Molecular insight into the network of Drosophila cytoplasmic piRNA pathway proteins through a combination of systematic interaction screening and structural prediction. bioRxiv. doi:

Salgania, H.K., Metz, J., Lingren, E., Bleischwitz, C., Hauser, D., Oliveras Máté, K., Bollack, D., Lahr, F.,Garbelyanski, A., Jeske, M. (2024)

ReLo is a simple and rapid colocalization assay to identify and characterize direct protein–protein interactions. Nat Commun. 15(1):2875

Salgania, H.K., Metz, J., Jeske, M. (2024)

RNA binding proteins Smaug and Cup induce CCR4-NOT-dependent deadenylation of the nanos mRNA in a reconstituted system. Nucleic Acids Research, 51 (8), 3950–3970.

Pekovic, F., Rammelt, C., Kubíková, J., Metz, J., Jeske, M., Wahle, E. (2023)

Structural basis for binding of Smaug to the GPCR Smoothened and to the germline inducer Oskar. bioRxiv. doi:

Kubíková, J., Ubartaitė, G., Metz, J., Jeske, M. (2023)

Structural basis for binding of Drosophila Smaug to the GPCR Smoothened and to the germline inducer Oskar. Proceedings of the National Academy of Sciences 120: e2304385120.

Kubíková, J., Ubartaitė, G., Metz, J., Jeske, M. (2023)

Adaptation to glucose starvation is associated with molecular reorganization of the circadian clock in Neurospora crassa. Elife. 2023; PMC9831608. doi:10.7554/eLife.79765.

Szőke, A., Sárkány, O., Schermann, G., Kapuy, O., Diernfellner, A. C. R., Brunner, M., Gyöngyösi, N. and Káldi, K. (2023)

Antisense Transcription of the Neurospora Frequency Gene Is Rhythmically Regulated by CSP-1 Repressor but Dispensable for Clock Function. J Biol Rhythms. 2023; doi:10.1177/07487304231153914.

Cemel, I. A., Diernfellner, A. C. R. and Brunner, M. (2023)

DEAD-box RNA helicases act as nucleotide exchange factors for casein kinase 2, Sci Signal 16: eabp8923. doi:

Fatti, E., Hirth, A., Švorinić, A., Günther, M., Cruciat, C.M., Stier, G., Acebron, S.P., Papageorgiou, D., Sinning, I., Krijgsveld, J., Höfer , T. & Niehrs, C. (2023)

Mechanistic insights into RNA surveillance by the canonical poly(A) polymerase Pla1 of the MTREC complex, Nat Commun. 14: 772. doi:

Soni, K., Sivadas, A., Horváth, A., Dobrev, N., Hayashi, R., Kiss, L., Simon, B., Wild, K. & Sinning*, I, Fischer*, T. (2023)

Methionine aminopeptidase 2 and its autoproteolysis product have different binding sites on the ribosome, bioRxiv doi: 535065.

Klein, M.A., Wild, K., Kisonaite, M. & Sinning, I. (2023)

Quantification of Dolichyl Phosphates Using Phosphate Methylation and Reverse-Phase Liquid Chromatography-High Resolution Mass Spectrometry.
Anal Chem. 2023 Feb 14;95(6):3210-3217. doi: 10.1021/acs.analchem.2c03623. Epub 2023 Jan 30. PMID: 36716239

Kale D, Kikul F, Phapale P, Beedgen L, Thiel C, Brügger B. (2023)

Structural inventory of cotranslational protein folding by the eukaryotic RAC complex, Structural inventory of cotranslational protein folding by the eukaryotic RAC complex, Nat. Struct. Mol. Biol. Apr 20. doi: (online ahead of print).

Kišonaitė, M., Wild, K., Lapouge, K., Valentín Gesé, G., Kellner, N., Hurt, E. & Sinning, I. (2023)

Transcription activator WCC recruits deacetylase HDA3 to control transcription dynamics and bursting in Neurospora. Sci Adv. 2023; PMC10313174. doi:10.1126/sciadv.adh0721.


Oehler, M., Geisser, L., Diernfellner, A. C. R. and Brunner, M. (2023)

Trim-Away degrades lysine-less substrates without requiring ligase autoubiquitination, Nat. Commun. 14: 2160. doi:

Kiss, L., Rhinesmith, T., Dickson, C.F., Weidenhausen, J., Smyly, S., Luptak, J., Yang, J.C., Maslen, S.L., Sinning, I., Neuhaus, D., Clift, D. & James, L.C. (2023)

ReLo: a simple colocalization assay to identify and characterize physical protein-protein interactions. bioRxiv. doi:

Salgania, H.K., Metz, J., and Jeske, M. (2022)

RNA binding proteins Smaug and Cup induce CCR4-NOT-dependent deadenylation of the nanos mRNA in a reconstituted system. bioRxiv. doi:

Pekovic, F., Rammelt, C., Kubíková, J., Metz, J., Jeske, M., Wahle, E. (2022)

A homologous recombination system to generate epitope-tagged target genes in Chaetomium thermophilum. Int. J. Mol. Sci., 23, 3198,

Nikola Kellner, Sabine Griesel and Ed Hurt (2022)

A Role for Liquid-Ordered Plasma Membrane Nanodomains Coordinating the Unconventional Secretory Pathway of Fibroblast Growth Factor 2? Front Cell Dev Biol. 2022 Apr 1;10:864257.
doi: 10.3389/fcell.2022.864257. eCollection 2022.

Lolicato, F., Nickel, W. (2022)

Antibacterial peptide CyclomarinA creates toxicity by deregulating the Mycobacterium tuberculosis ClpC1-ClpP1P2 protease. J. Biol. Chem. 298:102202. doi:

Taylor, G., Frommherz, Y., Katikaridis, P., Layer, D., Sinning, I., Carroni, M., Weber-Ban, E. & Mogk, A. (2022)

Applikationsgestützte Lernarrangements in der medizinischen Lehre. HINT Bd. 3, 141–166.

Demirel, E. (2022)

Biochemically validated structural model of the 15-subunit intraflagellar transport complex IFT-B. The EMBO journal, 41(24), e112440.

Petriman, N. A., Loureiro-López, M., Taschner, M., Zacharia, N. K., Georgieva, M. M., Boegholm, N., Wang, J., Mourão, A., Russell, R. B., Andersen, J. S., & Lorentzen, E. (2022)

Casein kinase 1 and disordered clock proteins form functionally equivalent, phospho-based circadian modules in fungi and mammals. Proc Natl Acad Sci U S A. 2022; PMC8892514. doi:10.1073/pnas.2118286119.

Marzoll, D., Serrano, F. E., Shostak, A., Schunke, C., Diernfellner, A. C. R. and Brunner, M. (2022)

Cholesterol promotes clustering of PI(4,5)P2 driving unconventional secretion of FGF2.
J Cell Biol. 2022 Nov 7;221(11):e202106123. doi: 10.1083/jcb.202106123. Epub 2022 Sep 29. PMID: 36173379

Lolicato F, Saleppico R, Griffo A, Meyer A, Scollo F, Pokrandt B, Müller HM, Ewers H, Hähl H, Fleury JB, Seemann R, Hof M, Brügger B, Jacobs K, Vattulainen I, Nickel W. (2022)

Cms1 coordinates stepwise local 90S pre-ribosome assembly with timely snR83 release. Cell Reports 41 (8), 111684.10.1016/j.celrep.2022.111684.

Benjamin Lau, Olga Beine-Golovchuk, Markus Kornprobst, Jingdong Cheng, Dieter Kressler, Beáta Jády, Tamás Kiss, Roland Beckmann, and Ed Hurt (2022)

Cryo-EM insights into tail-anchored membrane protein biogenesis in eukaryotes, Curr. Opin. Struct. Biol. 75: 102428. doi:

Sinning, I. and McDowell, M.A. (2022)

Data-driven modelling captures dynamics of the circadian clock of Neurospora crassa. PLoS Comput Biol. 2022; PMC9397904. doi:10.1371/journal.pcbi.1010331.

Singh, A., Li, C., Diernfellner, A. C. R., Höfer, T. and Brunner, M. (2022)

Dual nature of the nucleolus. Genes and Develop. 36, 765–769.

Alan Tartakoff, Patrick DiMario, Ed Hurt, Brian McStay, Vikram Panse and David Tollervey (2022)

Emergence of the primordial pre-60S from the 90S pre-ribosome. Cell Reports 39,

Ismail S, Flemming D, Thoms D, Gomes-Filho J, Randau L, Beckmann R, Hurt E (2022)

Eukaryotic tRNA splicing - one goal, two strategies, many players. Biological chemistry, 403(8-9), 765–778.

Gerber, J. L., Köhler, S., & Peschek, J (2022)

Extended N-Terminal Acetyltransferase Naa50 in Filamentous Fungi Adds to Naa50 Diversity. Int J Mol Sci. 2022 Sep 16;23(18):10805. doi: PMID: 36142717; PMCID: PMC9500918.

Weidenhausen J, Kopp J, Ruger-Herreros C, Stein F, Haberkant P, Lapouge K, Sinning I (2022)

Glypican-1 drives unconventional secretion of Fibroblast Growth Factor 2. Elife. 2022 Mar 29;11:e75545. doi: 10.7554/eLife.75545. Online ahead of print.

Sparn, C., Dimou, E., Meyer, A., Saleppico, R., Wegehingel, S., Gerstner, M., Klaus, S., Ewers, H. & Nickel, W. (2022)

Heilpflanzen: natürlich – sicher – wirksam? Skeptiker, 35(1), 4–15.

Schling, P. (2022)

High-resolution structures of a thermophilic eukaryotic 80S ribosome reveal atomistic details of translocation, Nat Comms. 13: 476.

Kišonaitė, M., Wild, K., Lapouge, K., Ruppert, T. & Sinning, I. (2022)

How circadian clocks keep time: the discovery of slowness. FEBS Lett. 2022; doi:10.1002/1873-3468.14432.

Partch, C. and Brunner, M. (2022)

HYPK promotes the activity of the Nα-acetyltransferase A complex to determine proteostasis of nonAc-X2/N-degron-containing proteins, Sci. Adv. 8:eabn6153. doi:

Miklánková, P., Linster, E., Boyer, J.B., Weidenhausen, J., Mueller, J., Armbruster, L., Lapouge, K., De La Torre, C., Bienvenut, W., Sticht, C., Mann, M., Meinnel, T., Sinning, I., Giglione, C., Hell, R. & Wirtz, M. (2022)

In vitro structural maturation of the primordial pre-40S coupled with U3 snoRNA release and central pseudoknot formation. Nucl. Acid Res. 50, 11916-11923.

Cheng J, La Venuta G, Lau B, Beckmann R, Hurt E (2022)

Introducing the Lipidomics Minimal Reporting Checklist.
Nat Metab. 2022 Sep;4(9):1086-1088. doi: 10.1038/s42255-022-00628-3. PMID: 35934691

McDonald JG, Ejsing CS, Kopczynski D, Holčapek M, Aoki J, Arita M, Arita M, Baker ES, Bertrand-Michel J, Bowden JA, Brügger B, Ellis SR, Fedorova M, Griffiths WJ, Han X, Hartler J, Hoffmann N, Koelmel JP, Köfeler HC, Mitchell TW, O'Donnell VB, Saigusa D, Schwudke D, Shevchenko A, Ulmer CZ, Wenk MR, Witting M, Wolrab D, Xia Y, Ahrends R, Liebisch G, Ekroos K. (2022)

Membranumbau durch ESCRT-III-Proteine BIOspektrum 28 363-365 (2022).

Moser von Filseck, J (2022)

Neurospora casein kinase 1a recruits the circadian clock protein FRQ via the C-terminal lobe of its kinase domain. FEBS Lett. 2022; doi:10.1002/1873-3468.14435.

Marzoll, D., Serrano, F. E., Diernfellner, A. C. R. and Brunner, M. (2022)

Never-homozygous genetic variants in healthy populations are potential recessive disease candidates. npj Genom. Med. 7, 54.

Schmenger, T., Diwan, G. D., Singh, G., Apic, G., & Russell, R. B. (2022)

PRECOGx: exploring GPCR signaling mechanisms with deep protein representations. Nucleic acids research, 50(W1), W598–W610.

Matic, M., Singh, G., Carli, F., De Oliveira Rosa, N., Miglionico, P., Magni, L., Gutkind, J. S., Russell, R. B., Inoue, A., & Raimondi, F (2022)

Regulation of mitochondrial proteostasis by the proton gradient. EMBO Journal

Patron M., Tarasenko D., Nolte H., Kroczek L., Ghosh M., Ohba Y., Lasarzewski Y, Alsadat Ahmadi Z., Cabrera-Orefice A., Eyiama A, Kellermann T., Rugarli EI. , Brandt U., Meinecke M., Langer T (2022)

Reticulon-like REEP4 at the inner nuclear membrane promotes nuclear pore complex formation. J Cell Biol; 221 (2): e202101049. doi:

Golchoubian, B., Brunner, A., Bragulat-Teixidor, H., Neuner, A., Akarlar, B.A., Ozlu, N. & Schlaitz, A.L. (2022)

The C-terminal tail of ribosomal protein Rps15 is engaged in cytoplasmic pre-40S maturation. RNA Biol. 19, 560-574.

Rössler I, Weigl S, Fernández-Fernández J, Martín-Villanueva S, Strauss D , Hurt E, de la Cruz J, Pertschy B (2022)

The human signal peptidase complex acts as a quality control enzyme for membrane proteins. Science. 2022 Dec 2;378(6623):996-1000. doi: 10.1126/science.abo5672. Epub 2022 Dec 1. PMID: 36454823.

Zanotti A, Coelho JPL, Kaylani D, Singh G, Tauber M, Hitzenberger M, Avci D, Zacharias M, Russell RB, Lemberg MK, Feige MJ (2022)

The inner nuclear membrane protein Lem2 coordinates RNA degradation at the nuclear periphery. Nat Struct Mol Biol. 2022 Sep;29(9):910-921. doi: 10.1038/s41594-022-00831-6. Epub 2022 Sep 19. PMID: 36123402; PMCID: PMC9507967.

Caballero, L.M., Capella, M., Barrales, R.R., Dobrev, N., van Emden, T., Fischer-Burkart, S., Kinugasa, Y., Hirano, Y., Sinning, I., Fischer, T., Hiraoka, Y. & Braun, S. (2022)

The nucleoplasmic phase of pre-40S formation prior to nuclear export. Nucl. Acid Res. 50, 11924-11937.

Cheng J, Lau B, Thoms M, Ameismeier M, Berninghausen O, Hurt E, Beckmann R. (2022)

The S-palmitoylome and DHHC-PAT interactome of Drosophila melanogaster S2R+ cells indicate a high degree of conservation to mammalian palmitoylomes. PloS one, 17(8), e0261543.

Porcellato, E., González-Sánchez, J. C., Ahlmann-Eltze, C., Elsakka, M. A., Shapira, I., Fritsch, J., Navarro, J. A., Anders, S., Russell, R. B., Wieland, F. T., & Metzendorf, C. (2022)

Transformation of Chaetomium thermophilum and affinity-purification of native thermostable protein complexes. Methods in Mol. Biol. 2502, 35-50.  

Nikola Kellner and Ed Hurt (2022)

Unconventional secretion mediated by direct protein self-translocation across the plasma membranes of mammalian cells, Trends Biochem Sci. 2022 Apr 27;S0968-0004(22)00086-X.
doi: 10.1016/j.tibs.2022.04.001. Online ahead of print.

Sparn, C., Meyer, A., Saleppico, R., Nickel, W. (2022)

Unconventional secretion mediated by direct protein self-translocation across the plasma membranes of mammalian cells. Trends Biochem Sci. 2022 Apr 27;S0968-0004(22)00086-X.
doi: 10.1016/j.tibs.2022.04.001. Online ahead of print.

Sparn, C., Meyer, A., Saleppico, R., Nickel, W. (2022)

Molekulare Funktionen von Keimbahn-spezifischen Proteinen. BIOspektrum. 27, 101.

Jeske, M. (2021)

Molecular functions of germline proteins. EU Research. SPR21, 18.

Jeske, M. (2021)

Mechanismen des nicht konventionellen RNA-Spleißens. BIOspektrum 27(3): 233–236

Peschek, J. (2021)

A short perinuclear amphipathic α-helix in Apq12 promotes nuclear pore complex biogenesis. Open biology, 11(11), 210250.

Zhang, W., Khan, A., Vitale, J., Neuner, A., Rink, K., Lüchtenborg, C., Brügger, B., Söllner, T. H., & Schiebel, E. (2021)

CaM Kinase II-δ Is Required for Diabetic Hyperglycemia and Retinopathy but Not Nephropathy. Diabetes; 70 (2): 616–626. doi:

Chen, J., Fleming, T., Katz, S., Dewenter, M., Hofmann, K., Saadatmand, A., Kronlage, M., Werner, M.P., Pokrandt, B., Schreiter, F., Lin, J., Katz, D., Morgenstern, J., Elwakiel, A., Sinn, P., Gröne, H.J., Hammes, H.P., Nawroth, P.P., Isermann, B., Sticht, C., Brügger, B., Katus, H.A., Hagenmueller, M. & Backs, J. (2021)

Catalyzing the Understanding of Enzyme Kinetics: A Consistent Application of Constructive Alignment and Its Evaluation. 7, 7–28.

Béthune, J. (2021)

Cellular cholesterol and how to find it. Biochim Biophys Acta Mol Cell Biol Lipids. 1866(9):158989.

Schoop, V., Martello, A., Eden, E.R., & Höglinger, D. (2021)

Convergent use of phosphatidic acid for hepatitis C virus and SARS-CoV-2 replication organelle formation. Nat Commun 12, 7276.

Tabata, K., Prasad, V., Paul, D., Lee, J.Y., Pham, M.T., Twu, W.I., Neufeldt, C.J., Cortese, M., Cerikan, B., Stahl, Y., Joecks, S., Tran, C.S., Lüchtenborg, C., V'kovski, P., Hörmann, K., Müller, A.C., Zitzmann, C., Haselmann, U., Beneke, J., Kaderali, L., Erfle, H., Thiel, V., Lohmann, V., Superti-Furga, G., Brügger, B. & Bartenschlager, R. (2021)

Cooperativity of membrane-protein and protein–protein interactions control membrane remodeling by epsin 1 and affects clathrin-mediated endocytosis. Cell. Mol. Life Sci. 78, 2355–2370. PDF.

Kroppen, B., Teske, N., Yambire, K., Denkert, N., Mukherjee, I., Tarasenko, D., Jaipura, G., Zweckstetter, M., Milosevic, I., Steinem, C. & Meinecke, M. (2021)

ENTH domain-dependent membrane remodelling. ENTH domain-dependent membrane remodelling. Soft matter, 17(2), 233–24.

Steinem C. & Meinecke M. (2021)

Global Transcriptome Characterization and Assembly of the Thermophilic Ascomycete Chaetomium thermophilum. Genes (Basel). 2021; PMC8535861. doi:10.3390/genes12101549.

Singh, A., Schermann, G., Reislöhner, S., Kellner, N., Hurt, E. and Brunner, M. (2021)

Gluten Sensitivity (1st ed.). Springer.

Harter, C. (2021)

Ice2 promotes ER membrane biogenesis in yeast by inhibiting the conserved lipin phosphatase complex. EMBO Journal. (abstract)

Papagiannidis D, Bircham PW, Lüchtenborg C, Pajonk O, Ruffini G, Brügger B, Schuck S (2021)

Identification of cis-acting determinants mediating the unconventional secretion of tau. Sci Rep 11, 12946.

Katsinelos, T., McEwan, W.A., Jahn, T.R. & Nickel, W. (2021)

Imbalances in the eye lens proteome are linked to cataract formation. Nat Struct Mol Biol. 2021 Feb;28(2):143-151. doi: 10.1038/s41594-020-00543-9. Epub 2021 Jan 11. PMID: 33432246

Schmid PWN, Lim NCH, Peters C, Back KC, Bourgeois B, Pirolt F, Richter B, Peschek J, Puk O, Amarie OV, Dalke C, Haslbeck M, Weinkauf S, Madl T, Graw J, Buchner J (2021)

Inositol triphosphate-triggered calcium release blocks lipid exchange at endoplasmic reticulum-Golgi contact sites. Nat Commun 12, 2673.

Malek, M., Wawrzyniak, A.M., Koch, P., Lüchtenborg, C., Hessenberger, M., Sachsenheimer, T., Jang, W., Brügger, B. & Haucke, V. (2021)

Mechnetor: a web server for exploring protein mechanism and the functional context of genetic variants. Nucleic Acids Res. 2021 Jul 2;49(W1):W366-W374. doi: 10.1093/nar/gkab399. PMID: 34076240

González-Sánchez JC, Ibrahim MFR, Leist IC, Weise KR, Russell RB (2021)

Metabolic memory underlying minimal residual disease in breast cancer. Mol Syst Biol. 17: e10141.

Radic, S.hechter, K., Kafkia, E., Zirngibl, K., Gawrzak, S., Alladin, A., Machado, D., Lüchtenborg, C., Sévin, D.C., Brügger, B., Patil, K.R. & Jechlinger, M. (2021)

MICOS and the mitochondrial inner membrane morphology – when things get out of shape. FEBS Lett, 595: 1159-1183.

Mukherjee, I., Ghosh, M. & Meinecke, M. (2021)

MXD/MIZ1 transcription regulatory complexes activate the expression of MYC-repressed genes. FEBS Lett. 2021; doi:10.1002/1873-3468.14097.

Shostak, A., Schermann, G., Diernfellner, A. and Brunner, M. (2021)

Next Generation Protein Structure Predictions and Genetic Variant Interpretation. J Mol Biol. 2021 Oct 1;433(20):167180. doi: 10.1016/j.jmb.2021.167180. Epub 2021 Aug 4. PMID: 34358547

Diwan GD, Gonzalez-Sanchez JC, Apic G, Russell RB (2021)

Principles of membrane remodeling by dynamic ESCRT-III polymers. Trends Cell Biol 31(10), 856-868.

Pfitzner, A.-K., Moser von Filseck, J., & Roux, A. (2021)

Protein-dependent membrane remodeling in mitochondrial morphology and clathrin-mediated endocytosis. European biophysics journal : EBJ, 50(2), 295–306.

Tarasenko, D. & Meinecke, M. (2021)

Protomer alignment modulates specificity of RNA substrate recognition by Ire1. eLife, 10.

Li, W.*, Crotty, K.*, Garrido Ruiz, D., Voorhies, M., Rivera, C., Sil, A., Mullins, R.D., Jacobson, M.P., Peschek, J. & Walter, P. (2021)

Public LC-orbitrap tandem mass spectral library for metabolite identification. Journal of Proteome Research, 20.

Phapale, P., Palmer, A., Gathungu, R.M., Kale, D., Brügger, B. & Alexandrov, T. (2021)

RhoGAP19D inhibits Cdc42 laterally to control epithelial cell shape and prevent invasion. J Cell Biol. 2021 Apr 5;220(4):e202009116. doi: 10.1083/jcb.202009116. PMID: 33646271


Fic W, Bastock R, Raimondi F, Los E, Inoue Y, Gallop JL, Russell RB, St Johnston D (2021)

Slk19 enhances cross-linking of microtubules by Ase1 and Stu1. Mol Biol Cell. 2021 Nov 1;32(21):ar22. doi: 10.1091/mbc.E21-05-0279. Epub 2021 Sep 8. PMID: 34495712

Norell S, Ortiz J, Lechner J. (2021)

SRP54 mutations induce congenital neutropenia via dominant-negative effects on XBP1 splicing. Blood, 137(10), 1340–1352.

Schürch, C., Schaefer, T., Müller, J. S., Hanns, P., Arnone, M., Dumlin, A., Schärer, J., Sinning, I., Wild, K., Skokowa, J., Welte, K., Carapito, R., Bahram, S., Konantz, M., & Lengerke, C. (2021)

Stearic acid blunts growth-factor signaling via oleoylation of GNAI proteins. Nature communications, 12(1), 4590.

Nůsková H, Serebryakova, M.V., Ferrer-Caelles, A., Sachsenheimer, T., Lüchtenborg, C., Miller, A.K., Brügger, B., Kordyukova, L.V. & Teleman, A.A. (2021)

Structural analysis of the SRP Alu domain from Plasmodium falciparum reveals a non-canonical open conformation. Commun Biol 4, 600.

Soni, K., Kempf, G., Manalastas-Cantos, K., Hendricks, A., Flemming, D., Guizetti, J., Simon, B., Frischknecht, F., Svergun, D.I., Wild, K., & Sinning, I. (2021)

Structural and functional characterization of the N-terminal acetyltransferase Naa50. Structure, 29(5), 413–425.e5.

Weidenhausen, J., Kopp, J., Armbruster, L., Wirtz, M., Lapouge, K., & Sinning, I. (2021)

Structural and functional impact of SRP54 mutations causing severe congenital neutropenia. Structure, 29. doi:

Juaire, K.D., Lapouge, K., Becker, M.M.M., Kotova, I., Michelhans, M., Carapito, R., Wild, K., Bahram, S. & Sinning, I. (2021)

Structural and molecular mechanisms for membrane protein biogenesis by the Oxa1 superfamily. Nat Struct Mol Biol 28, 234–239.

McDowell, M.A., Heimes, M. & Sinning, I. (2021)

Structural basis of Naa20 activity towards a canonical NatB substrate. Commun Biol 4, 2.

Layer, D., Kopp, J., Fontanillo, M., Köhn, M., Lapouge, K. & Sinning, I. (2021)

Synthesis and Biological Evaluation of Natural-Product-Inspired, Aminoalkyl-Substituted 1-Benzopyrans as Novel Antiplasmodial Agents. J Med Chem. 2021 May 13;64(9):6397-6409. doi: 10.1021/acs.jmedchem.1c00483. Epub 2021 Apr 26. PMID: 33901399

Uth JF, Börgel F, Lehmkuhl K, Schepmann D, Kaiser M, Jabor VAP, Nonato MC, Krauth-Siegel RL, Schmidt TJ, Wünsch B. (2021)

The circadian cryptochrome, CRY1, is a pro-tumorigenic factor that rhythmically modulates DNA repair. Nat Commun. 2021 Jan 15;12(1):401. doi: 10.1038/s41467-020-20513-5. PMID: 33452241

Shafi AA, McNair CM, McCann JJ, Alshalalfa M, Shostak A, Severson TM, Zhu Y, Bergman A, Gordon N, Mandigo AC, Chand SN, Gallagher P, Dylgjeri E, Laufer TS, Vasilevskaya IA, Schiewer MJ, Brunner M, Feng FY, Zwart W, Knudsen KE (2021)

The glucosylceramide synthase inhibitor PDMP causes lysosomal lipid accumulation and mTOR inactivation. Int J Mol Sci, 22(13):7065. doi:

Harwig, P. & Höglinger, D. (2021)

The Sense of Taste (1st ed.). Springer.

Schling, P. (2021)

The zinc-finger protein Red1 orchestrates MTREC submodules and binds the Mtl1 helicase arch domain. Nat Comms. 12: 3456. PMID: 34103492. doi:

Dobrev, N., Ahmed, Y.L., Sivadas, A., Fischer*, T. & Sinning*, I. (2021)

90S pre-ribosome transformation into the primordial 40S subunit.
Science369, 1470-1476.

Cheng J, Lau B, La Venuta G, Ameismeier M, Berninghausen O, Hurt E, Beckmann R. (2020)

LOTUS-domain proteins - Developmental effectors from a molecular perspective. Biol. Chem. 402, 7–23.

Kubíková, J., Reinig, R., Salgania, H.K., and Jeske, M. (2020)

Cellular senescence and quiescence are associated with altered ribosomal RNA methylation and processing. BioRxiv doi: 10.1101/2020.04.01.019653.

Yang,G., Heisenberger,C., Polacek,N., Grillari,J., Schosserer,M. and Koš,M. (2020)

Modulation of mammalian translation by a ribosome associated tRNA half. RNA Biol 30:1-12, doi: 10.1080/15476286.2020.1744296.

Gonskikh,Y., Gerstl,M., Koš,M., Borth,N., Schosserer,M., Grillari,J. and Polacek,N. (2020)

A novel neurodegenerative spectrum disorder in patients with MLKL deficiency. Cell Death Dis. 11(5):303.

Faergeman SL, Evans H, Attfield KE, Desel C, Kuttikkatte SB, Sommerlund M, Jensen LT, Frokiaer J, Friese MA, Matthews PM, Lüchtenborg C, Brügger B, Oturai AB, Dendrou CA, Fugger L. (2020)

A paralog-specific role of COPI vesicles in the neuronal differentiation of mouse pluripotent cells. Life Science Alliance 3, e202000714.

Jain Goyal, M., Zhao, X., Bozhinova, M., Andrade-López, K., de Heus, C., Schulze-Dramac, S., Müller-McNicoll, M., Klumperman, J., and Béthune, J. (2020)

An ESCRT-III Polymerization Sequence Drives Membrane Deformation and Fission. Cell 182, 1-16.

Pfitzner A-K, Mercier V, Jiang X, Moser von Filseck J, Baum B, Šarić A and Roux A. (2020)

Anisotropic ESCRT-III architecture governs helical membrane tube formation. Nat Commun 11, 1516.

Moser von Filseck J, Barberi L, Talledge N, Johnson I, Frost A, Lenz M and Roux A. (2020)

Arrangements of proteins at reconstituted synaptic vesicle fusion sites depend on membrane separation. FEBS Letters,

Ginger L, Malsam M, Sonnen A, Morado D, Scheutzow A, Söllner TH, Briggs J (2020)

Atg21 organizes Atg8 lipidation at the contact of the vacuole with the phagophore. Autophagy

Munzel L., Neumann P., Otto F.B., Krick R., Metje-Sprink J., Kroppen B., Karedla N., Enderlein J., Meinecke M., Ficner R., Thumm M. (2020)

Cholesterol localization around the metabotropic glutamate receptor 2, J. Phys. Chem. B 24: 9061-9078. PMID: 32954729.

Kurth, M., Lolicato, F., Sandoval-Perez, A., Amaya-Espinosa, H., Teslenko, A., Sinning, I., Beck, R., Brügger B. & Aponte-Santamaria, C.A. (2020)

Complexin suppresses spontaneous exocytosis by capturing the membrane-proximal regions of VAMP2 and SNAP25. Cell Reports, 32.

Malsam, J., Bärfuss, S., Trimbuch, T.h, Zarebidaki, F., Sonnen, A., Wild, K., Scheutzow, A., Rohland, L., Mayer, M., Sinning, I., Briggs, J., Rosenmund, C. & Söllner, T.H. (2020)

Construction of the Central Protuberance and L1 stalk during 60S subunit biogenesis Mol. Cell,

Lukas Kater, Valentin Mitterer, Matthias Thoms, Jingdong Cheng, Otto Berninghausen, Roland Beckmann and Ed Hurt (2020)

Dynamic palmitoylation events following T-cell receptor signaling. Commun Biol. 3(1):368.

Morrison E, Wegner T, Zucchetti AE, Álvaro-Benito M, Zheng A, Kliche S, Krause E, Brügger B, Hivroz C, Freund C. (2020)

EHD2-mediated restriction of caveolar dynamics regulates cellular fatty acid uptake. Proc Natl Acad Sci U S A. 117(13):7471-7481.

Matthaeus C, Lahmann I, Kunz S, Jonas W, Melo AA, Lehmann M, Larsson E, Lundmark R, Kern M, Blüher M, Olschowski H, Kompa J, Brügger B, Müller DN, Haucke V, Schürmann A, Birchmeier C, Daumke O. (2020)

ESCRT machinery mediates selective microautophagy of endoplasmic reticulum in yeast. EMBO Journal. (abstract)

Schäfer JA, Schessner JP, Bircham PW, Tsuji T, Funaya C, Pajonk O, Schaeff K, Ruffini G, Papagiannidis D, Knop M, Fujimoto T, Schuck S (2020)

ESCRTing endoplasmic reticulum to microautophagic degradation. Autophagy. Commentary (abstract)

Schäfer JA, Schuck S (2020)

Fettgewebe - zu Unrecht ungeliebt (1st ed.). Springer.

Schling, P. (2020)

FGF2 and IL-1β: Explorers of unconventional secrtory pathways. J Cell Sci 133(21):jcs250449.

Pallotta MT and Nickel W (2020)

Functional assay to correlate protein oligomerization states with membrane pore formation. Anal Chem 92(22):14861-14866.

Sachl R, Cujova S, Singh V, Riegerova P, Kapusta P, Müller HM, Steringer JP, Hof M and Nickel W (2020)

Functional implications of MIR domains in protein O-mannosylation, eLife 9: e61189. PMID: 33357379.

Chiapparino#, A., Grbavac#, A., Jonker, H.R.A., Hackmann, Y., Mortensen, S., Zatorska, E., Schott, A., Stier, G., Saxena, K., Wild, K., Schwalbe, H., Sabine Strahl*, S. & Sinning*, I. (2020)

Heme binding of transmembrane signaling proteins undergoing regulated intramembrane proteolysis. Commun Biol. 3(1):73.

Kupke T, Klare JP, Brügger B. (2020)

Hrd1 forms the retrotranslocation pore regulated by auto-ubiquitination and binding of misfolded proteins. Nature Cell Biology 22(3):274-281

Vasic V., Denkert N., Schmidt C., Riedel D., Stein A., Meinecke M. (2020)

Medusys. Ein kompetenzorientiertes Lernsystem für Lernende und Lehrende. So gelingt E-Learning. Reader zum Higher Education Summit 2019. Pearson: 132-137.

Merz WE (2020)

Membrane Biology: Disentangling Cellular Lipid Connections. Curr Biol. 30(19):R1090-R1092.

Brügger B. (2020)

MetAP-like Ebp1 occupies the human ribosomal tunnel exit and recruits flexible rRNA expansion segments, Nat Comms. 11: 776. PMID: 32034140.

Wild, K., Aleksić, M., Lapouge, K., Juaire, K.D., Flemming, D., Pfeffer, S. & Sinning, I. (2020)

Microautophagy - distinct molecular mechanisms handle cargoes of many sizes. Journal of Cell Science. Review (abstract)

Schuck S (2020)

Multiple random phosphorylations in clock proteins provide long delays and switches. Sci Rep. 2020; PMC7746754. doi:10.1038/s41598-020-79277-z.

Upadhyay, A., Marzoll, D., Diernfellner, A., Brunner, M. and Herzel, H. (2020)

NAA50 is an enzymatically active Nα-acetyltransferase that is crucial for the development and regulation of stress responses, Plant Physiol. 183: 1502-1516.

Armbruster, L., Linster, E., Boyer, J.B., Brünje, A., Eirich, J., Stephan, I., Bienvenut, W.V., Weidenhausen, J., Meinnel, T., Hell, R., Sinning, I., Finkemeier, I., Giglione,G. & Wirtz, M. (2020)

N-terminal acetylation by NatB affects growth and abiotic stress responses in Arabidopsis, Plant Physiol. 182: 792-806. PMID: 31744933.

Huber, M., Bienvenut, W.V., Linster, E., Stephan, I., Armbruster, L., Sticht, C., Layer, D., Lapouge, K., Meinnel, T., Sinning, I., Giglione, C., Hell, R. & Wirtz, M. (2020)

Phosphorylation Timers in the Neurospora crassa Circadian Clock. J Mol Biol. 2020; doi:10.1016/j.jmb.2020.04.004.

Diernfellner, A. C. R. and Brunner, M. (2020)

PI(4,5)P2-dependent regulation of exocytosis by amisyn, the vertebrate-specific competitor of synaptobrevin 2. PNAS

Kondratiuk I, Jakhanwal S, Jin J, Sathyanarayanan U, Kroppen B, Pobbati A, Krisko A, Ashery U, Meinecke M, Jahn R, Fasshauer D, Milosevic I. (2020)

Protease-resistant streptavidin for interaction proteomics. Molecular Systems Biology, 16: e9370.

Rafiee, M.-R., Sigismondo, G., Kalxdorf, M., Förster, L.-C., Brügger, B., Béthune, J., & Krijgsveld, J (2020)

Structural basis for the complex DNA binding behaviour of the plant stem cell regulator WUSCHEL, Nat. Comms. 11: 2223. PMID: 32376862.

Sloan, J., Hakenjos, J.P., Gebert, M., Ermakova, O., Gumiero, A., Stier, G., Wild, K., Sinning*, I. & Lohmann*, J.U. (2020)

Structural basis of tail-anchored membrane protein biogenesis by the GET insertase complex, Mol Cell 80: 72-86.e7. PMID: 32910895.

McDowell*, M.A., Heimes, M., Fiorentino, F., Mehmood, S., Farkas, Á., Coy-Vergara, J., Wu, D., Schmid, V., Heinze, R., Reddy Bolla, J., Wild, K., Flemming, D., Pfeffer, S., Schwappach, B., Robinson, C.V. & Sinning*, I. (2020)

Structure of the Maturing 90S Pre-ribosome in Association with the RNA Exosome. Mol. Cell .

Benjamin Lau, Jingdong Cheng, Dirk Flemming, Giusseppe La Venuta, Otto Berninghausen, Roland Beckmann and Ed Hurt (2020)

The Arabidopsis Nα-acetyltransferase NAA60 locates to the plasma membrane and is vital for the high salt stress response, New Phytologist, doi: 10.1111/nph.16747. Online ahead of print. PMID: 32548857

Linster#, E., Layer#, D., Bienvenut, W.V., Dinh-Van, T., Weyer, F., Lemhuis, W., Brünje, A., Hoffrichter, M., Miklankova, P., Sindlinger, J., Schwarzer, D., Kopp, J., Lapouge, K., Meinnel, T., Giglione, C., Finkemeier, I., Hell, R., Sinning*, I. & Wirtz*, M. (2020)

The endoplasmatic reticulum during mitosis. Biospektrum 26:739-742. (in German)

Schlaitz AL (2020)

The Interaction of Munc18-1 Helix 11 and 12 with the Central Region of the VAMP2 SNARE Motif Is Essential for SNARE Templating and Synaptic Transmission. eNeuro, 7(6), ENEURO.0278-20.2020.

André, T., Classen, J., Brenner, P., Betts, M. J., Dörr, B., Kreye, S., Zuidinga, B., Meijer, M., Russell, R. B., Verhage, M., & Söllner, T. H. (2020)

The Na,K-ATPase acts upstream of phosphoinositide PI(4,5)P2 facilitating unconventional secretion of Fibroblast Growth Factor 2. Commun Biol 3:141.

Legrand C, Saleppico R, Sticht J, Lolicato F, Müller HM, Wegehingel S, Dimou E, Steringer JP, Ewers E, Vattulainen I, Freund C, Nickel W (2020)

The ribosome-associated complex RAC serves in a relay that directs nascent chains to Ssb, Nat Comms. 11: 1504. PMID: 32198371.

Zhang*, Y., Valentín Gesé*, G., Conz, C., Lapouge, L., Kopp, J., Wölfle, T., Rospert, S. & Sinning, I. (2020)

TMEM147 interacts with Lamin B Receptor, regulates its localization and levels, and affects cholesterol homeostasis. J Cell Sci. jcs.245357.

Christodoulou A, Maimaris G, Makrigiorgi A, Charidemou E, Lüchtenborg C, Ververis A, Georgiou R, Lederer CW, Haffner C, Brügger B, Santama N. (2020)

tRNA ligase structure reveals kinetic competition between non-conventional mRNA splicing and mRNA decay. eLife 8:e44199

Peschek J & Walter P (2019)

A ribosome assembly stress response regulates transcription to maintain proteome homeostasis. eLife 2019;8:e45002 doi: 10.7554/eLife.45002

Albert, B., Kos-Braun, I.C., Henras, A.K., Dez, C., Rueda, M.P., Zhang, X., Gadal, O., Kos, M., and Shore, D. (2019)

At least two molecules of the RNA helicase Has1 are simultaneously present in pre-ribosomes during ribosome biogenesis. Nucl Acids Res pii: gkz767. doi: 10.1093/nar/gkz767

Gnanasundram,S.V., Kos-Braun,I.C. and Koš,M. (2019)

In vitro RNA Cleavage Assays to Characterize IRE1-dependent RNA Decay. Bio-protocol 9(14):e3307.

Karagöz GE, Peschek J, Walter P, Acosta-Alvear D (2019)

A method for the quantitative determination of glycerophospholipid regioisomers by UPLC-ESI-MS/MS. Anal Bioanal Chem 411(4):915-924. doi: 10.1007/s00216-018-1517-5.

Wozny K, Lehmann WD, Wozny M, Akbulut BS, Brügger B. (2019)

A pathway linking translation stress to checkpoint kinase 2 signaling in Neurospora crassa. Proc Natl Acad Sci U S A. 2019; PMC6717302. doi:10.1073/pnas.1815396116.

Diernfellner, A. C. R., Lauinger, L., Shostak, A. and Brunner, M. (2019)

A time-resolved live cell imaging assay to identify small molecule inhibitors of FGF2 signaling. FEBS Lett. 593:2162-2176.

Ahmed M, Legrand C, Yagüe Relimpio A, Beretta CA, Muschko A, Wegehingel S, Müller HM, Sehr P, Will DW, Lewis JD, Nickel W (2019)

An Electrostatic Energy Barrier for SNARE-Dependent Spontaneous and Evoked Synaptic Transmission. Cell Rep. 2019 Feb 26;26(9):2340-2352.e5. doi: 10.1016/j.celrep.2019.01.103.

Ruiter M, Kádková A, Scheutzow A, Malsam J, Söllner TH, Sørensen JB (2019)

An Inactivation Switch Enables Rhythms in a Neurospora Clock Model. Int J Mol Sci. 2019; PMC6627049. doi:10.3390/ijms20122985.

Upadhyay, A., Brunner, M. and Herzel, H. (2019)

Bi- and Trifunctional Lipids for Visualization of Sphingolipid Dynamics within the Cell. Methods Mol Biol, 1949:95-103, doi: 10.1007/978-1-4939-9136-5_8.

Höglinger D. (2019)

Blood vessels as regulators of neural stem cell properties. Front Mol Neurosci.

Karakatsani A , Shah B, Ruiz de Almodovar C. (2019)

CerS6-Derived Sphingolipids Interact with Mff and Promote Mitochondrial Fragmentation in Obesity. Cell 177 (6): 1536-1552.

Hammerschmidt P, Ostkotte D, Nolte H, Gerl, MJ, Jais A, Brunner HL, Sprenger HG, Awazawa M, Nicholls HT, Turpin-Nolan SM, Langer T, Krüger M, Brügger B, Brüning JC. (2019)

Crystal structures of Rea1-MIDAS bound to its ribosome assembly factor ligands resembling integrin–ligand-type complexes. Nat Commun 10, 3050.

Ahmed, Y.L., Thoms, M., Mitterer, V., Sinning, I., & Hurt, E. (2019)

Eucaryotic Ribosome Assembly. Annu Rev Biochem. 2019 Jun 20;88:281-306. doi: 10.1146/annurev-biochem-013118-110817.

Baßler J, Hurt E. (2019)

Help from my friends-cooperation of BMAL1 with noncircadian transcription factors. Genes Dev. 2019; PMC6411012. doi:10.1101/gad.324046.119.

Shostak, A. and Brunner, M. (2019)

Identification of YvcI as novel RNA pyrophospho-hydrolase from B. subtilis, J. Biol. Chem. 94: 19967-19977. PMID: 31740579.

Frindert, J., Kahloon, M.A., Zhang, Y., Ahmed, Y.L., Sinning, I., & Jäschke, A. (2019)

In vitro quantification of botulinum neurotoxin type A1 using immobilized nerve cell-mimicking nanoreactors in a microfluidic platform. Analyst. 144(19):5755-5765.

Weingart OG, Eyer K, Lüchtenborg C, Sachsenheimer T, Brügger B, van Oostrum M, Wollscheid B, Dittrich PS, Loessner MJ. (2019)

JASSY - a Chloroplast Outer Membrane Protein Required for Jasmonate Biosynthesis. PNAS 116, 10568-10575

Guan L, Denkert N, Eisa A, Lehmann M, Sjuts I, Weiberg A, Soll J, Meinecke M, Schwenkert S. (2019)

Loss of Neurological Disease HSAN-I-Associated Gene SPTLC2 Impairs CD8+ T Cell Responses to Infection by Inhibiting T Cell Metabolic Fitness. Immunity pii: S1074-7613(19)30095-0.

Wu J, Ma S, Sandhoff R, Ming Y, Hotz-Wagenblatt A, Timmerman V, Bonello-Palot N, Schlotter-Weigel B, Auer-Grumbach M, Seeman P, Löscher WN, Reindl M, Weiss F, Mah E, Weisshaar N, Madi A, Mohr K, Schlimbach T, Velasco Cárdenas RM, Koeppel J, Grünschläger F, Müller L, Baumeister M, Brügger B, Schmitt M, Wabnitz G, Samstag Y, Cui G. (2019)

Loss of the ribosomal RNA methyltransferase NSUN5 impairs global protein synthesis and normal growth. Nucleic acids research, 47(22), 11807–11825.

Heissenberger, C., Liendl, L., Nagelreiter, F., Gonskikh, Y., Yang, G., Stelzer, E.M., Krammer, T.L., Micutkova, L., Vogt, S., Kreil, D.P., Sekot, G., Siena, E., Poser, I., Harreither, E., Linder, A., Ehret, V., Helbich, T.H., Grillari-Voglauer, R., Jansen-Dürr, P., Koš M, Polacek, N., Grillari, J. & Schosserer, M. (2019)

Membrane-Associated RNA-Binding Proteins Orchestrate Organelle-Coupled Translation. Trends in Cell Biology 29, 178-188.

Béthune, J., Jansen, R.P., Feldbrugge, M., and Zarnack, K. (2019)

Novel variants and clinical symptoms in four new ALG3-CDG patients, review of the literature, and identification of AAGRP-ALG3 as a novel ALG3 variant with alanine and glycine-rich N-terminus. Hum Mutat. 40: 938-951. PMID: 31067009.

Himmelreich N, Dimitrov B, Geiger V, Zielonka M, Hutter AM, Beedgen L, Hüllen A, Breuer M, Peters V, Thiemann KC, Hoffmann GF, Sinning I, Dupré T, Vuillaumier-Barrot S, Barrey C, Denecke J, Kölfen W, Düker G, Ganschow R, Lentze MJ, Moore S, Seta N, Ziegler A, Thiel C. (2019)

NPC1 regulates ER contacts with endocytic organelles to mediate cholesterol egress. Nat Commun, 10(1):4276, doi: 10.1038/s41467-019-12152-2.

Höglinger D, Burgoyne T, Sanchez-Heras E, Hartwig P, Colaco A, Newton J, Futter C, Spiegel S, Platt F, Eden E. (2019)

Nucleoporin Nup155 is part of the p53 network in liver cancer. Mol Cell. 2019 Sep 19;75(6):1256-1269.e7. doi: 10.1016/j.molcel.2019.06.032.

Holzer K, Ori A, Cooke A, Dauch D, Drucker E, Riemenschneider P, Andres-Pons A, DiGuilio AL, Mackmull MT, Baßler J, Roessler S, Breuhahn K, Zender L, Glavy JS, Dombrowski F, Hurt E, Schirmacher P, Beck M, Singer S (2019)

Proteomics Profiling of Mammalian COPII and COPI Vesicles. Cell Reports 26, 250-265.

Adolf, F., Rhiel, M., Hessling, B., Gao, Q., Hellwig, A., Béthune, J., and Wieland, F. (2019)

Proteomik-Analyse von dynamischen Proteinkomplexen. Biospektrum (Springer Verlag) 01.19, 45-48.

Egetemaier, S. and Béthune, J.* (2019)

Quantification of phosphoinositides reveals strong enrichment of PIP2 in HIV-1 compared to producer cell membranes. Sci Rep. 9(1):17661.

Mücksch F, Citir M, Lüchtenborg C, Glass B, Traynor-Kaplan A, Schultz C, Brügger B, Kräusslich HG. (2019)

Reconstitution of the human SRP system and quantitative and systematic analysis of its ribosome interactions, Nucl. Acids Res. 47: 3184-3196.

Wild, K., D. Juaire, K.D., Soni, K., Shanmuganathan, V., Hendriks, A., Segnitz, B., Beckmann, R. & Sinning, I. (2019)

REEP3 and REEP4 determine the tubular morphology of the endoplasmic reticulum during mitosis. Mol Biol Cell 30:1377-1389.

Kumar D, Golchoubian B, Belevich I, Jokitalo E, Schlaitz AL (2019)

Simplified Fabrication for Ion-Selective Optical Emulsion Sensor with Hydrophobic Solvatochromic Dye Transducer: A Cautionary Tale. Anal Chem 91(14), 8973-8978.

Wang L, Sadler S, Cao T, Xie X, Moser von Filseck J and Bakker E. (2019)

Single event visualization of unconventional secretion of FGF2. J Cell Biol 218:683-699.

Dimou E, Cosentino K, Platonova, E, Ros U, Sadeghi M, Kashyap P, Katsinelos T, Wegehingel S, Noé F, García-Saéz AJ, Ewers H, Nickel W (2019)

Splenectomy reduces lung metastases and tumoral and metastatic niche inflammation. Int J Cancer. In press.

Stöth M, Freire Valls A, Chen M, Hidding S, Knipper K, Shen Y, Klose J, Ulrich A, Ruiz de Almodovar C, Schneider M, Schmidt T. (2019)

Structure, dynamics, and interactions of large SRP variants (review), Biol. Chem. 401: 63-80. PMID: 31408431.

Wild, K., Becker, MMM, Kempf, G. & Sinning, I. (2019)

Structure, Topology, and Dynamics of Membrane-Inserted Polypeptides and Lipids by Solid-State NMR Spectroscopy: Investigations of the Transmembrane Domains of the DQ Beta-1 Subunit of the MHC II Receptor and of the COP I Protein p24. Front Mol Biosci. 6:83. doi: 10.3389/fmolb.2019.00083. eCollection 2019.

Salnikov ES, Aisenbrey C, Pokrandt B, Brügger B*, Bechinger B*. (2019)

Synaptic vesicle fusion: today and beyond Nat Struct Mol Biol. Aug;26(8):663-668. doi: 10.1038/s41594-019-0277-z.

Brose N, Brunger A, Cafiso D, Chapman ER, Diao J, Hughson FM, Jackson MB, Jahn R, Lindau M, Ma C, Rizo J, Shin YK, Söllner TH, Tamm L, Yoon TY, Zhang Y (2019)

The proteasome biogenesis regulator Rpn4 cooperates with the unfolded protein response to promote ER stress resistance. eLife. (abstract)

Schmidt RM, Schessner JP, Borner GH, Schuck S (2019)

Thermophile 90S Pre-ribosome Structures Reveal the Reverse Order of Co-transcriptional 18S rRNA Subdomain Integration. Mol Cell. 2019 Sep 19;75(6):1256-1269.e7. doi: 10.1016/j.molcel.2019.06.032.

Cheng J, Baßler J, Fischer P, Lau B, Kellner N, Kunze R, Griesel S, Kallas M, Berninghausen O, Strauss D, Beckmann R, Hurt E. (2019)

Engineering ER-stress dependent non-conventional mRNA splicing. eLife 7: e35388.

Li W, Okreglak V, Peschek J, Kimmig P, Zubradt M, Weissman JS, Walter P (2018)

4EHP-independent repression of endogenous mRNAs by the RNA-binding protein GIGYF2. Nucleic Acids Res. 46(11):5792-5808.

Amaya Ramirez, C., Hubbe, P., Mandel, N., and Béthune, J.* (2018)

A click cage: Organelle-specific uncaging of lipid mes-sengers. Angew Chem Int Ed Engl, 57: 1-6, doi: 10.1002/anie.201807497

Wagner N, Stephan M, Höglinger D, Nadler A. (2018)

A glutaredoxin in the mitochondrial intermembrane space has stage-specific functions in the thermo-tolerance and proliferation of African trypanosomes. Redox Biology 15, 532-547.

Ebersoll, S., Musunda, B., Schmenger, T., Dirdjaja, N., Bonilla, M., Manta, B., Ulrich, K., Comini, M. A., and Krauth-Siegel, R. L. (2018)

A PRDX1-p38α heterodimer amplifies MET-driven invasion of IDH-wildtype and IDH-mutant gliomas. Int J Cancer.

Wirthschaft P, Bode J, Simon AEM, Hoffmann E, van Laack R, Krüwel T, Dietrich F, Bucher D, Hahn A, Sahm F, Breckwoldt MO, Kurz FT, Hielscher T, Fischer B, Dross N, Ruiz de Almodovar C, von Deimling A, Herold-Mende C, Plass C, Boulant S, Wiestler B, Reifenberger G, Lichter P, Wick W, Tews B. (2018)

Analyzing context-specific protein complexes. G.I.T: Laboratory Journal 2/18, 18-19.

Béthune, J.* (2018)

Assembly Kinetics of Vimentin Tetramers to Unit-Length Filaments: A Stopped-Flow Study. Biophys J. 2018 May 22;114(10):2408-2418. doi: 10.1016/j.bpj.2018.04.032.

N. Mücke, L. Kämmerer, S. Winheim, R. Kirmse, J. Krieger, M. Mildenberger, J. Baßler, E. Hurt, WH Goldmann, U. Aebi, K. Toth, J. Langowski, H. Hermann (2018)

Assembly of COPI and COPII Vesicular Coat Proteins on Membranes. Annu Rev Biophys. 47:63-83.

Béthune, J.*, and Wieland, F.T.* (2018)

Biological evaluation and X-ray co-crystal structures of cyclohexylpyrrolidine ligands for trypanothione reductase (TR), an enzyme from the redox metabolism of Trypanosoma. Chem. Med. Chem. 13, 957-967.

De Gasparo, R., Persch, E., Bryson, S. Hentzen, N., Kaiser, M., Pai, E. F., Krauth-Siegel, R. L., and Diederich, F. (2018)

Brr6 and Brl1 locate to nuclear pore complex assembly sites to promote their biogenesis. J Cell Biol. pii: jcb.201706024. doi: 10.1083/jcb. 201706024.

Zhang W, Neuner A, Rüthnick D, Sachsenheimer T, Lüchtenborg C, Brügger B, Schiebel E. (2018)

Cutis laxa, exocrine pancreatic insufficiency and altered cellular metabolomics as additional symptoms in a new patient with ATP6AP1-CDG. Mol Genet Metab. pii: S1096-7192(17)30764-3.

Dimitrov B, Himmelreich N, Hipgrave Ederveen AL, Lüchtenborg C, Okun JG, Breuer M, Hutter AM, Carl M, Guglielmi L, Hellwig A, Thiemann KC, Jost M, Peters V, Staufner C, Hoffmann GF, Hackenberg A, Paramasivam N, Wiemann S, Eils R, Schlesner M, Strahl S, Brügger B, Wuhrer M, Christoph Korenke G, Thiel C. (2018)

Defective Mitochondrial Cardiolipin Remodeling Dampens HIF-1α Expression in Hypoxia. Cell Rep. 25(3):561-570.e6.

Chowdhury A, Aich A, Jain G, Wozny K, Lüchtenborg C, Hartmann M, Bernhard O, Balleiniger M, Alfar EA, Zieseniss A, Toischer K, Guan K, Rizzoli SO, Brügger B, Fischer A, Katschinski DM, Rehling P, Dudek J. (2018)

DENR-MCTS1 heterodimerization and tRNA recruitment are required for translation reinitiation. PLoS Biol. 16: e2005160. PMID: 29889857.

Ahmed, Y.L., Schleich, S., Bohlen, J., Mandel, N., Simon, B., Sinning*, I. & Teleman*, A.A. (2018)

Frequency Modulation of Transcriptional Bursting Enables Sensitive and Rapid Gene Regulation. Cell Syst. 2018; doi:10.1016/j.cels.2018.01.012.

Li, C., Cesbron, F., Oehler, M., Brunner, M. and Höfer, T. (2018)

Inconspicuous Little Allies: How Membrane Lipids Help Modulate Protein Function. ACS Central Science 4(5), pp 530-531.

Brügger, B. (2018)

Molecular and structural architecture of polyQ aggregates in yeast. Proc Natl Acad Sci U S A. 115(15):E3446-E3453.

Gruber A, Hornburg D, Antonin M, Krahmer N, Collado J, Schaffer M, Zubaite G, Lüchtenborg C, Sachsenheimer T, Brügger B, Mann M, Baumeister W, Hartl FU, Hipp MS, Fernández-Busnadiego R. (2018)

Morning and Evening Peaking Rhythmic Genes are Regulated by Distinct Transcription Factors in Neurospora crassa. in Information- and communication Theory in Molecular Biology (ed. M. Bossert), pp. 199-210. Springer.

Lehmann, R., Herzel, H., Brunner, M., Sancar, G., Sancar, C. and Ananthasubramaniam, B. (2018)

Neurovascular Communication during CNS Development. Dev Cell. 45(1):10-32.

Paredes I, Himmels P, Ruiz de Almodóvar C. (2018)

Phospholipidation of nuclear proteins by the human papillomavirus E6 oncoprotein: implication in carcinogenesis. Oncotarget. 9(75):34142-34158.

Marx B, Hufbauer M, Zigrino P, Majewski S, Markiefka B, Sachsenheimer T, Brügger B, Akgül B. (2018)

Role of retinal pigment epithelium-derived exosomes and autophagy in new blood vessel formation. J Cell Mol Med. 22(11):5244-5256.

Atienzar-Aroca S, Serrano-Heras G, Freire Valls A, Ruiz de Almodovar C, Muriach M, Barcia JM, Garcia-Verdugo JM, Romero FJ, Sancho-Pelluz J. (2018)

SHRED is a regulatory cascade that reprograms Ubr1 substrate specificity for enhanced protein quality control during stress. Molecular Cell. (abstract)

Szoradi T, Schaeff K, Garcia-Rivera EM, Itzhak DN, Schmidt RM, Bircham PW, Leiss K, Diaz-Miyar J, Chen VK, Muzzey D, Borner GH, Schuck S (2018)

Split-BioID - Proteomic Analysis of Context-specific Protein Complexes in Their Native Cellular Environment. J Vis Exp. (134).

Schopp, I., and Béthune, J.* (2018)

Streptococcal Lancefield polysaccharides are critical cell wall determinants for human Group IIA secreted phospholipase A2 to exert its bactericidal effects. PLoS Pathog 14(10):e1007348.

van Hensbergen VP, Movert E, de Maat V, Lüchtenborg C, Le Breton Y, Lambeau G, Payré C, Henningham A, Nizet V, van Strijp JAG, Brügger B, Carlsson F, McIver KS, van Sorge NM. (2018)

Structure of the nuclear exosome captured on a maturing preribosome. Science. 2018 Apr 13;360(6385):219-222. doi: 10.1126/science.aar5428.

Jan Schuller, Sebastian Falk, Lisa Fromm, Ed Hurt and Elena Conti (2018)

Suppressor mutations in Rpf2-Rrs1 or Rpl5 bypass the Cgr1 function for pre-ribosomal 5S RNP-rotation. Nat Commun. 2018 Oct 5;9(1):4094. doi: 10.1038/s41467-018-06660-w.

Matthias Thoms, Valentin Mitterer, Lukas Kater, L. Falquet, Roland Beckmann, Dieter Kressler, Ed Hurt (2018)

Targeting myelin lipid metabolism as a potential therapeutic strategy in a model of CMT1A neuropathy. Nat Commun. 9(1):3025.

Fledrich R, Abdelaal T, Rasch L, Bansal V, Schütza V, Brügger B, Lüchtenborg C, Prukop T, Stenzel J, Rahman RU, Hermes D, Ewers D, Möbius W, Ruhwedel T, Katona I, Weis J, Klein D, Martini R, Brück W, Müller WC, Bonn S, Bechmann I, Nave KA, Stassart RM, Sereda MW. (2018)

The Escherichia coli SRP receptor forms a homodimer at the membrane, Structure 26:1440-1450.e5. PMID: 30146170.

Kempf, G., Stjepanovic, G., Hendricks, A., Lapouge, K., & Sinning, I. (2018)

The molecular mechanism underlying unconventional secretion of Fibroblast Growth Factor 2 from tumour cells. Sem Cell Dev Biol, PMID:29458182.

Steringer JP and Nickel W (2018)

Tyrosine phosphorylation of Munc18-1 inhibits synaptic transmission by preventin SNARE assembly. The EMBO Journal 37(2): 300-320

Meijer M., Dörr B., Lammertse H., Blithikioti C., van Weering J., Toonen R., Söllner T.H., Verhage M. (2018)

Ultradian Rhythms in the Transcriptome of Neurospora crassa. iScience 9, 475-486.

Ananthasubramaniam, B., Diernfellner, A., Brunner, M., and Herzel, H. (2018)

Unconventional mechanisms of eukaryotic protein secretion. Curr Biol 28:R406-R410.

Dimou E and Nickel W (2018)

Unconventional protein secretion: Diversity and consensus. Sem Cell Dev Biol, PMID:29549063.

Nickel W and Rabouille C (2018)

Unconventional Secretion Mediates the Trans-cellular Spreading of Tau. Cell reports, 23(7), 2039–2055.

Katsinelos, T., Zeitler, M., Dimou, E., Karakatsani, A., Müller, H.M., Nachman, E., Steringer, J.P., Ruiz de Almodovar, C., Nickel, W., & Jahn, T.R. (2018)

Uncovering the “secret” Lives of Vacuolar Fusion pores in living cells. EMBOJ 37 (19) DOI:10.15252/embj.2018100656.

Söllner, T. Malsam, J. (2018)

The LOTUS domain is a conserved DEAD-box RNA helicase regulator essential for the recruitment of Vasa to the germ plasm and nuage. Genes Dev. 31(9), 939-952.

Jeske, M., Müller, C.W., Ephrussi, A. (2017)

NSUN5 methylates ribosomal RNA and modulates ribosome function in human cells. Experimental Gerontology 94:115-116.

Heissenberger,C., Dimitrijevic,N., Gonskikh,Y., Linder,A., Grillari-Voglauer,R., Koš,M., Polacek,N., Grillari,J. and Schosserer,M. (2017)

Post-transcriptional regulation of ribosome biogenesis in yeast. Microbial Cell 4(5): 179-181. doi: 10.15698/mic2017.05.575 (invited microreview)

Kos-Braun,I.C. and Koš,M. (2017)

Tor1 and CK2 kinases control a switch between alternative ribosome biogenesis pathways in a growth dependent manner. PLoS Biol 15(3):e2000245. doi:10.1371/journal.pbio.2000245.

Kos-Braun,I.C., Jung,I. and Koš,M. (2017)

3.2 Angstrœm resolution structure of the 90S pre-ribosome before A1 pre-rRNA cleavage. Nat. Struct. Mol. Biol. doi:10.1038/nsmb.3476.

Jingdong Cheng, Nikola Kellner, Otto Berninghausen, Ed Hurt and Roland Beckmann (2017)

9Å structure of COPI coat reveals that the Arf1 GTPase occupies two contrasting molecular environments, Elife 6. pii: e26691.

Dodonova, S.O., Aderhold, P., Kopp, J., Ganeva, I., Röhling, S., Hagen, W.J.H., Sinning, I., Wieland, F., & Briggs, J.A.G. (2017)

A puzzle of life: crafting ribosomal subunits Trends Biochem. Sci. , in press.

Dieter Kressler, Ed Hurt and Jochen Bassler (2017)

Accumulation of phosphatidylcholine on gut intestinal mucosa surface is not dominated by electrostatic interactions, BBA Biomembranes 1859: 959-965.

Korytowski, A., Abuillan, W., Amadei, F., Makky, A., Gumiero, A., Sinning, I., Gauss, A., Stremmel, W. & Tanaka, M. (2017)

An emerging case for membrane pore formation as a common mechanism for the unconventional secretion of FGF2 and IL-1beta. J. Cell Sci 130:3197-3202.

Brough D, Pellegrin P, and Nickel W (2017)

Backbone NMR assignments of tryparedoxin, the central protein in the hydroperoxide detoxification cascade of African trypanosomes, in the oxidized and reduced form. Biomol NMR Assign. 11, 193-196.

Wagner, A., Diehl, E., Krauth-Siegel, R. L. and Hellmich, U. A. (2017)

Biogenese und Autophagie des Endoplasmatischen Retikulums. BIOspektrum. Review, in German (abstract)

Schäfer JA, Schuck S (2017)

Bistacrines as potential antitrypanosomal agents. Bioorg. Med. Chem. 25, 4526-4531.

Schmidt, I., Göllner, S., Fuß, A., Stich, A., Kucharski, A., Schirmeister, T., Katzowitsch, E., Bruhn, H., Miliu, A., Krauth-Siegel, R. L., Holzgrabe, U. (2017)

Cation selectivity of the presequence translocase channel Tim23 is crucial for efficient protein import. ELife pii: e28324

Denkert N, Schendzielorz AB, Barbot M, Versemann L, Richter F, Rehling P, Meinecke M. (2017)

CNS Macrophages Control Neurovascular Development via CD95L. Cell Rep. 19(7):1378-1393

Chen S, Tisch N, Kegel M, Yerbes R, Hermann R, Hudalla H, Zuliani C, Gülcüler GS, Zwadlo K, von Engelhardt J, Ruiz de Almodóvar C, Martin-Villalba A. (2017)

Correspondence: Reply to 'Oncogenic MYC persistently upregulates the molecular clock component REV-ERBα'. Nat Commun. 2017; PMC5376643. doi:10.1038/ncomms14918.

Shostak, A., Ruppert, B., Diernfellner, A. and Brunner, M. (2017)

Crassiflorone derivatives that inhibit Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase (TbGAPDH) and Trypanosoma cruzi trypanothione reductase (TcTR) and display activity against Trypanosoma brucei parasites. Eur. J. Med. Chem. 141, 138-148.

Uliassi, E. Fiorani, G., Krauth-Siegel, R. L., Bergamini, C., Fato, R., Bianchini, G., Menéndez, J. C., Molina, M. T., López-Montero, E., Falchi, F., Cavalli, A., Gul, S., Kuzikov, M., Ellinger, B., Moraes, C. B., Freitas-Junior, L. H., Borsari, C., Costi, M. P. and Bolognesi, M. L. (2017)

Cryo-EM structure of a late pre-40S ribosomal subunit from Saccharomyces cerevisiae. eLife, 6, e30189.

André Heuer, Emma Thomson, Christian Schmidt, Otto Berninghausen, Thomas Becker, Ed Hurt and Roland Beckmann (2017)

Development of novel peptide-based Michael acceptors targeting rhodesain and falcipain-2 for the treatment of neglected tropical diseases (NTDs). J. Med. Chem. 60, 6911-6923.

Previti, S., Ettari, R., Cosconati, S., Amendola, G., Chouchene, K., Wagner, A., Hellmich, U. A., Ulrich, K., Krauth-Siegel, R. L., Wich, P. R., Schmid, I., Schirmeister, T., Gut, J., Rosenthal, P. J., Grasso, S. and Zapalà, M. (2017)

Dynamic subunit turnover in ESCRT-III assemblies is regulated by Vps4 to mediate membrane remodeling during cytokinesis. Nat Cell Biol 19, 787-798.

Mierzwa BE, Chiaruttini N, Redondo-Morata L, Moser von Filseck J, König J, Larios J, Poser I, Müller-Reichert T, Scheuring S, Roux A and Gerlich DW. (2017)

Electrostatic anchoring precedes stable membrane attachment of SNAP25/SNAP23 to the plasma membrane. eLife 6:e19394. DOI: 10.7554/eLife.19394

Weber P., Batoulis H., Rink K.M., Dahlhoff S., Pinkwart K., Söllner T.H., Lang T. (2017)

Eukaryotic ribosome assembly, transport and quality control. Nat. Struct. Mol. Biol. 24, 689-699. doi: 10.1038/nsmb.3454.

Cohue Peña, Ed Hurt and Vikram Govind Panse (2017)

Evaluation of dipeptide nitriles as inhibitors of rhodesain, a major cysteine protease of Trypanosoma brucei. Bioorg. Med. Chem. Lett. 27, 45-50.

Schirmeister, T., Schmitz, J., Jung, S., Schmenger, T., Krauth-Siegel, R. L. and Gütschow, M. (2017)

Fe65-PTB2 dimerization mimics Fe65-APP interaction, Front. Mol Neurosci. 10: 140.

Feilen, L.P., Haubrich, K., Strecker, P., Probst, S., Eggert, S., Stier, G., Sinning, I., Konietzko, U., Kins, S., Simon, B. & Wild, K. (2017)

Identification of a feedback loop involving beta-glucosidase 2 and its product sphingosine sheds light on the molecular mechanisms in Gaucher disease. J Biol Chem. pii: jbc.M116.762831. doi: 10.1074/jbc.M116.762831. [Epub ahead of print]

Schonauer S, Körschen HG, Penno A, Rennhack A, Breiden B, Sandhoff K, Gutbrod K, Dörmann P, Raju DN, Haberkant P, Gerl MJ, Brügger B, Zigdon H, Vardi A, Futerman AH, Thiele C, Wachten D. (2017)

Interaction network of the ribosome assembly machinery from a eukaryotic thermophile. Protein science 26(2), 327–342.

Baßler, J., Ahmed, Y.L., Kallas, M., Kornprobst, M., Rodriguez-Calvino, F., Gnädig, M., Thoms, M., Stier, G., Ismail, S., Kharde, S., Castillo, N., Griesel, S., Bastuck, S., Bradatsch, B., Thomson, E., Flemming, D., Sinning, I.* & Hurt, E.* (2017)

Interdependent action of KH domain proteins Krr1 and Dim2 drive the 40S platform assembly. Nature Commun., in press.

Miriam Sturm, Jingdong Cheng, Jochen Bassler, Roland Beckmann and Ed Hurt (2017)

Key steps in unconventional secretion of fibroblast growth factor 2 reconstituted with purified components. eLife (e28985).

Steringer JP, Lange S, Čujová S, Šachl R, Poojari C, Lolicato F, Beutel O, Müller HM, Unger S, Coskun Ü, Honigmann A, Vattulainen I, Hof M, Freund C, Nickel W (2017)

Lysine relay mechanism coordinates intermediate transfer in vitamin B6 biosynthesis, Nat. Chem. Biol. 3: 290-294.

Rodrigues, M.J., Windeisen, V., Zhang,Y., Guédez,G., Weber, S., Strohmeier, M., Hanes, J.W., Royant, A., Evans, G., Sinning, I., Ealick, S.E., Begley, T.P. & Tews, I. (2017)

Motor neurons control blood vessel patterning in the developing spinal cord. Nat Commun. 8:14583.

Himmels P, Paredes I, Adler H, Karakatsani A, Luck R, Marti HH, Ermakova O, Rempel E, Stoeckli ET & Ruiz de Almodovar C. (2017)

Mpp10 represents a platform for the interaction of multiple factors within the 90S pre-ribosome, PlosOne 12: e0183272.

Sá-Moura, B., Kornprobst, M., Kharde, S., Ahmed, Y.L., Stier, G., Kunze, R., Sinning*, I. & Hurt*, E. (2017)

Neuronal LRP4 regulates synapse formation in the developing CNS. Development.

Karakatsani A, Marichal N, Urban S, Kalamakis G, Ghanem A, Schick A, Zhang Y, Conzelmann KK, Rüegg MA, Berninger B, Ruiz de Almodovar C, Gascón S, Kröger S. (2017)

Peroxisomal dysfunctions cause lysosomal storage and axonal Kv1 channel redistribution in peripheral neuropathy. Elife. 6.

Kleinecke S, Richert S, de Hoz L, Brügger B, Kungl T, Asadollahi E, Quintes S, Blanz J, McGonigal R, Naseri K, Sereda MW, Sachsenheimer T, Lüchtenborg C, Möbius W, Willison H, Baes M, Nave KA, Kassmann CM. (2017)

Pre-ribosomes escaping the nucleus are caught during translation by cytoplasmic quality control quality control mechanisms. Nat. Struct. Mol. Biol., doi: 10.1038/nsmb.349.

Anshuk Sarkar, Matthias Thoms, Clara Barrio-Garcia, Emma Thomson, Dirk Flemming, Roland Beckmann and Ed Hurt (2017)

Reconstitution of the complete pathway of of ITS2 processing at the pre-ribosome. Nature Commun., in press.

Lisa Fromm, Sebastian Falk, Dirk Flemming, Jan Schuller, Matthias Thoms, Elena Conti and Ed Hurt (2017)

RIPK1/RIPK3 promotes vascular permeability to allow tumor cell extravasation independent of its necroptotic function. Cell Death Dis. 8(2):e2588.

Hänggi K, Vasilikos L, Freire Valls A, Yerbes R, Knop J, Spilgies L, Rieck K, Misra T, Bertin J, Gough PJ, Schmidt T, Ruiz de Almodovar C & Wong WW. (2017)

Short linear motifs in scaffold Nups act as sensors to cooperatively connect pre-assembled modules during NPC biogenesis. Nature Commun. 8, 1107. doi: 10.1038.

Roman Teimer, Jan Kosinski, Alexander von Appen, Martin Beck and Ed Hurt (2017)

Split-BioID a conditional proteomics approach to monitor the composition of spatiotemporally defined protein complexes. Nature Commun 8, 15690.

Schopp, I., Amaya Ramirez, C., Debeljak, J., Kreibich, E., Skribbe, M., Wild, K., and Béthune, J.* (2017)

Stress-induced protein S-glutathionylation and S-trypanothiolation in African trypanosomes – a quantitative redox proteome and thiol analysis. Antiox. Redox Sign. 27, 517-533.

Ulrich, K., Finkenzeller, C., Merker, S., Rojas, F., Matthews, K., Ruppert, T. and Krauth-Siegel, R. L. (2017)

Structural basis for 5'-ETS recognition by Utp4 at the early stages of ribosome biogenesis. PLOS ONE 12(6): e0178752.

Calviño, F.R., Kornprobst, M., Schermann, G., Birkle, F., Wild, K., Fischer, T., Hurt, E., Ahmed, Y.L. & Sinning, I. (2017)

Structural basis of HypK regulating N-terminal acetylation by the NatA complex, Nat Comms 8: 15726.

Weyer, F.A., Gumiero, A., Lapouge, K., Bange, G., Kopp, J. & Sinning, I. (2017)

Structural insights into a unique Hsp70/Hsp40 interaction in the eukaryotic ribosome-associated complex, Nat. Struct. Mol. Biol. 24:144-151. F1000Prime recommended

Weyer, F. A., Gumiero, A., Valentín Gesé, G., Lapouge, K. & Sinning, I. (2017)

Structural insights into the interaction of the nuclear exosome helicase Mtr4 with the pre-ribosomal protein Nop53. RNA 23, 1780-1787. doi: 10.1261/rna.062901.117.

Sebastian Falk, Jan-Niklas Tants, Ed Hurt, Michael Sattler and Elena Conti (2017)

Structures of human SRP72 reveal its function in co-translational protein targeting, Nucl. Acids Res. 45: 470-481.

Becker, M.M.M., Lapouge, K., Segnitz, B., Wild, K. & Sinning, I. (2017)

Synthesis and in vitro antikinetoplastid activity of polyamine-hydroxybenzotriazole conjugates. Bioorg. Med. Chem. 25, 84-90.

Jagu, E., Pomel, S., Díez-Martínez, A., Ramiandrasoa, F., Krauth-Siegel, R. L., Pethe, S., Blonski, C., Labruère, R. and Loiseau, P. M. (2017)

The coding and noncoding transcriptome of Neurospora crassa. BMC Genomics. 2017; PMC5738166. doi:10.1186/s12864-017-4360-8.

Cemel, I. A., Ha, N., Schermann, G., Yonekawa, S. and Brunner, M. (2017)

The host-cell restriction factor SERINC5 restricts HIV-1 infectivity without altering the lipid composition and organization of viral particles. J Biol Chem. 292(33):13702-13713.

Trautz B, Wiedemann H, Lüchtenborg C, Pierini V, Kranich J, Glass B, Kräusslich HG, Brocker T, Pizzato M, Ruggieri A, Brügger B, Fackler OT. (2017)

The MICOS component Mic60 displays a conserved membrane-bending activity that is necessary for normal cristae morphology. Journal of Cell Biology 216, 889-899

Tarasenko D, Barbot M, Jans DC, Kroppen B, Sadowski B, Heim G, Möbius W, Jakobs S, Meinecke M. (2017)

The molecular mechanism underlying unconventional secretion of fibroblast growth factor 2 from tumor cells. Biol. Cell 109:375-380.

Steringer JP and Nickel W (2017)

The nuclear pore complex: understanding its function through structural insight. Nature Rev. Mol. Cell Biol. 18, 73-89.

Martin Beck and Ed Hurt (2017)

Thiolutin is a zinc chelator that inhibits the Rpn11 and other JAMM metalloproteases. Nat Chem Biol. 2017; PMC5792653. doi:10.1038/nchembio.2370.

Lauinger, L., Li, J., Shostak, A., Cemel, I. A., Ha, N., Zhang, Y., Merkl, P. E., Obermeyer, S., Stankovic-Valentin, N., Schafmeier, T., Wever, W. J., Bowers, A. A., Carter, K. P., Palmer, A. E., Tschochner, H., Melchior, F., Deshaies, R. J., Brunner, M. and Diernfellner, A. (2017)

Transcriptomic analysis displays the effect of (-)-roemerine on the motility and nutrient uptake in Escherichia coli. Curr Genet. 63(4):709-722.

Ayyildiz D, Arga KY, Avci FG, Altinisik FE, Gurer C, Gulsoy Toplan G, Kazan D, Wozny K, Brügger B, Mertoglu B, Sariyar Akbulut B. (2017)

Trifunctional lipid probes for comprehensive studies of single lipid species in living cells. PNAS 114; 7; 1566-1571; doi: 10.1073/pnas.1611096114

Höglinger D, Nadler A, Haberkant P, Kirkpatrick J, Schifferer M, Stein F, Hauke S, Porter FD, Schultz C. (2017)

Trypanocidal activity of quinoxaline 1,4 di-N-oxide derivatives as trypanothione reductase inhibitors. Molecules 22, 220

Chacón-Vargas, K. F., Nogueda-Torres, B.; Sánchez-Torres, L. E., Suarez-Contreras, E., Villalobos-Rocha, J. C., Torres-Martinez, Y., Lara-Ramirez, E. E., Fiorani, G., Krauth-Siegel, R. L., Bolognesi, M. L., Monge, A., Rivera, G. (2017)

Two chaperones locked in an embrace: Structure and function of the ribosome-associated complex RAC, Nat. Struct. Mol. Biol. 24: 611-619.

Zhang, Y., Sinning, I. & Rospert, S. (2017)

Tyrosine Kinase Expressed in Hepatocellular Carcinoma, TEC, Controls Pluripotency and Early Cell Fate Decisions of Human Pluripotent Stem Cells via Regulation of Fibroblast Growth Factor-2 Secretion. Stem Cells 35:2050-2059.

Vanova T, Konecna Z, Zbonakova Z, La Venuta G, Zoufalova K, Jelinkova S, Varecha M, Rotrekl V, Krejci P, Nickel W, Dvorak P, Kunova-Bosakova M (2017)

Visualizing the assembly pathway of nucleolar pre-60S ribosomes, Cell 171: 1599-1610.

Kater, L., Thoms, M., Barrio Garcia, C., Cheng, J., Ismail, S., Ahmed, Y.L., Bange, G., Kressler, D., Berninghausen, O., Sinning, I., Hurt, E. & Beckmann, R. (2017)

Visualizing the earliest steps during nucleolar pre-60S ribosome assembly. Cell 171, 1599–1610.

Lukas Kater, Matthias Thoms, Clara Barrio Garcia, Jingdong Cheng, Sherif Ismail, Yasar Luqman Ahmed, Gert Bange, Dieter Kressler, Otto Berninghausen, Irmi Sinning, Ed Hurt and Roland Beckmann (2017)

YAP/TAZ orchestrate VEGF signaling during developmental angiogenesis. Dev Cell. 42(5):462-478.e7.

Wang X, Freire Valls A, Shermann G, Shen Y, Moya IM, Castro L, Urban S, Solecki GM, Winkler F, Riedemann Lm Jain RK, Mazzone M, Schmidt T, Fischer T, Halder G, Ruiz de Almodovar C. (2017)

Structural and functional evaluation of interaction between mammalian ribosomal RNA with platinum-containing antineoplastic drugs. Toxicology Letters 242, 47-52.

Theile,D. and Koš,M. (2016)

A versatile multivariate image analysis pipeline reveals features of Xenopus extract spindles. J Cell Biol 213:127-136.

Grenfell AW, Strzelecka M, Crowder ME, Helmke KJ, Schlaitz AL, Heald R (2016)

Architecture of a ribosome assembly bound to a combined remodeling-checkpoint machinery. Nature Struct. Mol. Biol. 23, 37-44 doi:10.1038/nsmb.3132.

Clara Barrio-Garcia, Matthias Thoms, Dirk Flemming, Lukas Kater, Jochen Bassler, Roland Beckmann and Ed Hurt (2016)

Architecture of the 90S pre-ribosome: a structural view on the birth of the eukaryotic ribosome. Cell 166, 380–393.

Markus Kornprobst, Martin Turk, Nikola Kellner, Jing-Dong Cheng, Dirk Flemming, Martin Koš, Isabelle Ko&scaron, Matthias Thoms, Otto Berninghausen, Roland Beckmann and Ed Hurt (2016)

Architecture of the 90S Pre-ribosome: A Structural View on the Birth of the Eukaryotic Ribosome. Cell, 166(2), 380–393.

Kornprobst, M., Turk, M., Kellner, N., Cheng, J., Flemming, D., Koš-Braun, I., Koš, M., Thoms, M., Berninghausen, O., Beckmann, R., & Hurt, E. (2016)

Bifunctional Sphingosine for Cell-Based Analysis of Protein-Sphingolipid Interactions. ACS Chemical Biology 2016 11 (1), 222-230. doi: 10.1021/acschembio.5b00810

Haberkant, P., Stein, F., Höglinger, D., Gerl, M.J., Brügger, B., Van Veldhoven, P.P., Krijgsveld, J., Gavin, A.C., & Schultz, C. (2016)

Catalytic properties, localization, and in vivo role of Px IV, a novel tryparedoxin peroxidase of Trypanosoma brucei. Mol. Biochem. Parasitol. 207, 84-88.

Liu, I., Bogacz, M., Schaffroth, C., Dirdjaja, N., and Krauth-Siegel, R. L. (2016)

Concerted removal of the Erb1-Ytm1 complex in ribosome biogenesis relies on an elaborate interface, Nucl. Acids Res. 44: 926-39.

Thoms, M., Ahmed. Y.L., Maddi, K., Hurt, E. & Sinning, I. (2016)

Coupling ribosome stalk biogenesis with nuclear export factor recruitment to the nascent 60S subunit. Nat. Struct. Mol. Biol. 23, 1074-1082.

Anshuk Sarkar, Markus Pech, Matthias Thoms, Dirk Flemming, Roland Beckmann and Ed Hurt (2016)

Developing genetic tools to exploit Chaetomium thermophilum for biochemical analyses of eukaryotic macromolecular assemblies. Sci Rep. 5:15401. doi: 10.1038/srep15401.

Nikola Kellner, Johannes Schwarz, Miriam Sturm, Javier Fernandez-Martinez, Sabine Griesel, Wenzhu Zhang, Brian Chait, Michael P. Rout, Ulrich Kück and Ed Hurt (2016)

Dipeptidyl nitroalkenes as potent reversible inhibitors of cysteine proteases rhodesain and cruzain. ACS Medic. Chem. Letters 7, 1073-1076.

Latorre, A., Schirmeister, T., Kesselring, J., Jung, S., Johé, P., Hellmich, U. A., Heilos, A., Engels, B., Krauth-Siegel, R. L., Dirdjaja, N., Bou-Iserte, L., Rodríguez, S. and González, F. V. (2016)

Extension of Helix 12 in Munc18-1 Induces Vesicle Priming. J. Neurosci. 36(26): 6881-6891.

Munch, A.S., Kedar, G.H., van Weering, J.R.T., Vazquez-Sanchez, S., He, E., Andre, T., Braun, T., Söllner, T.H., Verhage, M., Sørensen, J.B. (2016)

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. Review (abstract)

Klionsky DJ, Abdelmohsen K, ..., Schuck S, ... Zughaier SM (2016)

In vitro and in vivo identification of tetradentated polyamine complexes as highly efficient metallodrugs against Trypanosoma cruzi. Exp. Parasitol. 164, 20-30.

Olmo, F., Cussó, O., Marín, C., Rosales, M. J., Urbonová, K., Krauth-Siegel, R. L., Costas, M., Ribas, X. and Sánchez-Moreno, M. (2016)

Inflammasome-dependent IL-1β release depends upon membrane permeabilisation. Cell Death Differ. 23:1219-31.

Martín-Sánchez F, Diamond C, Zeitler M, Gomez AI, Baroja-Mazo A, Bagnall J, Spiller D, White M, Daniels MJ, Mortellaro A, Peñalver M, Paszek P, Steringer JP, Nickel W, Brough D, Pelegrín P. (2016)

Inhibitory effect of phenothiazine- and phenoxazine-derived chloroacetamides on Leishmania major growth and Trypanosoma brucei trypanothione reductase. Eur. J. Med. Chem. 108, 436-443.

Marcu, A., Schurigt, U., Müller, K., Moll, H., Krauth-Siegel, R. L. and Prinz, H. (2016)

Interaction of the cotranslational Hsp70 Ssb with ribosomal proteins and rRNA depends on its lid domain, Nat. Comms. 7: 13563.

Gumiero, A., Conz, C., Valentín Gesé, G., Zhang, Y., Weyer, F. A., Lapouge, K., Kappes, J., von Plehwe, U., Schermann, G., Fitzke, E., Wölfle, T., Fischer, T., Rospert, S. & Sinning, I. (2016)

Interactions Between SNAP-25 and Synaptotagmin-1 Are Involved in Vesicle Priming, Clamping Spontaneous and Stimulating Evoked Neurotransmission. J Neurosci. 36(47):11865-11880

Schupp M, Malsam J, Ruiter M, Scheutzow A, Wierda KD, Söllner TH, Sørensen JB. (2016)

Mcp3 is a novel mitochondrial outer membrane protein that follows a unique IMP-dependent biogenesis pathway. EMBO Rep. 17(7):965-81.

Sinzel M, Tan T, Wendling P, Kalbacher H, Özbalci C, Chelius X, Westermann B, Brügger B, Rapaport D, Dimmer KS. (2016)

Molecular architecture of the inner ring scaffold of the human nuclear pore complex. Science 352, 363-365. doi: 10.1126/science.aaf0643.

Jan Kosinski, Shyamal Mosalaganti, Alexander von Appen, Roman Teimer, Amanda DiGuilio, William Wan, Huy Khahn Bui, Wim J.H. Hagen, John A.G. Briggs, Joseph S. Glavy, Ed Hurt and Martin Beck (2016)

Morphology and Molecular Composition of Purified Bovine Viral Diarrhea Virus Envelope. PLoS Pathog. 12(3).

Callens N, Brügger B, Bonnafous P, Drobecq H, Gerl MJ, Krey T, Roman-Sosa G, Rümenapf T, Lambert O, Dubuisson J, Rouillé Y. (2016)

MYC inhibits the clock and supports proliferation. Cell Cycle. 2016; PMC5224463. doi:10.1080/15384101.2016.1224760.

Shostak, A., Diernfellner, A. and Brunner, M. (2016)

MYC/MIZ1-dependent gene repression inversely coordinates the circadian clock with cell cycle and proliferation. Nat Commun. 2016; PMC4931031. doi:10.1038/ncomms11807.

Shostak, A., Ruppert, B., Ha, N., Bruns, P., Toprak, U. H., Eils, R., Schlesner, M., Diernfellner, A. and Brunner, M. (2016)

New molecular mechanisms of inter-organelle lipid transport. Biochem Soc Trans 44(2), 486-492.

Drin G, Moser von Filseck J and Copic A. (2016)

On keeping the right ER size. Nature Cell Biology. Commentary (abstract)

Schuck S (2016)

Pathogenic mycobacteria achieve cellular persistence by inhibiting the Niemann-Pick Type C disease cellular pathway. Wellcome Open Res 1;18; doi: 10.12688/wellcomeopenres.10036.1.

Fineran P, Lloyd-Evans E, Lack NA, Platt N, Davis LC, Morgan AJ, Höglinger D, Tatituri RV, Clark S, Williams IM, Tynan P, Al Eisa N, Nazarova E, Willians A, Galione A, Ory DS, Besra GS, Russell DG, Brenner MB, Sim E, Platt FM. (2016)

Phosphatase of regenerating liver (PRL)-3 disrupts epithelial architecture by altering the post-mitotic midbody position. J Cell Sci. 129(21):4130-4142.

Luján P, Varsano G, Rubio T, Hennrich ML, Sachsenheimer T, Gálvez-Santisteban M, Martín-Belmonte F, Gavin AC, Brügger B, Köhn M. (2016)

RNA-DNA hybrids and RNase H activity are required for efficient DSB repair, Cell 167: 1001-13.

Ohle, C., Tesorero, R., Schermann, G., Dobrev, N., Sinning, I. & Fischer, T. (2016)

Role of cation-dependent Nug1 GTPase in recruiting Dbp10 helicase to the undeveloped peptidyl transferase center of the pre-ribosome. Nucl Acid Res. doi: 10.1093/nar/gkw045.

George Manikas, Emma Thomson and Ed Hurt (2016)

Running up that hill: how to create cellular lipid gradients by lipid counter-flows. Biochimie 130, 115-121.

Moser von Filseck J and Drin G. (2016)

Small Molecule Inhibitors Targeting Tec Kinase Block Unconventional Secretion of Fibroblast Growth Factor 2. J. Biol. Chem. 291:17787-803.

La Venuta G, Wegehingel S, Sehr P, Müller HM, Dimou E, Steringer JP, Grotwinkel M, Hentze N, Mayer MP, Will DW, Uhrig U, Lewis JD, Nickel W (2016)

Sphingosine-1-Phosphate Lyase Deficient Cells as a Tool to Study Protein Lipid Interactions. PLOS ONE 11(4): e0153009.

Gerl, M.J., Bittl, V., Kirchner, S., Sachsenheimer, T., Brunner, H.L., Lüchtenborg, C., Özbalci, C., Wiedemann, H., Wegehingel, S., Nickel, W., Haberkant, P., Schultz, C., Krüger, M., & Brügger, B. (2016)

Structural basis for conserved regulation and adaptation of the signal recognition particle targeting complex, J. Mol. Biol. 428: 2880-97.

Wild, K., Bange, G., Motiejunas, D., Kribelbauer, J., Hendricks, A., Segnitz, B., Wade, R., & Sinning, I. (2016)

Structure and function of α-crystallins: Traversing from in vitro to in vivo. Biochim Biophys Acta 1860(1 Pt B):149-66. [Review]

Haslbeck M, Peschek, Buchner J, Weinkauf S (2016)

TAM receptors Tyro3 and Mer as novel targets in colorectal cancer. Oncotarget. Aug 30;7(35):56355-56370. doi: 10.18632/oncotarget.10889.

Schmitz R, Freire Valls A, Yerbes R, von Richter S, Kahlert C, Loges S, Weitz J, Schneider M, Ruiz de Almodovar C, Ulrigh A, Schmidt T. (2016)

The cytosolic or the mitochondrial glutathione peroxidase-type tryparedoxin peroxidase is sufficient to protect procyclic Trypanosoma brucei from iron-mediated mitochondrial damage and lysis. Mol. Microbiol. 99, 172-187.

Schaffroth, C., Bogacz, M., Dirdjaja, N., Nissen, A. and Krauth-Siegel, R. L. (2016)

The Oxygen Sensor PHD2 Controls Dendritic Spines and Synapses via Modification of Filamin A. Cell Rep. 14(11):2653-67.

Segura I, Lange C, Knevels E, Moskalyuk A, Pulizzi R, Eelen G, Chaze T, Tudor C, Boulegue C, Holt M, Daelemans D, Matondo M, Ghesquière B, Giugliano M, Ruiz de Almodovar C, Dewerchin M & Carmeliet P. (2016)

Thiol redox biology of trypanosomatids and potential targets for chemotherapy. Mol. Biochem. Parasitol. 206, 67-74.

Leroux, A. and Krauth-Siegel, R. L. (2016)

Vascular endothelial growth factor: a neurovascular target in neurological diseases. Nat Rev Neurol. 12(8):439-54.

Lange C, Storkebaum E, Ruiz de Almodovar C, Dewerchin M & Carmeliet P. (2016)

α1-Antitrypsin Combines with Plasma Fatty Acids and Induces Angiopoietin-like Protein 4 Expression. J Immunol. 11. pii: 1500740.

Frenzel E, Wrenger S, Brügger B, Salipalli S, Immenschuh S, Aggarwal N, Lichtinghagen R, Mahadeva R, Marcondes AM, Dinarello CA, Welte T, Janciauskiene S. (2015)

The crystal structure of the Drosophila germline-inducer Oskar identifies two domains with distinct Vasa helicase- and RNA-binding activities. Cell Rep. 12(4), 587-98.

Jeske, M., Bordi, M., Glatt, S., Müller, S., Rybin, V., Müller, C.W., Ephrussi, A. (2015)

A conformational RNA zipper promotes intron ejection during non-conventional XBP1 mRNA splicing. EMBO Rep. 16(12):1688-98.

Peschek J, Acosta-Alvear D, Mendez AS, Walter P (2015)

Fast protein depletion system utilizing tetracycline repressible promoter and N-end rule in yeast. Mol Biol Cell 26, 762-8.

Gnanasundram,S.V. and Koš,M. (2015)

Methylation of ribosomal RNA by Nsun5 is a conserved mechanism modulating organismal life span. Nat Commun 6, 6158.

Schosserer,M., Minois,N., Angerer,T.B., Amring,M., Dellago,H, Harreither,E., Calle-Perez,A., Pircher,A., Gerstl,M.P., Pfeifenberger,S., Brandl,C., Sonntagbauer,M., Kriegner,A., Linder,A., Weinhäusel,A., Mohr,T., Steiger,M., Mattanovich,D., Rinnerthaler,M., Karl,T., Sharma,S., Entian,K.-D., Koš,M., Breitenbach,M., Wilson,I.B.H., Polacek,N., Grillari-Voglauer,R., Breitenbach-Koller,L. and Grillari,J. (2015)

Self-association of Trimethylguanosine Synthase Tgs1 is required for efficient snRNA/snoRNA trimethylation and pre-rRNA processing. Sci Rep 5, 11282.

Boon,K.-L., Pearson,M.D. and Koš,M. (2015)

A Dual SILAC Proteomic Labeling Strategy for Quantifying Constitutive and Cell-Cell Induced Protein Secretion. J. Proteome Res. 14, 8, 3229–3238.

Stiess M, Wegehingel S, Nguyen C, Nickel W, Bradke F, Cambridge SB (2015)

A network of assembly factors is involved in remodeling rRNA elements during preribosome maturation, J. Cell Biol. 210: 169-70.

Bassler, J., Paternoga, H., Holdermann, I., Thoms, M., Grannemann, S., Barrio-Garcia, C., Nyarko, A., Lee, W. Stier, G., Clark, S., Schraivogel, D., Kallas, M., Beckmann, R., Tollervey, D., Barbar, E., Sinning*, I. & Hurt*, E. (2015)

A phosphatidylinositol 4-phosphate powered exchange mechanism to create a lipid gradient between membranes. Nat Commun 6, 6671 (2015).

Moser von Filseck J, Vanni S, Mesmin B, Antonny B and Drin G. (2015)

A post-docking role of synaptotagmin 1-C2B domain bottom residues R398/399 in mouse chromaffin cells. J. Neurosci. 35(42): 14172-14182.

Kedar, G.H., Munch, A.S., van Weering, J.R.T., Malsam, J., Scheutzow, A., de Wit, H., Houy, S., Tawfik, B., Söllner, T.H., Sørensen, J.B., Verhage, M. (2015)

A structure of the COPI coat and the role of coat proteins in membrane vesicle assembly. Science. 349:195-198.

Dodonova SO, Diestelkoetter-Bachert P, von Appen A, Hagen WJH, Beck R, Beck M, Wieland F, and Briggs JAG. (2015)

Accumulation of differentiating intestinal stem cell progenies drives tumorigenesis. Nat Commun. 2015; PMC4703904. doi:10.1038/ncomms10219.

Zhai, Z., Kondo, S., Ha, N., Boquete, J. P., Brunner, M., Ueda, R. and Lemaitre, B. (2015)

Architecture of a ribosome assembly bound to a combined remodeling-checkpoint machinery. Nature Struct. Mol. Biol.

Clara Barrio-Garcia, Matthias Thoms, Dirk Flemming, Lukas Kater, Jochen Bassler, Roland Beckmann and Ed Hurt (2015)

Architecture of the nuclear pore inner ring complex. Science 350, 56-64.

Tobias Stuwe, Christopher J. Bley, Karsten Thierbach, Stefan Petrovic, Sandra Schilbach, Daniel J. Mayo, Thibaud Perriches, Emily J. Rundlet, Young Jeon, Leslie N. Collins, Daniel H. Lin, Marcin Paduch, Akiko Koide, Vincent Lu, Jessica Fischer, Ed Hurt, Shohei Koide, Anthony A. Kossiakoff, André Hoelz (2015)

Cardiac-specific succinate dehydrogenase deficiency in Barth syndrome. EMBO Mol Med. pii: e201505644. epub

Dudek J, Cheng IF, Chowdhury A, Wozny K, Balleininger M, Reinhold R, Grunau S, Callegari S, Toischer K, Wanders RJ, Hasenfuß G, Brügger B, Guan K, Rehling P. (2015)

Characterization of the Chaetomium thermophilum TREX-2 complex and its interaction with the mRNA nuclear export factor MEX67:MTR2. Structure 23, 1246-1257.

Lyudmila Dimitrova, Eugine Valkow, Shinataro Aibara, Dirk Flemming, Steven McLaughlin, Ed Hurt and Murray Stewart (2015)

Combinatorial control of light induced chromatin remodeling and gene activation in Neurospora. PLoS Genet. 2015; PMC4378982. doi:10.1371/journal.pgen.1005105.

Sancar, C., Ha, N., Yilmaz, R., Tesorero, R., Fisher, T., Brunner, M. and Sancar, G. (2015)

Coordinated ITS2 rRNA processing by the Las1 complex integrating endonuclease, polynucleotide kinase and exonuclease activities Mol. Cell, 60(5):808-15. doi: 10.1016/j.molcel.2015.10.021.

Lisa Gasse, Dirk Flemming and Ed Hurt (2015)

Coordinated ribosomal L4 protein assembly into the pre-ribosome is regulated by its eukaryote-specific extension. Mol. Cell 58, 854-862.

Philipp Stelter, Ferdinand Huber, Ruth Kunze, Dirk Flemming, André Hoelz and Ed Hurt (2015)

Co-translational capturing of nascent ribosomal proteins by their dedicated chaperones. Nature communications, 6, 7494.

Pausch, P., Singh, U., Ahmed, Y. L., Pillet, B., Murat, G., Altegoer, F., Stier, G., Thoms, M., Hurt, E., Sinning, I., Bange, G., & Kressler, D. (2015)

Dawn- and dusk-phased circadian transcription rhythms coordinate anabolic and catabolic functions in Neurospora. BMC Biol 13, 17.

Sancar, C., Sancar, G., Ha, N., Cesbron, F. and Brunner, M. (2015)

Detection of thiol-based switch processes in parasites – facts and future. Biol. Chem. 396, 445-463.

Rahbari, M., Diederich, K., Becker, K., Krauth-Siegel, R. L. and Jortzik, E. (2015)

Direct and high throughput (HT) interactions on the ribosomal surface by iRIA. Sci Rep. 5:15401. doi: 10.1038/srep15401.

Elisa Pesce, Claudia Minici, Jochen Bassler, Ed Hurt, Massimo Degano, Piera Calamita and Stefano Biffo (2015)

Einblicke in die 'Kinderstube' während der Ribosomen-Entwicklung. Biospektrum (Springer Verlag) 02.15, 144-147.

Jochen Baßler und Ed Hurt (2015)

Expression of membrane proteins in the eyes of transgenic Drosophila melanogaster. Methods Enzymol. 556: 219-39.

Hackmann, Y., Jödicke, L., Panneels, V. & Sinning, I. (2015)

Formation of Disulfide Bridges Drives oligomerization, membrane pore formation and translocation of fibroblast growth factor 2 to cell surfaces, J. Biol. Chem. 290: 8925-37.

Müller, H.M., Steringer, J.S., Wegehingel, S., Bleicken, S., Münster, M., Dimou, E., Unger, S., Weidmann, G., Andreas H., Garcia-Saez, A., Wild, K., Sinning, I. & Nickel, W. (2015)

Glioma cell VEGFR-2 confers resistance to chemotherapeutic and antiangiogenic treatments in PTEN-deficient glioblastoma. Oncotarget. 6(31):31050-68.

Kessler T, Sahm F, Blaes J, Osswald M, Rübmann P, Milford D, Urban S, Jestaedt L, Heiland S, Bendszus M, Hertenstein A, Pfenning PN, Ruiz de Almodóvar C, Wick A, Winkler F, von Deimling A, Platten M, Wick W, Weiler M. (2015)

Glutaredoxin-deficiency confers bloodstream Trypanosoma brucei with improved thermotolerance. Mol. Biochem. Parasitol. 204, 93-105.

Musunda, B., Benítez, D., Dirdjaja, N., Comini, M. A. and Krauth-Siegel, R. L. (2015)

HIV-Tat Forms Phosphoinositide Dependent Membrane Pores Implicated in Unconventional Protein Secretion. J Biol Chem [Epub ahead of print].

Zeitler M, Steringer JP, Müller HM, Mayer MP, Nickel W (2015)

Homeostasis of phospholipids - The level of phosphatidylethanolamine tightly adapts to changes in ethanolamine plasmalogens. Biochim Biophys Acta. 1851(2):117-28.

Dorninger F, Brodde A, Braverman NE, Moser AB, Just WW, Forss-Petter S, Brügger B, Berger J. (2015)

Human mesenchymal stem cells enhance the systemic effects of radiotherapy. Oncotarget. 6(31):31164-80.

Farias VA, O'Valle F, Lerma BA, Ruiz de Almodóvar C, López-Peñalver JJ, Nieto A, Santos A, Fernández BI, Guerra-Librero A, Ruiz-Ruiz MC, Guirado D, Schmidt T, Oliver FJ, Ruiz de Almodóvar JM. (2015)

Inhibition of Ebola virus glycoprotein-mediated cytotoxicity by targeting its transmembrane domain and cholesterol. Nat Commun 6, 7688.

Hacke, M., Björkholm, A., Hellwig, P., Himmels, P., Ruiz de Almodóvar, C., Brügger, B., Wieland, F., & Ernst, A.M. (2015)

Intracellular sphingosine releases calcium from lysosomes. ELife. doi: 10.7554/eLife.10616

Höglinger D, Haberkant P, Aguilera-Romero A, Riezman H, Porter FD, Platt FM, Galione A, Schultz C. (2015)

Linker Nups connect the nuclear pore complex inner ring with outer ring and transport channel. Nature Struct. Mol. Biol. 22, 774-81.

Jessica Fischer, Roman Teimer, Stefan Amlacher, Ruth Kunze and Ed Hurt (2015)

Mammalian SRP receptor switches the Sec61 translocase from Sec62 to SRP-dependent translocation, Nat Comms. 6: 10133.

Jadhav, B., McKenna, M., Johnson, N., High, S., Sinning, I. & Pool, M.R. (2015)

Mic10 oligomerizes tob end mitochondrial inner membranes at cristae junctions. Cell Metabolism 21, 756-763

Barbot M, Jans DC, Schulz C, Denkert N, Kroppen B, Hoppert M, Jakobs S, Meinecke M. (2015)

NTF2-like domain of Tap plays a critical role in cargo mRNA recognition and export. Nucl. Acid Res 3, 1894-904.

Jun Katahira, Lyudmila Dimitrova, Yumiko Imai, Ed Hurt (2015)

Phosphatidylserine transport by ORP/Osh proteins is driven by phosphatidylinositol 4-phosphate. Science 349(6246), 432-436 (2015).

Moser von Filseck J, Copic A, Delfosse V, Vanni S, Jackson CL, Bourguet W and Drin G. (2015)

Quantitative analysis of the human T cell palmitome. Sci Rep. 5:11598.

Morrison E, Kuropka B, Kliche S, Brügger B, Krause E, Freund C. (2015)

Structural basis for assembly and function Nup82 complex in the nuclear pore scaffold. J. Cell Biol. 208, 283-297 doi/10.1083/jcb.201411003.

Monika Gaik, Dirk Flemming, Alexander von Appen, Panagiotis Kastritis, Philipp Stelter, Khanh Huy Bui, Alessandro Ori, Jochen Bassler, Jessica Fischer, Elisar Barbar, Martin Beck and Ed Hurt (2015)

Structural basis for cpSRP43 chromodomain selectivity and dynamics in Alb3 insertase interaction, Nat Comms. 6: 8875.

Horn, A., Hennig, J., Ahmed, J.L., Stier, G., Wild, K., Sattler, M. & Sinning, I. (2015)

Structural characterization of the principal mRNA export factor Mex67:Mtr2 from Chaetomium thermophilum. Acta Cryst.F71, 876-888.

Shintaro Aibara, Eugene Valkov, Meindert Lamers, Lyudimila Dimitrova, Ed Hurt and Murray Stewart (2015)

Structure and switch cycle of SRβ as ancestral eukaryotic GTPase associated with secretory membranes, Structure 23: 1838-47.

Jadhav, B., Wild, K., Pool, M.R. & Sinning, I. (2015)

Strukturelle Evolution des Signalerkennungspartikels, Biospektrum 02: 161-163.

Kempf, G., Wild, K. & Sinning, I. (2015)

Symportin 1 chaperones 5S RNP assembly during ribosome biogenesis by occupying an essential rRNA-binding site. Nat Commun 6, 6510.

Calviño, F.R., Kharde, S., Ori, A., Hendricks, A., Wild, K., Kressler, D., Bange, G., Hurt, E., Beck, M. & Sinning, I. (2015)

The chaperone αB-crystallin uses different interfaces to capture an amorphous and an amyloid client. Nat Struct Mol Biol. 22(11):898-905.

Mainz A, Peschek J, Stavropoulou M, Back KC, Bardiaux B, Asami S, Prade E, Peters C, Weinkauf S, Buchner J, Reif B (2015)

The exosome is recruited to RNA substrates through specific adapter proteins. Cell 162, 1029-1038.

Matthias Thoms, Emma Thomson Jochen Baßler, Marén Gnädig, Sabine Griesel and Ed Hurt (2015)

The fission yeast MTREC complex targets CUTs and unspliced pre-mRNAs to the nuclear exosome. Nat. Commun. 7:7050 (*These authors contributed equally.)

Zhou, Y.*, Zhu, J.*, Schermann, G., Ohle, C., Bendrin, K., Sugioka-Sugiyama, R., Sugiyama, T., and Fischer, T. (2015)

The Orphan Receptor Tie1 Controls Angiogenesis and Vascular Remodeling by Differentially Regulating Tie2 in Tip and Stalk Cells. Cell Rep. 12(11):1761-73.

Savant S, La Porta S, Budnik A, Busch K, Hu J, Tisch N, Korn C, Valls AF, Benest AV, Terhardt D, Qu X, Adams RH, Baldwin HS, Ruiz de Almodóvar C, Rodewald HR, Augustin HG. (2015)

The Startling Properties of Fibroblast Growth Factor 2: How to Exit Mammalian Cells Without a Signal Peptide at Hand? J Biol Chem. pii: jbc.R115.689257. [Epub ahead of print].

La Venuta G, Zeitler M, Steringer JP, Müller HM, Nickel W (2015)

The structure of Rpf2-Rrs1 explains its role in ribosome biogenesis, Nucl. Acids Res. 43: 7083-95.

Kharde, S., Calviño, F.R., Gumiero, A., Wild, K. & Sinning, I. (2015)

Toward understanding nuclear pore complex architecture and dynamics in the age of integrative structural analysis. Curr. Opin. Cell Biol. 34:31-38. doi: 10.1016/

Ed Hurt und Martin Beck (2015)

Transcriptional refractoriness is dependent on core promoter architecture. Nat Commun. 2015; doi:10.1038/ncomms7753.

Cesbron, F., Oehler, M., Ha, N., Sancar, G. and Brunner, M. (2015)

Translational arrest by a prokaryotic signal recognition particle is mediated by RNA interactions, Nat. Struct. Mol. Biol. 22: 767-73.

Beckert, B., Kedrov, A., Sohmen, D., Kempf, G., Wild, K., Sinning, I., Stahlberg, H., Wilson, D. & Beckmann, R. (2015)

Trypanothione reductase: A target protein for a combined in vitro and in silico screening approach. PLoS Negl. Trop. Dis. 9(6): e0003773.

Beig, M., Oellien, F., Garoff, L., Noack, S., Krauth-Siegel, R. L. and Selzer, P. M. (2015)

Assaying mRNA deadenylation in vitro. Methods Mol. Biol. 1125, 297–311.

Jeske, M., Temme, C., Wahle, E. (2014)

A cluster of methylations in the domain IV of 25S rRNA is required for ribosome stability. RNA 20, 1632-44.

Gigova A, Duggimpudi S, Pollex T, Schaefer M, Koš M. (2014)

60S ribosome biogenesis requires rotation of the 5S ribonucleoprotein particle, Nat. Commun. 5: 3491. doi: 10.1038/ncomms4491.

Leidig, C., Thoms, M., Holdermann, I., Bradatsch, B., Berninghausen, O., Bange, G., Sinning, I., Hurt, E. & Beckmann, R. (2014)

A direct role for ATP1A1 in unconventional secretion of fibroblast growth factor 2. J. Biol. Chem. 290:3654-3665.

Zacherl S, La Venuta G, Müller HM, Wegehingel S, Dimou E, Sehr P, Lewis JD, Erfle H, Pepperkok R, Nickel W (2014)

A network of assembly factors is involved in remodeling rRNA elements during preribosome maturation, J. Cell Biol. 207: 481-498.

Bassler, J., Paternoga, H., Holdermann, I., Thoms, M., Grannemann, S., Barrio-Garcia, C., Nyarko, A., Stier, G., Clark, S., Schraivogel, D., Kallas, M., Beckmann, R., Tollervey, D., Barbar, E., Sinning*, I. & Hurt*, E. (2014)

A pulse-chase epitope labeling to study cellular dynamics of newly synthesized proteins: a novel strategy to characterize NPC biogenesis and ribosome maturation/export,. Methods in Cell Biol. 122C,147-163. doi: 10.1016/B978-0-12-417160-2.00007-2 .

Philipp Stelter and Ed Hurt (2014)

Aim24 and MICOS modulate respiratory function, tafazzin-related cardiolipin modification and mitochondrial architecture. Elife. 3:e01684.

Harner ME, Unger AK, Izawa T, Walther DM, Ozbalci C, Geimer S, Reggiori F, Brügger B, Mann M, Westermann B, Neupert W. (2014)

Alteration of light-dependent gene regulation by the absence of the RCO-1/RCM-1 repressor complex in the fungus Neurospora crassa. PLoS One 9, e95069.

Ruger-Herreros, C., Gil-Sanchez Mdel, M., Sancar, G., Brunner, M., and Corrochano, L. M. (2014)

An Extended Helical Conformation in Domain 3a of Munc18-1 Provides a Template for SNARE (Soluble N-Ethylmaleimide-sensitive Factor Attachment Protein Receptor) Complex Assembly. J.Biol.Chem. 289, 9639-9650.

Parisotto, D., Pfau, M., Scheutzow, A., Wild, K., Mayer, M.P., Malsam, J., Sinning, I., & Söllner, T.H. (2014)

An integrated approach for genome annotation of the eukaryotic thermophile Chaetomium thermophilum. Nucleic acids research, 42(22), 13525–13533.

Bock, T., Chen, W. H., Ori, A., Malik, N., Silva-Martin, N., Huerta-Cepas, J., Powell, S. T., Kastritis, P. L., Smyshlyaev, G., Vonkova, I., Kirkpatrick, J., Doerks, T., Nesme, L., Baßler, J., Kos, M., Hurt, E., Carlomagno, T., Gavin, A. C., Barabas, O., Müller, C. W., van Noort, V., Beck, M., & Bork, P. (2014)

Analysis of transmembrane domains and lipid mdified peptides with matrix-assisted laser desorption ionization-time-of-flight mass spectrometry. Anal. Chem. 86, 8, 3722–3726.

Gerl MJ, Sachsenheimer T, Grzybek M, Coskun U, Wieland FT, & Brügger B. (2014)

Binding to large enzyme pockets: Small-molecule inhibitors of trypanothione reductase. Chem. Med. Chem. 9, 1880-1891.

Persch, E., Bryson, S., Todoroff, N. K., Eberle, C., Thelemann, J., Dirdjaja, N., Kaiser, M., Weber, M., Derbani, H., Brun, R., Schneider, G., Pai, E. F., Krauth-Siegel, R. L. and Diederich, F. (2014)

Building lipid ‘PIPelines’ throughout the cell by ORP/Osh proteins. Biochem Soc Trans 42(5), 1465-1470.

Moser von Filseck J, Mesmin B, Bigay J, Antonny B and Drin G. (2014)

Caged lipids as tools for investigating cellular signaling. Biochim Biophys Acta 1841; 1085-1096

Höglinger D, Nadler A, Schultz C. (2014)

Catalytic Rio1 kinase/ATPase mutant induces trapping of late pre-40S biogenesis factors in 80S-like ribosomes. Nucl. Acid Res. 1, doi: 10.1093/nar/gku542 .

Sébastien Ferreira-Cerca, Irene Kiburu, Emma Thomson, Nicole Laronde- Leblanc and Ed Hurt (2014)

Circadian clocks and energy metabolism. Cell Mol Life Sci. 2014; doi:10.1007/s00018-014-1574-7.

Sancar, G. and Brunner, M. (2014)

Coupled GTPase and remodeling ATPase activities form a checkpoint for ribosome export. Nature 505, 112-116 .

Yoshitaka Matsuo, Sander Granneman, Matthias Thoms, Rizos-Georgios Manikas, David Tollervey and Ed Hurt (2014)

Cytosolic peroxidases protect the lysosome of bloodstream African trypanosomes from iron-mediated membrane damage. PLoS Pathogens e1004075.

Hiller, C., Nissen, A., Benítez, D., Comini, M. A. and Krauth-Siegel, R. L. (2014)

Differentially localized acyl-CoA synthetase 4 isoenzymes mediate the metabolic channeling of fatty acids towards phosphatidylinositol. Biochim Biophys Acta. 1841(2):227-39.

Küch EM, Vellaramkalayil R, Zhang I, Lehnen D, Brügger B, Sreemmel W, Ehehalt R, Poppelreuther M, Füllekrug J. (2014)

Dynamin-related protein 1 (Drp1) promotes structural intermediates of membrane division. J. Biol. Chem. 289:30645-30656.

Ugarte-Uribe B, Müller HM, Otsuki M, Nickel W, García-Sáez AJ. (2014)

ER-phagy mediates selective degradation of endoplasmic reticulum independently of the core autophagy machinery. Journal of Cell Science. (abstract)

Schuck S, Gallagher CM, Walter P (2014)

Evidence for an evolutionary relationship between the large adaptor nucleoporin Nup192 and karyopherins. Proc. Natl. Acad. Sci. USA 18, 2530-2535 .

Tobias Stuwe, Daniel H. Lin, Leslie Collins, Ed Hurt and André Hoelz (2014)

Functional reconstitution of de novo mitochondrial Fe/S cluster synthesis reveals an essential role of ferredoxin. Nature Com. 5, doi:10.1038/ncomms6013 .

Stefan Amlacher, Ed Hurt, Ulrich Mühlenhoff, Lucia Banci and Roland Lill (2014)

Functional reconstitution of mitochondrial Fe/S cluster synthesis on Isu1 reveals the involvement of ferredoxin. Nat Commun 5, 5013.

Webert, H., Freibert, S.-A., Gallo, A., Heidenreich, T., Linne, U., Amlacher, S., Hurt, E., Mühlenhoff, U., Banci, L., & Lill, R. (2014)

Golgi phosphoprotein 3 trigers signal-mediated incorporation of glycosyltransferases into coatomer-coated (COPI) vesicles. J Biol Chem. 289(45):31319-29.

Eckert ESP, Reckmann I, Hellwig A, Röhling S, Battari AE, Wieland FT, and Popoff V. (2014)

Heterologous Src homology 4 domains support membrane anchoring and biological activity of HIV-1 Nef. J. Biol. Chem. 289:14030-14044.

Geist MM, Pan X, Bender S, Bartenschlager R, Nickel W, Fackler OT. (2014)

Identification of novel sphingolipid-binding motifs in mammalian membrane proteins. Biochimica et biophysica acta, 1838(8), 2066–2070.

Björkholm, P., Ernst, A. M., Hacke, M., Wieland, F., Brügger, B., & von Heijne, G. (2014)

Light-induced differences in conformational dynamics of the circadian clock regulator VIVID. J Mol Biol. 2014; doi:10.1016/j.jmb.2013.10.035.

Lee, C. T., Malzahn, E., Brunner, M. and Mayer, M. P. (2014)

Lipidomics: analysis of the lipid composition of cells and subcellular organelles by electrospray ionization mass spectrometry. Annu Rev Biochem. 83:79-98. Review.

Brügger B. (2014)

Longin and GAF Domains: Structural Evolution and Adaptation to the Subcellular Trafficking Machinery. Traffic 15: 104-21.

De Franceschi, N., Wild, K., Schlacht, A., Dacks, J.B., Sinning, I. & Filippini, F. (2014)

Microtubules as key coordinators of nuclear envelope and endoplasmic reticulum dynamics during mitosis. Bioessays 36: 665-671.

Schlaitz AL (2014)

Non-circadian expression masking clock-driven weak transcription rhythms in U2OS cells. PLoS One. 2014; PMC4090172. doi:10.1371/journal.pone.0102238.

Hoffmann, J., Symul, L., Shostak, A., Fischer, T., Naef, F. and Brunner, M. (2014)

Quantitative analysis and modeling of katanin function in flagellar length control. Molecular Biology of the Cell. (abstract)

Kannegaard E, Rego EH, Schuck S, Feldman JL, Marshall WF (2014)

RNA gymnastics in mammalian signal recognition particle assembly, RNA Biol. 11: 1330-1334.

Wild, K. & Sinning, I. (2014)

SNARE and regulatory proteins induce local membrane protrusions to prime docked vesicles for fast calsium-triggered fusion. EMBO reports 15:3, 308-314.

Bharat, T.A., Malsam, J., Hagen, W.J., Scheutzow, A., Söllner, T.H., Briggs, J.A. (2014)

Sphingolipids as modulators of membrane proteins. Biochim Biophys Acta. 1841(5):665-70. Review.

Ernst AM, Brügger B. (2014)

SRP RNA remodeling by SRP68 explains its role in protein translocation, Science 344: 101-104. DOI:10.1126/science.1249094.

Grotwinkel, J.T., Wild, K., Segnitz, B. & Sinning, I. (2014)

Structure of the tRNA-like bacterial Alu domain Nucl. Acids Res. 42: 12284-94.

Kempf, G., Wild, K. & Sinning, I. (2014)

The RNA helicase FRH is an ATP-dependent regulator of CK1a in the circadian clock of Neurospora crassa. Nat Commun. 2014; doi:10.1038/ncomms4598.

Lauinger, L., Diernfellner, A., Falk, S. and Brunner, M. (2014)

The structural analysis of shark IgNAR antibodies reveals evolutionary principles of immunoglobulins. PNAS 111(22):8155-60.

Feige MJ, Gräwert MA, Marcinowski M, Hennig J, Behnke J, Ausländer D, Herold EM, Peschek J, Castro CD, Flajnik M, Hendershot LM, Sattler M, Groll M, Buchner J (2014)

Tools to study lipid functions. Biochim Biophys Acta. 1841(8):1021.

Brügger B, Brown A. (2014)

Toward the development of dual-targeted glyceraldehyde-3-phosphate dehydrogenase/trypanothione reductase inhibitors against Trypanosoma brucei and Trypanosoma cruzi. Chem. Med. Chem. 9, 371-382.

Belluti, F., Uliassi, E., Veronesi, G., Bergamini, C., Kaiser, M., Brun, R., Viola, A., Fato, R., Michels, P. A. M., Krauth-Siegel, R. L., Cavalli, A. and Bolognesi, M. L. (2014)

Unconventional secretion of fibroblast growth factor 2 -- A novel type of protein translocation across membranes? J. Mol. Biol. 427:1202-1210.

Steringer JP, Müller HM, Nickel W (2014)

Utilizing the Dyn2-dimerization- zipper as a tool to probe NPC structure and function. Methods in Cell Biol. 122C, 99-115. doi: 10.1016/B978-0-12-417160-2.00005-9 .

Dirk Flemming, Philipp Stelter and Ed Hurt (2014)

Identification of Drosophila and human 7-methyl GMP-specific nucleotidases. J. Biol. Chem. 288(4), 2441-2451.

Buschmann, J., Moritz, B., Jeske, M., Lilie, H., Schierhorn, A., Wahle, E. (2013)

A Four-Step Cycle Driven by PI(4)P Hydrolysis Directs Sterol/PI(4)P Exchange by the ER-Golgi Tether OSBP. Cell 155, 830–843.

Mesmin B, Bigay J, Moser von Filseck J, Lacas-Gervais S, Drin G and Antonny B. (2013)

An auxiliary, membrane-based mechanism for nuclear migration in budding yeast. Mol. Biol. Cell doi:10.1091/mbc.E12-08-0602

Kirchenbauer M. and Liakopoulos,D. (2013)

CDC42 switches IRSp53 from inhibition of actin growth to elongation by clustering of VASP. EMBO J. 32:2735-50.

Disanza A, Bisi S, Winterhoff M, Milanesi F, Ushakov DS, Kast D, Marighetti P, Romet- Lemonne G, Müller HM, Nickel W, Linkner J, Waterschoot D, Ampè C, Cortellino S, Palamidessi A, Dominguez R, Carlier MF, Faix J, Scita G. (2013)

Chromosome segregation by the Escherichia coli Min system. Mol Syst Biol. 2013;9:686.

Di Ventura B, Knecht B, Andreas H, Godinez WJ, Fritsche M, Rohr K, Nickel W, Heermann DW, Sourjik V. (2013)

Comparative lipidomics analysis of HIV-1 particles and their producer cell membrane in different cell lines. Cellular microbiology, 15(2), 292–304.

Lorizate, M., Sachsenheimer, T., Glass, B., Habermann, A., Gerl, M. J., Kräusslich, H. G., & Brügger, B. (2013)

Consistent mutational paths predict eukaryotic thermostability. BMC evolutionary biology, 13, 7.

van Noort, V., Bradatsch, B., Arumugam, M., Amlacher, S., Bange, G., Creevey, C., Falk, S., Mende, D. R., Sinning, I., Hurt, E., & Bork, P. (2013)

Differential transport of Influenza A neuraminidase signal anchor peptides to the plasma membrane. FEBS letters, 587(9), 1411–1417.

Ernst, A. M., Zacherl, S., Herrmann, A., Hacke, M., Nickel, W., Wieland, F. T., & Brügger, B. (2013)

Dissecting the catalytic mechanism of Trypanosoma brucei trypanothione synthetase by kinetic analysis and computational modelling. J. Biol. Chem. 288, 23751-23764.

Leroux, A.L., Haanstra, J. R., Bakker, B. M. and Krauth-Siegel, R. L. (2013)

Endoplasmic reticulum Targeting and Insertion of Tail-anchored membrane proteins by the GET pathway. Cold Spring Harb Perspect Biol. 5(8). doi:pii: a013334.

Denic, V., Doetsch, V. & Sinning, I. (2013)

Eukaryotic Ribosome Biogenesis at a glance. J. Cell Sci. in press.

Emma Thomson, Sébastien Ferreira-Cerca and Ed Hurt (2013)

High-resolution structures of the IgM Fc domains reveal principles of its hexamer formation. PNAS 110(25):10183-8.

Müller R, Gräwert MA, Kern T, Madl T, Peschek J, Sattler M, Groll M, Buchner J (2013)

HIV-1 Nef disrupts membrane- microdomain-associated anterograde transport for plasma membrane delivery of selected Src family kinases. Cell Microbiol. 15:1605-21.

Pan X, Geist MM, Rudolph JM, Nickel W, Fackler OT (2013)

In vivo profiling and visualization of cellular protein-lipid interactions using bifunctional fatty acids. Angew Chem Int Ed Engl. 52(14):4033-8.

Haberkant P, Raijmakers R, Wildwater M, Sachsenheimer T, Brügger B, Maeda K, Houweling M, Gavin AC, Schultz C, van Meer G, Heck AJ, Holthuis JC. (2013)

Inhibition of Tumor Angiogenesis and Growth by a Small-Molecule Multi-FGF Receptor Blocker with Allosteric Properties. Cancer Cell. 23(4):477-488.

Bono F, De Smet F, Herbert C, De Bock K, Georgiadou M, Fons P, Tjwa M, Alcouffe C, Ny A, Bianciotto M, Jonckx B, Murakami M, Lanahan AA, Michielsen C, Sibrac D, Dol-Gleizes F, Mazzone M, Zacchigna S, Herault JP, Fischer C, Rigon P, Ruiz de Almodovar C, Claes F, Blanc I, Poesen K, Zhang J, Segura I, Gueguen G, Bordes MF, Lambrechts D, Broussy R, van de Wouwer M, Michaux C, Shimada T, Jean I, Blacher S, Noel A, Motte P, Rom E, Rakic JM, Katsuma S, Schaeffer P, Yayon A, Van Schepdael A, Schwalbe H, Gervasio FL, Carmeliet G, Rozensky J, Dewerchin M, Simons M, Christopoulos A, Herbert JM, Carmeliet P. (2013)

Iron-sulfur cluster (ISC) binding by mitochondrial monothiol glutaredoxin-1 of Trypanosoma brucei: molecular basis of ISC coordination and relevance for parasite infectivity. Antiox. Redox Sign. 19, 665-682.

Manta, B., Pavan, C., Sturlese, M., Medeiros, A., Crispo, M., Berndt, C., Krauth-Siegel, R. L., Bellanda, M. and Comini, M. A. (2013)

Light-dependent and circadian transcription dynamics in vivo recorded with a destabilized luciferase reporter in Neurospora. PLoS One. 2013; PMC3877077. doi:10.1371/journal.pone.0083660.

Cesbron, F., Brunner, M. and Diernfellner, A. C. (2013)

Mcp1 and Mcp2, two novel proteins involved in mitochondrial lipid homeostasis. J Cell Sci. 126(Pt 16):3563-74.

Tan T, Ozbalci C, Brügger B, Rapaport D, Dimmer KS. (2013)

Methionine oxidation activates a transcription factor in response to oxidative stress. PNAS 110(23):9493-8.

Drazic A, Miura H, Peschek J, Le Y, Bach NC, Kriehuber T, Winter J (2013)

Mono- and dithiol glutaredoxins in the trypanothione-based redox metabolism of pathogenic trypanosomes. Antiox. Redox Sign. 19, 708-722.

Comini, M. A., Krauth-Siegel, R. L. and Bellanda, M. (2013)

New twist to nuclear import: When two travel together, Com. & Int. Biol. 6:4, e24792; July/August 2013, Landes Bioscience).

Bange, G. , Murat, G., Sinning, I., Hurt, E. & Kressler, D. (2013)

Oligomerization and Ca2+/calmodulin control binding of the ER Ca2+-sensors STIM1 and STIM2 to plasma membrane lipids. Biosci Rep. 2013 Oct 31;33(5). (pii: e00077. doi: 10.1042/BSR20130089).

Bhardwaj R, Müller HM, Nickel W, Seedorf M. (2013)

Poxvirus membrane biogenesis: rupture not disruption. Cell Microbiol. 15(2):190-9.

Krijnse Locker J, Chlanda P, Sachsenheimer T, Brügger B. (2013)

Protein interfaces of the Conserved Nup84 Complex from Chaetomium thermophilum revealed by cross-linking mass spectrometry and electron microscopy. Structure 21, 9, 1672-1682.

Karsten Thierbach, Alexander von Appen, Matthias Thoms, Martin Beck, Dirk Flemming and Ed Hurt (2013)

Quantitative analysis of cellular lipids by nano-electrospray ionisation mass spectrometry. Methods Mol Biol. 1033:3-20.

Özbalci C, Sachsenheimer T, Brügger B. (2013)

Quantitative analysis of cellular lipids by nano-electrospray ionization mass spectrometry. Methods Mol Biol. 1033:3-20. doi: 10.1007/978-1-62703-487-6_1.

Ozbalci C, Sachsenheimer T, Brügger B. (2013)

REEP3/4 ensure endoplasmic reticulum clearance from metaphase chromatin and proper nuclear envelope architecture. Dev Cell 26:315-323.

Schlaitz AL, Thompson J, Wong CC, Yates JR, 3rd, Heald R (2013)

Regulated structural transitions unleash the chaperone activity of αB-crystallin. PNAS 110(40):E3780-9.

Peschek J, Braun N, Rohrberg J, Back KC, Kriehuber T, Kastenmüller A, Weinkauf S, Buchner J (2013)

Rrp5p, Noc1p and Noc2p form a protein module which is part of early large ribosomal subunit precursors in S. cerevisiae. Nucl. Acid Res. 41, 1191-1200.

Thomas Hierlmeier, Juliane Merl, Martina Sauert, Jorge Perez-Fernandez, Patrick Schultz, Astrid Bruckmann, Stephan Hamperl, Uli Ohmayer, Joachim Griesenbeck, Reinhard Rachel, Anja Jakob, Kristin Hergert, Rainer Deutzmann, Ed Hurt, Philipp Milkereit, Jochen Baßler and Herbert Tschochner (2013)

Scission of COPI and COPII vesicles is independent of GTP hydrolysis. Traffic. 14(8):922-32.

Adolf F, Herrmann A, Hellwig A, Beck R, Brügger B, Wieland FT. (2013)

SIMIBI Twins in protein targeting and localization, Nat. Struct. Mol. Biol. 20:776-80. doi: 10.1038/nsmb.2605.

Bange, G. & Sinning, I. (2013)

Sphingolipids as modulators of membrane proteins. Biochim Biophys Acta. Nov 5. doi:pii: S1388-1981(13)00239-4. 10.1016/ j.bbalip.2013.10.016. [Epub ahead of print]. Review.

Ernst AM, Brügger B. (2013)

Structural basis of histone H2A-H2B recognition by the essential chaperone FACT. Nature 499, 111-114.

Maria Hondele, Tobias Stuwe, Markus Hassler, Felix Halbach, Bianca Nijmeijer, Vladimir Rybin, Stefan Amlacher, Ed Hurt and Andreas Ladurner (2013)

Structural characterization of a eukaryotic co-translational chaperone, the ribosome-associated complex (RAC), Nat. Struct. Mol. Biol. 20:23-8.

Leidig, C., Bange, G., Kopp, J., Amlacher, S., Aravind, A., Wickles, S., Witte, G., Hurt, E., Beckmann, R. & Sinning, I. (2013)

Structures of the nuclear export receptor CRM1 in its free state reveal major structural rearrangements upon cargo binding. Proc. Natl. Acad. Sci. USA 110, 960-965 .

Thomas Monecke, David Haselbach, Piotr Neuman, Emma Thomson, Ed Hurt, Holger Stark, Achim Dickmanns and Ralf Ficner (2013)

Synthesis and biological properties of novel brefeldin A analogues. Journal of medicinal chemistry, 56(14), 5872–5884.

Seehafer K, Rominger F, Helmchen G, Langhans M, Robinson DG, Ozata B, Brügger B, Strating JR, van Kuppeveld FJ, Klein CD. (2013)

Targeting placental growth factor/neuropilin 1 pathway inhibits growth and spread of medulloblastoma. Cell, 152(5):1065-76. (*These authors contributed equally)

Snuderl M*, Batista A*, Kirkpatrick ND*, Ruiz de Almodovar C*, Riedemann L, Walsh EC, Anolik R, Huang Y, Martin JD, Kamoun W, Knevels E, Schmidt T, Farrar CT, Vakoc BJ, Mohan N, Chung E, Roberge S, Peterson T, Bais C, Zhelyazkova BH, Yip S, Hasselblatt M, Rossig C, Niemeyer E, Ferrara N, Klagsbrun M, Duda DG, Fukumura D, Xu L, Carmeliet P, Jain RK. (2013)

The great repression: Chromatin and cryptic transcription. Transcription 3: 97-101 (Review)

Hennig, B.P., and Fischer, T. (2013)

The NADPH oxidase Nox2 regulates VEGFR1/CSF-1R-mediated microglial chemotaxis and promotes early postnatal infiltration of phagocytes in the subventricular zone of the mouse cerebral cortex. Glia. 61(9):1542-55.

Lelli A, Gervais A, Colin C, Chéret C, Ruiz de Almodovar C, Carmeliet P, Krause KH, Boillée S, Mallat M. (2013)

The Neurospora photoreceptor VIVID exerts negative and positive control on light sensing to achieve adaptation. Mol Syst Biol. 2013; PMC4039372. doi:10.1038/msb.2013.24.

Gin, E., Diernfellner, A. C., Brunner, M. and Höfer, T. (2013)

VEGF ligands and receptors: implications in neurodevelopment and neurodegeneration. Cell Mol Life Sci. 70(10):1763-78.

Carmeliet, P, Ruiz de Almodovar, C. (2013)

A plant-derived flavonoid inhibits entry of all HCV genotypes into human hepatocytes. Gastroenterology. 143(1):213-222.

Haid S, Novodomská A, Gentzsch J, Grethe C, Geuenich S, Bankwitz D, Chhatwal P, Jannack B, Hennebelle T, Bailleul F, Keppler OT, Poenisch M, Bartenschlager R, Hernandez C, Lemasson M, Rosenberg AR, Wong-Staal F, Davioud-Charvet E, Pietschmann T. (2012)

Analysis of the yeast nucleoporin Nup188 reveals a conserved S-like structure with similarity to karyopherins. J. Struct. Biol. 177, 99-105.

Dirk Flemming, Damien Devos, Johannes Schwarz, Stefan Amlacher, Malik Lutzmann and Ed Hurt (2012)

Assembly of the eukaryotic PLP-synthase complex from Plasmodium and activation of the Pdx1 enzyme, Structure 20:172-84.

Guédez, G., Hipp, K., Windeisen, V., Derrer, B., Gengenbacher, M., Böttcher, B., Sinning, I., Kappes, B. & Tews, I. (2012)

ATPase-dependent role of the atypical kinase Rio2 on the evolving pre-40S ribosomal subunit. Nat. Struct. Mol. Biol. 19, 1316-1323.

Sébastien Ferreira-Cerca, Vatsala Sagar, Thorsten Schäfer, Anne-Maria Wesseling, Eileen Chai, Ed Hurt and Nicole LaRonde-LeBlanc (2012)

Bioinformatic and experimental fishing for artemisinin-interacting proteins from human nasopharyngeal cancer cells. Mol Biosyst. 8(4):1311-8.

Eichhorn T, Schloissnig S, Hahn B, Wendler A, Mertens R, Lehmann WD, Krauth-Siegel RL, Efferth T. (2012)

Chd1 chromatin remodelers maintain nucleosome organization and repress cryptic transcription. EMBO Rep 13, 997-1003.

Hennig, B.P., Bendrin, K., Zhou, Y., and Fischer, T. (2012)

Chromodomains read the arginine code of post-translational targeting, Nat. Struct. Mol. Biol. 19: 260-3.

Holdermann, I., Meyer, H., Round, A., Wild, K., Sattler, M. & Sinning, I. (2012)

Complexin arrests a pool of docked vesicles for fast Ca (2+)-dependent release. EMBO J. 31, 3270-3281

Malsam, J., Parisotto, D., Bharat, T.A., Scheutzow A., Krause, J.M., Briggs, J.A., Söllner, T.H. (2012)

Conjugation of quinones with natural polyamines: toward an expanded antitrypanosomatid profile. J Med Chem. 55(23):10490-500.

Lizzi F, Veronesi G, Belluti F, Bergamini C, López-Sánchez A, Kaiser M, Brun R, Krauth-Siegel RL, Hall DG, Rivas L, Bolognesi ML. (2012)

Distinct role of subcomplexes of the COPI coat in the regulation of ArfGAP2 activity. Traffic, 13(6), 849–856.

Pevzner, I., Strating, J., Lifshitz, L., Parnis, A., Glaser, F., Herrmann, A., Brügger, B., Wieland, F., & Cassel, D. (2012)

Diversity in unconventional protein secretion. J Cell Sci. 125:5251-5.

Rabouille C, Malhotra V, Nickel W. (2012)

Ergosterol content specifies targeting of tail-anchored proteins to mitochondrial outer membranes. Mol Biol Cell. 23(20):3927-35.

Krumpe K, Frumkin I, Herzig Y, Rimon N, Özbalci C, Brügger B, Rapaport D, Schuldiner M. (2012)

Exploring the trifluoromenadione core as a template to design antimalarial redox-active agents interacting with glutathione reductase. Org Biomol Chem. 10(24):4795-806.

Lanfranchi DA, Belorgey D, Müller T, Vezin H, Lanzer M, Davioud-Charvet E. (2012)

Functional and structural characterisation of the mammalian TREX-2 complex that links transcription with nuclear mRNA export. Nucl. Acid Res. 40, 4562-4573.

Divyang Jani, Sheila Lutz, Ed Hurt, Ronald Laskey, Murray Stewart and Vihandha Wickramasinghe (2012)

Glycogen synthase kinase is a regulator of the circadian clock of Neurospora crassa. J Biol Chem. 2012; PMC3481296. doi:10.1074/jbc.M112.396622.

Tataroğlu, Ö., Lauinger, L., Sancar, G., Jakob, K., Brunner, M. and Diernfellner, A. C. (2012)

High throughput screening against the peroxidase cascade of African trypanosomes identifies antiparasitic compounds that inactivate tryparedoxin. J Biol Chem. 287(12):8792-802.

Fueller F, Jehle B, Putzker K, Lewis JD, Krauth-Siegel RL. (2012)

Impaired neurotransmission in ether lipid-deficient nerve terminals. Hum Mol Genet. 21(12):2713-24

Brodde A, Teigler A, Brugger B, Lehmann WD, Wieland F, Berger J, Just WW. (2012)

Insight into the selenoproteome of the malaria parasite Plasmodium falciparum. Antioxid Redox Signal. 17(4):534-43.

Röseler A, Prieto JH, Iozef R, Hecker B, Schirmer RH, Külzer S, Przyborski J, Rahlfs S, Becker K (2012)

Kinetic analysis reveals successive steps leading to miRNA-mediated silencing in mammalian cells. EMBO Rep. 13(8), 716-723. → Highlighted by E. Izaurralde in EMBO Rep. 13(8), 662-663 (2012) → Research highlight in Nature Chem Biol 8, 679 (2012).

Béthune, J*, Artus-Revel, CG, and Filipowicz, W* (2012)

Large membrane domains in hair bundles specify spatially constricted radixin activation. J Neurosci. 32(13):4600-9.

Zhao H, Williams DE, Shin JB, Brügger B, Gillespie PG. (2012)

Lipids and vesicular transport. Biochim Biophys Acta 1821(8):1039.

Brügger B, Bankaitis VA. (2012)

Loss of ceramide synthase 3 causes lethal skin barrier disruption. Hum Mol Genet. 21:586-608.

Jennemann R, Rabionet M, Gorgas K, Epstein S, Dalpke A, Rothermel U, Bayerle A, van der Hoeven F, Imgrund S, Kirsch J, Nickel W, Willecke K, Riezman H, Gröne HJ, Sandhoff R. (2012)

Low-molecular-mass antioxidants in parasites. Antioxid Redox Signal. 17(4):583-607.

Krauth-Siegel RL, Leroux AE. (2012)

Metabolic compensation of the Neurospora clock by a glucose-dependent feedback of the circadian repressor CSP1 on the core oscillator. Genes Dev. 2012; PMC3490001. doi:10.1101/gad.199547.112.

Sancar, G., Sancar, C. and Brunner, M. (2012)

Molecular recognition of a single sphingolipid species by a protein's transmembrane domain. Nature, 481(7382), 525–529.

Contreras, F. X., Ernst, A. M., Haberkant, P., Björkholm, P., Lindahl, E., Gönen, B., Tischer, C., Elofsson, A., von Heijne, G., Thiele, C., Pepperkok, R., Wieland, F., & Brügger, B. (2012)

Monitoring Spatiotemporal Biogenesis of Macromolecular Assemblies by Pulse-chase Epitope Labeling. Mol. Cell 47, 788-796.

Matthias Thoms and Ed Hurt (2012)

Monitoring spatiotemporal biogenesis of macromolecular assemblies by pulse-chase epitope labeling. Molecular cell, 47(5), 788–796.

Stelter, P., Kunze, R., Radwan, M., Thomson, E., Thierbach, K., Thoms, M., & Hurt, E. (2012)

Mutual recognition of sphingolipid molecular species in membranes. Biochim Biophys Acta 1818(11):2616-2622.

Ernst AM, Contreras FX, Thiele C, Wieland F, Brügger B. (2012)

O-GlcNAcylation of a circadian clock protein: dPER taking its sweet time. Genes Dev. 2012; PMC3305979. doi:10.1101/gad.188524.112.

Diernfellner, A. C. and Brunner, M. (2012)

Peroxisome deficiency but not the defect in ether lipid synthesis causes activation of the innate immune system and axonal loss in the central nervous system. J Neuroinflammation. 9:61, 1742-62.

Bottelbergs A, Verheijden S, Van Veldhoven PP, Just W, Devos R, Baes M. (2012)

PI(4,5)P2-dependent oligomerization of fibroblast growth factor 2 (FGF2) triggers the formation of a lipidic membrane pore implicated in unconventional secretion. The Journal of biological chemistry, 287(33), 27659–27669.

Steringer, J. P., Bleicken, S., Andreas, H., Zacherl, S., Laussmann, M., Temmerman, K., Contreras, F. X., Bharat, T. A., Lechner, J., Müller, H. M., Briggs, J. A., García-Sáez, A. J., & Nickel, W. (2012)

Poxvirus membrane biogenesis: rupture not disruption. Cell Microbiol. doi: 10.1111/cmi.12072. [Epub ahead of print]

Krijnse Locker J, Chlanda P, Sachsenheimer T, Brügger B. (2012)

Quantification of Signaling Lipids by Nano-Electrospray Ionization Tandem Mass Spectrometry (Nano-ESI MS/MS). Metabolites 2(1), 57-76.

Haag M, Schmidt, A, Sachsenheimer, T, Brügger B. (2012)

Seg1 controls eisosome assembly and shape. Journal of Cell Biology. (abstract)

Moreira KE*, Schuck S*, Schrul B, Fröhlich F, Moseley JB, Walther TC, Walter P (2012)

SNAREpin Assembly by Munc18-1 Requires Previous Vesicle Docking by Synaptotagmin 1. J. Biol. Chem. 287, 31041-31049

Parisotto, D., Malsam, J., Scheutzow, A., Krause, J.M., Söllner, T.H. (2012)

Sphingomyelin organization is required for vesicle biogenesis at the Golgi complex. The EMBO journal, 31(24), 4535–4546.

Duran, J. M., Campelo, F., van Galen, J., Sachsenheimer, T., Sot, J., Egorov, M. V., Rentero, C., Enrich, C., Polishchuk, R. S., Goñi, F. M., Brügger, B., Wieland, F., & Malhotra, V. (2012)

Spindle positioning: structures and new concepts. Curr. Opin. Cell Biol. 24, 816-824.

Stevermann L. and Liakopoulos,D. (2012)

Structural basis for the assembly and nucleic acid binding of the TREX-2 transcription-export complex. Nat. Struct. Mol. Biol. 19, 328-336.

Andrew M. Ellisdon, Lyudmila Dimitrova, Ed Hurt and Murray Stewart (2012)

Structure and conservation of the periplasmic targeting factor tic22 protein from plants and cyanobacteria, J. Biol. Chem. 287: 24164-73.

Tripp, J., Hahn, A., Koenig, P., Flinner, N., Bublak, D., Ertel, F., Brouwer, E.M., Mirus, O., Sinning, I., Tews, I. & Schleiff, E. (2012)

Structure and dynamics of the ATP-bound open conformation of Hsp70 chaperones, Mol Cell, 2012 Nov 1. doi:pii: S1097-2765(12)00823-4. 10.1016/j.molcel.2012.09.023.

Kityk, R., Kopp, J., Sinning, I. & Mayer, M.P. (2012)

Structure of the pre-60S ribosomal subunit with nuclear export factor Arx1 bound at the exit tunnel. Nat. Struct. Mol. Biol 19, 1234-1241.

Bettina Bradatsch, Christoph Leidig, Sander Granneman, Marén Gnädig, Bettina Böttcher, David Tollervey, Roland Beckmann and Ed Hurt (2012)

Subcellular localization of adenylate kinases in Plasmodium falciparum. FEBS Lett. 586(19):3037-43.

Ma J, Rahlfs S, Jortzik E, Schirmer RH, Przyborski JM, Becker K (2012)

Synchronizing nuclear import of ribosomal proteins with ribosome assembly, Science 338: 666-71.

Kressler*, D., Bange, G. Ogawa, Y., Bradatsch, B., Pratte, D., Strauß, D., Amlacher, S., Yoneda,Y., Katahira, J., Sinning, I.*, & Hurt, E.* (2012)

The conserved Bud20 zinc finger protein is a new component of the ribosomal 60S subunit export machinery. Mol. Cell Biol., 32, 4898-912.

Jochen Baßler, Isabella Klein, Claudia Schmidt, Emma Thomson, Martina Kallas, Maria Anna Wagner, Gerald Rechberger, Heimo Strohmaier, Ed Hurt,Helmut Bergler (2012)

The power of AAA- ATPases on the road of pre-60S ribosome maturation - molecular machines that strip pre-ribosomal particles. Biochim. Biophys. Acta1823, 92-100.

Dieter Kressler, Ed Hurt, Helmut Bergler and Jochen Baßler (2012)

The Structures of COPI-Coated Vesicles Reveal Alternate Coatomer Conformations and Interactions. Science 336(6087): 1451-4.

Faini M, Prinz S, Beck R, Schorb M, Riches JD, Bacia K, Brügger B, Wieland FT, Briggs JA. (2012)

Trafficking and release of Leishmania metacyclic HASPB on macrophage invasion. Cell Microbiol. 14:740-761.

Maclean, LM, O'Toole, PJ, Stark, M, Marrison, J, Seelenmeyer, C, Nickel, W, and Smith, DF (2012)

"Lest we forget you--methylene blue...". Neurobiol Aging. 32(12):2325.e7-16.

Schirmer RH, Adler H, Pickhardt M, Mandelkow E (2011)

Smaug assembles an ATP-dependent stable complex repressing nanos mRNA translation at multiple levels. EMBO J. 30(1), 90-103.

Jeske, M., Moritz, B., Anders, A., Wahle, E. (2011)

A global circadian repressor controls antiphasic expression of metabolic genes in Neurospora. Mol Cell. 2011; doi:10.1016/j.molcel.2011.10.019.

Sancar, G., Sancar, C., Brügger, B., Ha, N., Sachsenheimer, T., Gin, E., Wdowik, S., Lohmann, I., Wieland, F., Höfer, T., Diernfellner, A. and Brunner, M. (2011)

A tryparedoxin-dependent peroxidase protects African trypanosomes from membrane damage. Free Radic. Biol. Med. 51, 856-868.

Diechtierow, M. and Krauth-Siegel, R.L. (2011)

Bange, Nico Kümmerer, Przemyslaw Grudnik, Robert Lindner, Georg Petzold, Dieter Kressler, Ed Hurt, Klemens Wild and Irmgard Sinning (2012) Structural basis for the molecular evolution of SRP-GTPase activation by protein. Nature Struct. Mol. Biol. 18, 1376-1380.

Dieter Kressler, Ed Hurt, Helmut Bergler and Jochen Baßler (2011)

BAX inhibitor-1 regulates autophagy by controlling the IRE1α branch of the unfolded protein response. EMBO Journal. (abstract)

Castillo K, Rojas-Rivera D, Lisbona F, Caballero B, Nassif M, Court FA, Schuck S, Ibar C, Walter P, Sierralta, J, Glavic A, Hetz C (2011)

Binding of chloroplast signal recognition particle to a thylakoid membrane protein substrate in aqueous solution and delineation of the cpSRP43-substrate interaction domain. Biochem J. 437(1):149-55.

Cain P, Holdermann I, Sinning I, Johnson AE, Robinson C. (2011)

Biochemical and morphological properties of hepatitis C virus particles and determination of their lipidome. J Biol Chem. 286(4):3018-32.

Merz A, Long G, Hiet MS, Brügger B, Chlanda P, Andre P, Wieland F, Krijnse-Locker J, Bartenschlager R. (2011)

Circadian conformational change of the Neurospora clock protein FREQUENCY triggered by clustered hyperphosphorylation of a basic domain. Mol Cell. 2011; doi:10.1016/j.molcel.2011.06.033.

Querfurth, C., Diernfellner, A. C., Gin, E., Malzahn, E., Höfer, T. and Brunner, M. (2011)

Circadian rhythms. FEBS Lett. 2011; doi:10.1016/j.febslet.2011.04.055.

Merrow, M. and Brunner, M. (2011)

Clr4/Suv39 and RNA quality control factors cooperate to trigger RNAi and suppress antisense RNA. Science 331, 1624-27.

Zhang, K., Fischer, T., Porter, R.L., Dhakshnamoorthy, J., Zofall, M., Zhou, M., Veenstra, T., and Grewal, S.I. (2011)

Coatomer and dimeric ADP ribosylation factor 1 promote distinct steps in membrane scission. J Cell Biol. 194(5):765-77.

Beck R, Prinz S, Diestelkötter-Bachert P, Röhling S, Adolf F, Hoehner K, Welsch S, Ronchi P, Brügger B, Briggs JA, Wieland F. (2011)

COPI Budding within the Golgi Stack. Cold Spring Harb Perspect Biol. 3(11). Review.

Popoff V, Adolf F, Brügger B, Wieland F. (2011)

Die Entstehung und Entwicklung des Biochemie-Zentrums. in Wissenschaftsatlas der Universität Heidelberg 1386 – 2011, pp. 222-224. BIBLIOTHECA PALATINA Verlag.

Schafmeier, T., Franke-Schaub, M., Schirmer, R. H. and Brunner, M. (2011)

Drosophila photoreceptor cells exploited for the production of eukaryotic membrane proteins: receptors, transporters and channels. PLoS One. 6(4):e18478.

Panneels V, Kock I, Krijnse-Locker J, Rezgaoui M, Sinning I. (2011)

Encephalopathy caused by ablation of very long acyl chain ceramide synthesis may be largely due to reduced galactosylceramide levels. J Biol Chem. 286(34):30022-33.

Ben-David O, Pewzner-Jung Y, Brenner O, Laviad EL, Kogot-Levin A, Weissberg I, Biton IE, Pienik R, Wang E, Kelly S, Alroy J, Raas-Rothschild A, Friedman A, Brügger B, Merrill AH Jr, Futerman AH. (2011)

Focus on…LKB1/AMPK signaling. FEBS Lett. 585(7):943

Just W. (2011)

Focus on…metastasis suppressors. FEBS Lett. 585(20):3147.

Just W. (2011)

GAPs in the context of COPI: Enzymes, coat components or both? Cell Logist. 1(2):52-54. Review.

Beck R, Brügger B, Wieland F. (2011)

Genome-wide and phase-specific DNA-binding rhythms of BMAL1 control circadian output functions in mouse liver. PLoS Biol. 2011; PMC3043000. doi:10.1371/journal.pbio.1000595.

Rey, G., Cesbron, F., Rougemont, J., Reinke, H., Brunner, M. and Naef, F. (2011)

Glucocorticoid Activity during Lung Maturation Is Essential in Mesenchymal and Less in Alveolar Epithelial Cells. Mol Endocrinol. 25(8):1280-8.

Habermehl D, Parkitna JR, Kaden S, Brügger B, Wieland F, Gröne HJ, Schütz G. (2011)

Glutathione reductase-catalyzed cascade of redox reactions to bioactivate potent antimalarial 1,4-naphthoquinones--a new strategy to combat malarial parasites. J Am Chem Soc. 133(30):11557-71.

Müller T, Johann L, Jannack B, Brückner M, Lanfranchi DA, Bauer H, Sanchez C, Yardley V, Deregnaucourt C, Schrével J, Lanzer M, Schirmer RH, Davioud-Charvet E (2011)

Homeostatic adaptation to endoplasmic reticulum stress depends on Ire1 kinase activity. Journal of Cell Biology. (abstract)

Rubio C, Pincus D, Korennykh A, Schuck S, El-Samad H, Walter P (2011)

Human regulatory T cells rapidly suppress T Cell Receptor-induced calcium signals, NF-κB and NFAT activation in conventional CD4+CD25- T cells. Sci Signal. ra90 
DOI: 10.1126/scisignal.2002179

Schmidt, A, Oberle, N, Weiß, EM, Vobis, D, Frischbutter, S, Baumgrass, R, Falk, CS, Haag, M, Brügger, B, Lin, H, Mayr, GW, Reichardt, P, Gunzer, M, Suri-Payer E, Krammer PH. (2011)

Improved inhibitors of trypanothione reductase by combination of motifs: Synthesis, inhibitory potency, binding mode, and antiprotozoal activities. Chem. Med. Chem. 6, 292-301.

Eberle, C., Lauber, B. S., Fankhausen, D., Kaiser, M., Brun, R., Krauth-Siegel, R. L. and Diederich, F. (2011)

Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile. Cell 146, 277-289, July 22.

Stefan Amlacher, Phillip Sarges, Dirk Flemming, Vera van Noort, Ruth Kunze, Damien Devos, Manimozhiyan Arumugam, Peer Bork and Ed Hurt (2011)

It takes two to Get3. Structure. 19(10):1353-55.

Sinning, I., Bange, G. & Wild, K. (2011)

Light input and processing in the circadian clock of Neurospora. FEBS Lett 585, 1467-1473.

Schafmeier, T., and Diernfellner, A. C. (2011)

Linking gene regulation to mRNA production and export. Curr. Opinion Cell Biol. 23, 302-309.

Susana Rodriguez-Navarro and Ed Hurt (2011)

Lipids trigger a conformational switch that regulates signal recognition particle (SRP)-mediated protein targeting. J Biol Chem. 286(26):23489-97. Epub 2011 May 3.

Stjepanovic G, Kapp K, Bange G, Graf C, Parlitz R, Wild K, Mayer MP, Sinning I. (2011)

Lipoamide dehydrogenase is essential for both bloodstream and procyclic Trypanosoma brucei. Mol. Microbiol. 81, 623-639.

Roldán, A., Comini, M. A., Crispo, M., and Krauth-Siegel, R. L. (2011)

Mdm38 is a 14-3-3-Like Receptor and Associates with the Protein Synthesis Machinery at the Inner Mitochondrial Membrane. Traffic. 12 (10):1457-66.

Lupo D, Vollmer C, Deckers M, Mick DU, Tews I, Sinning I, Rehling P. (2011)

Molecular Basis for the Unique Role of the AAA+ Chaperone ClpV in Type VI Protein Secretion. J Biol Chem. 286(34):30010-21.

Pietrosiuk A, Lenherr ED, Falk S, Bönemann G, Kopp J, Zentgraf H, Sinning I, Mogk A. (2011)

Multiple molecular architectures of the eye lens chaperone αB-crystallin elucidated by a triple hybrid approach. PNAS 108(51):20491-20496.

Braun N, Zacharias M, Peschek J, Kastenmüller A, Zou J, Hanzlik M, Haslbeck M, Rappsilber J, Buchner J, Weinkauf S (2011)

Organization of SNAREs within the Golgi stack. in ‘The Golgi’, Coldspring Harbor Perspectives in Biology (editors Warren, G. and Rothman, J.) Cold Spring Harbor Laboratory Press

Malsam, J., and Söllner, T.H. (2011)

Peroxisomal alterations in Alzheimer's disease. Acta Neuropathol. 122(3):271-83.

Kou J, Kovacs GG, Höftberger R, Kulik W, Brodde A, Forss-Petter S, Hönigschnabl S, Gleiss A, Brügger B, Wanders R, Just W, Budka H, Jungwirth S, Fischer P, Berger J. (2011)

Phenotypic profiling of the human genome reveals gene products involved in plasma membrane targeting of SRC kinases. Genome Res. 21(11):1955-68.

Ritzerfeld J, Remmele S, Wang T, Temmerman K, Brügger B, Wegehingel S, Tournaviti S, Strating JR, Wieland FT, Neumann B, Ellenberg J, Lawerenz C, Hesser J, Erfle H, Pepperkok R, Nickel W. (2011)

Phosphorylation of LRP1 regulates the interaction with Fe65. FEBS Lett. 585:3229-35.

Klug W, Dietl A, Simon B, Sinning I, Wild K. (2011)

Phosphorylations: Making the Neurosporacrassa circadian clock tick. FEBS Lett 585, 1461-1466.

Diernfellner, A. C., and Schafmeier, T. (2011)

Post-translational timing mechanisms of the Drosophila circadian clock. FEBS Lett. (585), 1443-1449.

F. Weber, D. Zorn, C. Rademacher and H-C. Hung (2011)

Probing the FG repeat network of nucleoporins defines structural and functional features of the nuclear pore complex. J. Cell Biol. 195, 183-192.

Philipp Stelter, Ruth Kunze, Jessica Fischer and Ed Hurt (2011)

Recombinant heptameric coatomer complexes: novel tools to study isoform-specific functions. Traffic 12(6):682-92

Sahlmüller MC, Strating JR, Beck R, Eckert P, Popoff V, Haag M, Hellwig A, Berger I, Brügger B, Wieland FT. (2011)

Resolving the Function of Distinct Munc18-1/SNARE Protein Interaction Modes in a Reconstituted Membrane Fusion. JBC 286 No. 35, 30582-30590.

Schollmeier, Y., Krause, J. M., Kreye, S., Malsam, J., Söllner, T.H. (2011)

Self-segregation of myelin membrane lipids in model membranes. Biophys J. 101(11):2713-20.

Yurlova L, Kahya N, Aggarwal S, Kaiser HJ, Chiantia S, Bakhti M, Pewzner-Jung Y, Ben-David O, Futerman AH, Brügger B, Simons M. (2011)

Several ADP-ribosylation factor (Arf) isoforms support COPI vesicle formation. J Biol Chem. 286(41):35634-42.

Popoff V, Langer JD, Reckmann I, Hellwig A, Kahn RA, Brügger B, Wieland FT. (2011)

Specificity of intramembrane protein-lipid interactions. Cold Spring Harb Perspect Biol. 3(6). pii: a004705. Review.

Contreras FX, Ernst AM, Wieland F, Brügger B. (2011)

Structural and biochemical consequences of NF1 associated nontruncating mutations in the Sec14-PH module of neurofibromin. Hum Mutat. 32(2):191-7.

Welti S, Kühn S, D'Angelo I, Brügger B, Kaufmann D, Scheffzek K. (2011)

Structural basis for tail-anchored membrane protein biogenesis by the Get3-receptor complex. Science. 333(6043):758-62.

Stefer S, Reitz S, Wang F, Wild K, Pang YY, Schwarz D, Bomke J, Hein C, Löhr F, Bernhard F, Denic V, Dötsch V, Sinning I. (2011)

Structural basis for the molecular evolution of SRP-GTPase activation by protein. Nat Struct Mol Biol. 8:1376-80.

Bange G, Kümmerer N, Grudnik P, Lindner R, Petzold G, Kressler D, Hurt E, Wild K, Sinning I. (2011)

Substrate binding disrupts dimerization and induces nucleotide exchange of the chloroplast GTPase Toc33. Biochem J. 436(2):313-9.

Oreb M, Höfle A, Koenig P, Sommer MS, Sinning I, Wang F, Tews I, Schnell DJ, Schleiff E. (2011)

Subversive substrates of glutathione reductases from Plasmodium falciparum-infected red blood cells as antimalarial agents. In: Apicomplexan parasites – Molecular approaches toward targeted drug development (Ed.: K. Becker), volume 2, 2011, from the series Drug Discovery in Infectious Diseases, (Ed.: P. M. Selzer), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, ISBN 978-3-527-32731-7.

Davioud-Charvet E, Lanfranchi DA. (2011)

Targeting of Nbp1 to the inner nuclear membrane is essential for spindle pole body duplication. EMBO J. 30(16):3337-52.

Kupke T, Di Cecco L, Müller HM, Neuner A, Adolf F, Wieland F, Nickel W, Schiebel E. (2011)

The bacterial redox signaller pyocyanin as an antiplasmodial agent: comparisons with its thioanalog methylene blue. Redox Rep. 16(4):154-65.

Kasozi DM, Gromer S, Adler H, Zocher K, Rahlfs S, Wittlin S, Fritz-Wolf K, Schirmer RH, Becker K (2011)

The E3 ubiquitin ligase CTRIP controls CLOCK levels and PERIOD oscillations in Drosophila. EMBO Rep. (12), 549-557.

A. Lamaze, A. Lamouroux, C. Vias, H-C. Hung, F. Weber and F. Rouyer (2011)

The phosphoinositide 3-kinase Vps34p is required for pexophagy in Saccharomyces cerevisiae. Biochem J. 434(1):161-70.

Grunau S, Lay D, Mindthoff S, Platta HW, Girzalsky W, Just WW, Erdmann R. (2011)

The reducing milieu of parasitized cells as a target of antimalarial agents: Methylene blue as an ethical drug In: Apicomplexan Parasites. Molecular Approaches toward Targeted Drug Development (Becker K ed), pp. 115-136, Wiley-VCH, Weinheim

Meissner P, Adler H, Kasozi D, Fritz-Wolf K, Schirmer RH. (2011)

The Unconventional Secretory Machinery of Fibroblast Growth Factor 2. Traffic 12:799-805.

Walter Nickel (2011)

Tumor-specific silencing of COPZ2 gene encoding coatomer protein complex subunit ζ 2 renders tumor cells dependent on its paralogous gene COPZ1. Proc Natl Acad Sci U S A. 108(30):12449-54.

Shtutman M, Baig M, Levina E, Hurteau G, Lim CU, Broude E, Nikiforov M, Harkins TT, Carmack CS, Ding Y, Wieland F, Buttyan R, Roninson IB. (2011)

VEGF mediates commissural axon chemoattraction through its receptor Flk1. Neuron (70):966-78. (*These authors contributed equally)

Ruiz de Almodovar, C*, Fabre, P*, Knevels, E, Coulon, C, Segura, I, Haddick, PCG, Aerts, L, Delattin, N, Strasser, G, Oh, WJ, Lange, C, Vinckier, S, Haigh, JJ, Fouquet, C, Henderson, C, Gu C, Alitalo K, Castellani V, Tessier-Lavigne M, Chedotal A, Charron F* and Carmeliet P*. (2011)

VEGF modulates NMDA receptor activity via a Src-family-kinase-dependent cross-talk. Proc Natl Acad Sci U S A. 108(33):13782-7. (*These authors contributed equally)

Meissirel, C*, Ruiz de Almodovar, C*, Knevels, E*, Coulon, C, Chounlamountri, N, Segura, I, de Rossi, P, Vinckier, S, Anthonis, K, Deléglise, B, de Mol, M, Ali, C, Dassonville, K, Loyens, E, Honnorat, J, Michotte, Y, Rogemond, V, Smolders, I, Voets, T, Vivien, D, Vanden Berghe, P, Van Den Bosch, L, Robberecht, W, Chédotal, A, Oliviero, S, Dewerchin, M, Schmucker, D, Thomasset, N, Salin, PA, & Carmeliet, P. (2011)

Deletion of Swm2p selectively impairs trimethylation of snRNAs by Trimethylguanosine synthase (Tgs1p). FEBS Lett. 584, 3299-3304.

Boon,K.-L. and Koš,M. (2010)

RiboSys, a high-resolution, quantitative approach to measure the in vivo kinetics of pre-mRNA splicing and 3’-end processing in Saccharomyces cerevisiae. RNA 16, 2570-80.

Alexander, R.D., Barrass, J.D., Dichtl,B., Koš,M., Obtulowicz,T., Robert,M.-C., Koper,M., Karkusiewicz,I., Mariconti,L., Tollervey,D., Dichtl,B., Kufel,J., Bertrand,E. and Beggs,J.D. (2010)

Yeast Pre-rRNA Processing and Modification Occur Cotranscriptionally. Mol. Cell 37, 809-820.

Koš,M. and Tollervey,D. (2010)

A critical role for ceramide synthase 2 in liver homeostasis: I. alterations in lipid metabolic pathways. J Biol Chem. 285(14):10902-10.

Pewzner-Jung Y, Park H, Laviad EL, Silva LC, Lahiri S, Stiban J, Erez-Roman R, Brügger B, Sachsenheimer T, Wieland F, Prieto M, Merrill AH Jr, Futerman AH. (2010)

A mitochondrial phosphatase required for cardiolipin biosynthesis: the PGP phosphatase Gep4. EMBO J. 29(12):1976-87.

Osman C, Haag M, Wieland FT, Brügger B, Langer T. (2010)

An epithelial-endothelial crostalk regulates differentiation in developing pancreas. Dev Biol 347(1): 216-27.

Pierreux, CE, Cordi, S, Hick, AC, Ruiz de Almodovar, C, Courtoy, PJ, Carmeliet, P & Lemaigre, FP. (2010)

Antimalarial versus cytotoxic properties of dual drugs derived from 4-aminoquinolines and Mannich bases: interaction with DNA. J Med Chem. 53(8):3214-26.

Wenzel NI, Chavain N, Wang Y, Friebolin W, Maes L, Pradines B, Lanzer M, Yardley V, Brun R, Herold-Mende C, Biot C, Tóth K, Davioud-Charvet E. (2010)

Arabidopsis stromal-derived Factor2 (SDF2) is a crucial target of the unfolded protein response in the endoplasmic reticulum. J Biol Chem. 285(23):18113-21.

Schott A, Ravaud S, Keller S, Radzimanowski J, Viotti C, Hillmer S, Sinning I, Strahl S. (2010)

Arp1, an actin-related protein, in Plasmodium berghei. Mol Biochem Parasitol. 173(2):88-96.

Siden-Kiamos I, Schüler H, Liakopoulos D, Louis C. (2010)

Cloning, recombinant production, crystallization and preliminary X-ray diffraction analysis of SDF2-like protein from Arabidopsis thaliana. Acta Crystallogr Sect F Struct Biol Cryst Commun. 66(Pt 1):12-4.

Radzimanowski J, Ravaud S, Schott A, Strahl S, Sinning I. (2010)

Conserved properties of polypeptide transport-associated (POTRA) domains derived from cyanobacterial Omp85. J Biol Chem. 285(23):18016-24.

König P, Mirus O, Haarmann R, Sommer MS, Sinning I, Schleiff E, Tews I. (2010)

cpSRP43 is a novel chaperone specific for light-harvesting chlorophyll a,b-binding proteins. J Biol Chem. 285(28):21655-61.

Falk S, Sinning I. (2010)

Defining the structural requirements for ribose 5-phosphate-binding and intersubunit cross-talk of the malarial pyridoxal 5-phosphate synthase. FEBS Lett. 584(19):4169-74.

Derrer B, Windeisen V, Guédez Rodríguez G, Seidler J, Gengenbacher M, Lehmann WD, Rippe K, Sinning I, Tews I, Kappes B. (2010)

Determinants of specificity at the protein-lipid interface in membranes. FEBS Lett. 584(9):1713-20. Review.

Ernst AM, Contreras FX, Brügger B, Wieland F. (2010)

Distinct Roles of Myosin Va in Membrane Remodeling and Exocytosis of Secretory Granules. Traffic, 11: 637-650.

Kögel, T., Rudolf, R., Hodneland, E., Hellwig, A., Kuznetsov, S., Seiler, F., Söllner, T.H., Barroso, J., Gerdes, H.-H. (2010)

Driving Ribosome Assembly. Biochim. Biophys. Acta 1803, 673-683.

Dieter Kressler, Ed Hurt and Jochen Bassler (2010)

Efficacy of methylene blue monotherapy in semi-immune adults with uncomplicated falciparum malaria: a controlled trial in Burkina Faso. Trop Med Int Health 15(6):713-7.

Bountogo M, Zoungrana A, Coulibaly B, Klose C, Mansmann U, Mockenhaupt FP, Burhenne J, Mikus G, Walter-Sack I, Schirmer RH, Sié A, Meissner P, Müller O (2010)

FCHo proteins are nucleators of clathrin-mediated endocytosis. Science 328, 1281-1284.

Henne WH, Boucrot E, Meinecke M, Evergren E, Vallis Y, Mittal R, McMahon HT. (2010)

FlhA provides the adaptor for coordinated delivery of late flagella building blocks to the type III secretion system. Proc Natl Acad Sci U S A. 107(25):11295-300.

Bange G, Kümmerer N, Engel C, Bozkurt G, Wild K, Sinning I. (2010)

Gene regulation by nucleoporins and links to cancer. Mol. Cell 38, 6-15.

Alwin Köhler and Ed Hurt (2010)

Genetic evidence for functional interaction of the Escherichia coli signal recognition particle receptor with acidic lipids in vivo. J Biol Chem. 285(52):40508-14.

Erez E, Stjepanovic G, Zelazny AM, Brügger B, Sinning I, Bibi E. (2010)

Impaired autonomic regulation of resistance arteries in mice with low vascular endothelial growth factor or upon vascular endothelial growth factor trap delivery. Circulation 122(3):273-81. (*These authors contributed equally)

Storkebaum, E*, Ruiz de Almodovar, C*, Meens, M, Zacchigna, S, Mazzone, M, Vanhoutte, G, Vinckier, S, Poesen, K, Lambrechts, D, Janssen, G, Fazzi, GE, Schiffers, PM, Rohrer, H, Van der Linden, A, DeMey, J. & Carmeliet, P. (2010)

Induction of cortical endoplasmic reticulum by dimerization of a coatomer-binding peptide anchored to endoplasmic reticulum membranes. Proc Natl Acad Sci U S A. 107(15):6876-81.

Lavieu G, Orci L, Shi L, Geiling M, Ravazzola M, Wieland F, Cosson P, Rothman JE. (2010)

Inhibition of hepatitis C virus entry by a plant-derived flavone. J. Hepatol. Suppl. 1, 52:S293.

Haid S, Gentzsch J, Jannack B, Bailleul F, Davioud-Charvet E, Pietschmann T. (2010)

Matrix-binding VEGF isoforms guide granule cell migration in the cerebellum via VEGF receptor Flk1. J. Neurosci 30(45): 15052-66. (*These authors contributed equally)

Ruiz de Almodovar, C*, Coulon, C*, Knevels, E, Salin, PA, Chounlamountri, N, Poesen, K, Hermans, K, Lambrechts, D, Van Geyte, K, Dhondt, J, Dresselaers, T, Renaud, J, Aragones, J, Zacchigna, S, Geudens, I, Gall, D, Stroobants, S, Mutin, M, Dassonville, K, Storkebaum, E, Jordan, BJ, Eriksson, U, Moons, L, D’Hooge, R, Haigh, JJ, Belin, MF, Schiffmann, S, Van Hecke, P, Gallez, B, Chedotal, A, Honnorat, J, Thomasset, N, Carmeliet, P, and Meissirel, C. (2010)

Membrane deformation and separation. F1000 Biol Rep. 2. pii: 35.

Beck R, Brügger B, Wieland FT. (2010)

Membrane protein expression in the eyes of transgenic flies. Methods Mol Biol. 601:135-47.

Panneels V, Sinning I. (2010)

Molecular genetics evidence for the in vivo roles of the two major NADPH-dependent disulfide reductases in the malaria parasite. J Biol Chem. 285(48):37388-95.

Buchholz K, Putrianti ED, Rahlfs S, Schirmer RH, Becker K, Matuschewski K (2010)

Of switches and hourglasses: regulation of subcellular traffic in circadian clocks by phosphorylation. EMBO Rep 11, 927-935.

Tataroglu, O., and Schafmeier, T. (2010)

Pathways of Unconventional Protein Secretion. Curr. Opin. Biotechnol. 21:621-626.

Walter Nickel (2010)

Photoadaptation in Neurospora by competitive interaction of activating and inhibitory LOV domains. Cell. 2010; doi:10.1016/j.cell.2010.08.010.

Malzahn, E., Ciprianidis, S., Káldi, K., Schafmeier, T. and Brunner, M. (2010)

Precise mapping of subunits in multiprotein complexes by a versatile EM-label. Nature Struct. Mol. Biol. in press.

Dirk Flemming, Karsten Thierbach, Philipp Stelter, Bettina Boettcher and Ed Hurt (2010)

RhoA regulates peroxisome association to microtubules and the actin cytoskeleton. PLoS One 5(11):e13886.

Schollenberger L, Gronemeyer T, Huber CM, Lay D, Wiese S, Meyer HE, Warscheid B, Saffrich R, Peränen J, Gorgas K, Just WW. (2010)

Role of Dll4/Notch in the formation and wiring of the lypmphatic network in zebrafish. Arterioscler Thromb Vasc Biol. (9):1605-702.

Geudens, I, Herpers, R, Hermans, K, Segura, I, Ruiz de Almodovar, C, Bussmann, J, De Smet, F, Vandevelde, W, Hogan, BM, Siekmann, A, Claes, F, Moore, J, Pistocchi, AS, Loges, S, Mazzone, M, Mariggi, MG, Bruyère, F, Cotelli, F, Kerjaschki, D, Noël, A, Foidart, J, Gerhardt, H, Ny, A, Langenberg, T, Lawson, N, Duckers, HJ, Schulte-Merker, S, Carmeliet, P. and Dewerchin, M. (2010)

Role of EBAG9 protein in coat protein complex I-dependent glycoprotein maturation and secretion processes in tumor cells. FASEB Journal. (abstract)

Wolf J, Reimer T, Schuck S, Rüder C, Gerlach K, Müller EC, Otto A, Dörken B, Rehm A (2010)

Signal peptide peptidase (SPP) assembles with substrates and misfolded membrane proteins into distinct oligomeric complexes. Biochem J. 427(3):523-34.

Schrul B, Kapp K, Sinning I, Dobberstein B. (2010)

Sphingolipid rheostat alterations related to transformation can be exploited for specific induction of lysosomal cell death in murine and human glioma. Glia 58(11):1364-83.

Mora R, Dokic I, Kees T, Hüber CM, Keitel D, Geibig R, Brügger B, Zentgraf H, Brady NR, Régnier-Vigouroux A. (2010)

Structural basis for assembly and activation of the heterotetrameric SAGA histone H2B deubiquitinase module. Cell 141, 606-617.

Alwin Köhler, Eric Zimmermann, Maren Schneider, Ed Hurt and Ning Zheng (2010)

Structural basis for the interaction between yeast Spt-Ada-Gcn5 acetyltransferase (SAGA) complex components Sgf11 and Sus1. J. Biol. Chem. 285, 3850-3856.

Andrew M. Ellisdon, Divyang Jani, Alwin Köhler, Ed Hurt and Murray Stewart (2010)

Structural insights into the assembly of the human and archaeal signal recognition particles. Acta Crystallogr D Biol Crystallogr. 66(Pt 3):295-303.

Wild K, Bange G, Bozkurt G, Segnitz B, Hendricks A, Sinning I. (2010)

Tec-kinase-mediated phosphorylation of fibroblast growth factor 2 is essential for unconventional secretion. Traffic 11(6):813-26.

Ebert AD, Laußmann M, Wegehingel S, Kaderali L, Erfle H, Reichert J, Lechner J, Beer HD, Pepperkok R, Nickel W. (2010)

The AAA-ATPase Rea1 drives removal of biogenesis factors during multiple stages of 60S ribosome assembly. Mol. Cell in press.

Jochen Baßler, Martina Kallas, Matthias Thoms, Cornelia Ulbrich, Brigitte Pertschy and Ed Hurt (2010)

The C terminus of Alb3 interacts with the chromodomains 2 and 3 of cpSRP43. J Biol Chem. 285(53):le25-6;

Falk S, Sinning I. (2010)

The C terminus of the Alb3 membrane insertase recruits cpSRP43 to the thylakoid membrane. J Biol Chem. 285(8):5954-62.

Falk S, Ravaud S, Koch J, Sinning I. (2010)

The conserved Cys76 plays a crucial role for the conformation of reduced glutathione peroxidase-type tryparedoxin peroxidase. FEBS Lett. 584(5):1027-32.

Muhle-Goll C, Füller F, Ulrich AS, Krauth-Siegel RL. (2010)

The dithiol glutaredoxins of african trypanosomes have distinct roles and are closely linked to the unique trypanothione metabolism. J Biol Chem. 285(45):35224-37.

Ceylan S, Seidel V, Ziebart N, Berndt C, Dirdjaja N, Krauth-Siegel RL. (2010)

The Peroxisomal Importomer Constitutes a Large and Highly Dynamic Pore. Nature Cell Biology 12, 273-277

Meinecke M, Cizmowski C, Schliebs W, Krüger V, Beck S, Wagner R, Erdmann R. (2010)

The silicon trypanosome. Parasitology. 137(9):1333-41. Review.

Bakker BM, Krauth-Siegel RL, Clayton C, Matthews K, Girolami M, Westerhoff HV, Michels PA, Breitling R, Barrett MP. (2010)

The structure of Get4 reveals an alpha-solenoid fold adapted for multiple interactions in tail-anchored protein biogenesis. FEBS Lett. 584(8):1509-14.

Bozkurt G, Wild K, Amlacher S, Hurt E, Dobberstein B, Sinning I. (2010)

Transcription factors in light and circadian clock signaling networks revealed by genomewide mapping of direct targets for neurospora white collar complex. Eukaryot Cell. 2010; PMC2950426. doi:10.1128/ec.00154-10.

Smith, K. M., Sancar, G., Dekhang, R., Sullivan, C. M., Li, S., Tag, A. G., Sancar, C., Bredeweg, E. L., Priest, H. D., McCormick, R. F., Thomas, T. L., Carrington, J. C., Stajich, J. E., Bell-Pedersen, D., Brunner, M. and Freitag, M. (2010)

Ubiquitylation regulates interactions of astral microtubules with the cleavage apparatus. Curr Biol. 20(14):1233-43.

Kammerer D, Stevermann L, Liakopoulos D. (2010)

(editors: Jacob BC and Winyard PG), book review in ChemMedChem. 4:2123-2127.

Krauth-Siegel RL. Redox signaling and regulation in biology and medicine. (2009)

2,3-diphenyl-1,4-naphthoquinone: a potential chemotherapeutic agent against Trypanosoma cruzi. J Parasitol. 95(2):461-6.

Ramos EI, Garza KM, Krauth-Siegel RL, Bader J, Martinez LE, Maldonado RA. (2009)

A conserved, lipid-mediated mechanism for the sorting of yeast Ist2 and mammalian STIM proteins to plasma membrane-associated domains of the peripheral ER. Traffic 10:1802-1818.

Ebru Ercan, Frank Momburg, Ulrike Engel, Koen Temmerman, Walter Nickel and Matthias Seedorf (2009)

A lipid-binding motif targets the yeast integral membrane protein Ist2 to domains of the cortical ER. Traffic 10:1084-1097.

Marcel A. Fischer, Koen Temmerman, Walter Nickel and Matthias Seedorf (2009)

A novel flow cytometric assay to quantify interactions between proteins and membrane lipids. J. Lipid Res. 50:1245-1254.

Koen Temmerman and Walter Nickel (2009)

A role of complexin-lipid interactions in membrane fusion. FEBS letters, 583: 2343-8.

Seiler, F., Malsam, J., Krause, JM., Söllner, T.H. (2009)

A signal comprising a basic cluster and an amphipathic α-helix interacts with lipids and is required for the transport of Ist2 to the yeast cortical ER. J. Cell Sci. 122:625-635.

Kiran Maass, Marcel André Fischer, Markus Seiler, Koen Temmerman, Walter Nickel and Matthias Seedorf (2009)

A toxic nucleoporin mutant induces abarrent nucleoporin foci in the cytoplasm. J. Cell Biol. 185, 387-396.

Dirk Flemming, Philipp Sarges, Philipp Stelter, Andrea Hellwig, Bettina Boettcher and Ed Hurt (2009)

Activity of the circadian transcription factor White Collar Complex is modulated by phosphorylation of SP-motifs. FEBS Lett. 2009; doi:10.1016/j.febslet.2009.04.042.

Sancar, G., Sancar, C., Brunner, M. and Schafmeier, T. (2009)

An endoribonuclease functionally linked to perinuclear mRNP quality control associates with the nuclear pore complexes. PLoS Biology 7 e8.

Michal Skruzny, Claudia Schneider, Attila Racz, Julan Weng, David Tollervey and Ed Hurt (2009)

An Intrinsic Quality Control Mechanism Ensures Unconventional Secretion of Fibroblast Growth Factor 2 in a Folded Conformation. J. Cell Sci. 122:3322-3329.

Lucía Cespón Torrado, Koen Temmerman, Hans-Michael Müller, Matthias P. Mayer, Claudia Seelenmeyer, Rafael Backhaus, and Walter Nickel (2009)

Antimalarial Antimalarial activities of ferroquine conjugates with either glutathione reductase inhibitors or glutathione depletors via a hydrolyzable amide linker. Bioorg. Med. Chem. 17:8048--8059."

Chavain N, Davioud-Charvet E, Trivelli X, Mbeki L, Rottmann M, Brun R, Biot C. (2009)

ArfGAP1 activity and COPI vesicle biogenesis. Traffic. 10(3):307-15.

Beck R, Adolf F, Weimer C, Bruegger B, Wieland FT. (2009)

Arrest by Ribosome. Nature 459, 46-47.

Sébastien Ferreira-Cerca and Ed Hurt (2009)

Artemisinin resistance on the Thai-Cambodian border. Lancet. 374(9699):1419.

Müller O, Sié A, Meissner P, Schirmer RH, Kouyaté B (2009)

CA/C1 peptidases of the malaria parasites Plasmodium falciparum and P. berghei and their mammalian hosts--a bioinformatical analysis. Biol Chem. 390(11):1185-97.

Xiao K, Jehle F, Peters C, Reinheckel T, Schirmer RH, Dandekar T. (2009)

Cholesterol regulates the endoplasmic reticulum exit of the major membrane protein P0 required for peripheral myelin compaction. J Neurosci. 29(19):6094-104.

Saher G, Quintes S, Möbius W, Wehr MC, Krämer-Albers EM, Brügger B, Nave KA. (2009)

Cytoplasmic interaction with CYCLE promotes the post-translational processing of the circadian CLOCK protein. FEBS Lett. (583), 1561-1566.

C. Maurer, H-C. Hung and F. Weber (2009)

Defects in myelination, paranode organization and Purkinje cell innervation in the ether lipid-deficient mouse cerebellum. Hum Mol Genet. 18(11):1897-908.

Teigler A, Komljenovic D, Draguhn A, Gorgas K, Just WW. (2009)

Delivering proteins for export from the cytosol. Nat Rev Mol Cell Biol. 10(4):255-64. Review.

Cross BC, Sinning I, Luirink J, High S. (2009)

Disruption of blood-testis barrier dynamics in ether-lipid-deficient mice. Cell Tissue Res. 337(2):281-99.

Komljenovic D, Sandhoff R, Teigler A, Heid H, Just WW, Gorgas K. (2009)

Dissection of contributions from invariant amino acids to complex formation and catalysis in the heteromeric pyridoxal 5-phosphate synthase complex from Bacillus subtilis. Biochemistry. 48(9):1928-35.

Wallner S, Neuwirth M, Flicker K, Tews I, Macheroux P. (2009)

Diverse roles of HP1 proteins in heterochromatin assembly and functions in fission yeast. Proc Natl Acad Sci U S A 106, 8998-9003.

Fischer, T., Cui, B., Dhakshnamoorthy, J., Zhou, M., Rubin, C., Zofall, M., Veenstra, T.D., and Grewal, S.I. (2009)

Following the fate in vivo of COPI vesicles generated in vitro. Traffic. 10(8):994-1005.

Rutz C, Satoh A, Ronchi P, Brügger B, Warren G, Wieland FT. (2009)

Generation of cubic membranes by controlled homotypic interaction of membrane proteins in the endoplasmic reticulum. Journal of Biological Chemistry. (abstract)

Lingwood D, Schuck S, Ferguson C, Gerl MJ, Simons K (2009)

Glyoxalase II does not support methylglyoxal detoxification but serves as a general trypanothione thioesterase in African trypanosomes. Mol Biochem Parasitol. 163(1):19-27.

Wendler A, Irsch T, Rabbani N, Thornalley PJ, Krauth-Siegel RL. (2009)

Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization. Cell 136(5):839-51.

Mazzone, M, Dettori, D, Leite de Oliveira, R, Loges, S, Schmidt, T, Jonckx, B, Tian, YM, Lanahan, AA, Pollard, P, Ruiz de Almodovar, C, De Smet, F, Vinckier, S, Aragones, J, Luttun, A, Wyns, S, Jordan, B, Pisacane, A, Gallez, B, Lampugnani, MG, Dejana, E, Simons, M, Ratcliffe, P, Maxwell, P. & Carmeliet, P. (2009)

Histone H2A.Z cooperates with RNAi and heterochromatin factors to suppress antisense RNAs. Nature 461, 419-422. (*These authors contributed equally.)

Zofall, M.*, Fischer, T.*, Zhang, K., Zhou, M., Cui, B., Veenstra, T.D., and Grewal, S.I. (2009)

HSP90, a capacitor of behavioural variation. J. Biol. Rhythms. (24), 183-192.

H-C. Hung, S. Kay and F. Weber (2009)

Inherited glutathione reductase deficiency and Plasmodium falciparum malaria--a case study. PLoS One. 4(10):e7303.

Gallo V, Schwarzer E, Rahlfs S, Schirmer RH, van Zwieten R, Roos D, Arese P, Becker K (2009)

Journeys through the Golgi--taking stock in a new era. J Cell Biol. 187(4):449-53. Review.

Emr S, Glick BS, Linstedt AD, Lippincott-Schwartz J, Luini A, Malhotra V, Marsh BJ, Nakano A, Pfeffer SR, Rabouille C, Rothman JE, Warren G, Wieland FT. (2009)

Linear ubiquitin fusion to Rps31 and its subsequent cleavage 1 are required for the efficient production and functional integrity of 40S ribosomal subunits. Mol. Microbiol. 72, 69-84.

Thierry Lacombe, Juan J. García-Gómez, Jesús de la Cruz, Daniela Roser, Ed Hurt, Patrick Linder and Dieter Kressler (2009)

Mechanisms of Regulated Unconventional Protein Secretion. Nat. Rev. Mol. Cell Biol. 10:148-155.

Walter Nickel and Catherine Rabouille (2009)

Mechanochemical Removal of Ribosome Biogenesis Factors from Nascent 60S Ribosomal Subunits. Cell 138, 911-922.

Cornelia Ulbrich, Meikel Diepholz, Jochen Baßler, Dieter Kressler, Brigitte Pertschy, Kiki Galani, Bettina Böttcher and Ed Hurt (2009)

Membrane expansion alleviates endoplasmic reticulum stress independently of the unfolded protein response. Journal of Cell Biology. (abstract)

Schuck S, Prinz WA, Thorn KS, Voss C, Walter P (2009)

Mimicking Ndc80 phosphorylation triggers spindle assembly checkpoint signalling. EMBO J. 28(8):1099-110.

Kemmler S, Stach M, Knapp M, Ortiz J, Pfannstiel J, Ruppert T, Lechner J. (2009)

Morphological homeostasis by autophagy. Autophagy. Commentary (abstract)

Lingwood D, Schuck S, Ferguson C, Gerl MJ, Simons K (2009)

Mutational Uncoupling of Sus1's role in NPC-targeting of an mRNA Export Complex and Histone H2B deubiquitination J. Biol. Chem. 284, 12049-12056.

Christoph Klöckner, Maren Schneider, Sheila Lutz, Dieter Kressler, Divyang Jani, Murray Stewart, Ed Hurt and Alwin Köhler (2009)

Myristoylated adenylate kinase-2 of Plasmodium falciparum forms a heterodimer with myristoyltransferase. Mol Biochem Parasitol. 163(2):77-84.

Rahlfs S, Koncarevic S, Iozef R, Mailu BM, Savvides SN, Schirmer RH, Becker K. (2009)

NMR assignments of oxidised thioredoxin from Plasmodium falciparum. Biomol NMR Assign. 3(2):159-61.

Munte CE, Becker K, Schirmer RH, Kalbitzer HR (2009)

Nucleus-Specific and Cell Cycle-Regulated Degradation of MAPK Scaffold Protein Ste5 Contributes to the Control of Signaling Competence. Mol. Cell Biol. 29, 582-601.

Lindsay S. Garrenton, Andreas Braunwarth, Stefan Irniger, Ed Hurt, Markus Künzler and Jeremy Thorner (2009)

Pentafluorosulfanyl as a novel building block for enzyme inhibitors: trypanothione reductase inhibition and antiprotozoal activities of diarylamines. Chembiochem. 10(1):79-83.

Stump B, Eberle C, Schweizer WB, Kaiser M, Brun R, Krauth-Siegel RL, Lentz D, Diederich F. (2009)

Phosphorylation modulates rapid nucleocytoplasmic shuttling and cytoplasmic accumulation of Neurospora clock protein FRQ on a circadian time scale. Genes Dev. 2009; PMC2751991. doi:10.1101/gad.538209.

Diernfellner, A. C., Querfurth, C., Salazar, C., Höfer, T. and Brunner, M. (2009)

Preparative enzymatic synthesis of trypanothione and trypanothione analogues. Int J Parasitol. 39(10):1059-62.

Comini MA, Dirdjaja N, Kaschel M, Krauth-Siegel RL. (2009)

Privileged structure-guided synthesis of quinazoline derivatives as inhibitors of trypanothione reductase. Bioorg Med Chem Lett. 19(11):3031-5.

Cavalli A, Lizzi F, Bongarzone S, Brun R, Luise Krauth-Siegel R, Bolognesi ML. (2009)

Probing HIV-1 membrane liquid order by Laurdan staining reveals producer cell-dependent differences. J Biol Chem. 284(33):22238-47.

Lorizate M, Brügger B, Akiyama H, Glass B, Müller B, Anderluh G, Wieland FT, Kräusslich HG. (2009)

Protein targeting by the signal recognition particle. Biol Chem. 390(8):775-82. Review.

Grudnik P, Bange G, Sinning I. (2009)

Purification of poly(A)-binding protein Nab2 reveals association with the yeast transcriptome and a messenger ribonucleoprotein (mRNP) core structure. J.Biol.Chem. 284, 354911-354917.

Julien Batisse, Claire Batisse, Aidan Budd, Bettina Böttcher and Ed Hurt (2009)

Remodelling the clock: Co-activators and signal transduction in the circadian clock works. Naturwissenschaften 2009 (96), 321-337. (Review)

F. Weber (2009)

Reversible Phosphorylation as a Molecular Switch to Regulate Plasma Membrane Targeting of Acylated SH4 Domain Proteins. Traffic 10:1047-1060.

Stella Tournaviti, Enrica San Pietro, Stefan Terjung, Tobias Schafmeier, Sabine Wegehingel, Julia Ritzerfeld, Juliane Schulz, Deborah F. Smith, Rainer Pepperkok, and Walter Nickel (2009)

RNA helicase Prp43 and its co-factor Pfa1 promote 20S to 18S rRNA processing catalyzed by the endonuclease Nob1. J.Biol.Chem. 284, 35079-35091.

Brigitte Pertschy, Claudia Schneider, Maren Gnädig, Thorsten Schäfer, David Tollervey and Ed Hurt (2009)

Role and theraputical potential of VEGF in the nervous system. Physiol Rev 89(2): 607-48.

Ruiz de Almodovar, C, Lambrechts, D, Mazzone, M & Carmeliet, P. (2009)

Role of spindle asymmetry in cellular dynamics. Int Rev Cell Mol Biol. 278: 149-213.

Barral Y and Liakopoulos, D. (2009)

Sem1 is a functional component of the nuclear pore complex associated mRNA export machinery. J. Cell Biol. 184, 833-846.

Marius Boulos Faza, Stefan Kemmler, Sonia Jimeno, Christina González-Aguilera, Andres Aguilera, Ed Hurt and Vikram Govind Panse (2009)

Sequential and compartment-specific phosphorylation controls the life cycle of the circadian CLOCK protein. J Biol Chem. (284), 23734-23742.

H-C. Hung, C. Maurer, D. Zorn, W-L. Chang and F. Weber (2009)

Signal sequences get active. Nat Chem Biol. 5(3):146-7.

Sinning I, Wild K, Bange G. (2009)

Strong gametocytocidal effect of methylene blue-based combination therapy against falciparum malaria: a randomised controlled trial. PLoS One. 4(5):e5318.

Coulibaly B, Zoungrana A, Mockenhaupt FP, Schirmer RH, Klose C, Mansmann U, Meissner PE, Müller O. (2009)

Structural basis for the Sus1:Sgf11 interaction in the yeast SAGA transcription activation complex. J. Biol. Chem. in press.

Andrew M. Ellisdon, Divyang Jani, Alwin Köhler, Ed Hurt and Murray Stewart (2009)

Structural insights into tail-anchored protein binding and membrane insertion by Get3. Proc Natl Acad Sci U S A. 106(50):21131-6.

Bozkurt G, Stjepanovic G, Vilardi F, Amlacher S, Wild K, Bange G, Favaloro V, Rippe K, Hurt E, Dobberstein B, Sinning I. (2009)

Stu1 inversely regulates kinetochore capture and spindle stability. Genes Dev. 23(23):2778-91.

Ortiz J, Funk C, Schäfer A, Lechner J. (2009)

Sus1, Cdc31, and the Sac3 CID region form a conserved interaction platform that promotes nuclear pore association and mRNA export. Mol Cell 33, 727-737.

Jani, D., Lutz, S., Marshall, N.J., Fischer, T., Kohler, A., Ellisdon, A.M., Hurt, E., and Stewart, M. (2009)

Synthesis, inhibition potency, binding mode, and antiprotozoal activities of fluorescent inhibitors of trypanothione reductase based on mepacrine-conjugated diaryl sulfide scaffolds. ChemMedChem. 4(12):2034-44.

Eberle C, Burkhard JA, Stump B, Kaiser M, Brun R, Krauth-Siegel RL, Diederich F. (2009)

Targeting of Drosophila rhodopsin requires helix 8 but not the distal C-terminus. PLoS One. 4(7):e6101.

Kock I, Bulgakova NA, Knust E, Sinning I, Panneels V. (2009)

The adaptor Aly and co-adaptor Thoc5 function in Tap-p15 mediated nuclear export of HSP70 mRNA. EMBO J. 28, 556-567.

Jun Katahira, Hitomi Inoue, Ed Hurt, Yoshihiro Yoneda (2009)

The carboxy-terminal domain of complexin I stimulates liposome fusion. Proc. Natl. Acad. Sci. USA, 106: 2001-2006.

Malsam, J., Seiler, F., Schollmeier, Y., Rusu, P., Krause, JM., Söllner, T.H. (2009)

The COPI system: molecular mechanisms and function. FEBS Lett. 583(17):2701-9. Review.
Corrigendum in: FEBS Lett. 583(21):3541

Beck R, Rawet M, Wieland FT, Cassel D. (2009)

The eye lens chaperone α-crystallin forms defined globular assemblies. PNAS 106(32):13272-13277.

Peschek J, Braun N, Franzmann TM, Georgalis Y, Haslbeck M, Weinkauf S, Buchner J (2009)

The genetic interactome of prohibitins: coordinated control of cardiolipin and phosphatidylethanolamine by conserved regulators in mitochondria. J Cell Biol. 184(4):583-96.

Osman C, Haag M, Potting C, Rodenfels J, Dip PV, Wieland FT, Brügger B, Westermann B, Langer T. (2009)

The Golgi-associated Protein p115 Mediates the Secretion of Macrophage Migration Inhibitory Factor. J. Immunol. 182:6896-6906.

Melanie Merk, John Baugh, Swen Zierow, Lin Leng, Utpal Pal, Seung Joon Lee, Antje D. Ebert, Yuka Mizue, John O. Trent, Robert Mitchell, Walter Nickel, Paula B. Kavathas, Jürgen Bernhagen, and Richard Bucala (2009)

The neurovascular link in health and disease: an update. Trends Mol Med. 15(10):439-51.

Segura, I, De Smet, F, Hohensinner, PJ, Ruiz de Almodovar, C. & Carmeliet, P. (2009)

Unsaturated Mannich bases active against multidrug-resistant Trypanosoma brucei brucei strains. ChemMedChem, 4(3), 339–351.

Wenzel, I. N., Wong, P. E., Maes, L., Müller, T. J., Krauth-Siegel, R. L., Barrett, M. P., & Davioud-Charvet, E. (2009)

X-ray crystal structure of Saccharomyces cerevisiae Pdx1 provides insights into the oligomeric nature of PLP synthases. FEBS Lett. 583(13):2179-86.

Neuwirth M, Strohmeier M, Windeisen V, Wallner S, Deller S, Rippe K, Sinning I, Macheroux P, Tews I. (2009)

Cell-free deadenylation assays with Drosophila embryo extracts. Meth. Enzymol. 448, 107-118.

Jeske, M., Wahle, E. (2008)

Quantitative analysis of snoRNA association with pre-ribosomes and release of snR30 by Rok1 helicase. EMBO Rep. 9, 1230-1236.

Bohnsack, M.T., Koš,M. and Tollervey,D. (2008)

1H, 13C, and 15N assignment of the oxidized and reduced forms of T. brucei glutathione peroxidase-type tryparedoxin peroxidase. Biomolecular NMR Assignments. 2:65-68.

Melchers J, Krauth-Siegel RL, Muhle-Goll C. (2008)

A conformational change in the alpha-subunit of coatomer induced by ligand binding to gamma-COP revealed by single-pair FRET. Traffic 9, 597-607.

Langer, JD, Roth, CM, Béthune, J, Stoops, EH, Brügger, B, Herten, DP, and Wieland, FT* (2008)

A sugar-modified phosphole gold complex with antiproliferative properties acting as a thioredoxin reductase inhibitor in MCF-7 cells. ChemMedChem. 3:1667–70.

Viry E, Battaglia E, Deborde V, Müller T, Réau R, Davioud-Charvet E, Bagrel D. (2008)

A versatile interaction platform on the Mex67-Mtr2 receptor creates an overlap between mRNA and ribosome export. EMBO J. 27, 6–16.

Wei Yao, Malik Lutzmann and Ed Hurt (2008)

Angiogenesis in the central nervous system. Book chapter in the book titled: Angiogenesis: an integrative approach from science to medicine. Edited by Figg and Folkman, Springer 489-504. (*These authors contributed equally)

Ruiz de Almodovar, C*, Zacchigna, S* & Carmeliet, P. (2008)

Antimalarial dual drugs based on potent inhibitors of glutathione reductase from Plasmodium falciparum. J Med Chem. 51(5):1260–77.

Friebolin W, Jannack B, Wenzel N, Furrer J, Oeser T, Sanchez CP, Lanzer M, Yardley V, Becker K, Davioud-Charvet E. (2008)

Arf1-GTP-induced tubule formation suggests a function of Arf family proteins in curvature acquisition at sites of vesicle budding. J Biol Chem. 283(41):27717-23.

Krauss M, Jia JY, Roux A, Beck R, Wieland FT, De Camilli P, Haucke V. (2008)

B- and T-cell development both involve activity of the unfolded protein response pathway. J Biol Chem. (283), 17954-17961.

R. Brunsing, S.A. Omori, F. Weber, A. Bicknell, L. Friend, R. Rickert, M. Niwa (2008)

Book Review on KC Nicolaou and T Montagnon. Molecules that changed the world. J Lab Med 32:382-383.

Schirmer H. (2008)

Ceramide triggers budding of exosome vesicles into multivesicular endosomes. Science. 319(5867):1244-7.

Trajkovic K, Hsu C, Chiantia S, Rajendran L, Wenzel D, Wieland F, Schwille P, Brügger B, Simons M. (2008)

Circadian activity and abundance rhythms of the Neurospora clock transcription factor WCC associated with rapid nucleo-cytoplasmic shuttling. Genes Dev. 2008; PMC2607078. doi:10.1101/gad.507408.

Schafmeier, T., Diernfellner, A., Schäfer, A., Dintsis, O., Neiss, A. and Brunner, M. (2008)

Cloning, functional analysis, and mitochondrial localization of Trypanosoma brucei monothiol glutaredoxin-1. Biol Chem. 389(1):21-32.

Filser M, Comini MA, Molina-Navarro MM, Dirdjaja N, Herrero E, Krauth-Siegel RL. (2008)

Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast. Science 322, 405-410.

Roguev, A., Bandyopadhyay, S., Zofall, M., Zhang, K., Fischer, T., Collins, S. R., Qu, H., Shales, M., Park, H. O., Hayles, J., Hoe, K. L., Kim, D. U., Ideker, T., Grewal, S. I., Weissman, J. S., & Krogan, N. J. (2008)

Crystal structure of the human Fe65-PTB1 domain. J Biol Chem. 283(34):23113-20.

Radzimanowski J, Ravaud S, Schlesinger S, Koch J, Beyreuther K, Sinning I, Wild K. (2008)

Cytotoxic interactions of methylene blue with trypanosomatid-specific disulfide reductases and their dithiol products. Mol Biochem Parasitol. 160(1):65-9.

Buchholz K, Comini MA, Wissenbach D, Schirmer RH, Krauth-Siegel RL, Gromer S. (2008)

Depletion of apical transport proteins perturbs epithelial cyst formation and ciliogenesis. Journal of Cell Science. (abstract)

Torkko JM, Manninen A, Schuck S, Simons K (2008)

Depletion of Plasmodium berghei plasmoredoxin reveals a non-essential role for life cycle progression of the malaria parasite. PLoS ONE. 3(6):e2474.

Buchholz K, Rahlfs S, Schirmer RH, Becker K, Matuschewski K. (2008)

Der Kernporenkomplex oder das Tor zur Welt des Zytoplasmas. Im Jahrbuch 2007 der Deutschen Akademie der Naturforscher Leopoldina. Leopoldina 53, 457-460.

Ed Hurt (2008)

Diaryl sulfide-based inhibitors of trypanothione reductase: inhibition potency, revised binding mode and antiprotozoal activities. Org Biomol Chem. 6(21):3935-47.

Stump B, Eberle C, Kaiser M, Brun R, Krauth-Siegel RL, Diederich F. (2008)

Differential roles of ArfGAP1, ArfGAP2, and ArfGAP3 in COPI trafficking. J Cell Biol. 183(4):725-35.

Weimer C, Beck R, Eckert P, Reckmann I, Moelleken J, Brügger B, Wieland F. (2008)

Distinct binding sites for the ATPase and substrate-binding domain of human Hsp70 on the cell surface of antigen presenting cells. Mol Immunol. 45(15):3974-83.

Zitzler S, Hellwig A, Hartl FU, Wieland F, Diestelkötter-Bachert P. (2008)

Disulfide reductases as drug targets: Methylene blue combination therapies for falciparum malaria in African children. (2008) Flavins and Flavoproteins 2008 (Frago S, Gómez-Moreno C, Medina M eds) Prensas Universitarias Zaragoza. 481-486.

Schirmer RH, Adler H, Zappe HA, Gromer S, Becker K, Coulibaly B, Meissner P (2008)

Finally: The digital, democratic age of scientific abstracts. FEBS Lett. 582(8):1169.

Superti-Furga G, Wieland F, Cesareni G. (2008)

In vitro assays to measure SNARE mediated membrane fusion. Methods in Mol. Biol. 440: 37-50.

Kreye, S., Malsam, J., Söllner, T.H. (2008)

Interactions of methylene blue with human disulfide reductases and their orthologues from Plasmodium falciparum. Antimicrob Agents Chemother. 52(1):183-91.

Buchholz K, Schirmer RH, Eubel JK, Akoachere MB, Dandekar T, Becker K, Gromer S. (2008)

Interlocked feedback loops of the circadian clock of Neurospora crassa. Mol Microbiol. 2008; doi:10.1111/j.1365-2958.2008.06148.x.

Brunner, M. and Káldi, K. (2008)

Lego clocks: building a clock from parts. Genes Dev. 2008; PMC2732415. doi:10.1101/gad.1686608.

Brunner, M., Simons, M. J. and Merrow, M. (2008)

Membrane curvature induced by Arf1-GTP is essential for vesicle formation. Proc Natl Acad Sci U S A 105, 11731-11736. → Highlighted by the Faculty of 1000 (

Beck, R, Sun, Z, Adolf, F, Rutz, C, Bassler, J, Wild, K, Sinning, I, Hurt, E, Brügger, B, Béthune, J*, and Wieland, F* (2008)

Membrane fusion: SNAREs and regulation. Cell Mol. Life. Sci., 65: 2814-2832.

Malsam, J., Kreye, S., Söllner, T.H. (2008)

Mercury-induced crystallization and SAD phasing of the human Fe65-PTB1 domain. Acta Crystallogr Sect F Struct Biol Cryst Commun. 64(Pt 5):382-5.

Radzimanowski J, Ravaud S, Beyreuther K, Sinning I, Wild K. (2008)

Monothiol glutaredoxin-1 is an essential iron-sulfur protein in the mitochondrion of African trypanosomes. J Biol Chem. 283(41):27785-98.

Comini MA, Rettig J, Dirdjaja N, Hanschmann EM, Berndt C, Krauth-Siegel RL. (2008)

Mutation of a single residue, beta-glutamate-20, alters protein-lipid interactions of light harvesting complex II. Mol Microbiol. 67(1):63-77.

Kwa LG, Wegmann D, Brügger B, Wieland FT, Wanner G, Braun P. (2008)

Nucleocytoplasmic shuttling of the Golgi phosphatidylinositol 4-kinase Pik1 is regulated by 14-3-3 proteins and coordinates Golgi function with cell growth. Mol Biol Cell 19:1046-1061.

Demmel L, Beck M, Klose C, Schlaitz AL, Gloor Y, Hsu PP, Havlis J, Shevchenko A, Krause E, Kalaidzidis Y, Walch-Solimena C (2008)

On the significance of Toc-GTPase homodimers. J Biol Chem. 283(34):23104-12.

König P, Oreb M, Rippe K, Muhle-Goll C, Sinning I, Schleiff E, Tews I. (2008)

Overproduction, purification, crystallization and preliminary X-ray analysis of human Fe65-PTB2 in complex with the amyloid precursor protein intracellular domain. Acta Crystallogr Sect F Struct Biol Cryst Commun. 64(Pt 5):409-12.

Radzimanowski J, Beyreuther K, Sinning I, Wild K. (2008)

pH Sensitivity of the GTPase Toc33 as a regulatory circuit for protein translocation into chloroplasts. Plant Cell Physiol. 49(12):1917-21.

Bionda T, König P, Oreb M, Tews I, Schleiff E. (2008)

Policing Tic 'n' Toc, the doorway to chloroplasts. Trends Cell Biol. 18(1):19-27. Review.

Oreb M, Tews I, Schleiff E. (2008)

Protein-sphingolipid interactions within cellular membranes. J Lipid Res. 49(1):251-62.

Haberkant P, Schmitt O, Contreras FX, Thiele C, Hanada K, Sprong H, Reinhard C, Wieland FT, Brügger B. (2008)

Purification, crystallization and preliminary structural characterization of the periplasmic domain P1 of the Escherichia coli membrane-protein insertase YidC. Acta Crystallogr Sect F Struct Biol Cryst Commun. 64(Pt 2):144-8.

Ravaud S, Wild K, Sinning I. (2008)

Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism. Biochim Biophys Acta. 1780(11):1236-48. Review.

Krauth-Siegel RL, Comini MA. (2008)

Regulation of mitotic spindle asymmetry by SUMO and the spindle-assembly checkpoint in yeast. Curr Biol. 18(16):1249-55.

Leisner C, Kammerer D, Denoth A, Britschi M, Barral Y, Liakopoulos D. (2008)

Rerouting of Fibroblast Growth Factor 2 to the Classical Secretory Pathway Results in Post-translational Modifications That Block Binding to Heparan Sulfate Proteoglycans. FEBS Lett. 582:2387-2392.

Sabine Wegehingel, Christoph Zehe, and Walter Nickel (2008)

Safety and efficacy of methylene blue combined with artesunate or amodiaquine for uncomplicated falciparum malaria: a randomized controlled trial from Burkina Faso. PLoS ONE. 3(2):e1630.

Zoungrana A, Coulibaly B, Sié A, Walter-Sack I, Mockenhaupt FP, Kouyaté B, Schirmer RH, Klose C, Mansmann U, Meissner P, Müller O. (2008)

Similarities between angiogenesis and neural development: what small animal models can tell us. Curr Top Dev Biol 80:1-55. (*These authors contributed equally)

Zacchigna, S*, Ruiz de Almodovar, C* & Carmeliet, P. (2008)

Structural basis for a distinct catalytic mechanism in Trypanosoma brucei tryparedoxin peroxidase. J Biol Chem. 283(44):30401-11.

Melchers J, Diechtierow M, Fehér K, Sinning I, Tews I, Krauth-Siegel RL, Muhle-Goll C. (2008)

Structural basis for specific substrate recognition by the chloroplast signal recognition particle protein cpSRP43. Science. 321(5886):253-6.

Stengel KF, Holdermann I, Cain P, Robinson C, Wild K, Sinning I. (2008)

Structural basis of the Nic96 subcomplex organization in the nuclear pore channel. Mol. Cell 29, 46-55.

Nils Schrader, Philipp Stelter, Dirk Flemming, Ruth Kunze, Ed Hurt* and Ingrid Vetter* (*corresponding authors) (2008)

Structure of the intracellular domain of the amyloid precursor protein in complex with Fe65-PTB2. EMBO Rep. 9(11):1134-40.

Radzimanowski J, Simon B, Sattler M, Beyreuther K, Sinning I, Wild K. (2008)

Synthesis of photo-reactive naphthoquinones for photoaffinity labeling of glutathione reductases. Flavins and Flavoproteins 2008 (Frago S, Gómez-Moreno C, Medina M eds) Prensas Universitarias Zaragoza. 16:443–52.

Müller T, Müller TJJ, Davioud-Charvet E. (2008)

The AAA-ATPase Rix7 powers progression of ribosome biogenesis by stripping Nsa1 from pre-60S particles. J. Cell Biol. 181, 835-844.

Dieter Kressler, Daniela Roser, Brigitte Pertschy and Ed Hurt (2008)

The aza-analogues of 1,4-naphthoquinones are potent substrates and inhibitors of plasmodial thioredoxin and glutathione reductases and of human erythrocyte glutathione reductase. Org. Biomol. Chem. 6(15):2731–42.

Morin C, Besset T, Moutet JC, Fayolle M, Brückner M, Limosin D, Becker K, Davioud-Charvet E. (2008)

The crystal structure of the periplasmic domain of the Escherichia coli membrane protein insertase YidC contains a substrate binding cleft. J Biol Chem. 283(14):9350-8.

Ravaud S, Stjepanovic G, Wild K, Sinning I. (2008)

The green yeast uses its plant-like clock to regulate its animal-like tail. Genes Dev. 2008; PMC2732389. doi:10.1101/gad.1664508.

Brunner, M. and Merrow, M. (2008)

The GTPase cycle of the chloroplast import receptors Toc33/Toc34: implications from monomeric and dimeric structures. Structure. 16(4):585-96.

König P, Oreb M, Höfle A, Kaltofen S, Rippe K, Sinning I, Schleiff E, Tews I. (2008)

The inner nuclear membrane protein Src1 associates with subtelomeric genes and alters their regulated gene expression. J Cell Biol 182, 897-910.

Grund, S.E., Fischer, T., Cabal, G.G., Antunez, O., Perez-Ortin, J.E., and Hurt, E. (2008)

Transcriptional regulation and function of the Neurospora clock gene white collar 2 and its isoforms. EMBO Rep. 2008; PMC2515204. doi:10.1038/embor.2008.113.

Neiss, A., Schafmeier, T. and Brunner, M. (2008)

Trypanothione reductase: a target protein for a combined in silico and in vitro screening approach. Flavins and Flavoproteins 2008 (Frago S, Gómez-Moreno C, Medina M eds) Prensas Universitarias Zaragoza. 5503-8.

Beig M, Bender F, Oellien F, Rohwer A, Gaßel M, Selzer P, Unden G, Krauth-Siegel RL. (2008)

Unconventional Mechanisms of Protein Transport to the Cell Surface of Eukaryotic Cells. Annu. Rev. Cell Dev. Biol. 24:287-308.

Walter Nickel and Matthias Seedorf (2008)

Unconventional Secretion of Fibroblast Growth Factor 2 and Galectin-1 Does Not Require Shedding of Plasma-Membrane-Derived Vesicles. FEBS Lett. 582:1362-1368.

Claudia Seelenmeyer, Carolin Stegmayer, and Walter Nickel (2008)

Yeast Ataxin-7 links histone deubiquitination with gene gating and mRNA export. Nat. Cell Biol. 10, 707-715.

Alwin Köhler, Maren Schneider, Ghislain Cabal, Ulf Nehrbass and Ed Hurt (2008)

Modelling yeast pre-rRNA processing. In the Proceedings of Computational Methods in Systems Biology (CMSB), 2007. To appear in LNBI, Springer.

Ciocchetta,F., Hillston,J., Koš,M. and Tollervey,D. (2007)

A role for the CREB-binding protein in behavioural regulation. BMC Neuroscience, Suppl. 1: P28.

Hung HC, Maurer C, Weber F. (2007)

Adjunct duties for karyopherins: Regulating septin sumoylation. Dev. Cell 12, 669-670.

Vikram Govind Panse and Ed Hurt (2007)

Antioxidative Enzyme des Malariaerregers als Drug Targets. BIOspektrum 13:138-141.

Becker K, Schirmer RH. (2007)

Arx1 functions as alternative nuclear export receptor for the 60S pre-ribosomal subunit. Mol. Cell 27, 767-779.

Bettina Bradatsch, Jun Katahira, Eva Kowalinski, Gert Bange, Wei Yao, Toshihiro Sekimoto, Viola Baumgärtel, Guido Boese, Jochen Bassler, Klemens Wild, Reiner Peters, Yoshihiro Yoneda, Irmi Sinning and Ed Hurt (2007)

Arx1 functions as an unorthodox nuclear export receptor for the 60S pre-ribosomal subunit, Molecular Cell 27:767-79.

Bradatsch B, Katahira J, Kowalinski E, Bange G, Yao W, Sekimoto T, Baumgärtel V, Boese G, Bassler J, Wild K, Peters R, Yoneda Y, Sinning I, Hurt E. (2007)

Attitudes towards colouration effects associated with methylene blue malaria treatment in rural Burkina Faso. Curare 30:27-34.

Sanon M, Mandi G, De Allegri M, Schirmer H, Meissner P, Müller O. (2007)

Axonal loss and neuroinflammation caused by peroxisome-deficient oligodendrocytes. Nat Genet. 39(8):969-76.

Kassmann CM, Lappe-Siefke C, Baes M, Brügger B, Mildner A, Werner HB, Natt O, Michaelis T, Prinz M, Frahm J, Nave KA. (2007)

Axonal loss and neuroinflammation caused by peroxisome-deficient oligodendrocytes. Nat Genet. 39(8):969-76.

Kassmann CM, Lappe-Siefke C, Baes M, Brügger B, Mildner A, Werner HB, Natt O, Michaelis T, Prinz M, Frahm J, Nave KA. (2007)

Betraying the Parasite's Redox System: Diaryl Sulfide-Based Inhibitors of Trypanothione Reductase: Subversive Substrates and Antitrypanosomal Properties. ChemMedChem. 2(12):1708-1712.

Stump B, Kaiser M, Brun R, Krauth-Siegel RL, Diederich F. (2007)

Buiding in resistance to cell death. Nat Genet Nov; 39(11):1308-1309.

Mazzone, M, Ruiz de Almodovar, C, Carmeliet, P. (2007)

Canonical Signal Recognition Particle Components Can Be Bypassed for Posttranslational Protein Targeting in Chloroplasts. Plant Cell 19:1635-48.

Tzvetkova-Chevolleau T, Hutin C, Noël LD, Goforth R, Carde JP, Caffarri S, Sinning I, Groves M, Teulon JM, Hoffman NE, Henry R, Havaux M, Nussaume L. (2007)

Catalytic mechanism of the glutathione peroxidase-type tryparedoxin peroxidase of Trypanosoma brucei. Biochem J. 405(3):445-54.

Schlecker T, Comini MA, Melchers J, Ruppert T, Krauth-Siegel RL. (2007)

Circadian transcription depends on limiting amounts of the transcription co-activator nejire/CBP. J Biol Chem. (282), 31349-31357.

Hung HC, Maurer C, Kay SA, Weber F. (2007)

Conformational changes of coat proteins during vesicle formation. FEBS Lett 581, 2083-2088.

Langer, JD, Stoops, EH, Béthune, J, and Wieland, FT* (2007)

Conformational changes of coat proteins during vesicle formation. FEBS Lett. 581: 2083-2088.

Langer JD, Stoops EH, Béthune J, Wieland FT. (2007)

Depletion of the thioredoxin homologue tryparedoxin impairs antioxidative defence in African trypanosomes. Biochem J. 402(1):43-9.

Comini MA, Krauth-Siegel RL, Flohé L. (2007)

Differential localization of coatomer complex isoforms within the Golgi apparatus. Proc Natl Acad Sci USA 104(11):4425-30.

Moelleken J, Malsam J, Betts MJ, Movafeghi A, Reckmann I, Meissner I, Hellwig A, Russell RB, Söllner T, Brügger B, Wieland FT. (2007)

Differential localization of coatomer complexes isoforms within the Golgi apparatus. Proc. Natl. Acad. Sci. USA 104: 4425-4430.

Moelleken J, Malsam J, Betts MJ, Movafeghi A, Reckmann I, Meissner I, Hellwig A, Russell RB, Söllner T, Brügger B, Wieland FT. (2007)

Differential localization of isoformic coatomer complexes within the Golgi apparatus. Proc. Natl. Acad. Sci. USA, 104: 4425-30.

Moelleken, J., Malsam, J., Betts, M.J., Movafeghi, A., Reckmann, I., Meissner, I., Hellwig, A., Russell, R.B., Söllner, T.H., Brügger, B., Wieland, F.T. (2007)

Dual roles of the transmembrane protein p23/TMP21 in the modulation of amyloid precursor protein metabolism. Mol. Neurodegener. 8, 2:4.

Vetrivel KS, Gong P, Bowen JW, Cheng H, Chen Y, Carter M, Nguyen PD, Placanica L, Wieland FT, Li YM, Kounnas MZ, Thinakaran G. (2007)

E. coli SRP-receptor FtsY contains an essential and autonomous membrane-binding amphipathic helix. J. Biol. Chem. 282:32176-184.

Parlitz R, Eitan A, Stjepanovic G, Bahari L, Bange G, Bibi E, Sinning I. (2007)

ER-phagy: selective autophagy of the endoplasmic reticulum. Autophagy. Commentary (abstract)

Bernales S*, Schuck S*, Walter P (2007)

Exporting RNA from the nucleus to the cytoplasm. Nature Rev. Mol. Cell Biol. 8, 761-773.

Alwin Köhler and Ed Hurt (2007)

Expression, purification and preliminary crystallographic characterization of FlhF from Bacillus subtilis, Acta Cryst F. 63: 449-451.

Bange G, Petzold G, Wild K, Sinning I. (2007)

Expression, purification, crystallization and preliminary crystallographic analysis of the proliferation associated protein Ebp1. Acta Cryst F 63: 768-770.

Kowalinski E, Bange G, Wild K, Sinning I. (2007)

Functional analysis of PDX2 from Arabidopsis, a glutaminase involved in vitamin B6 biosynthesis. Plant Physiol. 144:915-25.

Tambasco-Studart M, Tews I, Amrhein N, Fitzpatrick TB. (2007)

General concepts of angiogenesis and vasculogenesis. Book chapter for the book titled “Retinal vascular disease”. Edited by Joussen, Gardner Kirchhof & Ryan. Springer 38-65. (*These authors contributed equally)

Ruiz de Almodovar, C*, Ny, A* & Carmeliet, P. (2007)

Glutathionylation of trypanosomal thiol redox proteins. J Biol Chem. 282(12):8678-94.

Melchers J, Dirdjaja N, Ruppert T, Krauth-Siegel RL. (2007)

Guidance of Vascular and Neuronal Network Formation. Book chapter for the book titled “Tumor angiogenesis: Mechanisms and Cancer therapy”. Edited by Marmé, Fusenig and Norbert. Springer 2007: 47-65. (*These authors contributed equally)

Ruiz de Almodovar, C*, Zacchigna, S*, Autiero, M & Carmeliet, P. (2007)

Human chorionic gonadotropin (hCG) in the male reproductive tract.Mol. Cell. Endocrinol. 260-262:190-196.

Berger P, Gruschwitz M, Spoettl G, Dirnhofer S, Madersbacher S, Gerth R, Merz WE, Plas E, Sampson N. (2007)

Human immunodeficiency virus type 1 Nef protein modulates the lipid composition of virions and host cell membrane microdomains. Retrovirology 4:70.

Brügger B, Krautkrämer E, Tibroni N, Munte CE, Rauch S, Leibrecht I, Glass B, Breuer S, Geyer M, Kräusslich HG, Kalbitzer HR, Wieland FT, Fackler OT. (2007)

Human immunodeficiency virus type 1 Nef protein modulates the lipid composition of virions and host cell membrane microdomains. Retrovirology. 4:70

Brügger B, Krautkrämer E, Tibroni N, Munte CE, Rauch S, Leibrecht I, Glass B, Breuer S, Geyer M, Kräusslich HG, Kalbitzer HR, Wieland FT, Fackler OT. (2007)

Interactions of methylene blue with human disulfide reductases and their orthologues from Plasmodium falciparum. Antimicrob Agents Chemother Epub.

Buchholz K, Schirmer RH, Eubel JK, Akoachère MB, Dandekar T, Becker K, Gromer S. (2007)

Involvement of a Golgi-resident GPI-anchored Protein in Maintenance of the Golgi Structure. Mol. Biol. Cell 18:1261-1271.

Li X, Kaloyanova D, van Eijk M, Eerland R, van der Goot G, Oorschot V, Klumperman J, Lottspeich F, Starkuviene V, Wieland FT, Helms JB. (2007)

Kontrolle tropischer Infektionskrankheiten. Multidisziplinäre Forschungsprojekte in Burkina Faso. Flugmedizin, Tropenmedizin, Reisemedizin (FTR) 14: 31-32.

Müller O, Schirmer H. (2007)

Lipid droplets highjack SNAREs. Nat. Cell Biol., 9:1219-20.

Söllner, T.H. (2007)

Long and short isoforms of Neurospora clock protein FRQ support temperature-compensated circadian rhythms. FEBS Lett. 2007; PMC2704016. doi:10.1016/j.febslet.2007.11.043.

Diernfellner, A., Colot, H. V., Dintsis, O., Loros, J. J., Dunlap, J. C. and Brunner, M. (2007)

Malaria ist kein Tabu mehr. Focus Campus 20:52-55.

Rosskopf K, Schirmer H. (2007)

Membrane targeting of ribosomes and their release require distinct and separable functions of FtsY. J. Biol. Chem. 282:32168-175.

Bahari L, Parlitz R, Eitan A, Stjepanovic G, Bochkareva ES, Sinning I, Bibi E. (2007)

Membrane trafficking. FEBS Letters, 581: 2075.

Söllner, T.H. (2007)

Methylenblau in der Malariatherapie. Eine Alternative für Afrika? Flugmedizin, Tropenmedizin, Reisemedizin (FTR) 14: 33-35.

Müller O, Meissner P, Schirmer RH. (2007)

Molecular basis for the functional interaction of dynein light chain with the nuclear pore complex. Nature Cell Biology 9, Number 7, 788-796.

Philipp Stelter, Ruth Kunze, Dirk Flemming, Dominic Höpfner, Meikel Diepholz, Peter Philipsen, Bettina Böttcher and Ed Hurt (2007)

Molecular basis of glutathione reductase deficiency in human blood cells. Blood 109:3560-3566.

Kamerbeek NM, van Zwieten R, de Boer M, Morren G, Vuil H, Bannink N, Lincke C, Dolman KM, Becker K, Schirmer RH, Gromer S, Roos D. (2007)

Multiple and stepwise interactions between coatomer and ADP-ribosylation factor-1 (Arf1)-GTP. Traffic 8, 582-593.

Sun, Z, Anderl, F, Frohlich, K, Zhao, L, Hanke, S, Brugger, B, Wieland, F*, and Béthune, J* (2007)

Multiple and stepwise interactions between coatomer and ADP-ribosylation factor-1 (Arf1)-GTP. Traffic 8(5):582-93.

Sun Z, Anderl F, Fröhlich K, Zhao L, Hanke S, Brügger B, Wieland F, Béthune J. (2007)

Multiple and stepwise interactions between coatomer and ADP-ribosylation factor-1 (Arf1)-GTP. Traffic 8: 582-593.

Sun Z, Anderl F, Fröhlich K, Zhao L, Hanke S, Brügger B, Wieland F, Béthune J. (2007)

Non-assembled human chorionic gonadotropin subunits and αα-homodimers use fast-track processing in the secretory pathway in contrast to αβ-heterodimers. Endocrinology 148:5831-5841.

Merz WE, Krause JM, Roig J, Singh V, Berger P. (2007)

Nuclear export of ribosomal 60S subunits by the general mRNA export receptor Mex67-Mtr2. Mol. Cell 26, 51-62.

Wei Yao, Daniela Roser, Alwin Köhler, Bettina Bradatsch, Jochen Baßler and Ed Hurt (2007)

Posttranslational regulation of Neurospora circadian clock by CK1a-dependent phosphorylation. Cold Spring Harb Symp Quant Biol. 2007; doi:10.1101/sqb.2007.72.025.

Querfurth, C., Diernfellner, A., Heise, F., Lauinger, L., Neiss, A., Tataroglu, O., Brunner, M. and Schafmeier, T. (2007)

Protein translocation: Checkpoint role for SRP GTPase activation. Curr. Biol. 17:R980-R982.

Bange G, Wild K, Sinning I. (2007)

Proteomics characterization of mouse kidney peroxisomes by tandem mass spectrometry and protein correlation profiling. Mol Cell Proteomics 6(12):2045-57.

Wiese S, Gronemeyer T, Ofman R, Kunze M, Grou CP, Almeida JA, Eisenacher M, Stephan C, Hayen H, Schollenberger L, Korosec T, Waterham HR, Schliebs W, Erdmann R, Berger J, Meyer HE, Just W, Azevedo JE, Wanders RJ, Warscheid B. (2007)

Rab10 is involved in basolateral transport in polarized MDCK cells. Traffic. (abstract)

Schuck S*, Gerl MJ*, Ang AL, Manninen A, Keller P, Mellman I, Simons K (2007)

Rapid maturation of glycoprotein hormone free α-subunit (GPHα) and GPHαα homodimers.Mol. Endocrinol. 21(10):2551-2564.

Krause JM, Berger P, Roig J, Singh V, Merz WE. (2007)

Schistosome redox balance and thioredoxin glutathione reductase: An essential parasite enzyme and novel drug target. PLoS Med. 4(6):e206:1–16.

Kuntz, AN, Davioud-Charvet, E, Dessolin, J, Sayed, AA, Califf, LL, Arnér, ESJ, Williams DL. (2007)

SH4-domain-induced plasma membrane dynamization promotes bleb-associated cell motility. Journal of cell science, 120(Pt 21), 3820–3829.

Tournaviti, S., Hannemann, S., Terjung, S., Kitzing, T. M., Stegmayer, C., Ritzerfeld, J., Walther, P., Grosse, R., Nickel, W., & Fackler, O. T. (2007)

Structural and Thermodynamic Insights into the Assembly of the Heteromeric Pyridoxal Phosphate Synthase from Plasmodium falciparum. J Mol Biol. 374:732-48.

Flicker K, Neuwirth M, Strohmeier M, Kappes B, Tews I, Macheroux P. (2007)

The C. elegans RSA complex localizes protein phosphatase 2A to centrosomes and regulates mitotic spindle assembly. Cell 128:115-127.

Schlaitz AL, Srayko M, Dammermann A, Quintin S, Wielsch N, MacLeod I, de Robillard Q, Zinke A, Yates JR, 3rd, Muller-Reichert T, Shevchenko A, Oegema K, Hyman AA (2007)

The CORVET tethering complex interacts with the yeast Rab5 homolog Vps21 and is involved in endo-lysosomal biogenesis. Dev Cell. 12:739-50.

Peplowska K, Markgraf DF, Ostrowicz CW, Bange G, Ungermann C. (2007)

The crystal structure of Ebp1 reveals a methionine aminopeptidase fold as binding platform for multiple interactions. FEBS Letters 581: 4450-4454.

Kowalinski E, Bange G, Bradatsch B, Hurt E, Wild K, Sinning I. (2007)

The crystal structure of Ebp1 reveals how the methionine aminopeptidase fold serves as a binding platform for multiple interactions. FEBS Lett. 581, 4450-4454.

Eva Kowalinski, Gert Bange, Bettina Bradatsch, Ed Hurt, Klemens Wild and Irmi Sinning (2007)

The crystal structure of the third SRP GTPase FlhF reveals a homodimer with bound GTP. Proc. Natl. Acad.Sci. USA 104: 13621-13625.

Bange G, Petzold G, Wild K, Parlitz RO, Sinning I. (2007)

The structure of the chloroplast signal recognition particle (SRP) receptor reveals mechanistic details of SRP GTPase activation and a conserved membrane targeting site. FEBS Letters 581:5671-6.

Stengel KF, Holdermann I, Wild K, Sinning I. (2007)

The structure of the regulatory domain of the adenylyl cyclase Rv1264 from Mycobacterium tuberculosis with bound oleic acid. J Mol Biol. 369(5):1282-95.

Findeisen F, Linder JU, Schultz A, Schultz JE, Brügger B, Wieland F, Sinning I, Tews I. (2007)

The structure of the regulatory domain of the adenylyl cyclase Rv1264 from Mycobacterium tuberculosis with bound oleic acid. J. Mol. Biol. 369: 1282-1295.

Findeisen F, Linder JU, Schultz A, Schultz JE, Brügger B, Wieland F, Sinning I, Tews I. (2007)

The structure of the regulatory domain of the adenylyl cyclase Rv1264 from Mycobacterium tuberculosis with bound oleic acid. J. Mol. Biol. 369:1282-95.

Findeisen F, Linder JU, Schultz A, Schultz JE, Brügger B, Wieland F, Sinning I, Tews I. (2007)

The trypanothione system. Subcell Biochem. 44:231-51.

Krauth-Siegel LR, Comini MA, Schlecker T. (2007)

Thermodynamic characterization of the protein-protein interaction in the heteromeric Bacillus subtilis pyridoxalphosphate synthase. Biochemistry 46:5131-9.

Neuwirth M, Flicker K, Strohmeier M, Tews I, Macheroux P. (2007)

Time-dependent folding of immunological epitopes of the human chorionic gonadotropin β-subunit. Mol. Cell. Endocrinol. 260-262, 12-22.

Roig J, Krause JM, Berger P, Merz WE. (2007)

Two independent routes of de novo vitamin B6 biosynthesis: not that different after all. Biochem J. 407:1-13.

Fitzpatrick TB, Amrhein N, Kappes B, Macheroux P, Tews I, Raschle T. (2007)

Unconventional Protein Secretion: An Extracellular Trap For Nonclassical Export of Fibroblast Growth Factor 2. J. Cell Sci. 120:2295-2299.

Walter Nickel (2007)

Vascular and Neural development, intersecting parallelisms and crossroads. Book chapter for the book titled: Therapeutic Neovascularization-Quo Vadis?. Edited by Deindl and Kupatt. Springer 159-191.

Zacchigna, S, Ruiz de Almodovar, C, Lafuste, P & Carmeliet, P. (2007)

wa H, Priest C, Lechner J, Pereira G, Schiebel E. The yeast centrosome translates the positional information of the anaphase spindle into a cell cycle signal. J Cell Biol. 179(3):423-36.

Kemmler S, Stach M, Knapp M, Ortiz J, Pfannstiel J, Ruppert T, Lechner J. (2007)

Rapid ATP-dependent deadenylation of nanos mRNA in a cell-free system from Drosophila embryos. J. Biol. Chem. 281(35), 25124-25133.

Jeske, M., Meyer, S., Temme, C., Freudenreich, D., Wahle, E. (2006)

FLIPing heterokaryons to analyse nucleo-cytoplasmic shuttling of yeast proteins. RNA 12, 921-30.

Belaya,K., Tollervey,D., and Koš,M. (2006)

A fluoro analogue of the menadione derivative 6-[2'-(3'-methyl)-1',4'-naphthoquinolyl]hexanoic acid is a suicide substrate of glutathione reductase. Crystal structure of the alkylated human enzyme. J Am Chem Soc. 128(33):10784-94.

Bauer H, Fritz-Wolf K, Winzer A, Kühner S, Little S, Yardley V, Vezin H, Palfey B, Schirmer RH, Davioud-Charvet E. (2006)

A fluoro analogue of the menadione derivative 6-[2’-(3’-Methyl)-1’,4’-naphthoquinolyl]hexanoic acid is a suicide substrate of glutathione reductase. Crystal structure of the alkylated human enzyme. J. Am. Chem. Soc. 128:10784–94.

Bauer H, Fritz-Wolf K, Winzer A, Kühner S, Little S, Yardley V, Vezin H, Palfey B, Schirmer H, Davioud-Charvet E. (2006)

A new mouse model to study acquired lymphedema. PLoS Med, Jul; 3(7):e264.

Schenider, M, Ny, A, Ruiz de Almodovar, C & Carmeliet P. (2006)

A round of phosphorylation/de-phosphorylation triggers maturation of the pre-ribosomal 40S subunit. Nature 441, 651-655.

Thorsten Schäfer, Bohumil Maco, Elisabeth Petfalski, David Tollervey, Bettina Boettcher, Ueli Aebi and Ed Hurt (2006)

An SDF-1 trap for myeloid cells stimulates angiogenesis. Cell 124, 18-21.

Ruiz de Almodovar, C, Luttun, A & Carmeliet, P. (2006)

Cell surface heparan sulfate proteoglycans are essential components of the unconventional export machinery of FGF-2. Proc. Natl. Acad Sci. U.S.A. 103:15479-15484.

Christoph Zehe, André Engling, Sabine Wegehingel, Tobias Schäfer, and Walter Nickel (2006)

Coatomer, the coat protein of COPI transport vesicles, discriminates endoplasmic reticulum residents from p24 proteins. Mol Cell Biol 26, 8011-8021.

Béthune, J*, Kol, M, Hoffmann, J, Reckmann, I, Brugger, B, and Wieland, F* (2006)

Coatomer, the coat protein of COPI transport vesicles, discriminates endoplasmic reticulum residents from p24 proteins. Mol Cell Biol. 26(21):8011-21.

Béthune J, Kol M, Hoffmann J, Reckmann I, Brügger B, Wieland F. (2006)

Coatomer, the coat protein of COPI transport vesicles, discriminates endoplasmic reticulum residents from p24 proteins. Mol. Cell. Biol. 26:8011-8021.

J. Béthune, M. Kol, J. Hoffmann, I. Reckmann, B. Brügger, F. Wieland (2006)

Controversy fuels trafficking of GPI-anchored proteins. Journal of Cell Biology. Commentary (abstract)

Schuck S, Simons K (2006)

Coordinated nuclear import of RNA polymerase III subunits. Traffic 7, 465-473.

Ulrike Hardeland and Ed Hurt (2006)

COPI-mediated transport. J Membr Biol 211, 65-79.

Béthune, J*, Wieland, F, and Moelleken, J (2006)

COPI-mediated transport. J. Membr. Biol. 211:65-79.

J. Béthune, F. Wieland, J. Moelleken (2006)

Detergent-resistant membranes and the use of cholesterol depletion. In Cell Biology: A Laboratory Handbook, Volume 2. J. E. Celis, editor. Elsevier Science, USA. Book chapter (full text)

Schuck, S., Honsho, M., & Simons, K. (2006)

Eosin B as a novel antimalarial agent for drug-resistant Plasmodium falciparum. Antimicrob Agents Chemother. 50(9):3132-41.

Massimine KM, McIntosh MT, Doan LT, Atreya CE, Gromer S, Sirawaraporn W, Elliott DA, Joiner KA, Schirmer RH, Anderson KS. (2006)

Fatty acid regulation of adenylyl cyclase Rv2212 from Mycobacterium tuberculosis H37Rv. FEBS J. 273(18):4219-28.

Motaal A, Tews I, Schultz JE, Linder JU. (2006)

Following the signal sequence from ribosomal tunnel exit to signal recognition particle. Nature. 444(7118):507-11.

Halic M, Blau M, Becker T, Mielke T, Pool MR, Wild K, Sinning I, Beckmann R. (2006)

Formation and nuclear export of pre-ribosomes are functionally linked to the small-ubiquitin-related (SUMO) modifier pathway. Traffic 7, 1311-1321.

Vikram Govind Panse, Dieter Kressler, Andrea Pauli, Elisabeth Petfalski, Marén Gnädig, David Tollervey and Ed Hurt (2006)

Getting in touch with Candida albicans: the cell wall of a fungal pathogen. Curr Drug Targets. 7(4):505-512.

Sohn K, Schwenk J, Urban C, Lechner J, Schweikert M, Rupp S. (2006)

How temperature affects the circadian clock of Neurospora crassa. Chronobiol Int. 2006; doi:10.1080/07420520500545805.

Brunner, M. and Diernfellner, A. (2006)

Methylene blue for malaria in Africa: results from a dose-finding study in combination with chloroquine. Malar J. 5:84.

Meissner PE, Mandi G, Coulibaly B, Witte S, Tapsoba T, Mansmann U, Rengelshausen J, Schiek W, Jahn A, Walter-Sack I, Mikus G, Burhenne J, Riedel KD, Schirmer RH, Kouyaté B, Müller O. (2006)

Molecular Analysis of SAGA Mediated Gene Gating In Yeast. Nature 441, 770-773.

Ghislain Cabal, Susana Rodrigez-Navarro, August Genevesio, Jean-Christophe Olivo-Marin, Christophe Zimmer, Olivier Gadal, Frank Feuerbach-Fournier, Annick Lesne, Henri Buc, Ed Hurt* and Ulf Nehrbass* (*corresponding authors) (2006)

Molecular anatomy of a trafficking organelle. Cell 127(4):831-46.

Takamori S, Holt M, Stenius K, Lemke EA, Grønborg M, Riedel D, Urlaub H, Schenck S, Brügger B, Ringler P, Müller SA, Rammner B, Gräter F, Hub JS, De Groot BL, Mieskes G, Moriyama Y, Klingauf J, Grubmüller H, Heuser J, Wieland F, Jahn R. (2006)

Molecular Anatomy of a Trafficking Organelle. Cell 127:831-846.

S. Takamori, M. Holt, K. Stenius, E.A. Lemke, M. Grønborg, D. Riedel, H. Urlaub, S. Schenck, B. Brügger, P. Ringler, S.A. Müller, B. Rammner, F. Gräter, J.S. Hub, B.L. De Groot, G. Mieskes, Y. Moriyama, J. Klingauf, H. Grubmüller, J. Heuser, F. Wieland, and R. Jahn (2006)

Non-angiogenic functions of VEGF. Book chapter for the book titled “Angiogenesis: From Basic Science to Clinical Aspects”. Edited by N. Ferrara. CRC Taylor & Francis 133-155.

Haigh, JJ, Ruiz de Almodovar, C, Schneider, M & Carmeliet, P. (2006)

Novel antitrypanosomal agents based on palladium nitrofurylthiosemicarbazone complexes: DNA and redox metabolism as potential therapeutic targets. J Med Chem. 49(11):3322-31.

Otero L, Vieites M, Boiani L, Denicola A, Rigol C, Opazo L, Olea-Azar C, Maya JD, Morello A, Krauth-Siegel RL, Piro OE, Castellano E, González M, Gambino D, Cerecetto H. (2006)

Peroxisome biogenesis: where Arf and coatomer might be involved. Biochim Biophys Acta. 1763(12):1678-87.

Lay D, Gorgas K, Just WW. (2006)

Phosphoinositide synthesis and degradation in isolated rat liver peroxisomes. FEBS Lett. 580(25):5917-24.

Jeynov B, Lay D, Schmidt F, Tahirovic S, Just WW. (2006)

Phosphorylation-dependent maturation of Neurospora circadian clock protein from a nuclear repressor toward a cytoplasmic activator. Genes Dev. 2006; PMC1361701. doi:10.1101/gad.360906.

Schafmeier, T., Káldi, K., Diernfellner, A., Mohr, C. and Brunner, M. (2006)

responding author

Béthune, J*, Wieland, F, and Moelleken, J (2006)

Second messenger and Ras/MAPK signalling pathways regulate CLOCK/CYCLE-dependent transcription. J Neurochem. (98), 248-257.

Weber F, Hung HC, Maurer C, Kay SA. (2006)

Selective regulation of arterial branching morphogenesis by synectin. Dev Cell, Jun;10(6):783-95.

Chittenden, TW, Claes, F, Lanahan, AA, Autiero, M, Palac, RT, Tkachenko, EV, Elfenbein, A, Ruiz de Almodovar, C, Dedkov, E, Tomanek, R, Li, W, Westmore, M, Singh, J, Horowitz, A, Mulligan-Kehoe, MJ, Moodie, KL, Zhuang, ZW, Carmeliet, P & Simons, M. (2006)

Selenium metabolism in Trypanosoma: characterization of selenoproteomes and identification of a Kinetoplastida-specific selenoprotein. Nucleic Acids Res. 34(14):4012-24.

Lobanov AV, Gromer S, Salinas G, Gladyshev VN. (2006)

Signal recognition particle receptor exposes the ribosomal translocon binding site. Science. 312(5774):745-7.

Halic M, Gartmann M, Schlenker O, Mielke T, Pool MR, Sinning I, Beckmann R. (2006)

Specific inhibitors of Plasmodium falciparum thioredoxin reductase as potential antimalarial agents. Bioorg. Med. Chem. Lett. 16:2283–92.

Andricopulo AD, Akoachere MB, Krogh R, Nickel C, McLeish MJ, Kenyon GL, Arscott LD, Williams Jr, H, Davioud-Charvet E, Becker K. (2006)

Structure of a bacterial pyridoxal 5'-phosphate synthase complex. Proc Natl Acad Sci U S A. 103(51):19284-9.

Strohmeier M, Raschle T, Mazurkiewicz J, Rippe K, Sinning I, Fitzpatrick TB, Tews I. (2006)

TEDS site phosphorylation of the yeast myosins I is required for ligand-induced but not for constitutive endocytosis of the G protein-coupled receptor Ste2p. J Biol Chem. 281(16):11104-14.

Grosshans BL, Grötsch H, Mukhopadhyay D, Fernández IM, Pfannstiel J, Idrissi FZ, Lechner J, Riezman H, Geli MI. (2006)

The ether lipid-deficient mouse: tracking down plasmalogen functions. Biochim Biophys Acta. 1763(12):1511-26.

Gorgas K, Teigler A, Komljenovic D, Just WW. (2006)

The HIV lipidome: a raft with an unusual composition. Proc Natl Acad Sci USA 103(8):2641-6.

Brügger B, Glass B, Haberkant P, Leibrecht I, Wieland FT, Kräusslich HG. (2006)

The HIV lipidome: A raft with an unusual composition. Proc. Natl. Acad. Sci. USA 103:2641-2646. (10.452)

B. Brügger, B. Glass, P. Haberkant, I. Leibrecht, F.T. Wieland and H.-G. Kräusslich. (2006)

The molecular chaperone Hsp90 delivers precursor proteins to the chloroplast import receptor Toc64. EMBO J. 25(9):1836-47.

Qbadou S, Becker T, Mirus O, Tews I, Soll J, Schleiff E. (2006)

The mRNA Export Factor Sus1 Is Involved in SAGA-mediated H2B Deubiquitinylation through Its Interaction with Ubp8 and Sgf11. Mol. Biol. Cell. 17, 4228-4236.

Alwin Köhler, Pau Pascual-García, Ana Llopis, Meritxell Zapater, Francesc Posas, Ed Hurt and Susana Rodríguez-Navarro (2006)

The Nug1 GTPase reveals an N-terminal RNA binding domain that is essential for association with pre-60S subunits. J. Biol. Chem. 281, 24737-24744.

Jochen Baßler, Martina Kallas and Ed Hurt (2006)

The Plasmodium selenoproteome. Nucleic Acids Res. 34(2):496-505.

Lobanov AV, Delgado C, Rahlfs S, Novoselov SV, Kryukov GV, Gromer S, Hatfield DL, Becker K, Gladyshev VN. (2006)

The structure of the mammalian signal recognition particle (SRP) receptor as prototype for the interaction of small GTPases with Longin domains. J Biol Chem. 281(13):8898-906.

Schlenker O, Hendricks A, Sinning I, Wild K. (2006)

TOR regulates late steps of ribosome maturation in the nucleoplasm via Nog1 in response to nutrients. EMBO J. 25, 3832-3842.

Yoshimi Honma, Aiko Kitamura, Ryo Shioda, Hironori Maruyama, Kanako Ozaki, Yoko Oda, Thierry Mini, Paul Jen, Yasushi Maki, Kazuhito Yonezawa, Ed Hurt, Masaru Ueno, Masahiro Uritani, Michael N. Hall, and Takashi Ushimaru (2006)

Transcriptional regulation of the Neurospora circadian clock gene wc-1 affects the phase of circadian output. EMBO Rep. 2006; PMC1369249. doi:10.1038/sj.embor.7400595.

Káldi, K., González, B. H. and Brunner, M. (2006)

Undressing of phosphine gold(I) complexes as irreversible inhibitors of human disulfide reductases. Angew. Chem. Int. Ed. Engl. 45:1881–86.

Urig S., Fritz-Wolf K., Réau R., Herold-Mende C., Tóth K., Davioud-Charvet E., Becker K. (2006)

Vitamin B6 biosynthesis by the malaria parasite Plasmodium falciparum: Biochemical and structural insights. J Biol Chem. 281(6):3633-41.

Gengenbacher M, Fitzpatrick TB, Raschle T, Flicker K, Sinning I, Müller S, Macheroux P, Tews I, Kappes B. (2006)

(1)H, (13)C, and (15)N Sequence-specific Resonance Assignment and Secondary Structure of Plasmodium falciparum Thioredoxin. J Biomol NMR. 32(4):340.

Munte CE, Becker K, Schirmer RH, Kalbitzer HR. (2005)

The Putative RNA Helicase Dbp4p Is Required for Release of the U14 snoRNA from Preribosomes in Saccharomyces cerevisiae. Mol. Cell 20, 53-64.

Koš,M. and Tollervey,D. (2005)

ATP-independent control of Vac8 palmitoylation by a SNARE sub-complex on yeast vacuoles. J. Biol. Chem. 280, 15348-15355.

Dietrich, L.E.P., LaGrassa, T.J., Rohde, J., Cristodero, M., Meiringer, C., and Ungermann, C. (2005)

Binding and functions of ADP-ribosylation factor on mammalian and yeast peroxisomes. J Biol Chem. 280(41):34489-99.

Lay D, Grosshans BL, Heid H, Gorgas K, Just WW. (2005)

Cell Surface Counter Receptors are Essential Components of the Unconventional Export Machinery of Galectin-1. J. Cell Biol. 172:373-381.

Claudia Seelenmeyer, Sabine Wegehingel, Ivo Tews, Markus Künzler, Markus Aebi, and Walter Nickel (2005)

Characterization of the glyoxalases of the malarial parasite Plasmodium falciparum and comparison with their human counterparts. Biol Chem. 386(1):41-52.

Akoachere M, Iozef R, Rahlfs S, Deponte M, Mannervik B, Creighton DJ, Schirmer H, Becker K. (2005)

Comparative structural analysis of oxidized and reduced thioredoxin from Drosophila melanogaster. J Mol Biol. 345(5):1119-30.

Wahl MC, Irmler A, Hecker B, Schirmer RH, Becker K. (2005)

Diagnosis of red cell G6PD deficiency in rural Burkina Faso. Comparison of a rapid fluorescent enzyme test on filter paper with polymerase chain reaction based genotyping. Br J Haematol. 131: 395-9.

Meissner PE, Coulibaly B, Mandi G, Mansmann U, Witte S, Schiek W, Müller O, Schirmer RH, Mockenhaupt FP, Bienzle U. (2005)

Die große Schande. Frank Rund Plus. 272: 23.

Schirmer RH. (2005)

Direct Transport Across the Plasma Membrane of Mammalian Cells of Leishmania HASPB as Revealed by a CHO Export Mutant. J. Cell Sci. 118:517-527.

Carolin Stegmayer, Angelika Kehlenbach, Stella Tournaviti, Sabine Wegehingel, Christoph Zehe, Paul W. Denny, Deborah F. Smith, Blanche Schwappach, and Walter Nickel (2005)

Dithiol proteins as guardians of the intracellular redox milieu in parasites: old and new drug targets in trypanosomes and malaria-causing plasmodia. Angew Chem Int Ed. 44(5):690-715.

Krauth-Siegel RL, Bauer H, Schirmer RH. (2005)

Dithiolproteine als Hüter des intrazellulären Redoxmilieus bei Parasiten: alte und neue Wirkstoff-Targets bei Trypanosomiasis und Malaria. Angew Chem. 117:698-724.

Krauth-Siegel RL, Bauer H, Schirmer RH. (2005)

Dynamic transport of SNARE proteins in the Golgi apparatus. Proc Natl Acad Sci U S A, 102:14647-52.

Cosson, P., Ravazzola, M., Varlamov, O., Söllner, T.H., Di Liberto, M., Volchuk, A., Rothman J.E., Orci, L. (2005)

Effects of antioxidants on glutathione levels and clinical recovery from the malnutrition syndrome kwashiorkor - a pilot study. Redox Rep. 10(4):215-26.

Becker K, Pons-Kühnemann J, Fechner A, Funk M, Gromer S, Gross HJ, Grünert A, Schirmer RH. (2005)

Expanding dynamin: from fission to fusion. Nat. Cell Biol. 7, 103-104.

Peplowska, K., and Ungermann, C. (2005)

Functional link between ribosome formation and biogenesis of iron-sulfur proteins. EMBO J. 24, 580-588.

Alexander Yarunin, Vikram Panse, Elisabeth Petfalski, Christophe Dez, David Tollervey and Ed Hurt (2005)

Functions of SNAREs in intracellular membrane fusion and lipid bilayer mixing. J. Cell Sci. 118, 3819-3828.

Ungermann, C., and Langosch, D. (2005)

High cholesterol level is essential for myelin membrane growth. Nat Neurosci. 8(4):468-75.

Saher G, Brügger B, Lappe-Siefke C, Möbius W, Tozawa R, Wehr MC, Wieland F, Ishibashi S, Nave KA. (2005)

Human selenoproteins at a glance. Cell Mol Life Sci. 62: 2414-37.

Gromer S, Eubel JK, Lee BL, Jacob J. (2005)

In Vitro Assessment of Methylene Blue on Chloroquine-Sensitive and -Resistant Plasmodium falciparum Strains Reveals Synergistic Action with Artemisinins. Antimicrob Agents Chemother. 49(11):4592-7.

Akoachere M, Buchholz K, Fischer E, Burhenne J, Haefeli WE, Schirmer RH, Becker K. (2005)

Inhibitors of Trypanosoma cruzi trypanothione reductase revealed by virtual screening and parallel synthesis. J Med Chem. 48(15):4793-802.

Meiering S, Inhoff O, Mies J, Vincek A, Garcia G, Kramer B, Dormeyer M, Krauth-Siegel RL. (2005)

Irreversible inactivation of trypanothione reductase by unsaturated mannich bases: a divinyl ketone as key intermediate. J Med Chem. 48(23):7400-10.

Lee B, Bauer H, Melchers J, Ruppert T, Rattray L, Yardley V, Davioud-Charvet E, Krauth-Siegel RL. (2005)

Large thioredoxin reductases – A fairy tail story. Flavins and Flavoproteins 2005 (Nishino T, Miura R, Tanokura M, Fukui K Ed) ArchiTect Inc Tokyo. 295-306.

Gromer S, Jacob J, Schirmer RH. (2005)

Mass Spectrometric analysis of human glutathione reductase modified by a gold-phosphole inhibitor. Flavins and Flavoproteins 2005 (Nishino T, Miura R, Tanokura M, Fukui K Ed.) ArchiTect Inc Tokyo. 325–30.

Koncarevic S, Deponte M, Fritz-Wolf K, Meyer M, Urig S, Fischer M, Réau R, Davioud-Charvet E, Becker K. (2005)

Mechanistic studies of a novel, highly potent gold-phosphole inhibitor of human glutathione reductase. J. Biol. Chem. 280, 20628–37.

Deponte M, Urig S, Arscott LD, Fritz-Wolf K, Réau R, Herold-Mende C, Koncarevic S, Meyer M, Davioud-Charvet E, Ballou DP, Williams CH, Becker K. (2005)

Molecular mechanism of temperature sensing by the circadian clock of Neurospora crassa. Genes Dev. 2005; PMC1199567. doi:10.1101/gad.345905.

Diernfellner, A. C., Schafmeier, T., Merrow, M. W. and Brunner, M. (2005)

Reconstitution of Nup157 and Nup145N into the Nup84 complex. J. Biol. Chem. 280, 18442-18451.

Malik Lutzmann, Ruth Kunze, Karin Stangl, Philipp Stelter, Katalin Fejes Tóth, Bettina Boettcher and Ed Hurt (2005)

Recruitment of the human TREX complex to mRNA during splicing Genes and Develop.19, 1512-1517.

Seiji Masuda, Rita Das, Ed Hurt, Nijsje Dorman and Robin Reed (2005)

Role of dihydroxyacetonephosphate acyltransferase in the biosynthesis of plasmalogens and nonether glycerolipids. J Lipid Res. 46(4):727-35.

Liu D, Nagan N, Just WW, Rodemer C, Thai TP, Zoeller RA. (2005)

Safety of the combination of chloroquine and methylene blue in healthy adult men with G6PD deficiency from rural Burkina Faso. Trop Med Int Health. 10(1):32-8.

Mandi G, Witte S, Meissner P, Coulibaly B, Mansmann U, Rengelshausen J, Schiek W, Jahn A, Sanon M, Wüst K, Walter-Sack I, Mikus G, Burhenne J, Riedel KD, Schirmer H, Kouyate B, Müller O. (2005)

Safety of the methylene blue plus chloroquine combination in the treatment of uncomplicated falciparum malaria in young children of Burkina Faso [ISRCTN27290841]. Malar J. 4:45.

Meissner PE, Mandi G, Witte S, Coulibaly B, Mansmann U, Rengelshausen J, Schiek W, Jahn A, Sanon M, Tapsoba T, Walter-Sack I, Mikus G, Burhenne J, Riedel KD, Schirmer H, Kouyate B, Muller O. (2005)

Specific Inhibitors of Plasmodium falciparum thioredoxin reductase. Flavins and Flavoproteins 2005 (Nishino T, Miura R, Tanokura M, Fukui K Ed.) ArchiTect Inc Tokyo. 883–88.

Andricopulo, A. D., Akoachere, M. B., Krogh, R., Nickel, C., McLeish, M. J., Davioud-Charvet, E., Kenyon, G. L., Arscott, L. D., Williams, Jr., C. H., Becker, K. (2005)

Substrate specificity, localization, and essential role of the glutathione peroxidase-type tryparedoxin peroxidases in Trypanosoma brucei. J Biol Chem. 280(15):14385-94.

Schlecker T, Schmidt A, Dirdjaja N, Voncken F, Clayton C, Krauth-Siegel RL. (2005)

Synthesis of 5-nitro-2-furancarbohydrazides and their cis-diamminedichloroplatinum complexes as bitopic and irreversible human thioredoxin reductase inhibitors. J Med Chem. 48(22):7024-39.

Millet, R., Urig, S., Jacob, J., Amtmann, E., Moulinoux, J. P., Gromer, S., Becker, K., & Davioud-Charvet, E. (2005)

The conserved histidine 106 of large thioredoxin reductases is likely to have a structural role but not a base catalyst function. FEBS Lett. 579(3):745-8.

Jacob J, Schirmer RH, Gromer S. (2005)

The crystal structure of Plasmodium falciparum glutamate dehydrogenase, a putative target for novel antimalarial drugs. J Mol Biol. 349(3):597-607.

Werner C, Stubbs MT, Krauth-Siegel RL, Klebe G. (2005)

The DHHC protein Pfa3 affects vacuole-associated palmitoylation of the fusion factor Vac8. PNAS 102, 17366-17371.

Hou, H., Subramanian, K., LaGrassa, T.J., Markgraf, D., Dietrich, L.E.P., Decker, N., and Ungermann, C. (2005)

The SNARE Ykt6 gets released from yeast vacuoles during an early stage of fusion. EMBO Rep. 6, 245-250.

Dietrich, L.E.P., Peplowska, K., LaGrassa, T.J., Hou, H., Rohde, J., and Ungermann, C. (2005)

The structure of a pH sensing mycobacterial adenylyl cyclase holoenzyme, Science 308: 1020-1023.

Tews, I., Findeisen, F., Sinning, I., Schultz A., Schultz, J.E. & Linder, J.U. (2005)

The tRNA aminoacylation co-factor Arc1p is excluded from the nucleus by an Xpo1p-dependent mechanism. FEBS Lett. 579, 969-975.

Kyriaki Galani, Eduard C. Hurt and George Simos (2005)

The vacuolar kinase Yck3 maintains organelle fragmentation by regulating the HOPS tethering complex. J. Cell Biol. 168, 401-14.

LaGrassa, T.J., and Ungermann, C. (2005)

Transcriptional feedback of Neurospora circadian clock gene by phosphorylation-dependent inactivation of its transcription factor. Cell. 2005; doi:10.1016/j.cell.2005.05.032.

Schafmeier, T., Haase, A., Káldi, K., Scholz, J., Fuchs, M. and Brunner, M. (2005)

Trypanothione reductase and other flavoenzymes as targets of antiparasitic drugs. Flavins and Flavoproteins 2005 (Nishino T, Miura R, Tanokura M, Fukui K Ed.) ArchiTect Inc Tokyo. 867–76.

Krauth-Siegel RL, Davioud-Charvet E. (2005)

Unconventional Secretory Routes: Direct Protein Export Across the Plasma Membrane of Mammalian Cells. Traffic 6:607-614.

Walter Nickel (2005)

YANA - a software tool for analyzing flux modes, gene-expression and enzyme activities. BMC Bioinformatics. 6(1):135.

Schwarz R, Musch P, von Kamp A, Engels B, Schirmer H, Schuster S, Dandekar T. (2005)

5-substituted tetrazoles as bioisosteres of carboxylic acids. Bioisosterism and mechanistic studies on glutathione reductase inhibitors as antimalarials. J Med Chem. 47(24):5972-83.

Biot C, Bauer H, Schirmer RH, Davioud-Charvet E. (2004)

A nascent pre-ribosome with a tadpole-like structure functions in ATP-dependent maturation of 60S subunits. Mol. Cell 15, 295-301.

Tracy A. Nissan, Kyriaki Galani, Bohumil Maco, David Tollervey, Ueli Aebi and Ed Hurt (2004)

A proteome-wide approach identifies sumolyated substrate proteins in yeast. J. Biol. Chem., in press.

Vikram Govind Panse, Ulrike Hardeland, Thilo Werner, Bernhard Kuster and Ed Hurt (2004)

A structural step into the SRP cycle, Mol. Microbiol. 53: 357-63.

Wild, K., Rosendal, K. & Sinning, I. (2004)

Acyl-CoA binding protein, Acb1p, is required for normal vacuole function and ceramide synthesis in Saccharomyces cerevisiae. Biochem. J. 380, 907-18.

Faergeman, N.J., Feddersen, S., Christiansen, J.K., Larsen, M.K., Schneiter, R., Ungermann, C., Mutenda, K., Roepstorff, P., and Knudsen, J. (2004)

Adenylate kinase and GTP:AMP phosphotransferase of the malarial parasite Plasmodium falciparum. Central players in cellular energy metabolism. Mol Biochem Parasitol. 136(2):211-20.

Ulschmid JK, Rahlfs S, Schirmer RH, Becker K. (2004)

Biochemistry-based health care research. Methylene blue, malaria, methemoglobin, and malnutrition. Health Research in Developing Countries (Becher H, Kouyaté B eds). Springer Verlag, Berlin-Heidelberg. 285-297.

Coulibaly B, Eubel J, Gromer S, Schirmer RH. (2004)

Cotranscriptional recruitment of the serine-arginine-rich (SR)-like proteins Gbp2 and Hrb1 to nascent mRNA via the TREX complex. PNAS Vol. 101, no. 7, 1858-1862.

Ed Hurt, Ming-juan Luo, Susanne Röther, Robin Reed and Katja Sträßer (2004)

Co-translational protein targeting: SRP meets the ribosome, Nat. Struct. Mol. Biol. 11: 1049-53.

Wild, K., Halic, M., Sinning, I. & Beckmann, R. (2004)

Crystallization and preliminary X-ray diffraction studies of the crenarchaeal SRP core, Acta Cryst. D60: 140-143.

Rosendal, K.R., Sinning, I. & Wild, K. (2004)

Crystallization of a Golgi-associated PR-1 related protein (GAPR-1) that localizes to lipid-enriched microdomains, Acta Cryst. D60: 730–732.

Groves, M.R., Kuhn, A., Hendricks, A., Radke, S., Serrano, R.L., Helms, J.B & Sinning, I. (2004)

Crystallographic identification of Ca2+ and Sr2+ coordination sites in synaptotagmin I C2B domain. Protein Science, 13: 2665-2672.

Cheng, Y. Sequeira, S.M., Malinina, L., Tereshko, V., Söllner, T.H., and Patel, D.J. (2004)

Die Entdeckung der Nukleinsäure-Bausteine: ein Beitrag zum 150. Geburtstag Albrecht Kossels, Nobelpreisträger für Physiologie oder Medizin 1910. Klinische Chemie Mitteilungen. 35(3/4):46-54.

Steiner M, Schmidt H, Lindahl S, Kossel AH, Schuff-Werner P, Schirmer H. (2004)

Discriminatory aptamer reveals serum response element transcription regulated by cytohesin-2. Proc. Natl. Acad. Sci. U.S.A. 101:11221-11226.

M. G. Theis, A. Knorre, B. Kellersch, J. Moelleken, F. T. Wieland, W. Kolanus, and M. Famulok. (2004)

Dissection of septin actin interactions using actin overexpression in Saccharomyces cerevisiae. Mol Microbiol. 53(2): 469-83.

Norden C, Liakopoulos D, Barral Y. (2004)

Generation of single and double knockdowns in polarized epithelial cells by retrovirus-mediated RNA interference. Proceedings of the National Academy of Sciences USA. (abstract)

Schuck S*, Manninen A*, Honsho M, Füllekrug J, Simons K (2004)

Glyoxalase II of African trypanosomes is trypanothione-dependent. J Biol Chem. 279(21):22209-17.

Irsch T, Krauth-Siegel RL. (2004)

Hormone replacement therapy and the risk of developing breast cancer. MMW Fortschr Med. 146(9):26-8, 30.

Merz WE. (2004)

Identification and biophysical characterization of a very-long-chain-fatty-acid-substituted phosphatidylinositol in yeast subcellular membranes. Biochem. J. 381:941-949.

R. Schneiter, B. Brügger, C. M. Amann, G. D. Prestwich, R. F. Epand, G. Zellnig, F. T. Wieland, and R. M. Epand. (2004)

Interferon-gamma and TRAIL in human breast tumor cells, Vitam Horm, 67, 291-318.

Ruiz de Almodovar, C, Lopez-Rivas, A & Ruiz-Ruiz, C. (2004)

Intracellular and viral membrane fusion: a uniting mechanism. Curr. Opinion Cell Biol, 16: 429-435.

Söllner, T.H. (2004)

i-SNAREs, inhibitory SNAREs that fine-tune the specificity of membrane fusion. J. Cell Biol., 164: 79-88.

Varlamov, O., Volchuk, A., Rahimian, V., Doege, C.A. Paumet, F., Eng, W.S, Arango, N.C., Parlati, F., Ravazzola, M., Orci, L, Söllner, T.H., and Rothman, J.E. (2004)

Localization and activity of the SNARE Ykt6 determined by its regulatory domain and palmitoylation. Proc. Natl. Acad. Sci. USA, 101: 4815-1820.

Fukasawa, M., Varlamov, O., Eng, W.S., Söllner, T.H., and Rothman, J.E. (2004)

Longins and their longin domains: regulated SNAREs and multifunctional SNARE regulators. Trends Biochem. Sci. 29, 682-8.

Rossi, V., Banfield, D.K., Vacca, M., Dietrich, L.E.P, Ungermann, C., D'Esposito, M., Galli, T., and Filippini, F. (2004)

Mechanismen der COPI-Vesikelbiogenese. Biospektrum I, 30-33 (Review).

B. Brügger and F. T. Wieland (2004)

Medikamente für die Armen - Die Biomedizin des 21. Jahrhunderts darf nicht nur für die Minderheit der Wohlhabenden forschen. Spektrum der Wissenschaft. 110-113.

Schirmer H. (2004)

Novel isotypic g/z-subunits reveal three coatomer complexes in mammals. Mol. Cell. Biol. 3, 1070-1080. Supplemental Materials [PDF]

D. Wegmann, P. Hess, C. Baier, F. T. Wieland and C. Reinhard (2004)

On the mechanism of protein palmitoylation. EMBO Rep. 5, 1053-57.

Dietrich, L.E.P., and Ungermann, C. (2004)

Pharmacogenomic strategies against resistance development in microbial infections. Pharmacogenomics. 5(4):361-79.

Ziebuhr W, Xiao K, Coulibaly B, Schwarz R, Dandekar T. (2004)

Polarized sorting in epithelial cells: raft clustering and the biogenesis of the apical membrane. Journal of Cell Science. Review (abstract)

Schuck S, Simons K (2004)

Rea1, a dynein-related nuclear AAA-type ATPase, is involved in late 25S rRNA processing and nuclear export of 60S subunits. J. Biol. Chem. 279, 55411-55418.

Kyriaki Galani, Tracy A. Nissan, Elisabeth Petfalski, David Tollervey and Ed Hurt (2004)

Signal recognition particle mediates posttranslational targeting in eukaryotes, EMBO J. 23:2755-64.

Abell. B., Pool., M., Schlenker, O., Sinning, I. & High, S. (2004)

SRP-mediated protein targeting: structure and function revisited, BBA Mol. Cell Res. 1694: 17-35.

Luirink, J. & Sinning, I. (2004)

Structural analysis of the human Golgi-associated plant pathogenesis related protein GAPR-1 implicates dimerization as a regulatory mechanism, J. Mol. Biol. 339: 173-83.

Serrano, R.L., Kuhn, A., Hendricks, A., Helms, J.B., Sinning, I. & Groves, M.R. (2004)

Structural biology. Surprising news from the PCC. Science 303: 320-2.

Dobberstein, B. & Sinning. I. (2004)

Sus1, a functional component of the SAGA histone acetylase complex and the nuclear pore-associated mRNA export machinery. Cell. 116(1):75-86.

Rodriguez-Navarro S, Fischer T, Luo MJ, Antunez O, Brettschneider S, Lechner J, Perez-Ortin JE, Reed R, Hurt E. (2004)

The fission yeast kinetochore component Spc7 associates with the EB1 family member Mal3 and is required for kinetochore-spindle association. Mol Biol Cell. 15(12):5255-67.

Kerres A, Vietmeier-Decker C, Ortiz J, Karig I, Beuter C, Hegemann J, Lechner J, Fleig U. (2004)

The membrane domains occupied by glycosylphosphatidylinositol-anchored prion protein and Thy-1 differ in lipid composition. J Biol Chem. 279(9):7530-6.

Brügger B, Graham C, Leibrecht I, Mombelli E, Jen A, Wieland F, Morris R. (2004)

The SNARE Ykt6 mediates protein palmitoylation during an early stage of vacuole fusion. EMBO J. 23, 45-53.

Dietrich, L.E.P., Gurezka, R., Veit, M., and Ungermann, C. (2004)

The thioredoxin system - from science to clinic. Med Res Rev. 24(1):40-89.

Gromer S, Urig S, Becker K. (2004)

The up-regulation of human caspase-8 by interferon-gamma in breast tumor cells requires the induction and action of the transcription factor interferon regulatory factor-1, J Biol Chem, 279, 19712-20.

Ruiz-Ruiz, C, Ruiz de Almodovar, C, Rodriguez, A, Ortiz-Ferron, G, Redondo, J. M. & Lopez-Rivas, A. (2004)

The Yeast Kinase Swe1 is Required for proper Entry into a new Cell Cycle after Arrest due to Ribosome Biogenesis Defects. Cell Cycle 3, 648-54.

Francesca Saracino, Jochen Baßler, Diego Muzzini, Ed Hurt and Maria Luisa Agostoni Carbone (2004)

Transcriptional complexes engaged by apo-estrogen receptor-alpha isoforms have divergent outcomes. EMBO J. 23, 3653-3666.

Metivier,R., Penot,G., Carmouche,R.P., Hubner,M.R., Reid,G., Denger,S., Manu,D., Brand,H., Koš,M., Benes,V. and others (2004)

Transcriptional regulation of the TRAIL-R3 gene, Vitam Horm, 67, 51-63.

Ruiz de Almodovar, C, Lopez-Rivas, A, Redondo, J. M. & Rodriguez, A. (2004)

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) decoy receptor TRAIL-R3 is up-regulated by p53 in breast tumor cells through a mechanism involving an intronic p53-binding site, J Biol Chem, 279, 4093-101.

Ruiz de Almodovar, C, Ruiz-Ruiz, C, Rodriguez, A, Ortiz-Ferron, G, Redondo, J. M. & Lopez-Rivas, A. (2004)

Unconventional Protein Secretion: Membrane Translocation of FGF-2 Does Not Require Protein Unfolding. J. Cell Sci. 117:1727-1736.

Rafael Backhaus, Christoph Zehe, Sabine Wegehingel, Angelika Kehlenbach, Blanche Schwappach, and Walter Nickel (2004)

Unconventional secretion of fibroblast growth factor 2 is mediated by direct translocation across the plasma membrane of mammalian cells. J Biol Chem. 279(8):6244-51.

Schäfer T, Zentgraf H, Zehe C, Brügger B, Bernhagen J, Nickel W. (2004)

Yeast centrin Cdc31 is linked to the nuclear mRNA export machinery. Nat. Cell Biol. 6, 840—848.

Tamás Fischer, Susana Rodriguez-Navarro, Elmar Schiebel and Ed Hurt (2004)

Estrogen receptor-alpha directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter. Cell 115, 751-763.

Metivier,R., Penot,G., Hubner,M.R., Reid,G., Brand,H., Koš,M., and Gannon,F. (2003)

A Noc complex specifically involved in the formation and nuclear export of ribosomal 40 S subunits. The Journal of Biological Chemistry, Vol. 278, No. 6, pp. 4072-4081.

Milkereit, P., Strauss, D., Bassler, J., Gadal, O., Kühn, H., Schütz, S., Gas, N., Lechner, J., Hurt, E., & Tschochner, H. (2003)

A PERIOD-inhibitor buffer introduces a delay mechanism for CLK/CYC-activated transcription. FEBS Lett. (555), 341-345.

F. Weber and S.A. Ka (2003)

A putative glutathione peroxidase of Drosophila encodes a thioredoxin peroxidase that provides resistance against oxidative stress but fails to complement a lack of catalase activity. Biol Chem. 384:463-472.

Missirlis F, Rahlfs S, Dimopoulos N, Bauer H, Becker K, Hilliker A, Phillips JP, Jäckle H. (2003)

A SNARE required for retrograde transport to the endoplasmic reticulum. Proc. Natl. Acad. Sci. USA, 100: 9873-9877.

Burri, L., Varlamov, O., Doege, C., Hofman, K., Beilharz, T., Rothman, J.E., Söllner, T.H., and Lithgow, T. (2003)

Active sites of thioredoxin reductases: Why selenoproteins? Proc Natl Acad Sci U S A. 100(22):12618-12623

Gromer S, Johannson L, Bauer H, Arscott LD, Rauch S, Ballou D, Williams CH Jr, Schirmer RH, Arnér ESJ. (2003)

Biochemical characterization of the vacuolar palmitoyl acyltransferase. FEBS letters, 540, 101-105.

Veit, M., Dietrich, L.E.P., and Ungermann, C. (2003)

Choline head groups stabilize the matrix loop regions of the ATP/ADP carrier ScAAC2. Biochem. Biophys. Res. Com. 300: 65-74.

Panneels, V., Schüssler, U., Costagliola, S. & Sinning, I. (2003)

Control of eukaryotic membrane fusion by N-terminal domains of SNARE proteins. BBA reviews 1643, 111-119.

Dietrich, L.E.P., Boeddinghaus, C., LaGrassa, T.J., and Ungermann, C. (2003)

Crystal structure of the complete core of archaeal signal recognition particle and implications for inter-domain communication, Proc. Natl. Acad. Sci. USA 100: 14701-14706.

Rosendal, K.R., Wild, K., Montoya, G. & Sinning, I. (2003)

Definition of Domain Boundaries and Crystallization of the SMN Tudor Domain. Acta Cryst. D59: 366-368.

Sprangers, R., Selenko, P., Sattler, M., Sinning, I. & Groves, M.R. (2003)

Double-drug development against antioxidant enzymes from Plasmodium falciparum. Redox Report 8:280–83.

Biot C, Dessolin J, Grellier P, Davioud-Charvet E. (2003)

Formation and nuclear export of tRNA, rRNA and mRNA is regulated by the ubiquitin ligase Rsp5p. EMBO Rep. 4(12):1156-62.

Neumann S, Petfalski E, Brügger B, Grosshans H, Wieland F, Tollervey D, Hurt E. (2003)

Functional and physicochemical characterization of the thioredoxin system in Trypanosoma brucei. J Biol Chem. 278(47): 46329-36.

Schmidt H, Krauth-Siegel RL. (2003)

Functional reconstitution of COPI coat assembly and disassembly using chemically defined components. Proc. Natl. Acad Sci. U.S.A. 100:8253-8257.

Constanze Reinhard, Michael Schweikert, Felix T. Wieland, and Walter Nickel (2003)

Fusion of cells by flipped SNAREs. Science, 300: 1745-1749.

Hu, C., Ahmed, M., Melia, T.J., Söllner, T.H., Mayer, T., and Rothman, J.E. (2003)

Gene conversion in transposition of Escherichia coli element IS30. J Mol Biol 334, 967-978.

Olasz, F., Fischer, T., Szabo, M., Nagy, Z., and Kiss, J. (2003)

Glutamate binding affinity of Drosophila metabotropic glutamate receptor is modulated by association with lipid rafts. Proc. Natl. Acad. Sci. USA 100: 10219-10224.

Eroglu, C., Brügger, B., Wieland, F. & Sinning, I. (2003)

Glutathione reductase of the malarial parasite Plasmodium falciparum: crystal structure and inhibitor development. J Mol Biol. 328(4):893-907.

Sarma GN, Savvides SN, Becker K, Schirmer M, Schirmer RH, Karplus PA. (2003)

Glutathione-functions and metabolism in the malarial parasite Plasmodium falciparum. Biol Chem. 384(4):551-66.

Becker K, Rahlfs S, Nickel C, Schirmer RH. (2003)

Glyoxalase I of the malarial parasite Plasmodium falciparum. Evidence for subunit fusion. FEBS Lett. 554:284-288.

Iozef R, Rahlfs R, Chang T, Schirmer RH, Becker K. (2003)

High-resolution X-Ray and NMR structures of the SMN Tudor Domain: conformational variation in the binding site for symmetrically dimethylated arginines, J. Mol.Biol. 327: 507-520.

Sprangers, R., Groves, M.R., Sinning, I. & Sattler, M. (2003)

Identification and characterization of a novel RanGTP binding protein Yrb30. J. Biol. Chem. 278, 15397-15405.

Andreas Braunwarth, Michel Fromont-Racine, Pierre Legrain, Ralf Bischoff, Thomas Gerstberger, Ed Hurt and Markus Künzler (2003)

Inactivation of ether lipid biosynthesis causes male infertility, defects in eye development and optic nerve hypoplasia in mice. Hum Mol Genet. 12(15):1881-95.

Rodemer C, Thai TP, Brügger B, Kaercher T, Werner H, Nave KA, Wieland F, Gorgas K, Just WW. (2003)

Inhibition of glucose metabolism sensitizes tumor cells to death receptor-triggered apoptosis through enhancement of death-inducing signaling complex formation and apical procaspase-8 processing, J Biol Chem, 278, 12759-68.

Munoz-Pinedo, C, Ruiz-Ruiz, C, Ruiz de Almodovar, C, Palacios, C & Lopez-Rivas, A. (2003)

Intra-Golgi protein transport depends on a cholesterol balance in the lipid membrane. J Biol Chem. 278(52):53112-22.

Stüven E, Porat A, Shimron F, Fass E, Kaloyanova D, Brügger B, Wieland FT, Elazar Z, Helms JB. (2003)

Mechanism-based inactivation of thioredoxin reductase from Plasmodium falciparum by Mannich bases. Implications for cytotoxicity. Biochemistry 42(45):13319-13330.

Davioud-Charvet E, McLeish MJ, Veine DM, Giegel D, Arscott LD, Andricopulo AD, Becker K, Müller S, Schirmer RH, Williams CH Jr, Kenyon GL. (2003)

Methylene blue as an antimalarial agent. Redox Report 8(5):272-275.

Schirmer RH, Coulibaly B, Stich A, Scheiwein M, Merkle H, Eubel J, Becker K, Becher H, Müller O, Zich T, Schiek W, Kouyaté B. (2003)

Moral und Verteilungsethik des medizinischen Fortschritts. Ethisierung – Ethikferne. Wie viel Ethik braucht die Wissenschaft? (Becker K, Engelen EM, Vec M, Eds) Akademie Verlag Berlin :119-131.

Schirmer H. (2003)

Nsl1p is essential for the establishment of bipolarity and the localization of the Dam-Duo complex. The EMBO journal, 22(24), 6584–6597.

Scharfenberger M, Ortiz J, Grau N, Janke C, Schiebel E, Lechner J. (2003)

Parasite-specific trypanothione reductase as a drug target molecule. Parasitol Res. 90 Suppl 2: 77-85.

Krauth-Siegel RL, Inhoff O. (2003)

Pharmacological characterization and immunoaffinity purification of metabotropic glutamate receptor from Drosophila melanogaster overexpressed in SF9 cells, Prot. Exp. Pur. 30: 275-282.

Panneels, V., Eroglu, C., Cronet, P. & Sinning, I. (2003)

Phenothiazine radicals inactivate Trypanosoma cruzi dihydrolipoamide dehydrogenase: enzyme protection by radical scavengers. Free Radic Res. 37(3):281-91.

Gutierrez-Correa J, Krauth-Siegel RL, Stoppani AO. (2003)

Plasmodium falciparum thioredoxins and glutaredoxins as central players in redox metabolism. Redox Report 8(5):246-50.

Rahlfs S, Nickel Ch, Deponte M, Schirmer RH, Becker K. (2003)

Plasmoredoxin, a novel redox-active protein unique for malarial parasites. Eur J Biochem. 270(6):1057-64.

Becker K, Kanzok SM, Iozef R, Fischer M, Schirmer RH, Rahlfs S. (2003)

Pre-Ribosomes on the Road from the Nucleolus to the Cytoplasm. Trends Cell Biol. 13, 255-263.

Herbert Tschochner and Ed Hurt (2003)

Reconstituted TOM core complex and Tim9/Tim10 complex of mitochondria are sufficient for translocation of the ADP/ATP carrier across membranes, Mol. Biol. Cell 15: 1445-58.

Vasiljev, A., Ahting, U., Nargang, F.E., Go, N.E., Habib, S.J., Kozany, C., Panneels, V., Sinning, I., Prokisch, H., Neupert, W., Nussberger, S. & Rapaport, D. (2003)

Regulated exocytosis and SNARE function. Mol. Memb. Biol., 20: 209-220.

Söllner T.H. (2003)

Regulated secretion of macrophage migration inhibitory factor is mediated by a nonclassical pathway involving an ABC transporter. FEBS Lett. 551:78-86.

Oliver Flieger, André Engling, Richard Bucala, Hongqi Lue, Walter Nickel, and Jürgen Bernhagen (2003)

Resistance of cell membranes to different detergents. Proceedings of the National Academy of Sciences USA. (abstract)

Schuck S*, Honsho M*, Ekroos K, Shevchenko A, Simons K (2003)

Screening of P. falciparum iron superoxide dismutase inhibitors and accuracy of the SOD-assays. Bioorg. Med. Chem. 11:4941–44.

Soulère L, Delplace P, Davioud-Charvet E, Py S, Sergheraert C, Hoffmann P, Périé J, Ricard I, Dive D. (2003)

S-nitrosylation of NSF controls membrane trafficking. Cell, 115: 127-129.

Söllner, T.H., and Sequeira, S. (2003)

Spindle asymmetry: a compass for the cell. Trends Cell Biol. 13: 562-569.

Kusch, J., Liakopoulos, D. and Barral, Y. (2003)

Structure of thioredoxin from Trypanosoma brucei brucei. FEBS Lett. 554:301-305.

Friemann R, Schmidt H, Ramaswamy S, Forstner M, Krauth-Siegel RL, Eklund H. (2003)

Targeted Disruption Of Ether Lipid Synthesis In Mice. In: Roels F., Baes M., De Bie S. (eds) Peroxisomal Disorders and Regulation of Genes. Advances in Experimental Medicine and Biology, vol 544. Springer, Boston, MA.

Rodemer C, Thai TP, Brügger B, Gorgas K, Just W. (2003)

The cancer antigen CA125 represents a novel counter receptor for galectin-1. J Cell Sci. 116(Pt 7):1305-18.

Seelenmeyer C, Wegehingel S, Lechner J, Nickel W. (2003)

The kinase MSK1 is required for induction of c-fos by lysophosphatidic acid in mouse embryonic stem cells. BMC Molecular Biology (abstract)

Schuck S, Soloaga A, Schratt G, Arthur JS, Nordheim A (2003)

The mechanism of high Mr thioredoxin reductase from Drosophila melanogaster. J Biol Chem. 278(35):33020-8.

Bauer H, Massey V, Arscott LD, Schirmer RH, Ballou DP, Williams CH Jr. (2003)

The Mystery of Non-classical Protein Secretion: A Current View on Cargo Proteins and Potential Export Routes. Eur. J. Biochem. 270:2109-2119.

Walter Nickel (2003)

The parasite-specific trypanothione metabolism of trypanosoma and leishmania. Biol Chem. 384(4):539-49.

Krauth-Siegel RL, Meiering SK, Schmidt H. (2003)

The path from nucleolar 90S to cytoplasmic 40S pre-ribosomes. EMBO J. 22, 1370-1380.

Thorsten Schäfer, Daniela Strauß, Elisabeth Petfalski, David Tollervey and Ed Hurt (2003)

The thioredoxin system - from science to clinic. Med Res Rev. 24:40-89.

Gromer S, Urig S, Becker K. (2003)

The transmembrane domain of Vam3 affects the composition of cis- and trans- SNARE complexes to promote homotypic vacuole fusion. JBC 157, 79-89.

Rohde, J., Dietrich, L.S.P., Langosch, D., and Ungermann, C. (2003)

The tyrosine kinase Pyk2 regulates Arf1 activity by phosphorylation and inhibition of the Arf-GTPase-activating protein ASAP1. J Biol Chem. 278(32):29560-70.

A. Kruljac-Letunic, J. Moelleken, A. Kallin, F. T. Wieland, A. Blaukat (2003)

Thiol-based redox metabolism of protozoan parasites. Trends Parasitol. 19(7):320-8.

Müller S, Liebau E, Walter RD, Krauth-Siegel RL. (2003)

Thioredoxin reductase from the malaria mosquito Anopheles gambiae. Eur J Biochem. 270(21):4272-4281.

Bauer H, Gromer S, Urbani A, Schnölzer M, Schirmer RH, Müller HM. (2003)

Unconventional tethering of Ulp1 to the transport channel of the nuclear pore complex by karyopherins. Nature Cell Biology, Vol. 5, 21-27.

Panse V., Küster B., Gerstberger Th., Hurt E. (2003)

X-ray structure of glutathione S-transferase from the malarial parasite Plasmodium falciparum. Proc Natl Acad Sci U S A. 100(24):13821-6.

Fritz-Wolf K, Becker A, Rahlfs S, Harwaldt P, Schirmer RH, Kabsch W, Becker K. (2003)

A dynamic structural model for estrogen receptor-alpha activation by ligands, emphasizing the role of interactions between distant A and E domains. Mol. Cell 10, 1019-1032.

Metivier,R., Stark,A., Flouriot,G., Hubner,M.R., Brand,H., Penot,G., Manu,D., Denger,S., Reid,G., Koš,M. and others (2002)

A Novel Promoter Is Involved in the Expression of Estrogen Receptor alpha in Human Testis and Epididymis. Endocrinology 143, 3397-3404.

Brand,H., Koš,M., Denger,S., Flouriot,G., Gromoll,J., Gannon,F., and Reid,G. (2002)

Down but not out? A novel protein isoform of the estrogen receptor alpha is expressed in the estrogen receptor alpha knockout mouse. J. Mol. Endocrinol. 29, 281-286.

Koš,M., Denger,S., Reid,G., Korach,K.S., and Gannon,F. (2002)

Human estrogen receptor-alpha: regulation by synthesis, modification and degradation. Cell Mol. Life Sci. 59, 821-831.

Reid,G., Denger,S., Koš,M., and Gannon,F. (2002)

Upstream open reading frames regulate the translation of the multiple mRNA variants of the estrogen receptor alpha. J. Biol. Chem. 277, 37131-37138.

Koš,M., Denger,S., Reid,G., and Gannon,F. (2002)

60S pre-ribosome formation viewed from assembly in the nucleolus until export to the cytoplasm. EMBO J. 2002 Oct 15; 21(20):5539-47.

Nissan T., Bassler J., Petfalski E., Tollervey D., Hurt E. (2002)

90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factors. Mol Cell. 2002 Jul; 10(1):105-15.

Grandi P., Rybin V., Bassler J., Petfalski E., Strauss D., Marzioch M., Schaefer T., Kuster B., Tschochner H., Tollervey D., Gavin AC., Hurt E. (2002)

A conserved mRNA export machinery coupled to pre-mRNA splicing. Cell 108, 523-531.

Robin Reed and Ed Hurt (2002)

A cycle of Vam7p release from and PtdIns-3-P-dependent rebinding to the yeast vacuole is required for homotypic vacuole fusion. J. Cell Biol. 157, 79-90.

Boeddinghaus, C., Merz, A.J., Laage, R., and Ungermann, C. (2002)

A novel mechanism for inhibition of HIV-1 reverse transcriptase. Bioorg. Chem. 30:443–58.

Skillman AG, Maurer KW, Roe DC, Stauber MJ, Eargle D, Ewing TJ, Muscate A, Davioud-Charvet E, Medaglia MV, Fisher RJ, Arnold E, Gao HQ, Buckheit R, Boyer PL, Hughes SH, Kuntz ID, Kenyon GL. (2002)

Activation of tubular epithelial cells in diabetic nephropathy. Diabetes. 51(12):3532-44.

Morcos M, Sayed AA, Bierhaus A, Yard B, Waldherr R, Merz W, Kloeting I, Schleicher E, Mentz S, Abd el Baki RF, Tritschler H, Kasper M, Schwenger V, Hamann A, Dugi KA, Schmidt AM, Stern D, Ziegler R, Haering HU, Andrassy M, van der Woude F, Nawroth PP. (2002)

An intron in the YRA1 gene is required to control Yra1p protein expression and mRNA export. EMBO Rep. 3, 438-442.

Susana Rodríguez-Navarro, Katja Sträßer and Ed Hurt (2002)

Antitrypanosomal activities and cytotoxicity of 5-nitro-2-furancarbohydrazides. Bioorg. Med. Chem. Lett. 12, 3601–3604.

Millet, R., Maes, L., Landry, V., Sergheraert, C., Davioud-Charvet, E. (2002)

Asymmetric loading of Kar9 onto spindle poles and microtubules ensures proper spindle alignment. Cell. 2002, 112: 561-574.

Liakopoulos, D., Kusch, J. and Barral, Y. (2002)

Biosynthetic FGF-2 is Targeted to Non-Lipid Raft Microdomains Following Translocation to the Extracellular Surface of CHO cells. J. Cell Sci. 115:3619-3631.

André Engling, Rafael Backhaus, Carolin Stegmayer, Christoph Zehe, Claudia Seelenmeyer, Angelika Kehlenbach, Blanche Schwappach, Sabine Wegehingel, and Walter Nickel (2002)

BiP is feed-back regulated by control of protein translation efficiency. J Cell Sci. 115(Pt 11):2443-52.

Gülow K, Bienert D, Haas IG. (2002)

Calcium-independent stimulation of membrane fusion and SNAREpin formation by synaptotagmin I. The Journal of cell biology, 158(2), 273–282.

Mahal, L. K., Sequeira, S. M., Gureasko, J. M., & Söllner, T. H. (2002)

Catalytic properties, thiol pK value, and redox potential of Trypanosoma brucei tryparedoxin. J. Biol. Chem. 277, 17548-17555.

Reckenfelderbäumer, N., Krauth-Siegel, RL. (2002)

CD40, an extracellular receptor for binding and uptake of Hsp70-peptide complexes. J Cell Biol. 158(7):1277-85.

T. Becker, F. U. Hartl, F. T. Wieland (2002)

Chapter 6: Protein/Protein Interactions, in “Peptide arrays on membrane supports: Synthesis and applications” (J. Koch and M. Mahler, eds.) Springer Verlag Heidelberg, Germany, pp.83-96.

Groves, M., & Sinning, I. (2002)

Comparison of the inhibition of human and Trypanosoma cruzi prolyl endopeptidases. Bioorg. Med. Chem. 10:1719–29.

Vendeville S, Goossens F, Debreu-Fontaine MA, Landry V, Davioud-Charvet E, Grellier P, Scharpe S, Sergheraert C. (2002)

Complex Formation between Tap and p15 Affects Binding to FG-repeat Nucleoporins and Nucleocytoplasmic Shuttling. J. Biol. Chem., 11, No. 11, March, 9242-9246.

Jun Katahira, Katja Straesser, Takuya Saiwaki, Yoshihiro Yoneda, and Ed Hurt (2002)

Coupling of a competitive and an irreversible ligand generates mixed type inhibitors of Trypanosoma cruzi trypanothione reductase. J. Med. Chem. 45, 4524-4530.

Inhoff, O., Richards, J. M., Briet, J. W., Lowe, G., Krauth-Siegel, RL. (2002)

Crystal structure of the antioxidant enzyme glutathione reductase inactivated by peroxynitrite. J Biol Chem 277, 2779-2784

Savvides SN, Scheiwein M, Böhme CC, Arteel GE, Karplus PA, Becker K and Schirmer RH (2002)

Death on the beach: a rosy forecast for the 21st century, Cell Death Differ, 9, 1026-9. (*These authors contributed equally)

Munoz-Pinedo, C*, Ruiz de Almodovar, C* & Ruiz-Ruiz, C*. (2002)

Der parasitäre Trypanothion-Stoffwechsel-einzigartig und lebensnotwendig. BIOforum. 7-8:478-480.

Schmidt H., Schmidt A., Krauth-Siegel RL. (2002)

Distinct modes of Signal Recognition Particle interaction with the Ribosome, Science 297: 1345-8

Pool, M.R., Stumm, J., Fulga, T.A., Sinning, I. & Dobberstein, B. (2002)

Distinct SNARE complexes mediating membrane fusion in Golgi transport based on combinatorial specificity. Proc. Natl. Acad. Sci. USA, 99: 5424-5429.

Parlati, F., Varlamov, O., Paz, K., McNew, J.A., Hurtado, D., Söllner, T.H., and Rothman, J.E. (2002)

Disulfide reductases – current developments. Flavins and Flavoproteins 2002 (Chapman, S.K., Perham, R.N., Scrutton N.S., Eds.) Agency for Scientific Publications Berlin. 803–15.

Irmler A, Bechthold A, Davioud-Charvet E, Hofmann V, Réau R, Gromer S, Schirmer RH, Becker K. (2002)

Enzymes of the trypanothione metabolism as targets for antitrypanosomal drug development. Current Topics Med. Chem. 2, 1239-1259.

Schmidt, A., Krauth-Siegel, R. L. (2002)

Four new subunits of the Dam1-Duo1 complex reveal novel functions in sister kinetochore biorientation. EMBO J. 21(1-2):181-93.

Janke C, Ortíz J, Tanaka TU, Lechner J, Schiebel E. (2002)

Functional reconstitution of purified mGluR overexpressed in the eye of transgenic Drosophila melanogaster, EMBO Rep. 3: 491-496.

Eroglu, C., Cronet, P., Panneels, V., Beaufils, P. & Sinning, I. (2002)

Glutathione Reductase. In: Wiley Encyclopedia of Molecular Medicine (Creighton TE ed) pp 1471-1475 John Wiley & Sons, New York

Schirmer RH, Bauer H & Becker K (2002)

Growth inhibition of bloodstream forms of Trypanosoma brucei by the iron chelator deferoxamine. Int J Parasitol. 32(4):473-9.

Breidbach T, Scory S, Krauth-Siegel RL, Steverding D. (2002)

Hsp90 enables Ctf13p/Skp1p to nucleate the budding yeast kinetochore. Biochemistry 99(13):8585-90.

Stemmann O, Neidig A, Köcher T, Wilm M, Lechner J. (2002)

Human placenta thioredoxin reductase: Preparation and inhibitor studies. Meth Enzymol. 347:382-394

Gromer S, Merkle H, Schirmer RH, Becker K. (2002)

Mechanism of high Mr thioredoxin reductase from Drosophila melanogaster. Flavins and Flavoproteins July:131-136

Bauer H, Williams CH Jr, Schirmer RH, Massey V. (2002)

Methylseleninate is a substrate rather than an inhibitor of mammalian thioredoxin reductase. Implications for the antitumour effects of selenium. J Biol Chem 277, 9701-9706

Gromer S & Gross J (2002)

Mitochondrial protein import: molecular basis of the ATP-dependent interaction of MtHsp70 with Tim44. J Biol Chem. 2002; doi:10.1074/jbc.M107935200.

Moro, F., Okamoto, K., Donzeau, M., Neupert, W. and Brunner, M. (2002)

Modular Self-Assembly of a Y-Shaped Multiprotein Complex from Seven Nucleoporins. EMBO J., 21, No. 3, 387-397.

Malik Lutzmann, Ruth Kunze, Andrea Buerer, Ueli Aebi and Ed Hurt (2002)

Nuclear export of tRNA. Results Probl. Cell Differ. 35, 115-31.

Simos G, Grosshans H, Hurt E. (2002)

Oligomeric state and stoichiometry of p24 proteins in the early secretory pathway. J Biol Chem. 277(48):46504-11.

Jenne N, Frey K, Brügger B, Wieland FT. (2002)

Overexpression of the putative thiol conjugate transporter TbMRPA causes melarsoprol resistance in Trypanosoma brucei. Mol Microbiol. 43(5):1129-38.

Shahi SK, Krauth-Siegel RL, Clayton CE. (2002)

Regulation of membrane fusion by the membrane-proximal coil of the t SNARE during zippering of SNAREpins. J. Cell Biol, 158: 929-940.

Melia, T.J., Weber, T., McNew, J.A., Fisher, L.E., Johnston, R.J., Parlati, F., Mahal, L.K. Söllner, T.H., and Rothman, J.E. (2002)

Rlp7p is associated with 60S pre-ribosomes, restricted to the granular component of the nucleolus and required for pre-rRNA processing. J. Cell Biol. in press.

Olivier Gadal, Daniela Strauß, Elisabeth Petfalski, Pierre-Emmanuel Gleizes, Nicole Gas, David Tollervey, and Ed Hurt (2002)

Silencing of the thioredoxin gene in Trypanosoma brucei brucei. Mol. Biochem. Parasitol. 125:207-210

Schmidt A, Clayton C, Krauth-Siegel RL. (2002)

Structural plasticity and non-covalent substrate binding in the GroEL apical domain: A study using electrospray ionisation mass spectrometry and fluorescence binding studies. J Biol Chem. (277), 33115-33126.

A.E. Ashcroft, A. Brinker, J.E. Coyle, F. Weber, M. Kaiser, L. Moroder, M.R. Parsons,J. Jager, U.F. Hartl, M. Hayer-Hartl, S.E. Radford (2002)

Structure of the C-terminal FG-Nucleoporin binding domain of Tap/NXF1. Nat. Struct. Biol. 9, 247-251. (reprints not available)

Richard Grant , Ed Hurt, David Neuhaus and Murray Stewart (2002)

The crystal structure of lipoamide dehydrogenase from Trypanosoma cruzi: A target for the design of new drugs against Chagas’ disease. Flavins and Flavoproteins :917-922

Werner C, Stubbs MT, Klebe G, Krauth-Siegel RL. (2002)

The mRNA export machinery requires the novel Sac3p-Thp1p complex to dock at the nucleoplasmic entrance of the nuclear pores. Embo J. 21(21): 5843-5852.

Fischer, T., Sträßer, K., Rácz, A., Rodriguez-Navarro, S., Oppizzi, M., Ihrig, P., Lechner, J., & Hurt, E. (2002)

The protein import motor of mitochondria: a targeted molecular ratchet driving unfolding and translocation. Embo j. 2002; PMC126104. doi:10.1093/emboj/cdf358.

Okamoto, K., Brinker, A., Paschen, S. A., Moarefi, I., Hayer-Hartl, M., Neupert, W. and Brunner, M. (2002)

The Sur7p family defines novel cortical domains in Saccharomyces cerevisiae, affects sphingolipid metabolism, and is involved in sporulation. Mol Cell Biol. 22(3):927-34.

Young ME, Karpova TS, Brügger B, Moschenross DM, Wang GK, Schneiter R, Wieland FT, Cooper JA. (2002)

The thioredoxin system of Plasmodium falciparum and other parasites. Cell. Mol. Life Sci. 59:1024-1041

Rahlfs S, Schirmer RH & Becker K. (2002)

Thioredoxin, thioredoxin reductase, and thioredoxin peroxidase of the malaria parasite Plasmodium falciparum. Meth Enzymol 347, 371-381

Kanzok SM, Rahlfs S, Becker K & Schirmer RH (2002)

Thioredoxin-2 but not thioredoxin-1 is a substrate of thioredoxin peroxidase-1 from Drosophila melanogaster. J Biol Chem. 277(20):17457-17463

Bauer H, Kanzok SM, Schirmer RH. (2002)

Towards the structure of the mammalian signal recognition particle. Curr. Opin. Struct. Biol.12: 72–81.

Wild, K., Weichenrieder, O., Strub, K., Sinning, I. & Cusack, S. (2002)

Transcription initiation sites and promoter structure of the human TRAIL-R3 gene, FEBS Lett, 531, 304-8.

Ruiz de Almodovar, C, Lopez-Rivas, A, Redondo, J. M. & Rodriguez, A. (2002)

TREX is a conserved complex coupling transcription with mRNA export. Nature 417, 304-308.

Katja Sträßer, Seiji Masuda, Paul Mason, Jens Pfannstiel, Marisa Oppizzi, Susana Rodriguez-Navarro, Ana G. Rondón, Andres Aguilera, Kevin Struhl, Robin Reed and Ed Hurt (2002)

Trypanothione and tryparedoxin in ribonucleotide reduction. Methods Enzymol. 347:259-66.

Krauth-Siegel RL, Schmidt H. (2002)

Vesicular transport: the core machinery of COPI recruitment and budding. J Cell Sci. 115(Pt 16):3235-40. Review.

Nickel W, Brügger B, Wieland FT. (2002)

ERalpha gene expression in human primary osteoblasts: evidence for the expression of two receptor proteins. Mol. Endocrinol. 15, 2064-2077.

Denger,S., Reid,G., Koš,M., Flouriot,G., Parsch,D., Brand,H., Korach,K.S., Sonntag-Buck,V., and Gannon,F. (2001)

Minireview: genomic organization of the human ERalpha gene promoter region. Mol. Endocrinol. 15, 2057-2063.

Koš,M., Reid,G., Denger,S., and Gannon,F. (2001)

Tissue-specific expression of human ERalpha and ERbeta in the male. Mol. Cell Endocrinol. 178, 155-160.

Denger,S., Reid,G., Brand,H., Koš,M., and Gannon,F. (2001)

2- and 3-substituted-1,4-naphthoquinone derivatives as subversive substrates of trypanothione reductase and lipoamide dehydrogenase from Trypanosoma cruzi: synthesis and correlation between redox-cycling activities and in vitro cytotoxicity. J. Med. Chem. 44:548–65.

Salmon-Chemin L, Buisine E, Yardley V, Kohler S, Debreu MA, Landry V, Sergheraert C, Croft SL, Krauth-Siegel LR, Davioud-Charvet E. (2001)

A nuclear AAA-type ATPase (Rix7p) is required for large ribosomal subunit biogenesis and subsequent export to the cytoplasm. EMBO J., 20, 3695-3704.

Olivier Gadal, Daniela Strauß, Joris Braspenning, Dominic Hoepfner, Elisabeth Petfalski, Peter Philippsen, David Tollervey and Ed Hurt (2001)

A PEST-like element in FREQUENCY determines the length of the circadian period in Neurospora crassa. Embo j. 2001; PMC125781. doi:10.1093/emboj/20.24.7074.

Görl, M., Merrow, M., Huttner, B., Johnson, J., Roenneberg, T. and Brunner, M. (2001)

A prodrug form of a Plasmodium falciparum glutathione reductase inhibitor conjugated with a 4-anilinoquinoline. J. Med. Chem. 44:4268–76.

Davioud-Charvet E, Delarue S, Biot C, Schwöbel B, Böhme CC, Müssigbrodt A, Maes L, Sergheraert C, Grellier P, Schirmer RH, Becker K. (2001)

A t-SNARE of the endocytic pathway must be activated for fusion. J Cell Biol. 155(6):961-8.

Paumet F, Brügger B, Parlati F, McNew JA, Söllner TH, Rothman JE. (2001)

Antiplasmodial activity and cytotoxicity of bis- and triquinolines with linear or cyclic amino linkers. J. Med. Chem. 44, 1658–65.

Girault S, Grellier P, Berecibar A, Maes L, Lemière P, Mouray E, Davioud-Charvet E, Sergheraert C. (2001)

Arc1p Organizes the Yeast Aminoacyl-tRNA Synthetase Complex and Stabilizes Its Interaction with the Cognate tRNAs. J. Biol. Chem. 276, No. 8, February, 6000-6008.

Karina Deinert, Franco Fasiolo, Eduard C. Hurt and George Simos (2001)

Biogenesis of the Signal Recognition Particle Requires Nuclear Import of SRP proteins, Assembly with the SRP-RNA in the Nucleolus, and Xpo1p-mediated Nuclear Export. J. Cell Biol. 153, 745-62.

Helge Großhans, Karina Deinert, Ed Hurt and George Simos (2001)

Bromination studies of the 2,3-dimethylnaphthazarin core allowing easy access to naphthazarin derivatives. J. Org. Chem. 66:5616–19.

Dessolin J, Biot C, Davioud-Charvet E. (2001)

Circadian regulation of the light input pathway in Neurospora crassa. Embo j. 2001; PMC133466. doi:10.1093/emboj/20.3.307.

Merrow, M., Franchi, L., Dragovic, Z., Görl, M., Johnson, J., Brunner, M., Macino, G. and Roenneberg, T. (2001)

Crystal structure of an early protein-RNA assembly complex of human signal recognition particle. Science 294: 598-601.

Wild, K., Sinning, I. & Cusack , S. (2001)

Dissection of the ATP binding domain of the molecular chaperone hsc70 for interaction with the cofactor Hap46". J. Biol. Chem. 276, 10178-10184.

Petersen, G., Hahn, C., & Gehring, U. (2001)

Elongation factor like-1, a cytoplasmic GTPase homologous to the ribosomal translocases EF-G/EF-2 is required for ribosome export and a late cytoplasmic step of ribosomal assembly. Molecular Cell, 8, 1363-1373.

B. Senger, D. Lafontaine, O. Gadal, J. Graindorge, A. Camasses, A.Sanni, J. Garnier, M. Breitenbach, E. Hurt, and F. Fasiolo (2001)

Functional characterization of recombinant chloroplast signal recognition particle. J. Biol. Chem. 276: 27778-86.

Groves M., Mant A., Kuhn A., Koch J, Dubel S., Robinson C. & Sinning I. (2001)

Identification of a 60S preribosomal particle that is closely linked to nuclear export. Mol Cell 8:517-29.

Bassler, J., Grandi, P., Gadal, O., Lessmann, T., Petfalski, E., Tollervey, D., Lechner, J., & Hurt, E. (2001)

Impaired membrane traffic in defective ether lipid biosynthesis. Hum.Mol.Gen 10(2),127-136

T.P.Thai, C.Rodemer, A.Jauch, A.Hunziker, A.Moser, K.Gorgas and W.W.Just (2001)

Inhibition of the Ca(2+)-ATPase Pmc1p by the v-SNARE protein Nyv1p. J. Biol. Chem. 276, 6200-6.

Takita Y, Engstrom L, Ungermann C, Cunningham KW. (2001)

Maturation of Pre-Ribosomes Requires Noc-Proteins and is Coupled to Transport from the Nucleolus to the Nucleoplasm. Cell 105, 499-509.

Philipp Milkereit, Olivier Gadal, Alexander Podtelejniko V., Stephanie Trumtel, Nicole Gas, Elisabeth Petfalski, David Tollervey, Mathias Mann, Ed Hurt and Herbert Tschochner (2001)

Medical target prediction from genome sequence: Combining different sequence analysis algorithms with expert knowledge and input from artificial intelligence approaches Comput Chem 26, 15-21

Dandekar T, Du F, Schirmer RH & Schmidt S (2001)

Membrane Trafficking: How Transport Vesicles Fuse With Target Membranes in "Protein Modules in Cellular Signalling", eds Heilmeyer L. and Friedrich P. (IOS Press Amsterdam), pp. 257-261 (Review).

Walter Nickel, Britta Brügger and Felix T. Wieland (2001)

Modular structure of the TIM23 preprotein translocase of mitochondria. J Biol Chem. 2001; doi:10.1074/jbc.M102132200.

Milisav, I., Moro, F., Neupert, W. and Brunner, M. (2001)

Molecular Mechanisms of COPI Vesicle Formation in "Protein Modules in Cellular Signalling", eds. Heilmeyer L. and Friedrich P. (IOS Press Amsterdam), pp. 262-267 (Review).

Britta Brügger, Walter Nickel, and Felix T. Wieland (2001)

Mutations in the YRB1 Gene Encoding Yeast Ran-Binding-Protein-1 That Impair Nucleocytoplasmic Transport and Suppress Yeast Mating Defects. Genetics 157, 1089-1105.

Künzler M., Trueheart J., Sette C., Hurt E., Thorner J. (2001)

Nmd3p functions as a nuclear adaptor for Xpo1p-dependent export of 60S ribosomal subunits. Mol. Cell. Biol. 21, 3405-3415.

Olivier Gadal, Daniela Strauss, Jacques Kessl, Bernard Trumpower, David Tollervey and Ed Hurt (2001)

Otto Meyerhof und die Medizin in Heidelberg

Schirmer RH & Gromer S (2001)

Potent and specific inhibitors of trypanothione reductase from Trypanosoma cruzi: bis(2-aminodiphenylsulfides) for fluorescent labeling studies. Bioorg. Med. Chem. 9:837–46.

Girault S, Davioud-Charvet E, Maes L, Dubremetz J-F, Debreu M-A, Landry V, Sergheraert C. (2001)

Pus1p-dependent tRNA pseudouridinylation becomes essential when tRNA biogenesis is compromised in yeast. J. Biol. Chem. 276, 46333-46339.

Helge Großhans, Francois Lecointe, Henri Grosjean Ed Hurt, and George Simos (2001)

Recruitment to Golgi membranes of ADP-ribosylation factor 1 is mediated by the cytoplasmic domain of p23. The EMBO journal, 20(23), 6751–6760.

Gommel, D. U., Memon, A. R., Heiss, A., Lottspeich, F., Pfannstiel, J., Lechner, J., Reinhard, C., Helms, J. B., Nickel, W., & Wieland, F. T. (2001)

Regulation of intracellular location of aminoacyl-tRNA-synthetases by complex formation with Arc1p. EMBO J. 20, 6889-6898.

K. Galani, H. Großhans, Deinert, K., E. C. Hurt,and G. Simos (2001)

Role of the deafness dystonia peptide 1 (DDP1) in import of human Tim23 into the inner membrane of mitochondria. J Biol Chem. 2001; doi:10.1074/jbc.M105313200.

Rothbauer, U., Hofmann, S., Mühlenbein, N., Paschen, S. A., Gerbitz, K. D., Neupert, W., Brunner, M. and Bauer, M. F. (2001)

Serum response factor is required for immediate-early gene activation yet is dispensable for proliferation of embryonic stem cells. Molecular and Cellular Biology. (abstract)

Schratt G, Weinhold B, Lundberg A, Schuck S, Berger J, Schwarz H, Weinberg R, Ruther U, Nordheim A (2001)

Sphingomyelin-enriched microdomains at the Golgi complex. Mol Biol Cell 12(6):1819-33.

Gkantiragas I, Brügger B, Stüven E, Kaloyanova D, Li XY, Löhr K, Lottspeich F, Wieland FT, Helms JB. (2001)

SRbeta coordinates signal sequence release from SRP with ribosome binding to the translocon. EMBO J. 20: 2338-47.

Fulga, T., Sinning, I., Dobberstein, B. & Pool, M.R. (2001)

Targeting of Ran: variation on a common theme? J. Cell Sci. 114, 3233-3241.

Markus Künzler and Ed Hurt (2001)

The budding yeast proteins Spc24p and Spc25p interact with Ndc80p and Nuf2p at the kinetochore and are important for kinetochore clustering and checkpoint control. The EMBO journal, 20(4), 777–791.

Janke, C., Ortiz, J., Lechner, J., Shevchenko, A., Shevchenko, A., Magiera, M. M., Schramm, C., & Schiebel, E. (2001)

The differential sensitivity of Bcl-2-overexpressing human breast tumor cells to TRAIL or doxorubicin-induced apoptosis is dependent on Bcl-2 protein levels, Oncogene, 20, 7128-33.

Ruiz de Almodovar, C, Ruiz-Ruiz, C, Munoz-Pinedo, C, Robledo, G & Lopez-Rivas, A. (2001)

The ERK signaling cascade inhibits gonadotropin-stimulated steroidogenesis. J. Biol. Chem. 276, 13957-13964.

Seger, R., Hanoch, T., Rosenberg, R., Dantes, A., Merz, W.E., Strauss III, J.F. and Amsterdam, A. (2001)

The Nsp1p carboxy-terminal domain is organized into functionally distinct coiled-coil regions required for assembly of nucleoporin subcomplexes and nucleocytoplasmic transport. Mol. Cell. Biol., 21, 7944-7955.

Susanne M. Bailer, Carolin Balduf, and Ed Hurt (2001)

The N-terminal domain of the t-SNARE Vam3p coordinates priming and docking in yeast vacuole fusion. Mol. Biol. Cell.,12, 3375-3385.

Laage, R.,and Ungermann, C. (2001)

The splicing factor Sub2p interacts directly with the mRNA transport factor Yra1p and is required for nuclear mRNA export. Nature 413, 648-652.

Katja Sträßer and Ed Hurt (2001)

The thioredoxin system substitutes for glutathione reductase in Drosophila melanogaster Science 291, 643-646

Kanzok S, Fechner A, Bauer H, Ulschmid JK, Botella JA, Schneuwly S, Müller HM, Schirmer RH and Becker K (2001)

Transcriptional activation by the human Hsp70-associating protein Hap50. J. Cell Sci. 114, 1839-1845.

Niyaz, Y., Zeiner, M., Gehring, U. (2001)

Trypanosoma cruzi prolyl oligopeptidase Tc80 is involved in nonphagocytic mammalian cell invasion by trypomastigotes. J. Biol. Chem. 276:47078–86.

Grellier P, Vendeville S, Joyeau R, Bastos IM, Drobecq H, Frappier F, Teixeira AR, Schrevel J, Davioud-Charvet E, Sergheraert C, Santana JM. (2001)

Trypanothione-dependent synthesis of deoxyribonucleotides by Trypanosoma brucei ribonucleotide reductase. J. Biol. Chem. 276, 10602-10606.

Dormeyer, M., Reckenfelderbäumer, N., Lüdemann, H., Krauth-Siegel, RL. (2001)

Vac8p release from the SNARE complex and its palmitoylation are coupled and essential for vacuole fusion. EMBO J. 20, 3145-55.

Veit, M., Laage, R., Dietrich, L., Wang, L., and Ungermann, C. (2001)

Identification of a new isoform of the human estrogen receptor-alpha (hER-alpha) that is encoded by distinct transcripts and that is able to repress hER-alpha activation function 1. EMBO J. 19, 4688-4700.

Flouriot,G., Brand,H., Denger,S., Metivier,R., Koš,M., Reid,G., Sonntag-Buck,V., and Gannon,F. (2000)

Tissue-specific expression of multiple mRNA variants of the mouse estrogen receptor alpha gene. FEBS Lett. 477,15-20.

Koš,M., O'Brien,S., Flouriot,G. and Gannon,F. (2000)

A Generic Strategy to Analyze the Spatial Organization of Multi-Protein Complexes by Cross-Linking and Mass Spectrometry. Anal Chem.72, 267-75.

Juri Rappsilber, Symeon Siniossoglou, Eduard C. Hurt and Matthias Mann (2000)

A new role for a SNARE protein as a regulator of the Ypt/Rab-dependent stage of docking. PNAS 97, 8889-8891.

Ungermann, C., Price, A., and Wickner, W. (2000)

A spectroscopic method for observing the domain movement of the Rieske iron sulphur protein, Proc. Natl. Acad. Sci. USA 97: 2069-2074.

Brugna, M., Rodgers, S., Schricker, A., Montoya, G., Kazmeier, M., Nitschke, W. & Sinning, I. (2000)

Allosteric activation of acid a-glucosidase by the human papillomavirus E7 protein. J. Biol. Chem. 275:9534-9541.

Werner Zwerschke, Boris Mannhardt, Paola Massimi, Sonja Nauenburg, David Pim, Walter Nickel, Lawrence Banks, Arnold J. Reuser, Pidder Jansen-Dürr (2000)

An aminoacylation-dependent nuclear tRNA export pathway in yeast. Genes &. Dev. 14, 830-840.

Grosshans, H., E.C. Hurt and G. Simos (2000)

An intact SH3 domain is required for myosin-I induced actin polymerization. EMBO J. 19, 4281-4291.

Geli, M.I., Lombardi, R., Schmelzl, B., and Riezman, H. (2000)

Anionic phospholipids are involved in membrane association of the Signal Recognition Particle receptor FtsY and stimulate its GTPase activity, EMBO J. 19: 531-541.

de Leeuw, E., te Kaat, K., Moser, C., Menestrina, G., Demel, R., de Kruijff, B., Luirink, J. & Sinning, I. (2000)

Antimalarial, antitrypanosomal, antileishmanial activities and cytotoxicity of bis(9-amino-6-chloro-2-methoxyacridines): influence of the linker. J. Med. Chem. 43:2646–54.

Girault S, Grellier P, Berecibar A, Maes L, Mouray E, Lemière P, Debreu MA, Davioud-Charvet E, Sergheraert C. (2000)

ARF- and coatomer-mediated peroxisomal vesiculation. Cell Biochem. Biophys. 32, Spring: 27-36

M. Anton, M. Passreiter, D. Lay, T.P. Thai, K. Gorgas and W.W. Just (2000)

Binding of the Mex67p/Mtr2p Heterodimer to FXFG-, GLFG-, and FG-Repeat Nucleoporins is essential for Nuclear mRNA Export. J. Cell Biol., 150, 695-706.

Katja Sträßer, Jochen Bassler and Ed Hurt (2000)

Cloning and characterization of the Schizosaccharomyces pombe tRNA: pseudouridine synthase Pus1p. Nucleic Acids Research, Vol. 28, No. 23, 4604-4610.

Klaus Hellmuth, Henri Grosjean, Yuri Motorin, Karina Deinert, Ed Hurt and George Simos (2000)

Close is not enough: SNARE-dependent membrane fusion requires an active mechanism that transduces force to membrane anchors. J.Cell Biol., 150: 105-117.

McNew, J.A., Weber, T., Parlati, F., Johnston, R., Melia, T.J., Söllner, T.H., and Rothman, J.E. (2000)

Comparative spatial localization of Protein-A-tagged and authentic yeast nuclear pore complex proteins by immunogold electron microscopy. J. Struct. Biol.129, 295-305.

Birthe Fahrenkrog, John Aris, Ed Hurt, Nelly Panté and Ueli Aebi (2000)

Compartmental specificity of cellular membrane fusion encoded in SNARE proteins. Nature, 407: 153-159.

McNew, J.A., Parlati, F., Fukuda, R., Johnston, R.J., Paz, K., Paumet, F., Söllner, T.H., and Rothman, J.E. (2000)

Deletion of the 6-kDa subunit affects the activity and yield of the bc1 complex from Rhodovulum sulfidophilum. Eur. J. Biochem. 267: 3753-61.

Rodgers, S., Moser, C., Martinez-Julvez, M. & Sinning, I. (2000)

Dissociation from BiP and retrotranslocation of unassembled immunoglobulin light chains are tightly coupled to proteasome activity. Mol Biol Cell. 11(1):217-26.

Chillarón J, Haas IG. (2000)

Disulfide bond formation is not required for human chorionic gonadotropin subunit association. Studies with dithiothreitol in JEG-3 cells. J.Biol.Chem. 275, 11765-11770.

Singh, V. and Merz, W.E. (2000)

Evidence for segregation of sphingomyelin and cholesterol during formation of COPI-coated vesicles. J Cell Biol. 151(3):507-18.

Brügger B, Sandhoff R, Wegehingel S, Gorgas K, Malsam J, Helms JB, Lehmann WD, Nickel W, Wieland FT. (2000)

Functional Architecture of Intracellular t-SNAREs: Membrane Fusion by Isolated SNAREs of the Yeast Vacuole. Nature 407:198-202.

Ryouichi Fukuda, James A. McNew, Thomas Weber, Francesco Parlati, Thomas Engel, Walter Nickel, James E. Rothman, and Thomas H. Söllner (2000)

Homologs of the yeast Sec complex subunits Sec62p and Sec63p are abundant proteins in dog pancreas microsomes. Proc Natl Acad Sci U S A. 97(13):7214-9.

Tyedmers J, Lerner M, Bies C, Dudek J, Skowronek MH, Haas IG, Heim N, Nastainczyk W, Volkmer J, Zimmermann R. (2000)

Interaction of yeast kinetochore proteins with centromere-protein/transcription factor Cbf1. Proc Natl Acad Sci USA. 97(23):12583-12588. doi:10.1073/pnas.97.23.12583

Hemmerich P, Stoyan T, Wieland G, Koch M, Lechner J, Diekmann S. (2000)

Localization and topology of ratp28, a member of a novel family of putative steroid-binding proteins. Biochim. Biophys. Acta 1543, 123-130.

Nölte,I., Jeckel, D., Wieland, F.T., and Sohn, K. (2000)

Mannosidase action, independent of glucose trimming, is essential for proteasome-mediated degradation of unassembled glycosylated Ig light chains. Biol Chem. 381(12):1155-64.

Chillarón J, Adán C, Haas IG. (2000)

Mechanisms of mitochondrial protein import. Protoplasma. 2000; doi:10.1007/BF01280499.

Bauer, M. F., Paschen, S., Neupert, W. and Brunner, M. (2000)

Megavesicles implicated in the rapid transport of intracisternal aggregates across the Golgi stack. Cell 102(3):335-48.

Volchuk A, Amherdt M, Ravazzola M, Brügger B, Rivera VM, Clackson T, Perrelet A, Söllner TH, Rothman JE, Orci L. (2000)

Mex67p Mediates the Nuclear Export of a Variety of Pol II Transcripts. J. Biol. Chem. 275, 8361-8368.

Ed Hurt, Katja Sträßer, Alexandra Segref, Nick Schlaich, Carlo Presutti, David Tollervey and Ralf Jansen (2000)

Mlp2p, a component of nuclear pore attached intranuclear filaments, associates with Nic96p. J. Biol. Chem. 275:343-350.

Kosova, B., N. Panté, C.Rollenhagen, A. Podtelejnikov, M. Mann, U. Aebi and E. Hurt (2000)

Nup116p associates with the Nup82p-Nsp1p-Nup159p nucleoporin complex. J. Biol. Chem. 275, 23540-23548.

Susanne Bailer, C. Balduf, J. Katahira, A. Podtelejnikov, Ch. Rollenhagen, M. Mann, N. Panté and Ed Hurt (2000)

Organelle motility regulated by the cell´s environment. Dissection of signaling pathways regulating movements of peroxisomes. Protoplasma, in press.

C.M. Huber, R. Saffrich, K. Gorgas and W.W. Just (2000)

Parallel synthesis of a library of 1,4–naphthoquinones and automated screening of potential inhibitors of trypanothione reductase from Trypanosoma cruzi. Bioorg. Med. Chem. Lett. 10:631–35.

Salmon-Chemin L, Lemaire A, De Freitas S, Deprez B, Sergheraert C, Davioud-Charvet E. (2000)

Prevention of rhodanese aggregation by the chaperonin GroEL. Meth. in Mol. Biol. (140), 111-116.

F. Weber and M.K. Hayer-Hartl (2000)

Protein translocation into mitochondria: the role of TIM complexes. Trends Cell Biol. 2000; doi:10.1016/s0962-8924(99)01684-0.

Bauer, M. F., Hofmann, S., Neupert, W. and Brunner, M. (2000)

Proteins needed for vesicle budding from the Golgi complex are also required for the docking step of homotypic vacuole fusion. J. Cell Biol. 148, 1223-30.

Price A, Wickner W, Ungermann C. (2000)

Psr1p/Psr2p, two plasma membrane phosphatases with an essential DXDX(T/V) motif required for sodium stress response in yeast. J. Biol. Chem. 275, 19352-19360.

Symeon Siniossoglou, Ed Hurt and Hugh R. B. Pelham (2000)

Purification of ProteinA-Tagged Yeast Ran Reveals Association with a Novel Karyopherin beta Family Member Pdr6p. J. Biol. Chem. 275, 467-471.

Denise Lau, Markus Künzler, Andreas Braunwarth, Klaus Hellmuth, Alexandre Podtelejnikov, Matthias Mann and Ed Hurt (2000)

Putative fusogenic activity of NSF is restricted to a lipid mixture whose coalescence is also triggered by other factors. EMBO J. 19(6):1272-8.

Brügger B, Nickel W, Weber T, Parlati F, McNew JA, Rothman JE, Söllner T. (2000)

Receptor-Dependent Formation of COPI-Coated Vesicles From Chemically Defined Donor Liposomes. Methods Enzymol. 329:388-404.

Walter Nickel and Felix T. Wieland (2000)

Refolding of bovine mitochondrial rhodanese by chaperonins GroEL and GroES. Meth. in Mol. Biol. (140), 117-126.

F. Weber and M.K. Hayer-Hartl (2000)

Removing trace fluorescent contaminants from preparations of GroEL. Meth. in Mol. Biol. (140), 63-64.

F. Weber (2000)

SNAREpins are functionally resistant to disruption by NSF and aSNAP. J.Cell Biol., 149: 1063-1072.

Weber, T., Parlati, F., McNew, J.A., Johnston, R.J., Westermann, B., Söllner, T.H., and Rothman, J.E. (2000)

Structure and Assembly of the Nup84p Complex. J. Cell. Biol. 149, 41-53.

Symeon Siniossoglou, Malik Lutzmann, Helena Santos-Rosa, Kevin Leonard, Shirley Mueller, Ueli Aebi and Ed Hurt (2000)

Targeting of the 22 kDa integral peroxisomal membrane protein. FEBS-Lett. 471, 23-28.

B. Pause, R. Saffrich, A. Hunziker, W. Ansorge and W.W. Just (2000)

TASK (TWIK-related acid-sensitive K+ channel) is expressed in glomerulosa cells of rat adrenal cortex and inhibited by angiotensin II. Mol Endocrinol 14, 863-874.

Czirják, G., Fischer, T., Spät, A., Lesage, F., and Enyedi, P. (2000)

The budding yeast kinetochore: less simple than expected. Protoplasma 211:12-19.

Ortiz J, Lechner J. (2000)

The conserved redox-sensitive cysteine of the DNA-binding region in the c-Rel protein is involved in the regulation of the phosphorylation of the protein. Biochem. J. 352:583–91.

Glineur C, Davioud-Charvet E, Vandenbunder B. (2000)

The crystal structure of the conserved GTPase of SRP54 from the archaeon Acidianus ambivalens and its comparison with related structures suggests a model for the SRP/SR receptor complex, Struct. Fold. Des. 8: 515-525.

Montoya, G., te Kaat, K., Moll, R., Schäfer, G. & Sinning, I. (2000)

The cytochrome bc1 and cytochrome c oxidase complexes associate to form a single supracomplex in yeast mitochondria. J Biol Chem 275, 18093-18098.

Cruciat, C. M., Brunner, S., Baumann, F., Neupert, W., and Stuart, R. A. (2000)

The docking of primed vacuoles can be reversibly arrested by excess Sec17p (alpha-SNAP). J. Biol. Chem. 275, 22862-7.

Wang L, Ungermann C, Wickner W. (2000)

The docking stage of yeast vacuole fusion requires the transfer of proteins from a cis-SNARE complex to a Rab/Ypt protein. J. Cell Biol. 148, 1231-8.

Price A, Seals D, Wickner W, Ungermann C. (2000)

The protein ALY kinks pre-messenger-RNA splicing to nuclear export in metazoans. Nature, 407, 401-405.

Zhaolan Zhou, Ming-juan Luo, Katja Sträßer, Jun Katahira, Ed Hurt and Robin Reed (2000)

The role of the TIM8-13 complex in the import of Tim23 into mitochondria. Embo j. 2000; PMC305865. doi:10.1093/emboj/19.23.6392.

Paschen, S. A., Rothbauer, U., Káldi, K., Bauer, M. F., Neupert, W. and Brunner, M. (2000)

Thioredoxin reductase:Two modes of catalysis have evolved. Eur J Biochem 167, 6110-6117

Williams, CH Jr, Arscott LD, Müller S, Lennon BW, Ludwig, ML, Wang, PF, Veine D, Becker K & Schirmer RH (2000)

Tim23 links the inner and outer mitochondrial membranes. Cell. 2000; doi:10.1016/s0092-8674(00)80850-8.

Donzeau, M., Káldi, K., Adam, A., Paschen, S., Wanner, G., Guiard, B., Bauer, M. F., Neupert, W. and Brunner, M. (2000)

Topological restriction of SNARE-dependent membrane fusion. Nature, 407: 194-198.

Parlati, F., McNew, J.E., Fukuda, R., Miller, R., Söllner, T.H., and Rothman, J.E. (2000)

Transport of tRNA Out of the Nucleus - Direct Channeling to the Ribosome? J. Struct. Biol.129, 288-294.

Helge Grosshans, George Simos and Ed Hurt (2000)

Trypanothione reductase inhibition / trypanocidal activity relationships in a 1,4-bis(3-aminopropyl)piperazine series. Bioorg. Med. Chem. 8:95–103.

Bonnet B, Soullez D, Girault S, Maes L, Landry V, Davioud-Charvet E, Sergheraert C. (2000)

Yeast Nuclear Pore Complex Assembly Defects Determined by Nuclear Envelope Reconstruction. J. Struct. Biol., Vol. 132, No. 1, October 2000, 1-5.

Natalia Gomez-Ospina, Garry Morgan, Thomas H. Giddings Jr., Buket Kosova, Ed Hurt and Mark Winey (2000)

Yeast Ran-binding protein 1 (Yrb1) shuttles between nucleus and cytoplasm and is exported from the nucleus via a CRM1 (XPO1)-dependent pathway. Mol. Cell Biol. 20, 4295-4308.

Markus Künzler, Thomas Gerstberger, Francoise Stutz, and Ed Hurt (2000)

Yra1p, a conserved nuclear RNA-binding protein, interacts directly with Mex67p and is required for mRNA export. EMBO J. 19, 410-420.

Katja Sträßer and Ed Hurt (2000)

The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom. FEBS Lett. 1999; doi:10.1016/s0014-5793(99)01665-8.

Bauer, M. F., Rothbauer, U., Mühlenbein, N., Smith, R. J., Gerbitz, K., Neupert, W., Brunner, M. and Hofmann, S. (1999)

Changes of E-cadherin and beta-catenin levels during induced differentiation of colorectal carcinoma cells. Int. J. Mol. Med. 4, 541-544

Kučerová,D., Šloncová,E., Tuháčková,Z., Uhlířová,M., Koš,M., and Sovová,V. (1999)

A Novel In Vivo Assay Reveals Inhibition of Ribosomal Nuclear Export in Ran-Cycle and Nucleoporin Mutants. J. Cell Biol. 144(3):389-401.

Hurt, E.C., S. Hannus, B. Schmelzl, D. Lau, D. Tollervey and G. Simos (1999)

A putative protein complex consisting of Ctf19, Mcm21, and Okp1 represents a missing link in the budding yeast kinetochore. Genes Dev 13:1140-55.

Ortiz J, Stemmann O, Rank S, Lechner J. (1999)

A role for ADP-ribosylation factor in the control of cargo uptake during COPI-coated vesicle biogenesis. FEBS Lett. 462:267-272.

Jörg Malsam, Daniel Gommel, Felix. T. Wieland, and Walter Nickel (1999)

Alkyl-dihydroxyacetone phosphate synthase and dihydroxyacetone phosphate acyltransferase form a protein complex in peroxisomes. Eur J Biochem. 261(2), 492-9

J. Biermann, W.W. Just, R.J. Wanders and H. Van Den Bosch (1999)

Assignment of circadian function for the Neurospora clock gene frequency. Nature. 1999; doi:10.1038/21190.

Merrow, M., Brunner, M. and Roenneberg, T. (1999)

Automated Parellel Synthesis of a tetrahydroisoquinolin-based library: potential prolyl endopeptidase inhibitors. Bioorg. Med. Chem. Lett. 9:437–42.

Vendeville S, Bourel L, Davioud-Charvet E, Grellier P, Deprez B, Sergheraert C. (1999)

Cloning of a centromere binding factor 3d (CBF3D) gene from Candida glabrata. Yeast 15:793-8.

Stoyan T, Eck R, Lechner J, Hemmerich P, Kunkel W, Diekmann S. (1999)

Content mixing and membrane integrity during membrane fusion driven by pairing of isolated v-SNAREs and t-SNAREs. Proc. Natl. Acad Sci. U.S.A. 96 :12571-12576.

Walter Nickel, Thomas Weber, James A. McNew, Francesco Parlati, Thomas H. Söllner, and James E. Rothman (1999)

COPI-Mediated Protein and Lipid Sorting. Protoplasma 207:115-124 (Review).

Walter Nickel and Britta Brügger (1999)

Coupling of coat assembly and vesicle budding to packaging of putative cargo receptors. Cell 96, 495-506.

M. Bremser, W. Nickel, M. Schweikert, M. Ravazzola, M. Amherd, C.A. Hughes, T.H. Söllner, J. E. Rothman, and F. T. Wieland (1999)

Crystallization and preliminary X-ray diffraction studies on the conserved GTPase domain of the signal recognition particle from Acidianus ambivalens, Acta Cryst. D55: 1949-1951.

Montoya, G., te Kaat, K., Moll, R., Schäfer, G. & Sinning, I. (1999)

Cycloheximide, a new tool to dissect specific steps in ER-associated degradation of different substrates. Biol Chem. 380(6):669-77.

Amshoff C, Jäck HM, Haas IG. (1999)

Determination of cholesterol at the low picomole level by nano-electrospray ionization tandem mass spectrometry. J Lipid Res. 40(1):126-32.

Sandhoff R, Brügger B, Jeckel D, Lehmann WD, Wieland FT. (1999)

Electrospray ionization tandem mass spectrometry (ESI-MS/MS) analysis of the lipid molecular species composition of yeast subcellular membranes reveals acyl chain-based sorting/remodeling of distinct molecular species en route to the plasma membrane. J Cell Biol. 146(4):741-54.

Schneiter R, Brügger B, Sandhoff R, Zellnig G, Leber A, Lampl M, Athenstaedt K, Hrastnik C, Eder S, Daum G, Paltauf F, Wieland FT, Kohlwein SD. (1999)

Evidence for the co-existence of glutathione reductase and trypanothione reductase in the nontrypanosomatid Euglenozoa: Euglena gracilis Z. FEBS Lett. 442:29–33.

Montrichard F, Le Guen F, Laval-Martin DL, Davioud-Charvet E. (1999)

Genetic and structural characterization of the human mitochondrial inner membrane translocase. J Mol Biol. 1999; doi:10.1006/jmbi.1999.2751.

Bauer, M. F., Gempel, K., Reichert, A. S., Rappold, G. A., Lichtner, P., Gerbitz, K. D., Neupert, W., Brunner, M. and Hofmann, S. (1999)

GTP-dependent Binding of ARF to Coatomer in Close Proximity to the Binding Site for Dilysine Retrieval Motifs and p23. J. Biol. Chem. 274, 14198-14203.

L. Zhao, B. Helms, J. Brunner, and F. Wieland (1999)

Maturation of the axonal plasma membrane requires upregulation of sphingomyelin synthesis and formation of protein-lipid complexes. EMBO J. 18(7):1761-71.

Ledesma MD, Brügger B, Bünning C, Wieland FT, Dotti CG. (1999)

Mechanisms of vesicle formation: insights from the COP system. Curr. Opin. Cell Biol. 11(4), 440-446.

Wieland, F., & Harter, C. (1999)

Molecular characterization of a novel mammalian DnaJ-like Sec63p homolog. Biol Chem. 380(9):1133-8.

Skowronek MH, Rotter M, Haas IG. (1999)

Nuclear export of mRNA in yeast. FEBS Lett. 452:77 - 81.

Sträßer, K., and E.C. Hurt (1999)

Nup192p is a Conserved Nucleoporin with a Preferential Location at the Inner Site of the Nuclear Membrane. J. Biol. Chem. 274:22646 - 22651.

Kosova, B., N. Panté, C. Rollenhagen, and E.C. Hurt (1999)

p24 and p23, the major transmem-brane proteins of COPI-coated transport vesicles, form hetero-oligomeric complexes and cycle between the organelles of the early secretory pathway. FEBS Lett. 447:179-185.

D. Gommel, L. Orci, E.M. Emig, M.J. Hannah, M. Ravazzola, W. Nickel, J.B. Helms, F.T. Wieland and K. Sohn (1999)

Probing the Saccharomyces cerevisiae centromeric DNA (CEN DNA)-binding factor 3 (CBF3) kinetochore complex by using atomic force microscopy. Proc Natl Acad Sci U S A 96:3757-62.

Pietrasanta, L. I., Thrower, D., Hsieh, W., Rao, S., Stemmann, O., Lechner, J., Carbon, J., & Hansma, H. (1999)

Pseudouridine Mapping in the Yeast spliceosomal UsnRNAs Reveals that Pseudouridine Synthase Pus1p Exhibits a Dual Substrate Specificity for U2snRNA and tRNA. Mol. Cell. Biol. 19:2142 - 2154.

Massenet, S., Y. Motorin, E. Hurt, H. Grosjean and C. Branlant (1999)

Receptor induced polymerisation of coatomer. Proc. Natl. Acad. Sci U.S.A. 96, 1224-1228.

C. Reinhard, C. Harter, M. Bremser, B. Brügger, K. Sohn. B. Helms, and F. Wieland (1999)

Receptor-mediated regulation of peroxisomal motility in CHO and endothelial cells. EMBO J. 18, 5476-5485.

C.M. Huber, R. Saffrich, W. Ansorge and W.W. Just (1999)

Synthesis of alternative substrates for trypanothione reductase and thioredoxin reductase: an inexpensive microtiter colorimetric assay for inhibitor screening. Anal. Biochem. 268:1–8.

Davioud-Charvet E, Becker K, Landry V, Gromer S, Loge C, Sergheraert C. (1999)

Synthesis of plasmalogens in eye lens epithelial cells. FEBS-Lett. 456, 263-268.

P.T. Thai, C. Rodemer, J. Worsch, A. Hunziker, K. Gorgas and W.W. Just (1999)

Synthesis of polyamine derivatives for the preparation of affinity chromatography columns for the search of new Trypanosoma cruzi targets. Bioorg. Med. Chem. Lett. 9:1567–72.

Davioud-Charvet E, Berecibar A, Girault S, Landry V, Drobecq H, Sergheraert C. (1999)

The cytochrome bc1 complex from Rhodovulum sulfidophilum is a dimer with six quinones per monomer and an additional 6-kDa component, Eur. J. Biochem. 259: 709-718.

Montoya, G., te Kaat, K., Rodgers, S., Nitschke, W. & Sinning, I. (1999)

The hsp70-associating protein Hap46 binds to DNA and stimulates transcription. Proc. Natl. Acad. Sci. USA 96, 10194-10199.

Zeiner, M., Niyaz, Y., Gehring, U. (1999)

The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human. EMBO J., 18:2593-2609.

Katahira, J., K. Sträßer, A. Podtelejnikov, M. Mann, J. U. Jung, and E. C. Hurt (1999)

The TIM17.23 preprotein translocase of mitochondria: composition and function in protein transport into the matrix. Embo j. 1999; PMC1171444. doi:10.1093/emboj/18.13.3667.

Moro, F., Sirrenberg, C., Schneider, H. C., Neupert, W. and Brunner, M. (1999)

Three v-SNAREs and two t-SNAREs, present in a pentameric cis-SNARE complex on isolated vacuoles, are essential for homotypic fusion. J. Cell Biol. 145; 1435-42.

Ungermann C, von Mollard GF, Jensen ON, Margolis N, Stevens TH, Wickner W. (1999)

Tim9, a new component of the TIM22.54 translocase in mitochondria. Embo j. 1999; PMC1171126. doi:10.1093/emboj/18.2.313.

Adam, A., Endres, M., Sirrenberg, C., Lottspeich, F., Neupert, W. and Brunner, M. (1999)

Transport of the ADP/ATP carrier of mitochondria from the TOM complex to the TIM22.54 complex. Embo j. 1999; PMC1171402. doi:10.1093/emboj/18.12.3214.

Endres, M., Neupert, W. and Brunner, M. (1999)

tRNA aminoacylation - a visa to leave the nucleus. Curr. Biol. 9:R238 - R241.

Simos, G., and E.C. Hurt (1999)

Vacuole acidification is required for trans-SNARE pairing, LMA1 release, and homotypic fusion. PNAS 96, 11194-9.

Ungermann C, Wickner W, Xu Z. (1999)

'Rush Hour' am Zellkern. Ruperto Carola 1, 12 -17.

E. Hurt (1998)

Carrier protein import into mitochondria mediated by the intermembrane proteins Tim10/Mrs11 and Tim12/Mrs5. Nature. 1998; doi:10.1038/36136.

Sirrenberg, C., Endres, M., Fölsch, H., Stuart, R. A., Neupert, W. and Brunner, M. (1998)

A common motif of eukaryotic glycosyltransferases is essential for the enzyme activity of large clostridial cytotoxins. J.Biol.Chem. 273:19566-19572.

Busch, C., F. Hofmann, J. Selzer, S. Munro, D. Jeckel, K. Aktories (1998)

A Novel Complex of Membrane Proteins Required for Formation of a Spherical Nucleus. EMBO J. 17, 6449-6464.

S. Siniossoglou, H. Santos-Rosa, J. Rappsilber, M. Mann and E. Hurt (1998)

A putative heterotrimeric G protein inhibits the fusion of COPI-coated vesicles. Segregation of heterotrimeric G proteins from COPI-coated vesicles. J Biol Chem. 273(24):15203-8.

Helms JB, Helms-Brons D, Brügger B, Gkantiragas I, Eberle H, Nickel W, Nürnberg B, Gerdes HH, Wieland FT. (1998)

A single binding site for di-lysine motifs and p23 within the g-subunit of coatomer. Proc. Natl. Acad. Sci. USA. 95,11649-11654

C. Harter, and F. Wieland (1998)

A tRNA-binding domain within Arc1p delivers tRNA to two aminoacyl-tRNA synthetases. Molecular Cell 1, 235 - 242.

G. Simos, A. Sauer, F. Fasiolo, and E.C. Hurt (1998)

Affinity Purification of Protein A-Tagged Nuclear Pore Proteins from Yeast. Cell Biology A Laboratory Hand Book. Academic Press. Second Edition. Vol. 2, 159 - 164.

S. Siniossoglou, P. Grandi, and E.C. Hurt (1998)

Arrangement of subunits in 20 S particles consisting of NSF, SNAPs, and SNARE complexes. Mol. Cell, 2: 539-548.

Hohl., T.M., Parlati, F., Wimmer, C., Rothman, J.E., Söllner, T.H., and Engelhardt, H. (1998)

Biogenesis of Tim23 and Tim17, integral components of the TIM machinery for matrix-targeted preproteins. Embo j. 1998; PMC1170504. doi:10.1093/emboj/17.6.1569.

Káldi, K., Bauer, M. F., Sirrenberg, C., Neupert, W. and Brunner, M. (1998)

Biosynthetic Protein Transport Through the Early Secretory Pathway. Histochem. Cell Biol. 109:477-486 (Review).

Walter Nickel and Felix T. Wieland (1998)

C- to N-terminal translocation of preproteins into mitochondria. Embo j. 1998; PMC1170998. doi:10.1093/emboj/17.22.6508.

Fölsch, H., Gaume, B., Brunner, M., Neupert, W. and Stuart, R. A. (1998)

Characterization of yeast protein Deg1 as Pseudouridine synthase (Pus3) catalyzing the formation of Y38 and Y39 in tRNA anticodon loop. J. Biol. Chem. 273, 1316-1323.

F. Lecointe, G. Simos, A.Sauer, E.C. Hurt, Y. Motorin, and H. Grosjean (1998)

Crystallization and preliminary X-ray diffraction studies of phospho-adenylylsulfate (PAPS) reductase from E. coli. Acta crystallographica. Section D, Biological crystallography, 54(Pt 2), 281–283.

Montoya, G., Svensson, C., Savage, H., Schwenn, J. D., & Sinning, I. (1998)

Cse1p functions as the nuclear export receptor for importin alpha in yeast. FEBS Lett., 433, 185-190.

M. Künzler and E.C. Hurt (1998)

Distinct functions of calmodulin are required for the uptake step of receptor mediated-endocytosis in yeast: the type I myosin Myo5p is one of the calmodulin targets. EMBO J., 17, 635-647.

M. Isabel Geli, Andreas Wesp, and Howard Riezman. (1998)

Endocytic internalization in yeast and animal cells:similar and different. J. Cell Sci. 111, 1031-1037.

M. Isabel Geli and Howard Riezman. (1998)

Functional organization of the Golgi apparatus in glycosphingolipid biosynthesis. Lactosylceramide and subsequent glycosphingolipids are formed in the lumen of the late Golgi. J.Biol.Chem. 273:2939-2946.

Lannert, H., K. Gorgas, I. Meissner, F.T. Wieland, and D. Jeckel (1998)

Fzo1p is a mitochondrial outer membrane protein essential for the biogenesis of functional mitochondria in Saccharomyces cerevisiae. J Biol Chem. 1998; doi:10.1074/jbc.273.32.20150.

Rapaport, D., Brunner, M., Neupert, W. and Westermann, B. (1998)

Intracellular Transport of Glycoproteins and Glycolipids. Trends Glycosci. Glycotechnolog. 10:1-11 (Review).

Walter Nickel, Britta Brügger, and Felix T. Wieland (1998)

Molecular Architecture of the Yeast Nuclear Pore Complex: Localization of Nsp1p Subcomplexes. J. Cell Biol. 143, 577 ? 588.

B. Fahrenkrog, E.C. Hurt, U. Aebi, and N. Panté (1998)

Mtr10p Functions as a Nuclear Import Receptor for the mRNA Binding Protein Npl3p. EMBO J. 17, 2196-2207.

B. Senger, G. Simos, F.R. Bischoff, A. Podtelejnikov, M. Mann, and E.C. Hurt (1998)

Nuclear compartments and nuclear machines. Curr. Opin. Cell Biol. 10, 301 - 303.

E. Hurt and G. Schütz (1998)

Nuclear mRNA Export Requires Complex Formation between Mex67p and Mtr2p at the Nuclear Pores. Mol. Cell. Biol. 18(11) 6826-6838.

H. Santos-Rosa, H. Moreno, G. Simos, A. Segref, B. Fahrenkrog, N. Panté, and E.C. Hurt (1998)

Nup116p and Nup100p are Interchangeable through a Conserved Motif which Constitutes a Binding Site for the mRNA Transport Factor Gle2p/Nup40p. EMBO J. 17, 1107-1119.

S. Bailer, S. Siniossoglou, S. Podtelejnikov, A. Hellwig, M. Mann, and E.C. Hurt (1998)

Peroxisome biogenesis: involvement of ARF and coatomer. J. Cell Biol. 141, 373-383.

M. Passreiter, M. Anton, D. Lay, R. Frank, C. Harter, F.T. Wieland, K. Gorgas and W.W. Just (1998)

Protein and lipid sorting between the endoplasmic reticulum and the Golgi complex. Semin Cell Dev Biol. 9(5):493-501. Review.

Nickel W, Brügger B, Wieland FT. (1998)

Proteine auf Reisen. Einsichten 2, 14-17.

Bauer, M. F., Künkele, K. P., Neupert, W. and Brunner, M. (1998)

Recombinant Plasmodium falciparum glutathione reductase is inhibited by the antimalarial dye methylene blue. FEBS Lett. 422, 311-314

Färber PM, Arscott LD, Williams CH Jr, Becker K & Schirmer RH (1998)

Reversible dissociation of coatomer: Functional characterization of a b/d-coat protein subcomplex. Proc. Natl. Acad. Sci. U.S.A., 95, 2140-2145.

J. Pavel, C. Harter, and F. Wieland (1998)

SNAREpins: minimal machinery for membrane fusion. Cell, 92: 759-772.

Weber, T., Zemelman, B.V., McNew, J.A., Westermann, B., Gmachl, M., Parlati, F., Söllner, T.H., and Rothman, J.E. (1998)

The oligomeric structure of GroEL-GroES is required for biological significant chaperonin function in protein folding. Nature Struct. Biol. (11), 977-985.

F. Weber, F. Keppel, C. Georgopoulos, M.K. Hayer-Hartl and F.U. Hartl (1998)

The variable domain of nonassembled Ig light chains determines both their half-life and binding to the chaperone BiP. Proc Natl Acad Sci U S A. 95(4):1574-8.

Skowronek MH, Hendershot LM, Haas IG. (1998)

Unfolding of preproteins upon import into mitochondria. Embo j. 1998; PMC1170997. doi:10.1093/emboj/17.22.6497.

Gaume, B., Klaus, C., Ungermann, C., Guiard, B., Neupert, W. and Brunner, M. (1998)

Uptake by COPI-coated vesicles of both anterograde and retrograde cargo is inhibited by GTPgammaS in vitro. J. Cell Sci. 111:3081-3090.

Walter Nickel, Jörg Malsam, Karin Gorgas, Mariella Ravazzola, Nicole Jenne, J. Bernd Helms, and Felix T. Wieland (1998)

Yeast Los1p Has Properties of an Exportin-Like Nucleocytoplasmic Transport Factor for tRNA. Mol. Cell. Biol. 18(11) 6374-6386.

K. Hellmuth, D. Lau, R. Bischoff, M. Künzler, E.C. Hurt, and G. Simos (1998)

Yeast tRNA: pseudouridine synthase (Pus1p) displays a multisite substrate specificity. RNA 4, 856 - 869.

Y. Motorin, G. Keith, C. Simon, D. Foiret, G. Simos, E. Hurt, and H. Grosjean (1998)

A heterotrimeric G protein-phospholipase A2 signaling cascade is involved in the regulation of peroxisomal motility in CHO cells. J. Cell Sci. 110, 2955-2968.

C.M. Huber, R. Saffrich, M. Anton, M. Paßreiter, W. Ansorge, K. Gorgas and W.W. Just (1997)

Assembly of immunoglobulin light chains as a prerequisite for secretion. A model for oligomerization-dependent subunit folding. J Biol Chem. 272(5):3117-23.

Leitzgen K, Knittler MR, Haas IG. (1997)

Biogenesis of COPI-Coated Transport Vesicles. FEBS Lett. 413:395-400 (Review).

Walter Nickel and Felix T. Wieland (1997)

Crystal structure of phosphoadenylyl sulphate (PAPS) reductase: a new family of adenine nucleotide alpha hydrolases. Structure (London, England : 1993), 5(7), 895–906.

Savage, H., Montoya, G., Svensson, C., Schwenn, J. D., & Sinning, I. (1997)

Crystal structure of phosphoadenylyl sulphate (PAPS) reductase: a new family of adenine nucleotide alpha hydrolases. Structure, 5(7), 895–906.

Savage, H., Montoya, G., Svensson, C., Schwenn, J. D., & Sinning, I. (1997)

Crystal structure of the NG domain from the signal-recognition particle receptor FtsY. Nature, 385(6614), 365–368.

Montoya, G., Svensson, C., Luirink, J., & Sinning, I. (1997)

Cytosolic factors mediate protein insertion into the peroxisomal membrane. FEBS-Lett. 414, 95-98.

B. Pause, P. Diestelkötter, H. Heid and W.W. Just (1997)

Differential fate of glycoproteins carrying a monoglucosylated form of truncated N-glycan in a new CHO line, MadIA214214, selected for a thermosensitive secretory defect. J Cell Sci. 110 ( Pt 3):323-36

Ermonval M, Cacan R, Gorgas K, Haas IG, Verbert A, Buttin G. (1997)

Direct and GTP-dependent interaction of ADP ribosylation factor 1 with coatomer subunit beta. Proc Natl Acad Sci USA 94(9):4418-23.

Zhao L, Helms JB, Brügger B, Harter C, Martoglio B, Graf R, Brunner J, Wieland FT. (1997)

Ether lipid biosynthesis: isolation and molecular characterization of human dihydroxyacetonephosphate acyltransferase. FEBS-Lett. 420, 205-211.

P.T. Thai, H. Heid, H-R. Rackwitz, A. Hunziker, K. Gorgas and W.W. Just (1997)

Expression, crystallization and preliminary X-ray diffraction study of FtsY, the docking protein of the signal recognition particle of E. coli. Proteins, 28(2), 285–288.<285::aid-prot15>;2-e

Montoya, G., Svensson, C., Luirink, J., & Sinning, I. (1997)

From Nucleoporins to Functional Nuclear Pore Complexes. Curr. Opin. Cell Biol.9, 401 - 411.

V. Doye, and E.C. Hurt (1997)

Functional cooperation and stoichiometry of protein translocases of the outer and inner membranes of mitochondria. J Biol Chem. 1997; doi:10.1074/jbc.272.47.29963.

Sirrenberg, C., Endres, M., Becker, K., Bauer, M. F., Walther, E., Neupert, W. and Brunner, M. (1997)

In Vitro Reconstitution of a Heterotrimeric Nucleoporin Complex Consisting of Recombinant Nsp1p, Nup49p and Nup57p. Mol. Biol. Cell 8,33-46.

N.L. Schlaich, M. Häner, U. Aebi, and E.C. Hurt (1997)

Mammalian protein RAP46: an interaction partner and modulator of 70 kDa heat shock proteins. EMBO J. 16, 5483-5490.

Zeiner, M., Gebauer, M., Gehring, U. (1997)

Membrane association of FtsY, the E. coli SRP receptor. FEBS letters, 416(3), 225–229.

de Leeuw, E., Poland, D., Mol, O., Sinning, I., ten Hagen-Jongman, C. M., Oudega, B., & Luirink, J. (1997)

Mex67p, A Novel Factor for Nuclear mRNA Export, Binds to Both Poly(A)+ RNA and Nuclear Pores. EMBO J. 11, 3256 - 3271.

A. Segref, K. Sharma, V. Doye, A. Hellwig, J. Huber, R. Lührmann, and E.C. Hurt (1997)

Nucleolar KKE/D Repeat Proteins Nop56p and Nop58p Interact with Nop1p and Are Required for Ribosome Biogenesis. Mol. Cell. Biol. 17, 7088-7098.

T. Gautier, T. Bergès, D. Tollervey, and E.C. Hurt (1997)

Nup93a, a Vertebrate Homolog of Yeast Nic96p Form a Complex with a Novel 205 kDa Protein and Are Involved in Nuclear Pore Assembly and Nuclear Growth. Mol. Biol. Cell. 8, 2017 - 2038.

P. Grandi, T. Dang, N. Panti, A. Shevchenko, M. Mann, D. Forbes, and E.C. Hurt (1997)

p23, a major COPI-vesicle membrane protein, constitutively cycles through the early secretory pathway. Proc. Natl. Acad. Sci. U.S.A. 94, 11393-11398.

W. Nickel, K. Sohn, C. Bünning, and F. Wieland (1997)

Protein-Reifung: Transport, Faltung und Abbau. Biospektrum 4: 22-24 (Review).

Walter Nickel and Klaus Leitzgen (1997)

Quantitative analysis of biological membrane lipids at the low picomole level by nano-electrospray ionization tandem mass spectrometry. Proc Natl Acad Sci USA 94(6):2339-44.

Brügger B, Erben G, Sandhoff R, Wieland FT, Lehmann WD. (1997)

The crystal structure of the catalytic core domain of endoglucanase I from Trichoderma reesei at 3.6 A resolution, and a comparison with related enzymes. Journal of molecular biology, 272(3), 383–397.

Kleywegt, G. J., Zou, J. Y., Divne, C., Davies, G. J., Sinning, I., Stâhlberg, J., Reinikainen, T., Srisodsuk, M., Teeri, T. T., & Jones, T. A. (1997)

The hsp70-associating protein Hap46 binds to DNA and stimulates transcription. Proc. Natl. Acad. Sci. USA 96, 10194-10199.

Gebauer, M., Zeiner, M., Gehring, U. (1997)

The mechanism of thioredoxin reductase from human placenta is similar to the mechanism of lipoamide dehydrogenase and glutathione reductase and distinct from that of thioredoxin reductase from Escherichia coli. Proc Natl Acad Sci USA 94, 3126-3626

Arscott LD, Gromer S, Schirmer RH, Becker K & Williams CH Jr. (1997)

The signal recognition particle receptor of Escherichia coli (FtsY) has a nucleotide exchange factor built into the GTPase domain. Proc Natl Acad Sci USA., 94(21), 11339–11344.

Moser, C., Mol, O., Goody, R. S., & Sinning, I. (1997)

Throttles and Dampers: controlling the engine of membrane fusion. Science, 276: 1212-1213.

Rothman, J.E., and Söllner, T.H. (1997)

Two Functionally Distinct Domains Generated by in vivo Cleavage of Nup145p: a Novel Biogenesis Pathway for Nucleoporins. EMBO J. 16, 5086 - 5097.

M.T. Teixeira, S. Siniossoglou, S. Podtelejnikov, J.-C. Binichou, M. Mann, E.C. Hurt, and E. Fabre (1997)

Yeast genetics to dissect the nuclear pore complex and nucleocytoplasmic trafficking. Ann. Rev. Genet. 31, 277-313.

E. Fabre, and E.C. Hurt (1997)

Yeast mitochondrial F1F0-ATPase: the novel subunit e is identical to Tim11. FEBS Lett. 1997; doi:10.1016/s0014-5793(97)00691-1.

Arnold, I., Bauer, M. F., Brunner, M., Neupert, W. and Stuart, R. A. (1997)

A major transmembrane protein of Golgi-derived COPI-coated vesicles involved in coatomer binding. J. Cell Biol. 135, 1238-1248

K. Sohn, L. Orci, M. Ravazzola, M. Amherdt, M. Bremser, F. Lottspeich, K. Fiedler, J. B. Helms, and F. Wieland (1996)

A novel complex of nucleoporins, which includes Sec13p and Sec13p homolog, is essential for normal nuclear pores. Cell 84, 265 - 275.

S. Siniossoglou, C. Wimmer, M. Rieger, V. Doye, H. Tekotte, C. Weise, S. Emig, A. Segref, and E.C. Hurt (1996)

A v-SNARE implicated in intra-Golgi transport. J. Cell. Biol, 133: 507-516

Nagahama, M., Orci, L., Ravazzola, M., Amherdt, M., Lacomis, L., Tempst, P., Rothman, J.E., and Söllner, T.H. (1996)

Analysis of Nic96p Reveals that its Central Domain is Required for Nuclear Pore Formation and Together with its Carboxy-Terminal Domain Functionally Interacts with a Novel Nucleoporin Nup188p. J. Cell Biol. 133, 1141-1152.

U. Zabel, V. Doye, H. Tekotte, R. Wepf, and E.C. Hurt (1996)

Architecture of coatomer: molecular characterization of d-COP and protein interactions within the complex. J. Cell Biol. 135, 53-61.

D. Faulstich, S. Auerbach, L. Orci, M. Ravazzola, S. Wegehingel, F. Lottspeich, G. Stenbeck, C. Harter, F. T. Wieland, and H. Tschochner (1996)

Biosynthesis of human chorionic gonadotropin: a review. Eur.J.Endocrinol. 135, 269-284.

Merz, W.E. (1996)

Determinants in the presequence of cytochrome b2 for import into mitochondria and for proteolytic processing. Eur J Biochem. 1996; doi:10.1111/j.1432-1033.1996.00856.x.

Klaus, C., Guiard, B., Neupert, W. and Brunner, M. (1996)

Forskolin stimulates detoxification of brefeldin A. J. Biol. Chem. 271:15870-15873.

Walter Nickel, J. Bernd Helms, Richard E. Kneusel, and Felix T. Wieland (1996)

Import of carrier proteins into the mitochondrial inner membrane mediated by Tim22. Nature. 1996; doi:10.1038/384582a0.

Sirrenberg, C., Bauer, M. F., Guiard, B., Neupert, W. and Brunner, M. (1996)

Importins/karyopherins meet nucleoporins. Cell 84, 509-515.

E.C. Hurt (1996)

Long-term effect of cyclic AMP on N-glycosylation is caused by an increase in the activity of the cis-prenyl-transferase. Biochem.J. 316, 575-581.

Konrad, M. and Merz, W.E. (1996)

Mechanism of chaperonin action: GroES binding and release can drive GroEL-mediated protein folding in the absence of ATP. EMBO J. (15), 6111-6121.

M.K. Hayer-Hartl, F. Weber and F.U. Hartl (1996)

MHP1, an essential gene in Saccharomyces cervisiae required for microtubule function. J. Cell Biology 135, 1323 - 1340.

I. Irminger-Finger, E.C. Hurt, A. Roebuck, M. A. Collart, and S.J. Edelstein (1996)

Microtubule-based peroxisome movement. J. Cell Sci. 109, 837-849.

S. Rapp, R. Saffrich, M. Anton, U. Jäkle, W. Ansorge, K. Gorgas and W.W. Just (1996)

NBP35 encodes an essential and evolutionary conserved protein in Saccharomyces cerevisiae with homology to a superfamily of bacterial ATPases. Gene 178, 97-106.

G. Vitale, E. Fabre, and E.C. Hurt (1996)

Non-clathrin-coat protein g, a subunit of coatomer, binds to the cytoplasmic dilysine motif of membrane proteins of the early secretory pathway. Proc. Natl. Acad. Sci. U.S.A. 93, 1902-1906

C. Harter, J. Pavel, F. Coccia, E. Draken, S. Wegehingel, H. Tschochner, and F. Wieland (1996)

Nuclear Pore Proteins are Required for the Biogenesis of Functional tRNA. EMBO J. 15, 2285-2290.

G. Simos, H. Tekotte, H. Grosjean, A. Segref, K. Sharma, D. Tollervey, and E.C. Hurt (1996)

Protein import across the inner mitochondrial membrane. NATO ASI Series H96, 157-165.

Schneider, H. C., Berthold, J., Bauer, M. F., Klaus, C., Neupert, W. and Brunner, M. (1996)

Protein insertion into the peroxisomal membrane. Ann. N.Y. Acad. Sci. 804, 60-75.

W.W. Just and P. Diestelkötter (1996)

Protein sorting by transport vesicles. Science 272, 227-234.

*J. E. Rothman and F. T. Wieland (1996)

Role of Tim23 as voltage sensor and presequence receptor in protein import into mitochondria. Cell. 1996; doi:10.1016/s0092-8674(00)81320-3.

Bauer, M. F., Sirrenberg, C., Neupert, W. and Brunner, M. (1996)

Role of type I myosins in receptor-mediated endocytosis in yeast. Science, 272, 533-535.

M. Isabel Geli and Howard Riezman. (1996)

The nucleotide exchange factor MGE exerts a key function in the ATP-dependent cycle of mt-Hsp70-Tim44 interaction driving mitochondrial protein import. Embo j. 1996; PMC452327.

Schneider, H. C., Westermann, B., Neupert, W. and Brunner, M. (1996)

The Saccharomyces cerevisiae kinetochore contains a cyclin-CDK complexing homologue, as identified by in vitro reconstitution. Embo J 15:3611-20.

Stemmann O, Lechner J. (1996)

The Saccharomyces cerevisiae kinetochore. FEBS Lett 389:70-4.

Lechner J, Ortiz J. (1996)

The Yeast Protein Arc1p binds to tRNA and functions as a Cofactor for the Methionyl- and Glutamyl-tRNA Synthetases. EMBO J. 15, 5437 - 5448.

G. Simos, A. Segref, F. Fasiolo, K. Hellmuth, A. Shevchenko, M. Mann, and E.C. Hurt (1996)

Two-dimensional structure of light-harvesting complex II (LHII) from the purple bacterium Rhodovulum sulfidophilum and comparison with LHII from Rhodopseudomonas acidophila, Structure 4: 243-252.

Savage, H., Cyrklaff M., Montoya, G., Kühlbrandt, W. & Sinning, I. (1996)

Variable nuclear cytoplasmic distribution of the 11.5-kDa zinc-binding protein (parathymosin-alpha) and identification of a bipartite nuclear localization signal. J Biol Chem. 271(2):1187-93.

Trompeter HI, Blankenburg G, Brügger B, Menne J, Schiermeyer A, Scholz M, Söling HD. (1996)

Yeast nucleoporin mutants are defective in pre-tRNA splicing. Mol. Cell. Biol. 16, 294-301.

K. Sharma, E. Fabre, H. Tekotte, E.C. Hurt, and D. Tollervey (1996)

A novel nuclear pore protein Nup82p which specifically binds to a fraction of Nsp1p. J. Cell Biol. 130, 1263-1273.

P. Grandi, S. Emig, C. Weise, F. Hucho, T. Pohl, and E.C. Hurt (1995)

Coordination of immunoglobulin chain folding and immunoglobulin chain assembly is essential for the formation of functional IgG. Immunity. 2(6):629-37.

Kaloff CR, Haas IG. (1995)

Crystallographic refinement at 2.3 A resolution and refined model of the photosynthetic reaction centre from Rhodopseudomonas viridis. Journal of molecular biology, 246(3), 429–457.

Deisenhofer, J., Epp, O., Sinning, I., & Michel, H. (1995)

Disruption of the gene coding for the nuclear pore protein Nup1p leads to nuclear accumulation of poly(A)+ RNA. Eur. J. Cell Biol. 67, 8 -14.

N.L. Schlaich, and E.C. Hurt (1995)

Dissection of protein translocation across the mitochondrial outer and inner membranes. Cold Spring Harb Symp Quant Biol. 1995; doi:10.1101/sqb.1995.060.01.066.

Brunner, M., Schneider, H. C., Lill, R. and Neupert, W. (1995)

Disulfide-reductase inhibitors as chemotherapeutic agents: The design of drugs for trypanosomiasis and malaria. Angew Chem Int Ed Engl 34, 141-154

Schirmer RH, Müller JG & Krauth-Siegel RL (1995)

Functional interaction of Nic96p with a core nucleoporin complex consisting of Nsp1p, Nup49p and a novel protein Nup57p. EMBO J. 14, 76 - 87.

P. Grandi, N.L. Schlaich, H. Tekotte, and E.C. Hurt (1995)

Functional significance of arginine 15 in the active site of human class alpha glutathione transferase A1-1. Journal of molecular biology, 247(4), 765–773.

Björnestedt, R., Stenberg, G., Widersten, M., Board, P. G., Sinning, I., Jones, T. A., & Mannervik, B. (1995)

Genetic approaches to nuclear pore structure and function. Trends Genet. 11, 193-199.

V. Doye, and E.C. Hurt (1995)

Molecular chaperones involved in protein degradation in the endoplasmic reticulum: quantitative interaction of the heat shock cognate protein BiP with partially folded immunoglobulin light chains that are degraded in the endoplasmic reticulum. Proc Natl Acad Sci U S A. 92(5):1764-8.

Knittler MR, Dirks S, Haas IG. (1995)

Non-clathrin-coat protein a is a conserved subunit of coatomer and in Saccharomyces cerevisiae is essential for growth. Proc. Natl. Acad. Sci. U.S.A. 92, 3229-3233.

B. Gerich, L. Orci, H. Tschochner, F. Lottspeich, M. Ravazzola, M. Amherdt, F. Wieland, and C. Harter (1995)

Nucleocytoplasmic transport - factors and mechanisms. FEBS Lett. 369, 107-112.

G. Simos, and E.C. Hurt (1995)

Protein-mediated protein maturation in eukaryotes. FEBS Lett. 369(1):72-5. Review.

Haas IG. (1995)

Purification and characterization of mitochondrial processing peptidase of Neurospora crassa. Methods Enzymol. 1995; doi:10.1016/0076-6879(95)48048-x.

Brunner, M. and Neupert, W. (1995)

Roles of heavy and light chains in IgM polymerization. Proc Natl Acad Sci U S A. 92(11):4912-6.

Bornemann KD, Brewer JW, Beck-Engeser GB, Corley RB, Haas IG, Jäck HM. (1995)

Sorting and budding of constitutive secretory vesicles in hepatocytes and hepatoma cells. Adv. Enzyme Regul. 35:283-292.

Andreas Barthel, Walter Nickel, Christiane Tonko, and Hans-Dieter Söling (1995)

Structural analysis of human alpha-class glutathione transferase A1-1 in the apo-form and in complexes with ethacrynic acid and its glutathione conjugate. Structure, 3(7), 717–727.

Cameron, A. D., Sinning, I., L'Hermite, G., Olin, B., Board, P. G., Mannervik, B., & Jones, T. A. (1995)

The MIM complex mediates preprotein translocation across the mitochondrial inner membrane and couples it to the mt-Hsp70/ATP driving system. Cell. 1995; doi:10.1016/s0092-8674(05)80013-3.

Berthold, J., Bauer, M. F., Schneider, H. C., Klaus, C., Dietmeier, K., Neupert, W. and Brunner, M. (1995)

The nuclear pore complex in yeast. In Membrane Protein Transport. Editor S. S. Rothman, Jai Press Ltd., Vol. 2, 29-56.

P. Grandi, and E.C. Hurt (1995)

Two-dimensional crystallisation and structure determination of LHII from Rhv. sulfidophilum at 7 Å resolution. in : Photosynthesis : from Light to Biosphere (Mathis, P., ed.) Kluwer Academic Publishers, Dordrecht, Netherlands, pp 239-242.

Savage, H., Cyrklaff, M., Montoya, G., Kuhlbrandt, W. & Sinning, I. (1995)

Two-dimensional crystallization and preliminary structure analysis of light harvesting II (B800-850) complex from the purple bacterium Rhodovulum sulfidophilum. J. Mol. Biol. 250: 1-10.

Montoya, G., Cyrklaff, M. & Sinning, I. (1995)

VIP21/caveolin is a cholesterol-binding protein. Proc. Natl. Acad. Sci. U.S.A. 92, 10339-10343

M. Murata, J. Peränen, R. Schreiner, F. Wieland, T. V. Kurzchalia, and K. Simons (1995)

A novel nuclear pore protein Nup133p with Distinct Roles in poly(A)+ RNA Transport and Nuclear Pore Distribution. EMBO J. 13, 6062 - 6075.

V. Doye, R. Wepf, and E.C. Hurt (1994)

A rab protein is required for the assembly of SNARE complexes in the docking of transport vesicles. Cell, 78: 937-948.

Søgaard, M., Tani, K., Ye, R.R., Geromanos, S., Tempst, T., Kirchausen, T., Rothman, J.E., and Söllner, T. (1994)

A zinc finger protein, essential for chromosome segregation, constitutes a putative DNA binding subunit of the Saccharomyces cerevisiae kinetochore complex, Cbf3. Embo J 13:5203-11.

Lechner J. (1994)

ADP-ribosylation factor (ARF) and a 14 kDa Polypeptide Are Associated With Heparan Sulfate Proteoglycan-carrying Post-trans-Golgi network Secretory Vesicles. J. Cell Biol. 125:721-731.

Walter Nickel, Lukas A. Huber, Richard A. Kahn, Nicola Kipper, Andreas Barthel, Dirk Faßhauer, and Hans-Dieter Söling (1994)

ARF and VAPP14: Two Proteins Involved in the Delivery of Heparan Sulfate Proteoglycan From the TGN to the Cell Surface. Ann. NY Acad. Sci. 1994:344-356.

Walter Nickel, Richard A. Kahn, Nicola Kipper, Andreas Barthel, Dirk Faßhauer, and Hans-Dieter Söling (1994)

BiP (GRP78), an essential hsp70 resident protein in the endoplasmic reticulum. Experientia. 50(11-12):1012-20. Review.

Haas IG. (1994)

Characterization of the mitochondrial processing peptidase of Neurospora crassa. J Biol Chem 269, 4959-4967.

Arretz, M., Schneider, H., Guiard, B., Brunner, M., and Neupert, W. (1994)

Efficient but aberrant cleavage of mitochondrial precursor proteins by the chloroplast stromal processing peptidase. Eur J Biochem 221, 523-528.

Bassham, D. C., Creighton, A. M., Arretz, M., Brunner, M., and Robinson, C. (1994)

Funktionelle und strukturelle Untersuchungen zum vesikulären Golgi-Plasmamembran-Transport in Leberzellen. PhD thesis. Georg-August-Universität Göttingen. ©Cuvillier-Verlag Göttingen.

Walter Nickel (1994)

J. Chem. Soc. Dalton trans. (6), 799.

L.F. Julie, E. Schatz, M.D. Ward, F. Weber and L.J. Yellowlees (1994)

Lack of self- regulation of human chorionic gonadotropin biosynthesis in human choriocarcinoma cells. J.Clin.Endocr. Metab. 78, 1188-1194.

Licht, P., Cao, H., Zuo, J., Lei, Z.M., Rao, C.V., Merz, W.E., Day, T.G., jr. (1994)

Mammalian Proteins involved in membrane traffic in the Golgi and to the cell surface - SNAP. In Rothblatt, J, Novick, P and Stevens, T (eds.) Guidebook to the secretory pathway, Sambrook and Tooze publication at Oxford University press, 180-181.

Brunner, M. and Whiteheart, S. W. (1994)

Mitochondrial Hsp70/MIM44 complex facilitates protein import. Nature. 1994; doi:10.1038/371768a0.

Schneider, H. C., Berthold, J., Bauer, M. F., Dietmeier, K., Guiard, B., Brunner, M. and Neupert, W. (1994)

N-ethylmaleimide-sensitive fusion protein: a trimeric ATPase whose hydrolysis of ATP is required for membrane fusion. J Cell Biol. 1994; PMC2120109. doi:10.1083/jcb.126.4.945.

Whiteheart, S. W., Rossnagel, K., Buhrow, S. A., Brunner, M., Jaenicke, R. and Rothman, J. E. (1994)

Nuclear transport. Curr. Opin. Cell Biol. 6, 335-342.

E. Fabre, and E.C. Hurt (1994)

Nup145p is required for nuclear export of mRNA and binds homopolymeric RNA in vitro via a novel conserved motif. Cell 78, 275 - 289.

E. Fabre, W.C. Boelens, C. Wimmer, I. Mattaj, and E.C. Hurt (1994)

Regulation of N-glycosylation. Long term effect of cyclic AMP mediates enhanced synthesis of the dolichol pyrophosphate core oligosaccharide. J.Biol.Chem. 269, 8659-8666.

Konrad, M. and Merz, W.E. (1994)

Synthetic lethality with fibrillarin idenitifies NOP77p, a nucleolar protein required for pre-rRNA pprocessing and modification. EMBO J. 13, 3136-3148.

T. Berges, E. Petfalski, D. Tollervey, and E.C. Hurt (1994)

The mitochondrial processing peptidase. In Heijne, G (ed.) Signal Peptidases, RG Landes Comp, 73-86.

Brunner, M., Klaus, C. and Neupert, W. (1994)

A protein assembly - disassembly pathway that may correspond to sequential steps of synaptic vesicle docking, activation and fusion. Cell, 75: 409-418.

Söllner, T., Bennett, M.K., Whiteheart, S.W., Scheller, R.H., and Rothman, J.E. (1993)

A U3 snoRNP Protein with Homology to Splicing Factor PRP4 and Gb Domains is Required for Ribosomal RNA Processing. EMBO J. 12, 2549-2558.

R. P. Jansen, D. Tollervey, and E.C. Hurt (1993)

Analysis of bacterial glycoproteins. Methods Mol Biol 14:119-29.

Lechner J, Wieland F. (1993)

Analysis of nucleo-cytoplasmic transport in a thermo-sensitive mutant of nuclear pore protein NSP1. Eur. J. Cell Biol. 62, 1-12.

U. Nehrbass, E. Fabre, S. Dihlmann, W. Herth, and E.C. Hurt (1993)

Approaches towards a genetic analysis of the nuclear pore complex in yeast. In 'Protein Synthesis and Targeting' (eds. A.J.P. Brown, M.F. Tuite and J.E.G. McCarthy). NATO ASI Series, Vol. H 71, pp. 269-281, Springer-Verlag, Berlin-Heidelberg.

C. Wimmer, V. Doye, U. Nehrbass, N. L. Schlaich, and E.C. Hurt (1993)

b'-COP, a Novel Subunit of Coatomer. EMBO J. 12, 2841-2845

G. Stenbeck, C. Harter, A. Brecht, D. Herrmann, F. Lottspeich, L. Orci, and F. T. Wieland (1993)

Crystallization and preliminary X-ray studies on the core proteins of cellobiohydrolase I and endoglucanase I from Trichoderma reesei. J. Mol. Biol. 234: 905-907.

Divne, C., Sinning, I., Ståhlberg, J., Pettersson, G., Bailey, M., Siika-aho, M., Margolles-Clark, E., Teeri, T., & Jones, T. A. (1993)

Domain structure of an N-ethylmaleimide-sensitive fusion protein involved in vesicular transport. J Biol Chem 268, 2662-2666.

Tagaya, M., Wilson, D. W., Brunner, M., Arango, N., and Rothman, J. E. (1993)

Evidence that serine L223 is involved in the proton transfer pathway to QB in the photosynthetic reaction center of Rhodopseudomonas viridis. Biochemistry, 32(8), 1958–1964.

Leibl, W., Sinning, I., Ewald, G., Michel, H., & Breton, J. (1993)

Expression of highly active sex-inducing pheromone of Volvox carteri f. nagariensis in a mammalian cell system. FEBS Lett. 316(3):257-60.

Jaenicke L, Feldwisch O, Merkl B, Cremer A, Haas IG. (1993)

Import of firefly luciferase into peroxisomes of permeabilized Chinese hamster ovary cells: a model system to study peroxisomal protein import in vitro. Exp. Cell Res. 205, 59-65.

S. Rapp, U. Soto and W.W. Just (1993)

in (Tew, K.D. et al., eds) Structure and function of Glutathione transferases, CRC Press, pp. 29-38.

Mannervik, B., Berhane, K., Björnestedt, R., Board, P., Jones, T.A., Kolm, R.H., Olin, B., Sinning, I., Sroga, G.E., Stenberg, G., Tardioli, S. & Widersten, M. (1993)

in (Tew, K.D. et al., eds) Structure and function of Glutathione transferases, CRC Press, pp. 75-86.

Sinning, I., Kleywegt, G.J., Mannervik, B., Board, P. & Jones, T.A. (1993)

In vitro insertion of the 22-kD peroxisomal membrane protein into isolated rat liver peroxisomes. J. Cell Biol. 123, 1717-1725.

P. Diestelkötter and W.W. Just (1993)

Isolation and characterization of a gene (CBF2) specifying a protein component of the budding yeast kinetochore. J Cell Biol 121:513-9.

Jiang W, Lechner J, Carbon J. (1993)

Membrane topology of the 22 kDa integral peroxisomal membrane protein. FEBS Lett. 315(3), 217-22

K.Kaldi,P. Diestelkotter,G. Stenbeck,S. Auerbach,U. Jakle,H.J. Magert,F.T. Wieland and W.W. Just (1993)

Purification of NSP1 reveals complex formation with 'GLFG' nucleoporins and a novel nuclear pore protein NIC96. EMBO J. 12, 3061-3071.

P. Grandi, V. Doye, and E.C. Hurt (1993)

Reconstitution of nuclear protein transport with semi-intact yeast cells. J. Cell Biol. 123, 785-798.

G. Schlenstedt, E.C. Hurt, V. Doye, and P.A. Silver (1993)

SNAP family of NSF attachment proteins includes a brain-specific isoform. Nature 362, 353-355.

Whiteheart, S. W., Griff, I. C., Brunner, M., Clary, D. O., Mayer, T., Buhrow, S. A., and Rothman, J. E. (1993)

SNAP receptors implicated in vesicle targeting and fusion. Nature 362, 318-324.

Söllner, T., Whiteheart, S. W., Brunner, M., Erdjument-Bromage, H., Geromanos, S., Tempst, P., and Rothman, J. E. (1993)

Structure determination and refinement of human alpha class glutathione transferase A1-1, and a comparison with the Mu and Pi class enzymes. J. Mol. Biol. 232: 192-212.

Sinning, I., Kleywegt, G.J., Cowan, S.W., Reinemer, P., Dirr, H.W., Huber, R., Gilliland, G.L., Armstrong, R.N., Ji, X., Board, P., Olin, B., Mannervik, B. & Jones, T.A. (1993)

Temperature-sensitive mutations demonstrate roles for yeast fibrillarin in pre-rRNA processing, pre-rRNA methylation and ribosome assembly. Cell 72, 443-457.

D. Tollervey, H. Lehtonen, R. Jansen, H. Kern, and E.C. Hurt (1993)

The nuclear pore complex. FEBS Lett. 325, 76-80.

E.C. Hurt (1993)

A multisubunit particle implicated in membrane fusion. J Cell Biol 117, 531-538.

Wilson, D. W., Whiteheart, S. W., Wiedmann, M., Brunner, M., and Rothman, J. E. (1992)

A New Subclass of Nucleoporins that Functionally Interacts with Nuclear Pore Protein NSP1. EMBO J. 11, 5051-5061.

C. Wimmer, V. Doye, P. Grandi, U. Nehrbass, and E.C. Hurt (1992)

Biochem. Biophys. Acta 1098: 151-158.

Mathis, P., Sinning, I. & Michel, H. (1992)

Depletion of the nucleoporin NSP1 in yeast inhibits nuclear pore formation and nuclear transport of a nuclear reporter protein. Eur. J. Biol. 59, 280-295.

A. Mutvei, S. Dihlmann, W. Herth, and E.C. Hurt (1992)

Glucosylceramide is synthesized at the cytosolic surface of various Golgi subfractions. J. Cell Biol. 117, 259-267

D. Jeckel, A. Karrenbauer, K. N. J. Burger, G. van Meer, and F. Wieland (1992)

Interaction of BiP with newly synthesized immunoglobulin light chain molecules: cycles of sequential binding and release. EMBO J. 11(4):1573-81.

Knittler MR, Haas IG. (1992)

Interactions of Azidothymidine Triphosphate with the Cellular DNA Polymerases alpha, delta and epsilon and with DNA Primase. J. Biol. Chem. 267:848-854.

Walter Nickel, Sabine Austermann, Gabriele Bialek, and Frank Grosse (1992)

Nuclear transport and nuclear pores in yeast. Int. J. Gen. Mol. Microbiol. 62, 3-14.

U. Nehrbass, and E. C. Hurt (1992)

Peroxisomal protein import. In vivo evidence for a novel translocation competent compartment. FEBS-Lett. 300, 179-182.

P. Heinemann and W.W. Just (1992)

Soluble N-ethylmaleimide-sensitive fusion attachment proteins (SNAPs) bind to a multi-SNAP receptor complex in Golgi membranes. J Biol Chem 267, 12239-12243.

Whiteheart, S. W., Brunner, M., Wilson, D. W., Wiedmann, M., and Rothman, J. E. (1992)

The gene coding for the immunoglobulin heavy chain binding protein BiP (Hsce-70) maps to mouse chromosome 2. Mamm Genome. 3(11):659-60.

Haas IG, Simon-Chazottes D, Guénet JL. (1992)

The nuclear envelope of the yeast Saccharomyces cerevisiae. Int. Rev. Cytol. 136, 145-184.

E.C. Hurt, A. Mutvei, and M. Carmo-Fonseca (1992)

TIBS 17: 150-54.

Sinning, I. (1992)

A 240 kd multisubunit protein complex, CBF3, is a major component of the budding yeast centromere. Cell 64:717-25.

Lechner J, Carbon J. (1991)

A Coat Subunit of Golgi-Derived non-Clathrin Coated Vesicles with Homology to the Clathrin Coated Vesicle Coat Protein b-Adaptin. Nature 349, 215-220.

T. Serafini, G. Stenbeck, A. Brecht, F. Lottspeich, L. Orci, J. E. Rothman, and F. Wieland (1991)

Across the nuclear pores with the help of nucleoporins. Chromosoma 101, 199-205.

E.C. Hurt and M. Carmo-Fonseca (1991)

ADP-ribosylation factor is a subunit of the coat of Golgi-derived COP-coated vesicles: a novel role for a GTP-binding protein. Cell 67, 239-253.

Serafini, T., Orci, L., Amherdt, M., Brunner, M., Kahn, R. A., and Rothman, J. E. (1991)

Biochem. 30: 9110- 9116.

Baciou, L., Sinning, I. & Sebban, P. (1991)

BiP--a heat shock protein involved in immunoglobulin chain assembly. Curr Top Microbiol Immunol. 167:71-82. Review.

Haas IG. (1991)

Evolutionary conservation of the human protein fibrillarin and its functional expression in yeast. J. Cell Biol. 113, 715-727.

R.P. Jansen, E.C. Hurt, H. Kern, H. Lehtonen, M. Carmo-Fonseca, B. Lapeyere, and D. Tollervey (1991)

Human nucleoporin p62 and the essential yeast nuclear pore protein NSP1 show sequence homology and a similar domain organization. Eur. J. Cell Biol. 55, 17-30.

M. Carmo-Fonseca, H. Kern and E.C. Hurt (1991)

Mammalian nuclei contain foci which are highly enriched in components of the pre-mRNA splicing machinery. EMBO J. 10, 195-206.

M. Carmo-Fonseca, D. Tollervey, R. Pepperkok, S.M.L. Barabino, A. Merdes, C. Brunner, P.D. Zamore, M.R. Green, E.C. Hurt, and A.I. Lamond (1991)

The small nucleolar RNP protein NOP1 (fibrillarin) is required for pre-rRNA processing in yeast. EMBO J. 10, 573-583.

D. Tollervey, H. Lehtonen, M. Carmo-Fonseca, and E.C. Hurt (1991)

Biochem. Biophys. Acta 1018: 115-118.

Michel, H., Sinning, I., Koepke, J., Ewald, G. & Fritzsch, G. (1990)

FEBS Lett. 256: 192-194.

Sinning, I., Michel, H., Mathis, P. & Rutherford, A.W. (1990)

in ( M. Michel-Beyerle, ed.) Springer Series in Biophysics: Reaction Center of Photosynthetic Bacteria Vol.6, Springer Verlag, pp. 199-208.

Sinning, I., Koepke, J. & Michel, H. (1990)

in (M. Baltscheffsky, ed.) Current Research in Photosynthesis, Vol.I, Kluwer Acad. Publishers, Netherlands, pp. 173-176.

Sinning, I., Koepke, J., Schiller, B., Mathis, P., Rutherford, A.W. & Michel, H. (1990)

NSP1: a yeast nuclear envelope protein localized at the nuclear pores exerts its essential function by its carboxy-terminal domain. Cell 61, 979-989.

U. Nehrbass, H. Kern, A. Mutvei, H. Horstmann, B. Marshallsay, and E. C. Hurt (1990)

Targeting of a cytosolic protein to the nuclear periphery. J. Cell Biol. 111, 2829-2837.

E.C. Hurt (1990)

The Rate of Bulk Flow from the Golgi to the Plasma Membrane. Cell 63, 259-267.

A. Karrenbauer, D. Jeckel. W. Just, R. Birk, R. R. Schmidt, J. E. Rothman, and F. Wieland (1990)

The role of small nucleolar ribonucleoproteins in ribosome biogenesis. Mol. Biol. Report 14, 103-206.

D. Tollervey, and E. C. Hurt (1990)

Z. Naturforsch. 45c: 455-458.

Sinning, I., Koepke, J., Schiller, B. & Michel , H. (1990)

A 40 kDa nuclear membrane protein changes its concentration and localization within the nuclear envelope of the yeast Saccharomyces cerevisiae in a cell cycle dependent manner. Eur. J. Cell Biol. 49, 33-41.

T. Schimmang and E. C. Hurt (1989)

A yeast nucleolar protein related to human fibrillarin is associated with small nucleolar RNA and essential for viability. EMBO J. 8, 4015-4025.

T. Schimmang, D. Tollervey, H. Kern, R. Frank and E. C. Hurt (1989)

Biochem. 28: 5544-5553.

Sinning, I., Michel, H., Mathis, P. & Rutherford, A.W. (1989)

Der Elektronenakzeptorkomplex im photosynthetischen Reaktionszentrum des Purpurbakteriums Rps. viridis , in Wissenschaftl. Forschungsbeiträge Biologie, Biochemie, Chemie, Bd. 32, Verlag Intemann, Prien a. Chiemsee, ISBN 3-926323-36-1.

Sinning, I. (1989)

in (J. Jortner & B. Pullman, eds.) Perspectives in Photosynthesis, Kluwer Academic Publ., Netherlands, pp. 413- 421.

Parak, F., Birk, A., Frolov, E., Goldanskii, V., Sinning, I. & Michel, H. (1989)

NSP1, a yeast protein located at the nuclear periphery is required for the cell-cycle of Saccharomyces cerevisiae. J. Cell Sci. 12, 243-252.

E. C. Hurt (1989)

Structure and biosynthesis of prokaryotic glycoproteins. Annu Rev Biochem 58:173-94.

Lechner J, Wieland F. (1989)

A novel nucleosceletal-like protein located at the nuclear periphery is required for the life cycle of Saccharomyces cerevisiae. EMBO J. 7, 4323-4334.

E.C. Hurt (1988)

cDNA cloning of the immunoglobulin heavy chain binding protein. Proc Natl Acad Sci U S A. 85(7):2250-4.

Haas IG, Meo T. (1988)

Nucleolar and nuclear envelope proteins of the yeast Saccharomyces cerevisiae. Eur. J. Cell Biol. 46, 554-563.

E.C. Hurt, A. McDowell, and T. Schimmang (1988)

Purification of an N-Ethylmaleimide-Sensitive Protein Catalyzing Vesicular Transport. Proc. Natl. Acad. Sci.U.S.A. 85, 7852-7856.

M. R. Block, B. S. Glick, C. A. Wilcox, F. Wieland, and J. Rothman (1988)

J. Biggins (ed.) Progress in Photosynthesis Res. Vol.III, Martinus Nijhoff Publ., Dordrecht,

Sinning, I. & Michel, H. (1987)

Promoter recognition and promoter strength in the Escherichia coli system. EMBO J 6, 3139-3144.

Brunner, M., and Bujard, H. (1987)

The primary structure of a procaryotic glycoprotein. Cloning and sequencing of the cell surface glycoprotein gene of halobacteria. J Biol Chem 262:9724-9.

Lechner J, Sumper M. (1987)

The Rate of Bulk Flow from the Endoplasmic Reticulum to the Cell Surface. Cell 50, 289-300.

F. Wieland, M. Gleason, T. Serafini, J. Rothman (1987)

Z. Naturforsch. 42c: 751-754.

Sinning, I. & Michel, H. (1987)

Asparaginyl-N-Acetylgalactosamine: Linkage Unit of Halobacterial Glycosaminoglycan. J. Biol. Chem. 261, 1020-1024.

G. Paul, F. Lottspeich, and F. Wieland (1986)

Iduronic acid is a constituent of sulfated dolichyl phosphate oligosaccharides in halobacteria. FEBS Lett. 195:77-81.

Wieland F, Lechner J, Sumper M. (1986)

Sulfated Dolicholphosphate Oligosaccharides are Transiently Methylated during Biosynthesis of Halobacterial Glycoproteins. System. Appl. Microbiol. 7:286-392.

Wieland F, Lechner J, Sumper M. (1986)

Biosynthesis of sulfated saccharides N-glycosidically linked to the protein via glucose. Purification and identification of sulfated dolichyl monophosphoryl tetrasaccharides from halobacteria. J Biol Chem 260:860-6.

Lechner J, Wieland F, Sumper M. (1985)

Transient methylation of dolichyl oligosaccharides is an obligatory step in halobacterial sulfated glycoprotein biosynthesis. J Biol Chem 260:8984-9.

Lechner J, Wieland F, Sumper M. (1985)

Immunoglobulin heavy chain toxicity in plasma cells is neutralized by fusion to pre-B cells. Proc Natl Acad Sci U S A. 81(22):7185-8.

Haas IG, Wabl MR. (1984)

Asparaginyl-Glucose: Novel Type of Carbohydrate Linkage. Proc. Natl. Acad. Sci. U.S.A 80, 5470-5474

F. Wieland, R. Heitzer, and W. Schäfer (1983)

Immunoglobulin heavy chain binding protein. Nature 24-30;306(5941):387-9.

Haas IG, Wabl M. (1983)

The Cell Wall Glycoprotein of Halobacteria: Structural, Functional and Biosynthetiv Aspects. Zentralbl. Bacteriol. Mikrobiol. Hyg. 1 Abt. Orig. C 3,:161-170.

Wieland F, Lechner J, Sumper M. (1982)

Sulfation of a repetitive saccharide in halobacterial cell wall glycoprotein. FEBS Lett 132:319-323.

Wieland F, Lechner J, Bernhardt G, Sumper M. (1981)

Effect of the aggregational state on the mitogenicity of lipoprotein from the outer membrane of Escherichia coli. Immunobiology. 156(4-5):418-28.

Haas IG, Simon E, Bessler WG. (1980)

Simultaneous expression of mouse immunoglobulins M and D is determined by the same homolog of chromosome 12. Proc Natl Acad Sci U S A. 77(11):6793-6.

Wabl MR, Johnson JP, Haas IG, Tenkhoff M, Meo T, Inan R. (1980)

Principles of Protein Structure, 314 pages, Springer Verlag, New York. Japanese 1979, 1991; Russian 1982.

Schulz, G. E., & Schirmer, R. H. (1979)

Distribution of Yeast Fatty Acid Synthetase subunits: Threedimensional Model of the Enzyme. Proc. Natl. Acad. Sci. U.S.A. 75, 5792-5796.

F. Wieland, E. A. Siess, L. Renner, C. Verfürth, and F. Lynen (1978)

No data found
No data found
No data found

Topological comparison of adenyl kinase with other proteins. Nature, 250(462), 142–144.

Schulz, G. E., & Schirmer, R. H. (1974)