di-lysine motifs and p23 within the g-subunit of coatomer. Proc. Natl. Acad. Sci. USA. 95,11649-11654
C. Harter, and F. Wieland (1998)A tRNA-binding domain within Arc1p delivers tRNA to two aminoacyl-tRNA synthetases. Molecular Cell 1, 235 - 242.
G. Simos, A. Sauer, F. Fasiolo, and E.C. Hurt (1998)Affinity Purification of Protein A-Tagged Nuclear Pore Proteins from Yeast. Cell Biology A Laboratory Hand Book. Academic Press. Second Edition. Vol. 2, 159 - 164.
S. Siniossoglou, P. Grandi, and E.C. Hurt (1998)Arrangement of subunits in 20 S particles consisting of NSF, SNAPs, and SNARE complexes. Mol. Cell, 2: 539-548.
Hohl., T.M., Parlati, F., Wimmer, C., Rothman, J.E., Söllner, T.H., and Engelhardt, H. (1998)Biogenesis of Tim23 and Tim17, integral components of the TIM machinery for matrix-targeted preproteins. Embo j. 1998; PMC1170504. doi:10.1093/emboj/17.6.1569.
Káldi, K., Bauer, M. F., Sirrenberg, C., Neupert, W. and Brunner, M. (1998)Biosynthetic Protein Transport Through the Early Secretory Pathway. Histochem. Cell Biol. 109:477-486 (Review).
Walter Nickel and Felix T. Wieland (1998)C- to N-terminal translocation of preproteins into mitochondria. Embo j. 1998; PMC1170998. doi:10.1093/emboj/17.22.6508.
Fölsch, H., Gaume, B., Brunner, M., Neupert, W. and Stuart, R. A. (1998)Characterization of yeast protein Deg1 as Pseudouridine synthase (Pus3) catalyzing the formation of Y38 and Y39 in tRNA anticodon loop. J. Biol. Chem. 273, 1316-1323.
F. Lecointe, G. Simos, A.Sauer, E.C. Hurt, Y. Motorin, and H. Grosjean (1998)Crystallization and preliminary X-ray diffraction studies of phospho-adenylylsulfate (PAPS) reductase from E. coli. Acta crystallographica. Section D, Biological crystallography, 54(Pt 2), 281–283. https://doi.org/10.1107/s0907444997010019
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M. Künzler and E.C. Hurt (1998)Distinct functions of calmodulin are required for the uptake step of receptor mediated-endocytosis in yeast: the type I myosin Myo5p is one of the calmodulin targets. EMBO J., 17, 635-647.
M. Isabel Geli, Andreas Wesp, and Howard Riezman. (1998)Endocytic internalization in yeast and animal cells:similar and different. J. Cell Sci. 111, 1031-1037.
M. Isabel Geli and Howard Riezman. (1998)Functional organization of the Golgi apparatus in glycosphingolipid biosynthesis. Lactosylceramide and subsequent glycosphingolipids are formed in the lumen of the late Golgi. J.Biol.Chem. 273:2939-2946.
Lannert, H., K. Gorgas, I. Meissner, F.T. Wieland, and D. Jeckel (1998)Fzo1p is a mitochondrial outer membrane protein essential for the biogenesis of functional mitochondria in Saccharomyces cerevisiae. J Biol Chem. 1998; doi:10.1074/jbc.273.32.20150.
Rapaport, D., Brunner, M., Neupert, W. and Westermann, B. (1998)Intracellular Transport of Glycoproteins and Glycolipids. Trends Glycosci. Glycotechnolog. 10:1-11 (Review).
Walter Nickel, Britta Brügger, and Felix T. Wieland (1998)Molecular Architecture of the Yeast Nuclear Pore Complex: Localization of Nsp1p Subcomplexes. J. Cell Biol. 143, 577 ? 588.
B. Fahrenkrog, E.C. Hurt, U. Aebi, and N. Panté (1998)Mtr10p Functions as a Nuclear Import Receptor for the mRNA Binding Protein Npl3p. EMBO J. 17, 2196-2207.
B. Senger, G. Simos, F.R. Bischoff, A. Podtelejnikov, M. Mann, and E.C. Hurt (1998)Nuclear compartments and nuclear machines. Curr. Opin. Cell Biol. 10, 301 - 303.
E. Hurt and G. Schütz (1998)Nuclear mRNA Export Requires Complex Formation between Mex67p and Mtr2p at the Nuclear Pores. Mol. Cell. Biol. 18(11) 6826-6838.
H. Santos-Rosa, H. Moreno, G. Simos, A. Segref, B. Fahrenkrog, N. Panté, and E.C. Hurt (1998)Nup116p and Nup100p are Interchangeable through a Conserved Motif which Constitutes a Binding Site for the mRNA Transport Factor Gle2p/Nup40p. EMBO J. 17, 1107-1119.
S. Bailer, S. Siniossoglou, S. Podtelejnikov, A. Hellwig, M. Mann, and E.C. Hurt (1998)Peroxisome biogenesis: involvement of ARF and coatomer. J. Cell Biol. 141, 373-383.
M. Passreiter, M. Anton, D. Lay, R. Frank, C. Harter, F.T. Wieland, K. Gorgas and W.W. Just (1998)Protein and lipid sorting between the endoplasmic reticulum and the Golgi complex. Semin Cell Dev Biol. 9(5):493-501. Review.
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J. Pavel, C. Harter, and F. Wieland (1998)SNAREpins: minimal machinery for membrane fusion. Cell, 92: 759-772.
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Walter Nickel, Jörg Malsam, Karin Gorgas, Mariella Ravazzola, Nicole Jenne, J. Bernd Helms, and Felix T. Wieland (1998)Yeast Los1p Has Properties of an Exportin-Like Nucleocytoplasmic Transport Factor for tRNA. Mol. Cell. Biol. 18(11) 6374-6386.
K. Hellmuth, D. Lau, R. Bischoff, M. Künzler, E.C. Hurt, and G. Simos (1998)Yeast tRNA: pseudouridine synthase (Pus1p) displays a multisite substrate specificity. RNA 4, 856 - 869.
Y. Motorin, G. Keith, C. Simon, D. Foiret, G. Simos, E. Hurt, and H. Grosjean (1998)A heterotrimeric G protein-phospholipase A2 signaling cascade is involved in the regulation of peroxisomal motility in CHO cells. J. Cell Sci. 110, 2955-2968.
C.M. Huber, R. Saffrich, M. Anton, M. Paßreiter, W. Ansorge, K. Gorgas and W.W. Just (1997)Assembly of immunoglobulin light chains as a prerequisite for secretion. A model for oligomerization-dependent subunit folding. J Biol Chem. 272(5):3117-23.
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Walter Nickel and Felix T. Wieland (1997)Crystal structure of phosphoadenylyl sulphate (PAPS) reductase: a new family of adenine nucleotide alpha hydrolases. Structure (London, England : 1993), 5(7), 895–906. https://doi.org/10.1016/s0969-2126(97)00244-x
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B. Pause, P. Diestelkötter, H. Heid and W.W. Just (1997)Differential fate of glycoproteins carrying a monoglucosylated form of truncated N-glycan in a new CHO line, MadIA214214, selected for a thermosensitive secretory defect. J Cell Sci. 110 ( Pt 3):323-36
Ermonval M, Cacan R, Gorgas K, Haas IG, Verbert A, Buttin G. (1997)Direct and GTP-dependent interaction of ADP ribosylation factor 1 with coatomer subunit beta. Proc Natl Acad Sci USA 94(9):4418-23.
Zhao L, Helms JB, Brügger B, Harter C, Martoglio B, Graf R, Brunner J, Wieland FT. (1997)Ether lipid biosynthesis: isolation and molecular characterization of human dihydroxyacetonephosphate acyltransferase. FEBS-Lett. 420, 205-211.
P.T. Thai, H. Heid, H-R. Rackwitz, A. Hunziker, K. Gorgas and W.W. Just (1997)Expression, crystallization and preliminary X-ray diffraction study of FtsY, the docking protein of the signal recognition particle of E. coli. Proteins, 28(2), 285–288. https://doi.org/10.1002/(sici)1097-0134(199706)28:2<285::aid-prot15>3.0.co;2-e
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V. Doye, and E.C. Hurt (1997)Functional cooperation and stoichiometry of protein translocases of the outer and inner membranes of mitochondria. J Biol Chem. 1997; doi:10.1074/jbc.272.47.29963.
Sirrenberg, C., Endres, M., Becker, K., Bauer, M. F., Walther, E., Neupert, W. and Brunner, M. (1997)In Vitro Reconstitution of a Heterotrimeric Nucleoporin Complex Consisting of Recombinant Nsp1p, Nup49p and Nup57p. Mol. Biol. Cell 8,33-46.
N.L. Schlaich, M. Häner, U. Aebi, and E.C. Hurt (1997)Mammalian protein RAP46: an interaction partner and modulator of 70 kDa heat shock proteins. EMBO J. 16, 5483-5490.
Zeiner, M., Gebauer, M., Gehring, U. (1997)Membrane association of FtsY, the E. coli SRP receptor. FEBS letters, 416(3), 225–229. https://doi.org/10.1016/s0014-5793(97)01238-6
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A. Segref, K. Sharma, V. Doye, A. Hellwig, J. Huber, R. Lührmann, and E.C. Hurt (1997)Nucleolar KKE/D Repeat Proteins Nop56p and Nop58p Interact with Nop1p and Are Required for Ribosome Biogenesis. Mol. Cell. Biol. 17, 7088-7098.
T. Gautier, T. Bergès, D. Tollervey, and E.C. Hurt (1997)Nup93a, a Vertebrate Homolog of Yeast Nic96p Form a Complex with a Novel 205 kDa Protein and Are Involved in Nuclear Pore Assembly and Nuclear Growth. Mol. Biol. Cell. 8, 2017 - 2038.
P. Grandi, T. Dang, N. Panti, A. Shevchenko, M. Mann, D. Forbes, and E.C. Hurt (1997)p23, a major COPI-vesicle membrane protein, constitutively cycles through the early secretory pathway. Proc. Natl. Acad. Sci. U.S.A. 94, 11393-11398.
W. Nickel, K. Sohn, C. Bünning, and F. Wieland (1997)Protein-Reifung: Transport, Faltung und Abbau. Biospektrum 4: 22-24 (Review).
Walter Nickel and Klaus Leitzgen (1997)Quantitative analysis of biological membrane lipids at the low picomole level by nano-electrospray ionization tandem mass spectrometry. Proc Natl Acad Sci USA 94(6):2339-44.
Brügger B, Erben G, Sandhoff R, Wieland FT, Lehmann WD. (1997)The crystal structure of the catalytic core domain of endoglucanase I from Trichoderma reesei at 3.6 A resolution, and a comparison with related enzymes. Journal of molecular biology, 272(3), 383–397. https://doi.org/10.1006/jmbi.1997.1243
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Gebauer, M., Zeiner, M., Gehring, U. (1997)The mechanism of thioredoxin reductase from human placenta is similar to the mechanism of lipoamide dehydrogenase and glutathione reductase and distinct from that of thioredoxin reductase from Escherichia coli. Proc Natl Acad Sci USA 94, 3126-3626
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M.T. Teixeira, S. Siniossoglou, S. Podtelejnikov, J.-C. Binichou, M. Mann, E.C. Hurt, and E. Fabre (1997)Yeast genetics to dissect the nuclear pore complex and nucleocytoplasmic trafficking. Ann. Rev. Genet. 31, 277-313.
E. Fabre, and E.C. Hurt (1997)Yeast mitochondrial F1F0-ATPase: the novel subunit e is identical to Tim11. FEBS Lett. 1997; doi:10.1016/s0014-5793(97)00691-1.
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K. Sohn, L. Orci, M. Ravazzola, M. Amherdt, M. Bremser, F. Lottspeich, K. Fiedler, J. B. Helms, and F. Wieland (1996)A novel complex of nucleoporins, which includes Sec13p and Sec13p homolog, is essential for normal nuclear pores. Cell 84, 265 - 275.
S. Siniossoglou, C. Wimmer, M. Rieger, V. Doye, H. Tekotte, C. Weise, S. Emig, A. Segref, and E.C. Hurt (1996)A v-SNARE implicated in intra-Golgi transport. J. Cell. Biol, 133: 507-516
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U. Zabel, V. Doye, H. Tekotte, R. Wepf, and E.C. Hurt (1996)Architecture of coatomer: molecular characterization of d-COP and protein interactions within the complex. J. Cell Biol. 135, 53-61.
D. Faulstich, S. Auerbach, L. Orci, M. Ravazzola, S. Wegehingel, F. Lottspeich, G. Stenbeck, C. Harter, F. T. Wieland, and H. Tschochner (1996)Biosynthesis of human chorionic gonadotropin: a review. Eur.J.Endocrinol. 135, 269-284.
Merz, W.E. (1996)Determinants in the presequence of cytochrome b2 for import into mitochondria and for proteolytic processing. Eur J Biochem. 1996; doi:10.1111/j.1432-1033.1996.00856.x.
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Walter Nickel, J. Bernd Helms, Richard E. Kneusel, and Felix T. Wieland (1996)Import of carrier proteins into the mitochondrial inner membrane mediated by Tim22. Nature. 1996; doi:10.1038/384582a0.
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E.C. Hurt (1996)Long-term effect of cyclic AMP on N-glycosylation is caused by an increase in the activity of the cis-prenyl-transferase. Biochem.J. 316, 575-581.
Konrad, M. and Merz, W.E. (1996)Mechanism of chaperonin action: GroES binding and release can drive GroEL-mediated protein folding in the absence of ATP. EMBO J. (15), 6111-6121.
M.K. Hayer-Hartl, F. Weber and F.U. Hartl (1996)MHP1, an essential gene in Saccharomyces cervisiae required for microtubule function. J. Cell Biology 135, 1323 - 1340.
I. Irminger-Finger, E.C. Hurt, A. Roebuck, M. A. Collart, and S.J. Edelstein (1996)Microtubule-based peroxisome movement. J. Cell Sci. 109, 837-849.
S. Rapp, R. Saffrich, M. Anton, U. Jäkle, W. Ansorge, K. Gorgas and W.W. Just (1996)NBP35 encodes an essential and evolutionary conserved protein in Saccharomyces cerevisiae with homology to a superfamily of bacterial ATPases. Gene 178, 97-106.
G. Vitale, E. Fabre, and E.C. Hurt (1996)Non-clathrin-coat protein g, a subunit of coatomer, binds to the cytoplasmic dilysine motif of membrane proteins of the early secretory pathway. Proc. Natl. Acad. Sci. U.S.A. 93, 1902-1906
C. Harter, J. Pavel, F. Coccia, E. Draken, S. Wegehingel, H. Tschochner, and F. Wieland (1996)Nuclear Pore Proteins are Required for the Biogenesis of Functional tRNA. EMBO J. 15, 2285-2290.
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W.W. Just and P. Diestelkötter (1996)Protein sorting by transport vesicles. Science 272, 227-234.
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M. Isabel Geli and Howard Riezman. (1996)The nucleotide exchange factor MGE exerts a key function in the ATP-dependent cycle of mt-Hsp70-Tim44 interaction driving mitochondrial protein import. Embo j. 1996; PMC452327.
Schneider, H. C., Westermann, B., Neupert, W. and Brunner, M. (1996)The Saccharomyces cerevisiae kinetochore contains a cyclin-CDK complexing homologue, as identified by in vitro reconstitution. Embo J 15:3611-20.
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