Research Group Leaders

Research

Our Lab delves into the intricacies of the dynamic interplay between proteins and lipids within cellular membranes. Our multidisciplinary approach combines state-of-the-art computer simulations with in vitro reconstitution experiments to uncover the mysteries that govern these complex systems.

A fundamental question that drives our investigations is the presence of numerous lipid types in cellular membranes, even when a single lipid type can form a stable membrane. We are intrigued by the possibility that proteins may possess a distinctive lipid signature, prompting us to explore the consequences of engineering the lipid environment surrounding these proteins.
 

	Pore-Forming Proteins: BAX/BOK, GSDM, and FGF2 Our current focal point involves unraveling the physical-chemical properties of pore-forming proteins, with particular emphasis on BAX/BOK, GSDM, and FGF2. We aim to expand our understanding of their complex characteristics and functional roles within cellular membranes.
	Virology: Influenza A, SARS-CoV-2, and Ebola Viruses We utilize cutting-edge computer simulations to investigate the mechanics of virus entry, self-assembly, and cellular manipulation. Our emphasis is deciphering the complex transitions of viruses, particularly Influenza A, SARS-CoV-2, and Ebola, as they navigate the complex landscape of host adaptation. For more insights, refer to our recent press release: Luring the Virus into a Trap.
	Lipid Binding and Transfer Proteins Our research extends to understanding how certain proteins bind to specific lipids within the cell membrane selectively. Furthermore, we explore the dynamics of lipid transfer proteins, unraveling how proteins take and release lipids from cell membranes and how the composition of membrane lipids influences these interactions.
	Computational Structural Biology By employing advanced techniques such as docking, modeling, and molecular dynamics simulations, We refine Cryo-EM/ET, NMR, crystallography, and AlphaFold structures to understand intricate 3D biomolecular architectures and their interaction with membranes.

For more details, please visit the lab homepage: https://fabiololicato.com