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BIOCHEMIEZENTRUM HEIDELBERG UNIVERSITY OF HEIDELBERG
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Groupleader: Cristina Paulino

Structural Biology 

Group Leader Cristina Paulino

Cristina Paulino

Structural Biology

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Information 


RESEARCH FOCUS

The Paulino Lab is focused on elucidating the mechanism of action of membrane transporters (secondary- and primary-active) and channels on a molecular level. Although of high pharmacological relevance (> 60% of current drugs target membrane proteins), how their three-dimensional structure relates to their function and vice-versa is poorly understood and requires an interdisciplinary approach at the interface of biology, chemistry and physics. To address these questions, we employ cryo-electron microscopy and contrast our findings with comprehensive functional studies. Projects in our group are driven by the fundamental question of how membrane transporters work: how does the protein architecture translate into function; what is the exact mechanism of action during translocation of compounds from one side of the membrane to the other; how are they regulated; how is malfunction related to a disease? Over the past years, we have gained a particular interest in membrane transport proteins that fall out-of-the-box, challenging the conceptual boundaries present when classifying transport mechanisms into merely primary-active transporters, secondary-active transporters, or channels. It is becoming increasingly evident that in the course of evolution conserved protein architectures not only evolved from one another but can merge together to adapt to different environmental and cellular requirements.

For more details, please visit the lab homepage: www.paulinolab.com

CV 


since 2023        Professor in Structural Biology
                                Heidelberg University Biochemistry Center

2022-2023       Associate Professor & Head of the cryo-EM facility
                                 University of Groningen, The Netherlands

2017-2022       Assistant Professor & Head of cryo-Electron Microscopy Unit
                                 University of Groningen, The Netherlands

2014-2017       Postdoctoral Fellow with Prof. Raimund Dutzler
                                 University of Zurich, Switzerland

2008-2014       PhD Student
                                 Max-Planck Institute of Biophysics, Frankfurt a. M.

Lab Members 



Ursula Göbel
TA

Lab:Room 221 / Phone: +49 6221 54-5343
Mail:uschi.goebel@bzh.uni-heidelberg.de

 RoomPhone
LAB 221 +49 6221 54-5343
E-Mail uschi.goebel@bzh.uni-heidelberg.de
Linda Markus
PhD student

Lab:Room 425 / Phone: +49 6221 54-4176
Mail:linda.markus@bzh.uni-heidelberg.de

 RoomPhone
LAB 425 +49 6221 54-4176
E-Mail linda.markus@bzh.uni-heidelberg.de
Martin Peter
postdoc

Office:Room 425 / Phone: +49 6221 54-4176
Mail:martin.peter@bzh.uni-heidelberg.de

 RoomPhone
OFFICE 425 +49 6221 54-4176
E-Mail martin.peter@bzh.uni-heidelberg.de
Jan Rheinberger
postdoc

Office:Room 264 b / Phone: +49 6221 54-4122
Mail:jan.rheinberger@bzh.uni-heidelberg.de

 RoomPhone
OFFICE 264 b +49 6221 54-4122
E-Mail jan.rheinberger@bzh.uni-heidelberg.de

Publications 


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Open Positions 


Contact



Heidelberg University
Biochemistry Center (BZH)
Im Neuenheimer Feld 328
69120 Heidelberg

Office:
+49 6221 54-4173
Fax:
+49 6221 54-4369
E-Mail:
cristina.paulino@bzh.uni-heidelberg.de


LOGO Biochemizentrum Heidelberg Heidelberg University Biochemistry Center (BZH)
Im Neuenheimer Feld 328
69120 Heidelberg
RESEARCH GROUPS
  • Brügger
  • Brunner
  • Höglinger
  • Jeske
  • Meinecke
  • Moser von Filseck
  • Nickel
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  • Russell
  • Schuck
  • Sinning
  • Söllner
  • Former Research Groups »
PAGES
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    • Ed Hurt
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