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SFB 638 Projects and PIs

Project	Title	Field of research	Principal investigator(s), institute, location		Duration of tenure
A	*Biosynthetic transport from the ribosome to the endomembrane system*
A1	Mechanism of action of ribosome-associated chaperones in co-translational folding and transport of proteins	Molecular Biology, Biochemistry	Bukau, Bernd Deuerling, Elke (01/2004 - 03/2007) Kramer, Günter (04/2007 – 12/2015) ZMBH Heidelberg		2004 - 2015
A2	Signal peptides and the insertion of tail-anchored (TA) proteins into the membrane of the endoplasmic reticulum	Cell Biology	Dobberstein, Bernhard ZMBH Heidelberg		2004 - 2011
A3	Structure and dynamics of protein/RNA complexes in SRP-mediated protein transport	Protein Crystallography, Structural Biology, Biochemistry	Sinning, Irmgard Wild, Klemens (01/2012 – 12/2015) BZH Heidelberg		2004 - 2015
A4	Mechanism and regulation of Arginine-signal mediated ER localization	Biochemistry, Molecular Cell Biology	Schwappach, Blanche ZMBH Heidelberg		2004 - 2007
A5	Biogenesis, structure and dynamics of flaviviral replication complexes	Molecular and Cellular Biology of Dengue Virus Replication and Assembly	Bartenschlager, Ralf Medizinische Fakultät Heidelberg		2004 - 2015
A7	Biogenesis of peroxisomes	Biochemistry, Molecular Cell Biology	Just, Wilhelm BZH Heidelberg		2004 - 2007
A8	Unconventional protein secretion	Molecular Cell Biology, Biochemistry	Nickel, Walter BZH Heidelberg		2004 - 2015
A9	Formation and dynamic alterations of retroviral transport, assembly and budding complexes	Virology, Cell Biology	Kräusslich, Hans-Georg Medizinische Fakultät Heidelberg		2004 - 2015
A10	Dynamics of COPI assembly	Cell Biology, Biochemistry	Brügger, Britta Wieland, Felix T. BZH Heidelberg		2004 - 2015
A11	Modulation of architecture and function of the immunological synapse by the HIV pathogenesis factor Nef	Virology, Cell Biology	Fackler, Oliver T. Medizinische Fakultät Heidelberg		2004 - 2015
A13	Mechanism and dynamics of Hsp70- and Hsp90-assisted folding of eukaryotic transcription factors and kinases	Molecular Biology, Biochemistry, Biophysics	Mayer, Matthias Peter ZMBH Heidelberg		2004 - 2015
A15	Coordination and regulation of the homotypic fusion of yeast vacuoles; mechanism and function of the palmitoylation of fusion factors	Biochemistry, Molecular Cell Biology	Ungermann, Christian BZH Heidelberg		2004 - 2005 Some PhD-projects are continued in the SFB 431 of the University of Osnabrück.
A16	Structural dynamics of coatomer	Structural Biology, Membrane Traffic	Briggs, John EMBL Heidelberg Wieland, Felix T. BZH Heidelberg		2008 - 2015
A18	Structure and dynamics of the protein O-mannosylation machinery	Biochemistry, Glycobiology, Molecular Biology	Strahl, Sabine COS Heidelberg		2008 - 2015
A19	Structure and dynamics of protein complexes in tail-anchored membrane protein biogenesis	Cell Biology	Sinning, Irmgard Maria BZH Heidelberg		2012 - 2015
B	*The transport between nucleus and cytoplasm*
B1	Transport between nucleus and cytoplasm	Molecular Cell Biology		Görlich, Dirk ZMBH Heidelberg	2004 - 2007
B2	Structure, function and reconstitution of the nuclear pore complex	Biochemistry, Molecular Cell Biology, Structural Biology		Hurt, Ed Flemming, Dirk (01/2012 – 12/2015 BZH Heidelberg	2004 - 2015
B3	Formation, maturation and nuclear export of mRNPs	Biochemistry, Molecular Cell Biology, Structural Biology		Hurt, Ed Rodriguez-Navarro, Susana (01/2004 – 04/2004) Köhler, Alwin (01/2008 – 12/2009) BZH Heidelberg	2004 - 2015
B4	Temporal and spatial dynamics of the circadian clock of Neurospora	Biochemistry		Brunner, Michael BZH Heidelberg	2004 - 2015
B5	Regulation of complexes involved in spindle positioning	Biochemistry, Cell Biology		Liakopoulos, Dimitris BZH Heidelberg	10/2005 – 09/2010 (Junior Research Group)
B7	Nuclear envelope insertion of the yeast centrosome	Cdc14, Cell Cycle Regulation, Spindle Assembly, Spindle Pole Body, Human Centrosome Duplication		Schiebel, Elmar ZMBH Heidelberg	2008 - 2015
B8	Sumoylation of nuclear transport receptors	Biochemistry, Cell Biology, Posttranslational Modification, Ubiquitin Related Proteins, SUMO, Nucleocytoplasmic Transport		Melchior, Frauke ZMBH Heidelberg	2012 - 2015
B9	Coupling of RNA quality control to nuclear export	Biochemistry, Molecular Cell Biology		Fischer,Tamás BZH Heidelberg	2012 - 2015
Z1	Protein analysis by mass spectrometry	Bioanalytic Research		Lechner, Johannes BZH Heidelberg Ruppert, Thomas ZMBH Heidelberg	2004-2015
Z2	Central tasks - administration			Wieland, Felix T. BZH Heidelberg	2004 - 2015
Z2 Lump sum funds	Role of COPI transport vesicles in mRNA localization and regulation	Molecular Cell Biology		Béthune, Julien BZH Heidelberg	07/2013 – 12/2015 (Junior Research Group)
Z3	Flow Cytometry/Fluorescence Activated Cell Sorting (FACS)	Cell Biology, Molecular Biology		Sourjik, Victor (01/2008 – 10/2013) Knop, Michael (11/2013 – 12/2015) ZMBH Heidelberg	2008 - 2015
Z4	HTP-Protein crystallization platform and X-ray structure determination	Structural Biology		Sinning, Irmgard Maria BZH Heidelberg	2012 - 2015

New Positions of PIs:

A 2: Signal peptides and the insertion of proteins into
the membrane of the endoplasmatic reticulum
(terminated on January 1st, 2012)

Principal investigator: Prof. Dr. Bernhard Dobberstein
now: Professor emeritus

A 4: Mechanism and regulation of Arginine-signal mediated ER
localization(terminated on January 1st, 2008)

Principal investigator: Dr. Blanche Schwappach,
now: University Medical Center Göttingen

A 7: Biogenesis of peroxisomes (terminated on January 1st, 2008)

Principal investigator: Prof. Dr. Wilhelm Just, BZH, Heidelberg
now: Professor emeritus

A 15: Coordination and regulation of yeast homotypic vacuole fusion;
mechanism and function of palmitoylation of fusion factors
(terminated on January 1st, 2006)

Principal investigator: Prof. Dr. Christian Ungermann,
now: Speaker of the SFB 944, University of Osnabrück

B 1: Transport between nucleus and cytoplasm
(terminated on January 1st, 2008)

Principal investigator: Prof. Dr. Dirk Görlich,
now: Director of the Max-Planck-Institut für biophysikalische Chemie, Göttingen

B 5: Regulation of complexes involved in spindle positioning
(Junior Research Group funded from October 2005 to September 2010)

Principal investigator: Dr. Dimitris Liakopoulos,
now: Centre de Recherche de Biochimie Macromoléculaire, Montpellier

Dr. Elke Deuerling, TP A1
(from January 2004 - March 2007)

now: Professor, University of Konstanz, Department of Biology

Dr. Alwin Köhler, TP B3
(from Januaray 2008 - December 2009)

now: Junior Group Leader, Max F. Perutz Laboratories, Vienna, Austria

Dr. Susana Rodriguez-Navarro, TP B3
(from January - April 2004)

now: Group Leader, Prince Felipe Research Centre (CIPF), Valencia

Prof. Dr. Victor Sourjik, TP Z3
(from January 2012 - October 2013)

now: Max-Planck-Institute of Terrestrial Microbiology in Marburg

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SFB 638 Projects and PIs

Title

New Positions of PIs:

A 2: Signal peptides and the insertion of proteins into the membrane of the endoplasmatic reticulum (terminated on January 1st, 2012)

A 4: Mechanism and regulation of Arginine-signal mediated ER localization(terminated on January 1st, 2008)

A 7: Biogenesis of peroxisomes (terminated on January 1st, 2008)

A 15: Coordination and regulation of yeast homotypic vacuole fusion; mechanism and function of palmitoylation of fusion factors (terminated on January 1st, 2006)

B 1: Transport between nucleus and cytoplasm (terminated on January 1st, 2008)

B 5: Regulation of complexes involved in spindle positioning (Junior Research Group funded from October 2005 to September 2010)

Dr. Elke Deuerling, TP A1 (from January 2004 - March 2007)

Dr. Alwin Köhler, TP B3 (from Januaray 2008 - December 2009)

Dr. Susana Rodriguez-Navarro, TP B3 (from January - April 2004)

Prof. Dr. Victor Sourjik, TP Z3 (from January 2012 - October 2013)