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Groupleader: Britta Brügger
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Britta Brügger
Modulation of protein activities by interactions with lipids & Lipidomics
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Research
The traditional view of membrane lipids serving only as structural barriers between compartments and as solvents for membrane lipids has fundamentally changed over the past years. Our current perception of biological membranes is that these are dynamic assemblies of microdomains characterised by different protein and lipid compositions. Coexistence of such domains is thought to help organise important membrane activities in a reversible manner. Given the fact that membranes are composed of hundreds of different lipid species, it is believed that individual lipid species fulfill very specific functions, e.g. in generating specialised membrane domains or in specifically interacting with membrane proteins. While there are many examples of proteins interacting with lipid head groups, specific interactions of membrane proteins with lipids within the hydrophobic phase of the lipid bilayer are largely unexplored.
We have established novel in vivo and in vitro chemical biology tools to address the question if and how single lipid species interact specifically with proteins within the lipid bilayer. Capitalising on these tools we discovered a direct and highly specific interaction of one sphingomyelin SM species with the transmembrane domain TMD of p24, a protein involved in vesicular trafficking. This specific interaction is defined by a signature within the transmembrane domain of p24 that is responsible for lipid selection. Bioinformatic analyses that were performed in the laboratory of Gunnar von Heijne (Stockholm) using transmembrane proteins predict that this signature represents a conserved sphingolipid-binding motif in mammalian membrane proteins.
Our goal is to define structural determinants and functional consequences of lipid binding (covalent and non-covalent) to proteins. We are using multidisciplinary approach using chemical biology, biochemistry, cell biology and mass spectrometry to unequivocally identify lipids bound to motif-containing protein candidates and to understand functions of such protein-lipid interactions. Candidate proteins under investigation are cell surface receptors such as proteins of the family of metabotropic glutamate receptors. A potential function of non-annular lipids as cofactors for receptor activity, e.g. by facilitating dimerisation/assembly of (e.g. signalling-) active complexes makes these protein-lipid interactions a novel target for the development of small molecule-based drugs with a future perspective for translational medicine approaches.
Lipidomics
Lipidomics aims at providing qualitative and quantitative data on lipid profiles of a given sample being it as simple as a single lipid binding to a protein or as complex as subcellular organelles, tissues, up to multicellular organisms with the ultimate goal to understand biological functions of lipids in health and disease. Although this research field has emerged only recently, it is rapidly expanding. Lipids are increasingly recognised as important modulators of many intracellular processes, from regulation of protein function to modulation of cellular pathways. Mass spectrometric shotgun lipidomics approaches allow assessing the lipid composition of either total membranes or protein-lipid-assemblies directly from extracts of biological samples.
The Lipidomics facility builds on unique expertise in qualitative and quantitative lipid analysis by nano-mass spectrometry. Depending on the scientifc question, four complementary nano-platforms are available: a hybrid quadrupol Oribtrap mass spectrometer, a hybrid quadrupol time-of-flight mass spectrometer, a hybrid triple quadrupole linear ion trap mass spectrometer, and a triple quadrupole mass spectrometer. The triple qudrupole system operates in single injection mode, whereas the other three instruments are coupled to Nanomate devises. Sample analysis can be performed directly with an online nano-UPLC separation of lipid species prior to the MS experiment.
Over the last ten years we have continuously expanded our methods and tools towards a comprehensive and quantitative analysis of lipids.
Our ambition is to develop a technology platform that will cover analysis of this whole range of lipids within one laboratory. A long-term goal we aim at is analysing the lipid composition of single cells. First reports in the literature indicate that this goal can be achieved by optimizing novel nanostructured-surfaces. This approach would allow, for the first time, to analyse dynamic changes of lipids within a single cell rather than to measure a pool of cells in different states.
For details see also @ Facilities/Lipidomics
Download BZH Report Brügger 2014-2016
CV
| 1998 | Dr. phil. nat. (Biochemistry), University of Frankfurt |
| 1998-2000 | Postdoc with James E. Rothman, MSKCC, New York |
| 2000-2002 | Postdoc with Felix Wieland, BZH |
| 2002-2014 | Research Scientist with Felix Wieland, BZH |
| since 07/2014 |
Professor for Biochemistry/Chemical Biology at the BZH |
Lab Members
Rainer Beck
staff scientist
staff scientist
Lab:Room 226
Office:Room 210
/ Phone: +49 6221 54-5452
Mail:rainer.beck@bzh.uni-heidelberg.de
Monika Bertram
secretary
secretary
Office:Room 209
/ Phone: +49 6221 54-4152
Mail:monika.bertram@bzh.uni-heidelberg.de
Helena Brandt
PhD student
PhD student
Lab:Room 224
/ Phone: +49 6221 54-6812
Mail:helena.brandt@bzh.uni-heidelberg.de
Nachiket Dhonnar
PhD student
PhD student
Lab:Room 226
/ Phone: +49 6221 54-4478
Office:Room 269
/ Phone: +49 6221 54-4758
Mail:nachiket.dhonnar@bzh.uni-heidelberg.de
Alexia Herrmann
TA
TA
Lab:Room 226
/ Phone: +49 6221 54-4478
Mail:alexia.herrmann@bzh.uni-heidelberg.de
Jochen Koddebusch
technician
technician
Lab:Room 227
/ Phone: +49 6221 54-4196
Office:Room 269
/ Phone: +49 6221 54-4758
Mail:jochen.koddebusch@bzh.uni-heidelberg.de
Mitarbeiter der Lipidomics Plattform
Thomas Kupke
postdoc
postdoc
Lab:Room 226
/ Phone: +49 6221 54-4478
Office:Room 269
/ Phone: +49 6221 54-4758
Mail:thomas.kupke@bzh.uni-heidelberg.de
Jyothirmai Nethi
PhD student
PhD student
Lab:Room 224
/ Phone: +49 6221 54-6812
Mail:jyothirmai.nethi@bzh.uni-heidelberg.de
Jürgen Reichert
TA
TA
Lab:Room 227
/ Phone: +49 6221 54-4196
Office:Room 269
/ Phone: +49 6221 54-4758
Mail:juergen.reichert@bzh.uni-heidelberg.de
Timo Sachsenheimer
technician
technician
Lab:Room 227
/ Phone: +49 6221 54-4196
Office:Room 269
/ Phone: +49 6221 54-4758
Mail:timo.sachsenheimer@bzh.uni-heidelberg.de
Mitarbeiter der Lipidomics-Plattform Heidelberg
Roberto Saleppico
postdoc
postdoc
Lab:Room 226
/ Phone: +49 6221 54-4478
Office:Room 269
/ Phone: +49 6221 54-4758
Mail:roberto.saleppico@bzh.uni-heidelberg.de
Antonia Schuppener
PhD student
PhD student
Lab:Room 224
/ Phone: +49 6221 54-6812
Mail:antonia.schuppener@bzh.uni-heidelberg.de
Rosangela Silva Santos
PhD student
PhD student
Lab:Room 227
/ Phone: +49 6221 54-4196
Office:Room 269
/ Phone: +49 6221 54-4758
Mail:rosangela.santos@bzh.uni-heidelberg.de
Publications
Quantification of Dolichyl Phosphates Using Phosphate Methylation and Reverse-Phase Liquid Chromatography-High Resolution Mass Spectrometry.
Anal Chem. 2023 Feb 14;95(6):3210-3217. doi: 10.1021/acs.analchem.2c03623. Epub 2023 Jan 30. PMID: 36716239
Kale D, Kikul F, Phapale P, Beedgen L, Thiel C, Brügger B. (2023)
Cholesterol promotes clustering of PI(4,5)P2 driving unconventional secretion of FGF2.
J Cell Biol. 2022 Nov 7;221(11):e202106123. doi: 10.1083/jcb.202106123. Epub 2022 Sep 29. PMID: 36173379
Lolicato F, Saleppico R, Griffo A, Meyer A, Scollo F, Pokrandt B, Müller HM, Ewers H, Hähl H, Fleury JB, Seemann R, Hof M, Brügger B, Jacobs K, Vattulainen I, Nickel W. (2022)
Introducing the Lipidomics Minimal Reporting Checklist.
Nat Metab. 2022 Sep;4(9):1086-1088. doi: 10.1038/s42255-022-00628-3. PMID: 35934691 McDonald JG, Ejsing CS, Kopczynski D, Holčapek M, Aoki J, Arita M, Arita M, Baker ES, Bertrand-Michel J, Bowden JA, Brügger B, Ellis SR, Fedorova M, Griffiths WJ, Han X, Hartler J, Hoffmann N, Koelmel JP, Köfeler HC, Mitchell TW, O'Donnell VB, Saigusa D, Schwudke D, Shevchenko A, Ulmer CZ, Wenk MR, Witting M, Wolrab D, Xia Y, Ahrends R, Liebisch G, Ekroos K. (2022)
A short perinuclear amphipathic α-helix in Apq12 promotes nuclear pore complex biogenesis. Open biology, 11(11), 210250. https://doi.org/10.1098/rsob.210250
Zhang, W., Khan, A., Vitale, J., Neuner, A., Rink, K., Lüchtenborg, C., Brügger, B., Söllner, T. H., & Schiebel, E. (2021)
CaM Kinase II-δ Is Required for Diabetic Hyperglycemia and Retinopathy but Not Nephropathy. Diabetes; 70 (2): 616–626. doi: https://doi.org/10.2337/db19-0659 Chen, J., Fleming, T., Katz, S., Dewenter, M., Hofmann, K., Saadatmand, A., Kronlage, M., Werner, M.P., Pokrandt, B., Schreiter, F., Lin, J., Katz, D., Morgenstern, J., Elwakiel, A., Sinn, P., Gröne, H.J., Hammes, H.P., Nawroth, P.P., Isermann, B., Sticht, C., Brügger, B., Katus, H.A., Hagenmueller, M. & Backs, J. (2021)
Convergent use of phosphatidic acid for hepatitis C virus and SARS-CoV-2 replication organelle formation. Nat Commun 12, 7276. https://doi.org/10.1038/s41467-021-27511-1 Tabata, K., Prasad, V., Paul, D., Lee, J.Y., Pham, M.T., Twu, W.I., Neufeldt, C.J., Cortese, M., Cerikan, B., Stahl, Y., Joecks, S., Tran, C.S., Lüchtenborg, C., V'kovski, P., Hörmann, K., Müller, A.C., Zitzmann, C., Haselmann, U., Beneke, J., Kaderali, L., Erfle, H., Thiel, V., Lohmann, V., Superti-Furga, G., Brügger, B. & Bartenschlager, R. (2021)
Ice2 promotes ER membrane biogenesis in yeast by inhibiting the conserved lipin phosphatase complex. EMBO Journal. (abstract) Papagiannidis D, Bircham PW, Lüchtenborg C, Pajonk O, Ruffini G, Brügger B, Schuck S (2021)
Inositol triphosphate-triggered calcium release blocks lipid exchange at endoplasmic reticulum-Golgi contact sites. Nat Commun 12, 2673. https://doi.org/10.1038/s41467-021-22882-x Malek, M., Wawrzyniak, A.M., Koch, P., Lüchtenborg, C., Hessenberger, M., Sachsenheimer, T., Jang, W., Brügger, B. & Haucke, V. (2021)
Metabolic memory underlying minimal residual disease in breast cancer. Mol Syst Biol. 17: e10141. https://doi.org/10.15252/msb.202010141 Radic, S.hechter, K., Kafkia, E., Zirngibl, K., Gawrzak, S., Alladin, A., Machado, D., Lüchtenborg, C., Sévin, D.C., Brügger, B., Patil, K.R. & Jechlinger, M. (2021)
Public LC-orbitrap tandem mass spectral library for metabolite identification. Journal of Proteome Research, 20. https://doi.org/10.1021/acs.jproteome.0c00930 Phapale, P., Palmer, A., Gathungu, R.M., Kale, D., Brügger, B. & Alexandrov, T. (2021)
Stearic acid blunts growth-factor signaling via oleoylation of GNAI proteins. Nature communications, 12(1), 4590. https://doi.org/10.1038/s41467-021-24844-9 Nůsková H, Serebryakova, M.V., Ferrer-Caelles, A., Sachsenheimer, T., Lüchtenborg, C., Miller, A.K., Brügger, B., Kordyukova, L.V. & Teleman, A.A. (2021)
A novel neurodegenerative spectrum disorder in patients with MLKL deficiency. Cell Death Dis. 11(5):303.
Faergeman SL, Evans H, Attfield KE, Desel C, Kuttikkatte SB, Sommerlund M, Jensen LT, Frokiaer J, Friese MA, Matthews PM, Lüchtenborg C, Brügger B, Oturai AB, Dendrou CA, Fugger L. (2020)
Cholesterol localization around the metabotropic glutamate receptor 2, J. Phys. Chem. B 24: 9061-9078. PMID: 32954729. Kurth, M., Lolicato, F., Sandoval-Perez, A., Amaya-Espinosa, H., Teslenko, A., Sinning, I., Beck, R., Brügger B. & Aponte-Santamaria, C.A. (2020)
Dynamic palmitoylation events following T-cell receptor signaling. Commun Biol. 3(1):368.
Morrison E, Wegner T, Zucchetti AE, Álvaro-Benito M, Zheng A, Kliche S, Krause E, Brügger B, Hivroz C, Freund C. (2020)
EHD2-mediated restriction of caveolar dynamics regulates cellular fatty acid uptake. Proc Natl Acad Sci U S A. 117(13):7471-7481.
Matthaeus C, Lahmann I, Kunz S, Jonas W, Melo AA, Lehmann M, Larsson E, Lundmark R, Kern M, Blüher M, Olschowski H, Kompa J, Brügger B, Müller DN, Haucke V, Schürmann A, Birchmeier C, Daumke O. (2020)
Heme binding of transmembrane signaling proteins undergoing regulated intramembrane proteolysis. Commun Biol. 3(1):73.
Kupke T, Klare JP, Brügger B. (2020)
Membrane Biology: Disentangling Cellular Lipid Connections. Curr Biol. 30(19):R1090-R1092.
Brügger B. (2020)
Protease-resistant streptavidin for interaction proteomics. Molecular Systems Biology, 16: e9370. https://doi.org/10.15252/msb.20199370 Rafiee, M.-R., Sigismondo, G., Kalxdorf, M., Förster, L.-C., Brügger, B., Béthune, J., & Krijgsveld, J (2020)
TMEM147 interacts with Lamin B Receptor, regulates its localization and levels, and affects cholesterol homeostasis. J Cell Sci. jcs.245357.
Christodoulou A, Maimaris G, Makrigiorgi A, Charidemou E, Lüchtenborg C, Ververis A, Georgiou R, Lederer CW, Haffner C, Brügger B, Santama N. (2020)
A method for the quantitative determination of glycerophospholipid regioisomers by UPLC-ESI-MS/MS. Anal Bioanal Chem 411(4):915-924. doi: 10.1007/s00216-018-1517-5.
Wozny K, Lehmann WD, Wozny M, Akbulut BS, Brügger B. (2019)
CerS6-Derived Sphingolipids Interact with Mff and Promote Mitochondrial Fragmentation in Obesity. Cell 177 (6): 1536-1552.
Hammerschmidt P, Ostkotte D, Nolte H, Gerl, MJ, Jais A, Brunner HL, Sprenger HG, Awazawa M, Nicholls HT, Turpin-Nolan SM, Langer T, Krüger M, Brügger B, Brüning JC. (2019)
In vitro quantification of botulinum neurotoxin type A1 using immobilized nerve cell-mimicking nanoreactors in a microfluidic platform. Analyst. 144(19):5755-5765.
Weingart OG, Eyer K, Lüchtenborg C, Sachsenheimer T, Brügger B, van Oostrum M, Wollscheid B, Dittrich PS, Loessner MJ. (2019)
Loss of Neurological Disease HSAN-I-Associated Gene SPTLC2 Impairs CD8+ T Cell Responses to Infection by Inhibiting T Cell Metabolic Fitness. Immunity pii: S1074-7613(19)30095-0.
Wu J, Ma S, Sandhoff R, Ming Y, Hotz-Wagenblatt A, Timmerman V, Bonello-Palot N, Schlotter-Weigel B, Auer-Grumbach M, Seeman P, Löscher WN, Reindl M, Weiss F, Mah E, Weisshaar N, Madi A, Mohr K, Schlimbach T, Velasco Cárdenas RM, Koeppel J, Grünschläger F, Müller L, Baumeister M, Brügger B, Schmitt M, Wabnitz G, Samstag Y, Cui G. (2019)
Quantification of phosphoinositides reveals strong enrichment of PIP2 in HIV-1 compared to producer cell membranes. Sci Rep. 9(1):17661.
Mücksch F, Citir M, Lüchtenborg C, Glass B, Traynor-Kaplan A, Schultz C, Brügger B, Kräusslich HG. (2019)
Structure, Topology, and Dynamics of Membrane-Inserted Polypeptides and Lipids by Solid-State NMR Spectroscopy: Investigations of the Transmembrane Domains of the DQ Beta-1 Subunit of the MHC II Receptor and of the COP I Protein p24. Front Mol Biosci. 6:83. doi: 10.3389/fmolb.2019.00083. eCollection 2019.
Salnikov ES, Aisenbrey C, Pokrandt B, Brügger B*, Bechinger B*. (2019)
Brr6 and Brl1 locate to nuclear pore complex assembly sites to promote their biogenesis. J Cell Biol. pii: jcb.201706024. doi: 10.1083/jcb. 201706024.
Zhang W, Neuner A, Rüthnick D, Sachsenheimer T, Lüchtenborg C, Brügger B, Schiebel E. (2018)
Cutis laxa, exocrine pancreatic insufficiency and altered cellular metabolomics as additional symptoms in a new patient with ATP6AP1-CDG. Mol Genet Metab. pii: S1096-7192(17)30764-3.
Dimitrov B, Himmelreich N, Hipgrave Ederveen AL, Lüchtenborg C, Okun JG, Breuer M, Hutter AM, Carl M, Guglielmi L, Hellwig A, Thiemann KC, Jost M, Peters V, Staufner C, Hoffmann GF, Hackenberg A, Paramasivam N, Wiemann S, Eils R, Schlesner M, Strahl S, Brügger B, Wuhrer M, Christoph Korenke G, Thiel C. (2018)
Defective Mitochondrial Cardiolipin Remodeling Dampens HIF-1α Expression in Hypoxia. Cell Rep. 25(3):561-570.e6.
Chowdhury A, Aich A, Jain G, Wozny K, Lüchtenborg C, Hartmann M, Bernhard O, Balleiniger M, Alfar EA, Zieseniss A, Toischer K, Guan K, Rizzoli SO, Brügger B, Fischer A, Katschinski DM, Rehling P, Dudek J. (2018)
Inconspicuous Little Allies: How Membrane Lipids Help Modulate Protein Function. ACS Central Science 4(5), pp 530-531.
Brügger, B. (2018)
Molecular and structural architecture of polyQ aggregates in yeast. Proc Natl Acad Sci U S A. 115(15):E3446-E3453.
Gruber A, Hornburg D, Antonin M, Krahmer N, Collado J, Schaffer M, Zubaite G, Lüchtenborg C, Sachsenheimer T, Brügger B, Mann M, Baumeister W, Hartl FU, Hipp MS, Fernández-Busnadiego R. (2018)
Phospholipidation of nuclear proteins by the human papillomavirus E6 oncoprotein: implication in carcinogenesis. Oncotarget. 9(75):34142-34158.
Marx B, Hufbauer M, Zigrino P, Majewski S, Markiefka B, Sachsenheimer T, Brügger B, Akgül B. (2018)
Streptococcal Lancefield polysaccharides are critical cell wall determinants for human Group IIA secreted phospholipase A2 to exert its bactericidal effects. PLoS Pathog 14(10):e1007348.
van Hensbergen VP, Movert E, de Maat V, Lüchtenborg C, Le Breton Y, Lambeau G, Payré C, Henningham A, Nizet V, van Strijp JAG, Brügger B, Carlsson F, McIver KS, van Sorge NM. (2018)
Targeting myelin lipid metabolism as a potential therapeutic strategy in a model of CMT1A neuropathy. Nat Commun. 9(1):3025.
Fledrich R, Abdelaal T, Rasch L, Bansal V, Schütza V, Brügger B, Lüchtenborg C, Prukop T, Stenzel J, Rahman RU, Hermes D, Ewers D, Möbius W, Ruhwedel T, Katona I, Weis J, Klein D, Martini R, Brück W, Müller WC, Bonn S, Bechmann I, Nave KA, Stassart RM, Sereda MW. (2018)
Identification of a feedback loop involving beta-glucosidase 2 and its product sphingosine sheds light on the molecular mechanisms in Gaucher disease. J Biol Chem. pii: jbc.M116.762831. doi: 10.1074/jbc.M116.762831. [Epub ahead of print]
Schonauer S, Körschen HG, Penno A, Rennhack A, Breiden B, Sandhoff K, Gutbrod K, Dörmann P, Raju DN, Haberkant P, Gerl MJ, Brügger B, Zigdon H, Vardi A, Futerman AH, Thiele C, Wachten D. (2017)
Peroxisomal dysfunctions cause lysosomal storage and axonal Kv1 channel redistribution in peripheral neuropathy. Elife. 6.
Kleinecke S, Richert S, de Hoz L, Brügger B, Kungl T, Asadollahi E, Quintes S, Blanz J, McGonigal R, Naseri K, Sereda MW, Sachsenheimer T, Lüchtenborg C, Möbius W, Willison H, Baes M, Nave KA, Kassmann CM. (2017)
The host-cell restriction factor SERINC5 restricts HIV-1 infectivity without altering the lipid composition and organization of viral particles. J Biol Chem. 292(33):13702-13713.
Trautz B, Wiedemann H, Lüchtenborg C, Pierini V, Kranich J, Glass B, Kräusslich HG, Brocker T, Pizzato M, Ruggieri A, Brügger B, Fackler OT. (2017)
Transcriptomic analysis displays the effect of (-)-roemerine on the motility and nutrient uptake in Escherichia coli. Curr Genet. 63(4):709-722.
Ayyildiz D, Arga KY, Avci FG, Altinisik FE, Gurer C, Gulsoy Toplan G, Kazan D, Wozny K, Brügger B, Mertoglu B, Sariyar Akbulut B. (2017)
Bifunctional Sphingosine for Cell-Based Analysis of Protein-Sphingolipid Interactions. ACS Chemical Biology 2016 11 (1), 222-230. doi: 10.1021/acschembio.5b00810 Haberkant, P., Stein, F., Höglinger, D., Gerl, M.J., Brügger, B., Van Veldhoven, P.P., Krijgsveld, J., Gavin, A.C., & Schultz, C. (2016)
Mcp3 is a novel mitochondrial outer membrane protein that follows a unique IMP-dependent biogenesis pathway. EMBO Rep. 17(7):965-81.
Sinzel M, Tan T, Wendling P, Kalbacher H, Özbalci C, Chelius X, Westermann B, Brügger B, Rapaport D, Dimmer KS. (2016)
Morphology and Molecular Composition of Purified Bovine Viral Diarrhea Virus Envelope. PLoS Pathog. 12(3).
Callens N, Brügger B, Bonnafous P, Drobecq H, Gerl MJ, Krey T, Roman-Sosa G, Rümenapf T, Lambert O, Dubuisson J, Rouillé Y. (2016)
Phosphatase of regenerating liver (PRL)-3 disrupts epithelial architecture by altering the post-mitotic midbody position. J Cell Sci. 129(21):4130-4142.
Luján P, Varsano G, Rubio T, Hennrich ML, Sachsenheimer T, Gálvez-Santisteban M, Martín-Belmonte F, Gavin AC, Brügger B, Köhn M. (2016)
Sphingosine-1-Phosphate Lyase Deficient Cells as a Tool to Study Protein Lipid Interactions. PLOS ONE 11(4): e0153009. https://doi.org/10.1371/journal.pone.0153009 Gerl, M.J., Bittl, V., Kirchner, S., Sachsenheimer, T., Brunner, H.L., Lüchtenborg, C., Özbalci, C., Wiedemann, H., Wegehingel, S., Nickel, W., Haberkant, P., Schultz, C., Krüger, M., & Brügger, B. (2016)
α1-Antitrypsin Combines with Plasma Fatty Acids and Induces Angiopoietin-like Protein 4 Expression. J Immunol. 11. pii: 1500740.
Frenzel E, Wrenger S, Brügger B, Salipalli S, Immenschuh S, Aggarwal N, Lichtinghagen R, Mahadeva R, Marcondes AM, Dinarello CA, Welte T, Janciauskiene S. (2015)
Cardiac-specific succinate dehydrogenase deficiency in Barth syndrome. EMBO Mol Med. pii: e201505644. epub
Dudek J, Cheng IF, Chowdhury A, Wozny K, Balleininger M, Reinhold R, Grunau S, Callegari S, Toischer K, Wanders RJ, Hasenfuß G, Brügger B, Guan K, Rehling P. (2015)
Homeostasis of phospholipids - The level of phosphatidylethanolamine tightly adapts to changes in ethanolamine plasmalogens. Biochim Biophys Acta. 1851(2):117-28.
Dorninger F, Brodde A, Braverman NE, Moser AB, Just WW, Forss-Petter S, Brügger B, Berger J. (2015)
Inhibition of Ebola virus glycoprotein-mediated cytotoxicity by targeting its transmembrane domain and cholesterol. Nat Commun 6, 7688. https://doi.org/10.1038/ncomms8688 Hacke, M., Björkholm, A., Hellwig, P., Himmels, P., Ruiz de Almodóvar, C., Brügger, B., Wieland, F., & Ernst, A.M. (2015)
Quantitative analysis of the human T cell palmitome. Sci Rep. 5:11598.
Morrison E, Kuropka B, Kliche S, Brügger B, Krause E, Freund C. (2015)
Aim24 and MICOS modulate respiratory function, tafazzin-related cardiolipin modification and mitochondrial architecture. Elife. 3:e01684.
Harner ME, Unger AK, Izawa T, Walther DM, Ozbalci C, Geimer S, Reggiori F, Brügger B, Mann M, Westermann B, Neupert W. (2014)
Analysis of transmembrane domains and lipid mdified peptides with matrix-assisted laser desorption ionization-time-of-flight mass spectrometry. Anal. Chem. 86, 8, 3722–3726. https://doi.org/10.1021/ac500446z Gerl MJ, Sachsenheimer T, Grzybek M, Coskun U, Wieland FT, & Brügger B. (2014)
Differentially localized acyl-CoA synthetase 4 isoenzymes mediate the metabolic channeling of fatty acids towards phosphatidylinositol. Biochim Biophys Acta. 1841(2):227-39.
Küch EM, Vellaramkalayil R, Zhang I, Lehnen D, Brügger B, Sreemmel W, Ehehalt R, Poppelreuther M, Füllekrug J. (2014)
Identification of novel sphingolipid-binding motifs in mammalian membrane proteins. Biochimica et biophysica acta, 1838(8), 2066–2070. https://doi.org/10.1016/j.bbamem.2014.04.026 Björkholm, P., Ernst, A. M., Hacke, M., Wieland, F., Brügger, B., & von Heijne, G. (2014)
Lipidomics: analysis of the lipid composition of cells and subcellular organelles by electrospray ionization mass spectrometry. Annu Rev Biochem. 83:79-98. Review.
Brügger B. (2014)
Sphingolipids as modulators of membrane proteins. Biochim Biophys Acta. 1841(5):665-70. Review.
Ernst AM, Brügger B. (2014)
Tools to study lipid functions. Biochim Biophys Acta. 1841(8):1021.
Brügger B, Brown A. (2014)
Comparative lipidomics analysis of HIV-1 particles and their producer cell membrane in different cell lines. Cellular microbiology, 15(2), 292–304. https://doi.org/10.1111/cmi.12101 Lorizate, M., Sachsenheimer, T., Glass, B., Habermann, A., Gerl, M. J., Kräusslich, H. G., & Brügger, B. (2013)
Differential transport of Influenza A neuraminidase signal anchor peptides to the plasma membrane. FEBS letters, 587(9), 1411–1417. https://doi.org/10.1016/j.febslet.2013.03.019 Ernst, A. M., Zacherl, S., Herrmann, A., Hacke, M., Nickel, W., Wieland, F. T., & Brügger, B. (2013)
In vivo profiling and visualization of cellular protein-lipid interactions using bifunctional fatty acids. Angew Chem Int Ed Engl. 52(14):4033-8.
Haberkant P, Raijmakers R, Wildwater M, Sachsenheimer T, Brügger B, Maeda K, Houweling M, Gavin AC, Schultz C, van Meer G, Heck AJ, Holthuis JC. (2013)
Mcp1 and Mcp2, two novel proteins involved in mitochondrial lipid homeostasis. J Cell Sci. 126(Pt 16):3563-74. Tan T, Ozbalci C, Brügger B, Rapaport D, Dimmer KS. (2013)
Poxvirus membrane biogenesis: rupture not disruption. Cell Microbiol. 15(2):190-9.
Krijnse Locker J, Chlanda P, Sachsenheimer T, Brügger B. (2013)
Quantitative analysis of cellular lipids by nano-electrospray ionisation mass spectrometry. Methods Mol Biol. 1033:3-20.
Özbalci C, Sachsenheimer T, Brügger B. (2013)
Scission of COPI and COPII vesicles is independent of GTP hydrolysis. Traffic. 14(8):922-32. Adolf F, Herrmann A, Hellwig A, Beck R, Brügger B, Wieland FT. (2013)
Synthesis and biological properties of novel brefeldin A analogues. Journal of medicinal chemistry, 56(14), 5872–5884. https://doi.org/10.1021/jm400615g Seehafer K, Rominger F, Helmchen G, Langhans M, Robinson DG, Ozata B, Brügger B, Strating JR, van Kuppeveld FJ, Klein CD. (2013)
Distinct role of subcomplexes of the COPI coat in the regulation of ArfGAP2 activity. Traffic, 13(6), 849–856. https://doi.org/10.1111/j.1600-0854.2012.01349.x Pevzner, I., Strating, J., Lifshitz, L., Parnis, A., Glaser, F., Herrmann, A., Brügger, B., Wieland, F., & Cassel, D. (2012)
Ergosterol content specifies targeting of tail-anchored proteins to mitochondrial outer membranes. Mol Biol Cell. 23(20):3927-35. Krumpe K, Frumkin I, Herzig Y, Rimon N, Özbalci C, Brügger B, Rapaport D, Schuldiner M. (2012)
Impaired neurotransmission in ether lipid-deficient nerve terminals. Hum Mol Genet. 21(12):2713-24 Brodde A, Teigler A, Brugger B, Lehmann WD, Wieland F, Berger J, Just WW. (2012)
Large membrane domains in hair bundles specify spatially constricted radixin activation. J Neurosci. 32(13):4600-9. Zhao H, Williams DE, Shin JB, Brügger B, Gillespie PG. (2012)
Lipids and vesicular transport. Biochim Biophys Acta 1821(8):1039.
Brügger B, Bankaitis VA. (2012)
Molecular recognition of a single sphingolipid species by a protein's transmembrane domain. Nature, 481(7382), 525–529. https://doi.org/10.1038/nature10742 Contreras, F. X., Ernst, A. M., Haberkant, P., Björkholm, P., Lindahl, E., Gönen, B., Tischer, C., Elofsson, A., von Heijne, G., Thiele, C., Pepperkok, R., Wieland, F., & Brügger, B. (2012)
Mutual recognition of sphingolipid molecular species in membranes. Biochim Biophys Acta 1818(11):2616-2622. Ernst AM, Contreras FX, Thiele C, Wieland F, Brügger B. (2012)
Quantification of Signaling Lipids by Nano-Electrospray Ionization Tandem Mass Spectrometry (Nano-ESI MS/MS). Metabolites 2(1), 57-76.
Haag M, Schmidt, A, Sachsenheimer, T, Brügger B. (2012)
Sphingomyelin organization is required for vesicle biogenesis at the Golgi complex. The EMBO journal, 31(24), 4535–4546. https://doi.org/10.1038/emboj.2012.317 Duran, J. M., Campelo, F., van Galen, J., Sachsenheimer, T., Sot, J., Egorov, M. V., Rentero, C., Enrich, C., Polishchuk, R. S., Goñi, F. M., Brügger, B., Wieland, F., & Malhotra, V. (2012)
The Structures of COPI-Coated Vesicles Reveal Alternate Coatomer Conformations and Interactions. Science 336(6087): 1451-4. Faini M, Prinz S, Beck R, Schorb M, Riches JD, Bacia K, Brügger B, Wieland FT, Briggs JA. (2012)
A global circadian repressor controls antiphasic expression of metabolic genes in Neurospora. Mol Cell. 2011; doi:10.1016/j.molcel.2011.10.019. Sancar, G., Sancar, C., Brügger, B., Ha, N., Sachsenheimer, T., Gin, E., Wdowik, S., Lohmann, I., Wieland, F., Höfer, T., Diernfellner, A. and Brunner, M. (2011)
Biochemical and morphological properties of hepatitis C virus particles and determination of their lipidome. J Biol Chem. 286(4):3018-32. Merz A, Long G, Hiet MS, Brügger B, Chlanda P, Andre P, Wieland F, Krijnse-Locker J, Bartenschlager R. (2011)
Coatomer and dimeric ADP ribosylation factor 1 promote distinct steps in membrane scission. J Cell Biol. 194(5):765-77. Beck R, Prinz S, Diestelkötter-Bachert P, Röhling S, Adolf F, Hoehner K, Welsch S, Ronchi P, Brügger B, Briggs JA, Wieland F. (2011)
COPI Budding within the Golgi Stack. Cold Spring Harb Perspect Biol. 3(11). Review. Popoff V, Adolf F, Brügger B, Wieland F. (2011)
Encephalopathy caused by ablation of very long acyl chain ceramide synthesis may be largely due to reduced galactosylceramide levels. J Biol Chem. 286(34):30022-33. Ben-David O, Pewzner-Jung Y, Brenner O, Laviad EL, Kogot-Levin A, Weissberg I, Biton IE, Pienik R, Wang E, Kelly S, Alroy J, Raas-Rothschild A, Friedman A, Brügger B, Merrill AH Jr, Futerman AH. (2011)
GAPs in the context of COPI: Enzymes, coat components or both? Cell Logist. 1(2):52-54. Review. Beck R, Brügger B, Wieland F. (2011)
Glucocorticoid Activity during Lung Maturation Is Essential in Mesenchymal and Less in Alveolar Epithelial Cells. Mol Endocrinol. 25(8):1280-8. Habermehl D, Parkitna JR, Kaden S, Brügger B, Wieland F, Gröne HJ, Schütz G. (2011)
Human regulatory T cells rapidly suppress T Cell Receptor-induced calcium signals, NF-κB and NFAT activation in conventional CD4+CD25- T cells. Sci Signal. ra90 DOI: 10.1126/scisignal.2002179 Schmidt, A, Oberle, N, Weiß, EM, Vobis, D, Frischbutter, S, Baumgrass, R, Falk, CS, Haag, M, Brügger, B, Lin, H, Mayr, GW, Reichardt, P, Gunzer, M, Suri-Payer E, Krammer PH. (2011)
Peroxisomal alterations in Alzheimer's disease. Acta Neuropathol. 122(3):271-83. Kou J, Kovacs GG, Höftberger R, Kulik W, Brodde A, Forss-Petter S, Hönigschnabl S, Gleiss A, Brügger B, Wanders R, Just W, Budka H, Jungwirth S, Fischer P, Berger J. (2011)
Phenotypic profiling of the human genome reveals gene products involved in plasma membrane targeting of SRC kinases. Genome Res. 21(11):1955-68. Ritzerfeld J, Remmele S, Wang T, Temmerman K, Brügger B, Wegehingel S, Tournaviti S, Strating JR, Wieland FT, Neumann B, Ellenberg J, Lawerenz C, Hesser J, Erfle H, Pepperkok R, Nickel W. (2011)
Recombinant heptameric coatomer complexes: novel tools to study isoform-specific functions. Traffic 12(6):682-92 Sahlmüller MC, Strating JR, Beck R, Eckert P, Popoff V, Haag M, Hellwig A, Berger I, Brügger B, Wieland FT. (2011)
Self-segregation of myelin membrane lipids in model membranes. Biophys J. 101(11):2713-20. Yurlova L, Kahya N, Aggarwal S, Kaiser HJ, Chiantia S, Bakhti M, Pewzner-Jung Y, Ben-David O, Futerman AH, Brügger B, Simons M. (2011)
Several ADP-ribosylation factor (Arf) isoforms support COPI vesicle formation. J Biol Chem. 286(41):35634-42. Popoff V, Langer JD, Reckmann I, Hellwig A, Kahn RA, Brügger B, Wieland FT. (2011)
Specificity of intramembrane protein-lipid interactions. Cold Spring Harb Perspect Biol. 3(6). pii: a004705. Review. Contreras FX, Ernst AM, Wieland F, Brügger B. (2011)
Structural and biochemical consequences of NF1 associated nontruncating mutations in the Sec14-PH module of neurofibromin. Hum Mutat. 32(2):191-7. Welti S, Kühn S, D'Angelo I, Brügger B, Kaufmann D, Scheffzek K. (2011)
A critical role for ceramide synthase 2 in liver homeostasis: I. alterations in lipid metabolic pathways. J Biol Chem. 285(14):10902-10. Pewzner-Jung Y, Park H, Laviad EL, Silva LC, Lahiri S, Stiban J, Erez-Roman R, Brügger B, Sachsenheimer T, Wieland F, Prieto M, Merrill AH Jr, Futerman AH. (2010)
A mitochondrial phosphatase required for cardiolipin biosynthesis: the PGP phosphatase Gep4. EMBO J. 29(12):1976-87. Osman C, Haag M, Wieland FT, Brügger B, Langer T. (2010)
Determinants of specificity at the protein-lipid interface in membranes. FEBS Lett. 584(9):1713-20. Review. Ernst AM, Contreras FX, Brügger B, Wieland F. (2010)
Genetic evidence for functional interaction of the Escherichia coli signal recognition particle receptor with acidic lipids in vivo. J Biol Chem. 285(52):40508-14. Erez E, Stjepanovic G, Zelazny AM, Brügger B, Sinning I, Bibi E. (2010)
Membrane deformation and separation. F1000 Biol Rep. 2. pii: 35. Beck R, Brügger B, Wieland FT. (2010)
Sphingolipid rheostat alterations related to transformation can be exploited for specific induction of lysosomal cell death in murine and human glioma. Glia 58(11):1364-83. Mora R, Dokic I, Kees T, Hüber CM, Keitel D, Geibig R, Brügger B, Zentgraf H, Brady NR, Régnier-Vigouroux A. (2010)
ArfGAP1 activity and COPI vesicle biogenesis. Traffic. 10(3):307-15. Beck R, Adolf F, Weimer C, Bruegger B, Wieland FT. (2009)
Cholesterol regulates the endoplasmic reticulum exit of the major membrane protein P0 required for peripheral myelin compaction. J Neurosci. 29(19):6094-104. Saher G, Quintes S, Möbius W, Wehr MC, Krämer-Albers EM, Brügger B, Nave KA. (2009)
Following the fate in vivo of COPI vesicles generated in vitro. Traffic. 10(8):994-1005. Rutz C, Satoh A, Ronchi P, Brügger B, Warren G, Wieland FT. (2009)
Probing HIV-1 membrane liquid order by Laurdan staining reveals producer cell-dependent differences. J Biol Chem. 284(33):22238-47. Lorizate M, Brügger B, Akiyama H, Glass B, Müller B, Anderluh G, Wieland FT, Kräusslich HG. (2009)
The genetic interactome of prohibitins: coordinated control of cardiolipin and phosphatidylethanolamine by conserved regulators in mitochondria. J Cell Biol. 184(4):583-96. Osman C, Haag M, Potting C, Rodenfels J, Dip PV, Wieland FT, Brügger B, Westermann B, Langer T. (2009)
A conformational change in the alpha-subunit of coatomer induced by ligand binding to gamma-COP revealed by single-pair FRET. Traffic 9, 597-607. https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1600-0854.2007.00697.x Langer, JD, Roth, CM, Béthune, J, Stoops, EH, Brügger, B, Herten, DP, and Wieland, FT* (2008)
Ceramide triggers budding of exosome vesicles into multivesicular endosomes. Science. 319(5867):1244-7. Trajkovic K, Hsu C, Chiantia S, Rajendran L, Wenzel D, Wieland F, Schwille P, Brügger B, Simons M. (2008)
Differential roles of ArfGAP1, ArfGAP2, and ArfGAP3 in COPI trafficking. J Cell Biol. 183(4):725-35. Weimer C, Beck R, Eckert P, Reckmann I, Moelleken J, Brügger B, Wieland F. (2008)
Membrane curvature induced by Arf1-GTP is essential for vesicle formation. Proc Natl Acad Sci U S A 105, 11731-11736. → Highlighted by the Faculty of 1000 (F1000.com/1119165). http://www.pnas.org/content/105/33/11731 Beck, R, Sun, Z, Adolf, F, Rutz, C, Bassler, J, Wild, K, Sinning, I, Hurt, E, Brügger, B, Béthune, J*, and Wieland, F* (2008)
Mutation of a single residue, beta-glutamate-20, alters protein-lipid interactions of light harvesting complex II. Mol Microbiol. 67(1):63-77. Kwa LG, Wegmann D, Brügger B, Wieland FT, Wanner G, Braun P. (2008)
Protein-sphingolipid interactions within cellular membranes. J Lipid Res. 49(1):251-62. Haberkant P, Schmitt O, Contreras FX, Thiele C, Hanada K, Sprong H, Reinhard C, Wieland FT, Brügger B. (2008)
Axonal loss and neuroinflammation caused by peroxisome-deficient oligodendrocytes. Nat Genet. 39(8):969-76.
Kassmann CM, Lappe-Siefke C, Baes M, Brügger B, Mildner A, Werner HB, Natt O, Michaelis T, Prinz M, Frahm J, Nave KA. (2007)
Differential localization of coatomer complex isoforms within the Golgi apparatus. Proc Natl Acad Sci USA 104(11):4425-30.
Moelleken J, Malsam J, Betts MJ, Movafeghi A, Reckmann I, Meissner I, Hellwig A, Russell RB, Söllner T, Brügger B, Wieland FT. (2007)
Human immunodeficiency virus type 1 Nef protein modulates the lipid composition of virions and host cell membrane microdomains. Retrovirology 4:70.
Brügger B, Krautkrämer E, Tibroni N, Munte CE, Rauch S, Leibrecht I, Glass B, Breuer S, Geyer M, Kräusslich HG, Kalbitzer HR, Wieland FT, Fackler OT. (2007)
Multiple and stepwise interactions between coatomer and ADP-ribosylation factor-1 (Arf1)-GTP. Traffic 8(5):582-93.
Sun Z, Anderl F, Fröhlich K, Zhao L, Hanke S, Brügger B, Wieland F, Béthune J. (2007)
The structure of the regulatory domain of the adenylyl cyclase Rv1264 from Mycobacterium tuberculosis with bound oleic acid. J Mol Biol. 369(5):1282-95.
Findeisen F, Linder JU, Schultz A, Schultz JE, Brügger B, Wieland F, Sinning I, Tews I. (2007)
Coatomer, the coat protein of COPI transport vesicles, discriminates endoplasmic reticulum residents from p24 proteins. Mol Cell Biol. 26(21):8011-21.
Béthune J, Kol M, Hoffmann J, Reckmann I, Brügger B, Wieland F. (2006)
Molecular anatomy of a trafficking organelle. Cell 127(4):831-46. Takamori S, Holt M, Stenius K, Lemke EA, Grønborg M, Riedel D, Urlaub H, Schenck S, Brügger B, Ringler P, Müller SA, Rammner B, Gräter F, Hub JS, De Groot BL, Mieskes G, Moriyama Y, Klingauf J, Grubmüller H, Heuser J, Wieland F, Jahn R. (2006)
The HIV lipidome: a raft with an unusual composition. Proc Natl Acad Sci USA 103(8):2641-6.
Brügger B, Glass B, Haberkant P, Leibrecht I, Wieland FT, Kräusslich HG. (2006)
High cholesterol level is essential for myelin membrane growth. Nat Neurosci. 8(4):468-75. Saher G, Brügger B, Lappe-Siefke C, Möbius W, Tozawa R, Wehr MC, Wieland F, Ishibashi S, Nave KA. (2005)
Identification and biophysical characterization of a very-long-chain-fatty-acid-substituted phosphatidylinositol in yeast subcellular membranes. Biochem. J. 381:941-949. R. Schneiter, B. Brügger, C. M. Amann, G. D. Prestwich, R. F. Epand, G. Zellnig, F. T. Wieland, and R. M. Epand. (2004)
Mechanismen der COPI-Vesikelbiogenese. Biospektrum I, 30-33 (Review). B. Brügger and F. T. Wieland (2004)
The membrane domains occupied by glycosylphosphatidylinositol-anchored prion protein and Thy-1 differ in lipid composition. J Biol Chem. 279(9):7530-6. Brügger B, Graham C, Leibrecht I, Mombelli E, Jen A, Wieland F, Morris R. (2004)
Unconventional secretion of fibroblast growth factor 2 is mediated by direct translocation across the plasma membrane of mammalian cells. J Biol Chem. 279(8):6244-51. Schäfer T, Zentgraf H, Zehe C, Brügger B, Bernhagen J, Nickel W. (2004)
Formation and nuclear export of tRNA, rRNA and mRNA is regulated by the ubiquitin ligase Rsp5p. EMBO Rep. 4(12):1156-62. Neumann S, Petfalski E, Brügger B, Grosshans H, Wieland F, Tollervey D, Hurt E. (2003)
Glutamate binding affinity of Drosophila metabotropic glutamate receptor is modulated by association with lipid rafts. Proc. Natl. Acad. Sci. USA 100: 10219-10224. Eroglu, C., Brügger, B., Wieland, F. & Sinning, I. (2003)
Inactivation of ether lipid biosynthesis causes male infertility, defects in eye development and optic nerve hypoplasia in mice. Hum Mol Genet. 12(15):1881-95. Rodemer C, Thai TP, Brügger B, Kaercher T, Werner H, Nave KA, Wieland F, Gorgas K, Just WW. (2003)
Intra-Golgi protein transport depends on a cholesterol balance in the lipid membrane. J Biol Chem. 278(52):53112-22. Stüven E, Porat A, Shimron F, Fass E, Kaloyanova D, Brügger B, Wieland FT, Elazar Z, Helms JB. (2003)
Targeted Disruption Of Ether Lipid Synthesis In Mice. In: Roels F., Baes M., De Bie S. (eds) Peroxisomal Disorders and Regulation of Genes. Advances in Experimental Medicine and Biology, vol 544. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9072-3_46 Rodemer C, Thai TP, Brügger B, Gorgas K, Just W. (2003)
Oligomeric state and stoichiometry of p24 proteins in the early secretory pathway. J Biol Chem. 277(48):46504-11. Jenne N, Frey K, Brügger B, Wieland FT. (2002)
The Sur7p family defines novel cortical domains in Saccharomyces cerevisiae, affects sphingolipid metabolism, and is involved in sporulation. Mol Cell Biol. 22(3):927-34. Young ME, Karpova TS, Brügger B, Moschenross DM, Wang GK, Schneiter R, Wieland FT, Cooper JA. (2002)
Vesicular transport: the core machinery of COPI recruitment and budding. J Cell Sci. 115(Pt 16):3235-40. Review. Nickel W, Brügger B, Wieland FT. (2002)
A t-SNARE of the endocytic pathway must be activated for fusion. J Cell Biol. 155(6):961-8. Paumet F, Brügger B, Parlati F, McNew JA, Söllner TH, Rothman JE. (2001)
Membrane Trafficking: How Transport Vesicles Fuse With Target Membranes in "Protein Modules in Cellular Signalling", eds Heilmeyer L. and Friedrich P. (IOS Press Amsterdam), pp. 257-261 (Review). Walter Nickel, Britta Brügger and Felix T. Wieland (2001)
Molecular Mechanisms of COPI Vesicle Formation in "Protein Modules in Cellular Signalling", eds. Heilmeyer L. and Friedrich P. (IOS Press Amsterdam), pp. 262-267 (Review). Britta Brügger, Walter Nickel, and Felix T. Wieland (2001)
Sphingomyelin-enriched microdomains at the Golgi complex. Mol Biol Cell 12(6):1819-33. Gkantiragas I, Brügger B, Stüven E, Kaloyanova D, Li XY, Löhr K, Lottspeich F, Wieland FT, Helms JB. (2001)
Evidence for segregation of sphingomyelin and cholesterol during formation of COPI-coated vesicles. J Cell Biol. 151(3):507-18. Brügger B, Sandhoff R, Wegehingel S, Gorgas K, Malsam J, Helms JB, Lehmann WD, Nickel W, Wieland FT. (2000)
Megavesicles implicated in the rapid transport of intracisternal aggregates across the Golgi stack. Cell 102(3):335-48.
Volchuk A, Amherdt M, Ravazzola M, Brügger B, Rivera VM, Clackson T, Perrelet A, Söllner TH, Rothman JE, Orci L. (2000)
Putative fusogenic activity of NSF is restricted to a lipid mixture whose coalescence is also triggered by other factors. EMBO J. 19(6):1272-8. Brügger B, Nickel W, Weber T, Parlati F, McNew JA, Rothman JE, Söllner T. (2000)
COPI-Mediated Protein and Lipid Sorting. Protoplasma 207:115-124 (Review). Walter Nickel and Britta Brügger (1999)
Determination of cholesterol at the low picomole level by nano-electrospray ionization tandem mass spectrometry. J Lipid Res. 40(1):126-32. Sandhoff R, Brügger B, Jeckel D, Lehmann WD, Wieland FT. (1999)
Electrospray ionization tandem mass spectrometry (ESI-MS/MS) analysis of the lipid molecular species composition of yeast subcellular membranes reveals acyl chain-based sorting/remodeling of distinct molecular species en route to the plasma membrane. J Cell Biol. 146(4):741-54. Schneiter R, Brügger B, Sandhoff R, Zellnig G, Leber A, Lampl M, Athenstaedt K, Hrastnik C, Eder S, Daum G, Paltauf F, Wieland FT, Kohlwein SD. (1999)
Maturation of the axonal plasma membrane requires upregulation of sphingomyelin synthesis and formation of protein-lipid complexes. EMBO J. 18(7):1761-71. Ledesma MD, Brügger B, Bünning C, Wieland FT, Dotti CG. (1999)
Receptor induced polymerisation of coatomer. Proc. Natl. Acad. Sci U.S.A. 96, 1224-1228. C. Reinhard, C. Harter, M. Bremser, B. Brügger, K. Sohn. B. Helms, and F. Wieland (1999)
A putative heterotrimeric G protein inhibits the fusion of COPI-coated vesicles. Segregation of heterotrimeric G proteins from COPI-coated vesicles. J Biol Chem. 273(24):15203-8. Helms JB, Helms-Brons D, Brügger B, Gkantiragas I, Eberle H, Nickel W, Nürnberg B, Gerdes HH, Wieland FT. (1998)
Intracellular Transport of Glycoproteins and Glycolipids. Trends Glycosci. Glycotechnolog. 10:1-11 (Review). Walter Nickel, Britta Brügger, and Felix T. Wieland (1998)
Protein and lipid sorting between the endoplasmic reticulum and the Golgi complex. Semin Cell Dev Biol. 9(5):493-501. Review. Nickel W, Brügger B, Wieland FT. (1998)
Direct and GTP-dependent interaction of ADP ribosylation factor 1 with coatomer subunit beta. Proc Natl Acad Sci USA 94(9):4418-23. Zhao L, Helms JB, Brügger B, Harter C, Martoglio B, Graf R, Brunner J, Wieland FT. (1997)
Quantitative analysis of biological membrane lipids at the low picomole level by nano-electrospray ionization tandem mass spectrometry. Proc Natl Acad Sci USA 94(6):2339-44. Brügger B, Erben G, Sandhoff R, Wieland FT, Lehmann WD. (1997)
Variable nuclear cytoplasmic distribution of the 11.5-kDa zinc-binding protein (parathymosin-alpha) and identification of a bipartite nuclear localization signal. J Biol Chem. 271(2):1187-93.
Trompeter HI, Blankenburg G, Brügger B, Menne J, Schiermeyer A, Scholz M, Söling HD. (1996)
Anal Chem. 2023 Feb 14;95(6):3210-3217. doi: 10.1021/acs.analchem.2c03623. Epub 2023 Jan 30. PMID: 36716239
Kale D, Kikul F, Phapale P, Beedgen L, Thiel C, Brügger B. (2023)
Cholesterol promotes clustering of PI(4,5)P2 driving unconventional secretion of FGF2.
J Cell Biol. 2022 Nov 7;221(11):e202106123. doi: 10.1083/jcb.202106123. Epub 2022 Sep 29. PMID: 36173379
Lolicato F, Saleppico R, Griffo A, Meyer A, Scollo F, Pokrandt B, Müller HM, Ewers H, Hähl H, Fleury JB, Seemann R, Hof M, Brügger B, Jacobs K, Vattulainen I, Nickel W. (2022)
Introducing the Lipidomics Minimal Reporting Checklist.
Nat Metab. 2022 Sep;4(9):1086-1088. doi: 10.1038/s42255-022-00628-3. PMID: 35934691 McDonald JG, Ejsing CS, Kopczynski D, Holčapek M, Aoki J, Arita M, Arita M, Baker ES, Bertrand-Michel J, Bowden JA, Brügger B, Ellis SR, Fedorova M, Griffiths WJ, Han X, Hartler J, Hoffmann N, Koelmel JP, Köfeler HC, Mitchell TW, O'Donnell VB, Saigusa D, Schwudke D, Shevchenko A, Ulmer CZ, Wenk MR, Witting M, Wolrab D, Xia Y, Ahrends R, Liebisch G, Ekroos K. (2022)
A short perinuclear amphipathic α-helix in Apq12 promotes nuclear pore complex biogenesis. Open biology, 11(11), 210250. https://doi.org/10.1098/rsob.210250
Zhang, W., Khan, A., Vitale, J., Neuner, A., Rink, K., Lüchtenborg, C., Brügger, B., Söllner, T. H., & Schiebel, E. (2021)
CaM Kinase II-δ Is Required for Diabetic Hyperglycemia and Retinopathy but Not Nephropathy. Diabetes; 70 (2): 616–626. doi: https://doi.org/10.2337/db19-0659 Chen, J., Fleming, T., Katz, S., Dewenter, M., Hofmann, K., Saadatmand, A., Kronlage, M., Werner, M.P., Pokrandt, B., Schreiter, F., Lin, J., Katz, D., Morgenstern, J., Elwakiel, A., Sinn, P., Gröne, H.J., Hammes, H.P., Nawroth, P.P., Isermann, B., Sticht, C., Brügger, B., Katus, H.A., Hagenmueller, M. & Backs, J. (2021)
Convergent use of phosphatidic acid for hepatitis C virus and SARS-CoV-2 replication organelle formation. Nat Commun 12, 7276. https://doi.org/10.1038/s41467-021-27511-1 Tabata, K., Prasad, V., Paul, D., Lee, J.Y., Pham, M.T., Twu, W.I., Neufeldt, C.J., Cortese, M., Cerikan, B., Stahl, Y., Joecks, S., Tran, C.S., Lüchtenborg, C., V'kovski, P., Hörmann, K., Müller, A.C., Zitzmann, C., Haselmann, U., Beneke, J., Kaderali, L., Erfle, H., Thiel, V., Lohmann, V., Superti-Furga, G., Brügger, B. & Bartenschlager, R. (2021)
Ice2 promotes ER membrane biogenesis in yeast by inhibiting the conserved lipin phosphatase complex. EMBO Journal. (abstract) Papagiannidis D, Bircham PW, Lüchtenborg C, Pajonk O, Ruffini G, Brügger B, Schuck S (2021)
Inositol triphosphate-triggered calcium release blocks lipid exchange at endoplasmic reticulum-Golgi contact sites. Nat Commun 12, 2673. https://doi.org/10.1038/s41467-021-22882-x Malek, M., Wawrzyniak, A.M., Koch, P., Lüchtenborg, C., Hessenberger, M., Sachsenheimer, T., Jang, W., Brügger, B. & Haucke, V. (2021)
Metabolic memory underlying minimal residual disease in breast cancer. Mol Syst Biol. 17: e10141. https://doi.org/10.15252/msb.202010141 Radic, S.hechter, K., Kafkia, E., Zirngibl, K., Gawrzak, S., Alladin, A., Machado, D., Lüchtenborg, C., Sévin, D.C., Brügger, B., Patil, K.R. & Jechlinger, M. (2021)
Public LC-orbitrap tandem mass spectral library for metabolite identification. Journal of Proteome Research, 20. https://doi.org/10.1021/acs.jproteome.0c00930 Phapale, P., Palmer, A., Gathungu, R.M., Kale, D., Brügger, B. & Alexandrov, T. (2021)
Stearic acid blunts growth-factor signaling via oleoylation of GNAI proteins. Nature communications, 12(1), 4590. https://doi.org/10.1038/s41467-021-24844-9 Nůsková H, Serebryakova, M.V., Ferrer-Caelles, A., Sachsenheimer, T., Lüchtenborg, C., Miller, A.K., Brügger, B., Kordyukova, L.V. & Teleman, A.A. (2021)
A novel neurodegenerative spectrum disorder in patients with MLKL deficiency. Cell Death Dis. 11(5):303.
Faergeman SL, Evans H, Attfield KE, Desel C, Kuttikkatte SB, Sommerlund M, Jensen LT, Frokiaer J, Friese MA, Matthews PM, Lüchtenborg C, Brügger B, Oturai AB, Dendrou CA, Fugger L. (2020)
Cholesterol localization around the metabotropic glutamate receptor 2, J. Phys. Chem. B 24: 9061-9078. PMID: 32954729. Kurth, M., Lolicato, F., Sandoval-Perez, A., Amaya-Espinosa, H., Teslenko, A., Sinning, I., Beck, R., Brügger B. & Aponte-Santamaria, C.A. (2020)
Dynamic palmitoylation events following T-cell receptor signaling. Commun Biol. 3(1):368.
Morrison E, Wegner T, Zucchetti AE, Álvaro-Benito M, Zheng A, Kliche S, Krause E, Brügger B, Hivroz C, Freund C. (2020)
EHD2-mediated restriction of caveolar dynamics regulates cellular fatty acid uptake. Proc Natl Acad Sci U S A. 117(13):7471-7481.
Matthaeus C, Lahmann I, Kunz S, Jonas W, Melo AA, Lehmann M, Larsson E, Lundmark R, Kern M, Blüher M, Olschowski H, Kompa J, Brügger B, Müller DN, Haucke V, Schürmann A, Birchmeier C, Daumke O. (2020)
Heme binding of transmembrane signaling proteins undergoing regulated intramembrane proteolysis. Commun Biol. 3(1):73.
Kupke T, Klare JP, Brügger B. (2020)
Membrane Biology: Disentangling Cellular Lipid Connections. Curr Biol. 30(19):R1090-R1092.
Brügger B. (2020)
Protease-resistant streptavidin for interaction proteomics. Molecular Systems Biology, 16: e9370. https://doi.org/10.15252/msb.20199370 Rafiee, M.-R., Sigismondo, G., Kalxdorf, M., Förster, L.-C., Brügger, B., Béthune, J., & Krijgsveld, J (2020)
TMEM147 interacts with Lamin B Receptor, regulates its localization and levels, and affects cholesterol homeostasis. J Cell Sci. jcs.245357.
Christodoulou A, Maimaris G, Makrigiorgi A, Charidemou E, Lüchtenborg C, Ververis A, Georgiou R, Lederer CW, Haffner C, Brügger B, Santama N. (2020)
A method for the quantitative determination of glycerophospholipid regioisomers by UPLC-ESI-MS/MS. Anal Bioanal Chem 411(4):915-924. doi: 10.1007/s00216-018-1517-5.
Wozny K, Lehmann WD, Wozny M, Akbulut BS, Brügger B. (2019)
CerS6-Derived Sphingolipids Interact with Mff and Promote Mitochondrial Fragmentation in Obesity. Cell 177 (6): 1536-1552.
Hammerschmidt P, Ostkotte D, Nolte H, Gerl, MJ, Jais A, Brunner HL, Sprenger HG, Awazawa M, Nicholls HT, Turpin-Nolan SM, Langer T, Krüger M, Brügger B, Brüning JC. (2019)
In vitro quantification of botulinum neurotoxin type A1 using immobilized nerve cell-mimicking nanoreactors in a microfluidic platform. Analyst. 144(19):5755-5765.
Weingart OG, Eyer K, Lüchtenborg C, Sachsenheimer T, Brügger B, van Oostrum M, Wollscheid B, Dittrich PS, Loessner MJ. (2019)
Loss of Neurological Disease HSAN-I-Associated Gene SPTLC2 Impairs CD8+ T Cell Responses to Infection by Inhibiting T Cell Metabolic Fitness. Immunity pii: S1074-7613(19)30095-0.
Wu J, Ma S, Sandhoff R, Ming Y, Hotz-Wagenblatt A, Timmerman V, Bonello-Palot N, Schlotter-Weigel B, Auer-Grumbach M, Seeman P, Löscher WN, Reindl M, Weiss F, Mah E, Weisshaar N, Madi A, Mohr K, Schlimbach T, Velasco Cárdenas RM, Koeppel J, Grünschläger F, Müller L, Baumeister M, Brügger B, Schmitt M, Wabnitz G, Samstag Y, Cui G. (2019)
Quantification of phosphoinositides reveals strong enrichment of PIP2 in HIV-1 compared to producer cell membranes. Sci Rep. 9(1):17661.
Mücksch F, Citir M, Lüchtenborg C, Glass B, Traynor-Kaplan A, Schultz C, Brügger B, Kräusslich HG. (2019)
Structure, Topology, and Dynamics of Membrane-Inserted Polypeptides and Lipids by Solid-State NMR Spectroscopy: Investigations of the Transmembrane Domains of the DQ Beta-1 Subunit of the MHC II Receptor and of the COP I Protein p24. Front Mol Biosci. 6:83. doi: 10.3389/fmolb.2019.00083. eCollection 2019.
Salnikov ES, Aisenbrey C, Pokrandt B, Brügger B*, Bechinger B*. (2019)
Brr6 and Brl1 locate to nuclear pore complex assembly sites to promote their biogenesis. J Cell Biol. pii: jcb.201706024. doi: 10.1083/jcb. 201706024.
Zhang W, Neuner A, Rüthnick D, Sachsenheimer T, Lüchtenborg C, Brügger B, Schiebel E. (2018)
Cutis laxa, exocrine pancreatic insufficiency and altered cellular metabolomics as additional symptoms in a new patient with ATP6AP1-CDG. Mol Genet Metab. pii: S1096-7192(17)30764-3.
Dimitrov B, Himmelreich N, Hipgrave Ederveen AL, Lüchtenborg C, Okun JG, Breuer M, Hutter AM, Carl M, Guglielmi L, Hellwig A, Thiemann KC, Jost M, Peters V, Staufner C, Hoffmann GF, Hackenberg A, Paramasivam N, Wiemann S, Eils R, Schlesner M, Strahl S, Brügger B, Wuhrer M, Christoph Korenke G, Thiel C. (2018)
Defective Mitochondrial Cardiolipin Remodeling Dampens HIF-1α Expression in Hypoxia. Cell Rep. 25(3):561-570.e6.
Chowdhury A, Aich A, Jain G, Wozny K, Lüchtenborg C, Hartmann M, Bernhard O, Balleiniger M, Alfar EA, Zieseniss A, Toischer K, Guan K, Rizzoli SO, Brügger B, Fischer A, Katschinski DM, Rehling P, Dudek J. (2018)
Inconspicuous Little Allies: How Membrane Lipids Help Modulate Protein Function. ACS Central Science 4(5), pp 530-531.
Brügger, B. (2018)
Molecular and structural architecture of polyQ aggregates in yeast. Proc Natl Acad Sci U S A. 115(15):E3446-E3453.
Gruber A, Hornburg D, Antonin M, Krahmer N, Collado J, Schaffer M, Zubaite G, Lüchtenborg C, Sachsenheimer T, Brügger B, Mann M, Baumeister W, Hartl FU, Hipp MS, Fernández-Busnadiego R. (2018)
Phospholipidation of nuclear proteins by the human papillomavirus E6 oncoprotein: implication in carcinogenesis. Oncotarget. 9(75):34142-34158.
Marx B, Hufbauer M, Zigrino P, Majewski S, Markiefka B, Sachsenheimer T, Brügger B, Akgül B. (2018)
Streptococcal Lancefield polysaccharides are critical cell wall determinants for human Group IIA secreted phospholipase A2 to exert its bactericidal effects. PLoS Pathog 14(10):e1007348.
van Hensbergen VP, Movert E, de Maat V, Lüchtenborg C, Le Breton Y, Lambeau G, Payré C, Henningham A, Nizet V, van Strijp JAG, Brügger B, Carlsson F, McIver KS, van Sorge NM. (2018)
Targeting myelin lipid metabolism as a potential therapeutic strategy in a model of CMT1A neuropathy. Nat Commun. 9(1):3025.
Fledrich R, Abdelaal T, Rasch L, Bansal V, Schütza V, Brügger B, Lüchtenborg C, Prukop T, Stenzel J, Rahman RU, Hermes D, Ewers D, Möbius W, Ruhwedel T, Katona I, Weis J, Klein D, Martini R, Brück W, Müller WC, Bonn S, Bechmann I, Nave KA, Stassart RM, Sereda MW. (2018)
Identification of a feedback loop involving beta-glucosidase 2 and its product sphingosine sheds light on the molecular mechanisms in Gaucher disease. J Biol Chem. pii: jbc.M116.762831. doi: 10.1074/jbc.M116.762831. [Epub ahead of print]
Schonauer S, Körschen HG, Penno A, Rennhack A, Breiden B, Sandhoff K, Gutbrod K, Dörmann P, Raju DN, Haberkant P, Gerl MJ, Brügger B, Zigdon H, Vardi A, Futerman AH, Thiele C, Wachten D. (2017)
Peroxisomal dysfunctions cause lysosomal storage and axonal Kv1 channel redistribution in peripheral neuropathy. Elife. 6.
Kleinecke S, Richert S, de Hoz L, Brügger B, Kungl T, Asadollahi E, Quintes S, Blanz J, McGonigal R, Naseri K, Sereda MW, Sachsenheimer T, Lüchtenborg C, Möbius W, Willison H, Baes M, Nave KA, Kassmann CM. (2017)
The host-cell restriction factor SERINC5 restricts HIV-1 infectivity without altering the lipid composition and organization of viral particles. J Biol Chem. 292(33):13702-13713.
Trautz B, Wiedemann H, Lüchtenborg C, Pierini V, Kranich J, Glass B, Kräusslich HG, Brocker T, Pizzato M, Ruggieri A, Brügger B, Fackler OT. (2017)
Transcriptomic analysis displays the effect of (-)-roemerine on the motility and nutrient uptake in Escherichia coli. Curr Genet. 63(4):709-722.
Ayyildiz D, Arga KY, Avci FG, Altinisik FE, Gurer C, Gulsoy Toplan G, Kazan D, Wozny K, Brügger B, Mertoglu B, Sariyar Akbulut B. (2017)
Bifunctional Sphingosine for Cell-Based Analysis of Protein-Sphingolipid Interactions. ACS Chemical Biology 2016 11 (1), 222-230. doi: 10.1021/acschembio.5b00810 Haberkant, P., Stein, F., Höglinger, D., Gerl, M.J., Brügger, B., Van Veldhoven, P.P., Krijgsveld, J., Gavin, A.C., & Schultz, C. (2016)
Mcp3 is a novel mitochondrial outer membrane protein that follows a unique IMP-dependent biogenesis pathway. EMBO Rep. 17(7):965-81.
Sinzel M, Tan T, Wendling P, Kalbacher H, Özbalci C, Chelius X, Westermann B, Brügger B, Rapaport D, Dimmer KS. (2016)
Morphology and Molecular Composition of Purified Bovine Viral Diarrhea Virus Envelope. PLoS Pathog. 12(3).
Callens N, Brügger B, Bonnafous P, Drobecq H, Gerl MJ, Krey T, Roman-Sosa G, Rümenapf T, Lambert O, Dubuisson J, Rouillé Y. (2016)
Phosphatase of regenerating liver (PRL)-3 disrupts epithelial architecture by altering the post-mitotic midbody position. J Cell Sci. 129(21):4130-4142.
Luján P, Varsano G, Rubio T, Hennrich ML, Sachsenheimer T, Gálvez-Santisteban M, Martín-Belmonte F, Gavin AC, Brügger B, Köhn M. (2016)
Sphingosine-1-Phosphate Lyase Deficient Cells as a Tool to Study Protein Lipid Interactions. PLOS ONE 11(4): e0153009. https://doi.org/10.1371/journal.pone.0153009 Gerl, M.J., Bittl, V., Kirchner, S., Sachsenheimer, T., Brunner, H.L., Lüchtenborg, C., Özbalci, C., Wiedemann, H., Wegehingel, S., Nickel, W., Haberkant, P., Schultz, C., Krüger, M., & Brügger, B. (2016)
α1-Antitrypsin Combines with Plasma Fatty Acids and Induces Angiopoietin-like Protein 4 Expression. J Immunol. 11. pii: 1500740.
Frenzel E, Wrenger S, Brügger B, Salipalli S, Immenschuh S, Aggarwal N, Lichtinghagen R, Mahadeva R, Marcondes AM, Dinarello CA, Welte T, Janciauskiene S. (2015)
Cardiac-specific succinate dehydrogenase deficiency in Barth syndrome. EMBO Mol Med. pii: e201505644. epub
Dudek J, Cheng IF, Chowdhury A, Wozny K, Balleininger M, Reinhold R, Grunau S, Callegari S, Toischer K, Wanders RJ, Hasenfuß G, Brügger B, Guan K, Rehling P. (2015)
Homeostasis of phospholipids - The level of phosphatidylethanolamine tightly adapts to changes in ethanolamine plasmalogens. Biochim Biophys Acta. 1851(2):117-28.
Dorninger F, Brodde A, Braverman NE, Moser AB, Just WW, Forss-Petter S, Brügger B, Berger J. (2015)
Inhibition of Ebola virus glycoprotein-mediated cytotoxicity by targeting its transmembrane domain and cholesterol. Nat Commun 6, 7688. https://doi.org/10.1038/ncomms8688 Hacke, M., Björkholm, A., Hellwig, P., Himmels, P., Ruiz de Almodóvar, C., Brügger, B., Wieland, F., & Ernst, A.M. (2015)
Quantitative analysis of the human T cell palmitome. Sci Rep. 5:11598.
Morrison E, Kuropka B, Kliche S, Brügger B, Krause E, Freund C. (2015)
Aim24 and MICOS modulate respiratory function, tafazzin-related cardiolipin modification and mitochondrial architecture. Elife. 3:e01684.
Harner ME, Unger AK, Izawa T, Walther DM, Ozbalci C, Geimer S, Reggiori F, Brügger B, Mann M, Westermann B, Neupert W. (2014)
Analysis of transmembrane domains and lipid mdified peptides with matrix-assisted laser desorption ionization-time-of-flight mass spectrometry. Anal. Chem. 86, 8, 3722–3726. https://doi.org/10.1021/ac500446z Gerl MJ, Sachsenheimer T, Grzybek M, Coskun U, Wieland FT, & Brügger B. (2014)
Differentially localized acyl-CoA synthetase 4 isoenzymes mediate the metabolic channeling of fatty acids towards phosphatidylinositol. Biochim Biophys Acta. 1841(2):227-39.
Küch EM, Vellaramkalayil R, Zhang I, Lehnen D, Brügger B, Sreemmel W, Ehehalt R, Poppelreuther M, Füllekrug J. (2014)
Identification of novel sphingolipid-binding motifs in mammalian membrane proteins. Biochimica et biophysica acta, 1838(8), 2066–2070. https://doi.org/10.1016/j.bbamem.2014.04.026 Björkholm, P., Ernst, A. M., Hacke, M., Wieland, F., Brügger, B., & von Heijne, G. (2014)
Lipidomics: analysis of the lipid composition of cells and subcellular organelles by electrospray ionization mass spectrometry. Annu Rev Biochem. 83:79-98. Review.
Brügger B. (2014)
Sphingolipids as modulators of membrane proteins. Biochim Biophys Acta. 1841(5):665-70. Review.
Ernst AM, Brügger B. (2014)
Tools to study lipid functions. Biochim Biophys Acta. 1841(8):1021.
Brügger B, Brown A. (2014)
Comparative lipidomics analysis of HIV-1 particles and their producer cell membrane in different cell lines. Cellular microbiology, 15(2), 292–304. https://doi.org/10.1111/cmi.12101 Lorizate, M., Sachsenheimer, T., Glass, B., Habermann, A., Gerl, M. J., Kräusslich, H. G., & Brügger, B. (2013)
Differential transport of Influenza A neuraminidase signal anchor peptides to the plasma membrane. FEBS letters, 587(9), 1411–1417. https://doi.org/10.1016/j.febslet.2013.03.019 Ernst, A. M., Zacherl, S., Herrmann, A., Hacke, M., Nickel, W., Wieland, F. T., & Brügger, B. (2013)
In vivo profiling and visualization of cellular protein-lipid interactions using bifunctional fatty acids. Angew Chem Int Ed Engl. 52(14):4033-8.
Haberkant P, Raijmakers R, Wildwater M, Sachsenheimer T, Brügger B, Maeda K, Houweling M, Gavin AC, Schultz C, van Meer G, Heck AJ, Holthuis JC. (2013)
Mcp1 and Mcp2, two novel proteins involved in mitochondrial lipid homeostasis. J Cell Sci. 126(Pt 16):3563-74. Tan T, Ozbalci C, Brügger B, Rapaport D, Dimmer KS. (2013)
Poxvirus membrane biogenesis: rupture not disruption. Cell Microbiol. 15(2):190-9.
Krijnse Locker J, Chlanda P, Sachsenheimer T, Brügger B. (2013)
Quantitative analysis of cellular lipids by nano-electrospray ionisation mass spectrometry. Methods Mol Biol. 1033:3-20.
Özbalci C, Sachsenheimer T, Brügger B. (2013)
Scission of COPI and COPII vesicles is independent of GTP hydrolysis. Traffic. 14(8):922-32. Adolf F, Herrmann A, Hellwig A, Beck R, Brügger B, Wieland FT. (2013)
Synthesis and biological properties of novel brefeldin A analogues. Journal of medicinal chemistry, 56(14), 5872–5884. https://doi.org/10.1021/jm400615g Seehafer K, Rominger F, Helmchen G, Langhans M, Robinson DG, Ozata B, Brügger B, Strating JR, van Kuppeveld FJ, Klein CD. (2013)
Distinct role of subcomplexes of the COPI coat in the regulation of ArfGAP2 activity. Traffic, 13(6), 849–856. https://doi.org/10.1111/j.1600-0854.2012.01349.x Pevzner, I., Strating, J., Lifshitz, L., Parnis, A., Glaser, F., Herrmann, A., Brügger, B., Wieland, F., & Cassel, D. (2012)
Ergosterol content specifies targeting of tail-anchored proteins to mitochondrial outer membranes. Mol Biol Cell. 23(20):3927-35. Krumpe K, Frumkin I, Herzig Y, Rimon N, Özbalci C, Brügger B, Rapaport D, Schuldiner M. (2012)
Impaired neurotransmission in ether lipid-deficient nerve terminals. Hum Mol Genet. 21(12):2713-24 Brodde A, Teigler A, Brugger B, Lehmann WD, Wieland F, Berger J, Just WW. (2012)
Large membrane domains in hair bundles specify spatially constricted radixin activation. J Neurosci. 32(13):4600-9. Zhao H, Williams DE, Shin JB, Brügger B, Gillespie PG. (2012)
Lipids and vesicular transport. Biochim Biophys Acta 1821(8):1039.
Brügger B, Bankaitis VA. (2012)
Molecular recognition of a single sphingolipid species by a protein's transmembrane domain. Nature, 481(7382), 525–529. https://doi.org/10.1038/nature10742 Contreras, F. X., Ernst, A. M., Haberkant, P., Björkholm, P., Lindahl, E., Gönen, B., Tischer, C., Elofsson, A., von Heijne, G., Thiele, C., Pepperkok, R., Wieland, F., & Brügger, B. (2012)
Mutual recognition of sphingolipid molecular species in membranes. Biochim Biophys Acta 1818(11):2616-2622. Ernst AM, Contreras FX, Thiele C, Wieland F, Brügger B. (2012)
Quantification of Signaling Lipids by Nano-Electrospray Ionization Tandem Mass Spectrometry (Nano-ESI MS/MS). Metabolites 2(1), 57-76.
Haag M, Schmidt, A, Sachsenheimer, T, Brügger B. (2012)
Sphingomyelin organization is required for vesicle biogenesis at the Golgi complex. The EMBO journal, 31(24), 4535–4546. https://doi.org/10.1038/emboj.2012.317 Duran, J. M., Campelo, F., van Galen, J., Sachsenheimer, T., Sot, J., Egorov, M. V., Rentero, C., Enrich, C., Polishchuk, R. S., Goñi, F. M., Brügger, B., Wieland, F., & Malhotra, V. (2012)
The Structures of COPI-Coated Vesicles Reveal Alternate Coatomer Conformations and Interactions. Science 336(6087): 1451-4. Faini M, Prinz S, Beck R, Schorb M, Riches JD, Bacia K, Brügger B, Wieland FT, Briggs JA. (2012)
A global circadian repressor controls antiphasic expression of metabolic genes in Neurospora. Mol Cell. 2011; doi:10.1016/j.molcel.2011.10.019. Sancar, G., Sancar, C., Brügger, B., Ha, N., Sachsenheimer, T., Gin, E., Wdowik, S., Lohmann, I., Wieland, F., Höfer, T., Diernfellner, A. and Brunner, M. (2011)
Biochemical and morphological properties of hepatitis C virus particles and determination of their lipidome. J Biol Chem. 286(4):3018-32. Merz A, Long G, Hiet MS, Brügger B, Chlanda P, Andre P, Wieland F, Krijnse-Locker J, Bartenschlager R. (2011)
Coatomer and dimeric ADP ribosylation factor 1 promote distinct steps in membrane scission. J Cell Biol. 194(5):765-77. Beck R, Prinz S, Diestelkötter-Bachert P, Röhling S, Adolf F, Hoehner K, Welsch S, Ronchi P, Brügger B, Briggs JA, Wieland F. (2011)
COPI Budding within the Golgi Stack. Cold Spring Harb Perspect Biol. 3(11). Review. Popoff V, Adolf F, Brügger B, Wieland F. (2011)
Encephalopathy caused by ablation of very long acyl chain ceramide synthesis may be largely due to reduced galactosylceramide levels. J Biol Chem. 286(34):30022-33. Ben-David O, Pewzner-Jung Y, Brenner O, Laviad EL, Kogot-Levin A, Weissberg I, Biton IE, Pienik R, Wang E, Kelly S, Alroy J, Raas-Rothschild A, Friedman A, Brügger B, Merrill AH Jr, Futerman AH. (2011)
GAPs in the context of COPI: Enzymes, coat components or both? Cell Logist. 1(2):52-54. Review. Beck R, Brügger B, Wieland F. (2011)
Glucocorticoid Activity during Lung Maturation Is Essential in Mesenchymal and Less in Alveolar Epithelial Cells. Mol Endocrinol. 25(8):1280-8. Habermehl D, Parkitna JR, Kaden S, Brügger B, Wieland F, Gröne HJ, Schütz G. (2011)
Human regulatory T cells rapidly suppress T Cell Receptor-induced calcium signals, NF-κB and NFAT activation in conventional CD4+CD25- T cells. Sci Signal. ra90 DOI: 10.1126/scisignal.2002179 Schmidt, A, Oberle, N, Weiß, EM, Vobis, D, Frischbutter, S, Baumgrass, R, Falk, CS, Haag, M, Brügger, B, Lin, H, Mayr, GW, Reichardt, P, Gunzer, M, Suri-Payer E, Krammer PH. (2011)
Peroxisomal alterations in Alzheimer's disease. Acta Neuropathol. 122(3):271-83. Kou J, Kovacs GG, Höftberger R, Kulik W, Brodde A, Forss-Petter S, Hönigschnabl S, Gleiss A, Brügger B, Wanders R, Just W, Budka H, Jungwirth S, Fischer P, Berger J. (2011)
Phenotypic profiling of the human genome reveals gene products involved in plasma membrane targeting of SRC kinases. Genome Res. 21(11):1955-68. Ritzerfeld J, Remmele S, Wang T, Temmerman K, Brügger B, Wegehingel S, Tournaviti S, Strating JR, Wieland FT, Neumann B, Ellenberg J, Lawerenz C, Hesser J, Erfle H, Pepperkok R, Nickel W. (2011)
Recombinant heptameric coatomer complexes: novel tools to study isoform-specific functions. Traffic 12(6):682-92 Sahlmüller MC, Strating JR, Beck R, Eckert P, Popoff V, Haag M, Hellwig A, Berger I, Brügger B, Wieland FT. (2011)
Self-segregation of myelin membrane lipids in model membranes. Biophys J. 101(11):2713-20. Yurlova L, Kahya N, Aggarwal S, Kaiser HJ, Chiantia S, Bakhti M, Pewzner-Jung Y, Ben-David O, Futerman AH, Brügger B, Simons M. (2011)
Several ADP-ribosylation factor (Arf) isoforms support COPI vesicle formation. J Biol Chem. 286(41):35634-42. Popoff V, Langer JD, Reckmann I, Hellwig A, Kahn RA, Brügger B, Wieland FT. (2011)
Specificity of intramembrane protein-lipid interactions. Cold Spring Harb Perspect Biol. 3(6). pii: a004705. Review. Contreras FX, Ernst AM, Wieland F, Brügger B. (2011)
Structural and biochemical consequences of NF1 associated nontruncating mutations in the Sec14-PH module of neurofibromin. Hum Mutat. 32(2):191-7. Welti S, Kühn S, D'Angelo I, Brügger B, Kaufmann D, Scheffzek K. (2011)
A critical role for ceramide synthase 2 in liver homeostasis: I. alterations in lipid metabolic pathways. J Biol Chem. 285(14):10902-10. Pewzner-Jung Y, Park H, Laviad EL, Silva LC, Lahiri S, Stiban J, Erez-Roman R, Brügger B, Sachsenheimer T, Wieland F, Prieto M, Merrill AH Jr, Futerman AH. (2010)
A mitochondrial phosphatase required for cardiolipin biosynthesis: the PGP phosphatase Gep4. EMBO J. 29(12):1976-87. Osman C, Haag M, Wieland FT, Brügger B, Langer T. (2010)
Determinants of specificity at the protein-lipid interface in membranes. FEBS Lett. 584(9):1713-20. Review. Ernst AM, Contreras FX, Brügger B, Wieland F. (2010)
Genetic evidence for functional interaction of the Escherichia coli signal recognition particle receptor with acidic lipids in vivo. J Biol Chem. 285(52):40508-14. Erez E, Stjepanovic G, Zelazny AM, Brügger B, Sinning I, Bibi E. (2010)
Membrane deformation and separation. F1000 Biol Rep. 2. pii: 35. Beck R, Brügger B, Wieland FT. (2010)
Sphingolipid rheostat alterations related to transformation can be exploited for specific induction of lysosomal cell death in murine and human glioma. Glia 58(11):1364-83. Mora R, Dokic I, Kees T, Hüber CM, Keitel D, Geibig R, Brügger B, Zentgraf H, Brady NR, Régnier-Vigouroux A. (2010)
ArfGAP1 activity and COPI vesicle biogenesis. Traffic. 10(3):307-15. Beck R, Adolf F, Weimer C, Bruegger B, Wieland FT. (2009)
Cholesterol regulates the endoplasmic reticulum exit of the major membrane protein P0 required for peripheral myelin compaction. J Neurosci. 29(19):6094-104. Saher G, Quintes S, Möbius W, Wehr MC, Krämer-Albers EM, Brügger B, Nave KA. (2009)
Following the fate in vivo of COPI vesicles generated in vitro. Traffic. 10(8):994-1005. Rutz C, Satoh A, Ronchi P, Brügger B, Warren G, Wieland FT. (2009)
Probing HIV-1 membrane liquid order by Laurdan staining reveals producer cell-dependent differences. J Biol Chem. 284(33):22238-47. Lorizate M, Brügger B, Akiyama H, Glass B, Müller B, Anderluh G, Wieland FT, Kräusslich HG. (2009)
The genetic interactome of prohibitins: coordinated control of cardiolipin and phosphatidylethanolamine by conserved regulators in mitochondria. J Cell Biol. 184(4):583-96. Osman C, Haag M, Potting C, Rodenfels J, Dip PV, Wieland FT, Brügger B, Westermann B, Langer T. (2009)
A conformational change in the alpha-subunit of coatomer induced by ligand binding to gamma-COP revealed by single-pair FRET. Traffic 9, 597-607. https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1600-0854.2007.00697.x Langer, JD, Roth, CM, Béthune, J, Stoops, EH, Brügger, B, Herten, DP, and Wieland, FT* (2008)
Ceramide triggers budding of exosome vesicles into multivesicular endosomes. Science. 319(5867):1244-7. Trajkovic K, Hsu C, Chiantia S, Rajendran L, Wenzel D, Wieland F, Schwille P, Brügger B, Simons M. (2008)
Differential roles of ArfGAP1, ArfGAP2, and ArfGAP3 in COPI trafficking. J Cell Biol. 183(4):725-35. Weimer C, Beck R, Eckert P, Reckmann I, Moelleken J, Brügger B, Wieland F. (2008)
Membrane curvature induced by Arf1-GTP is essential for vesicle formation. Proc Natl Acad Sci U S A 105, 11731-11736. → Highlighted by the Faculty of 1000 (F1000.com/1119165). http://www.pnas.org/content/105/33/11731 Beck, R, Sun, Z, Adolf, F, Rutz, C, Bassler, J, Wild, K, Sinning, I, Hurt, E, Brügger, B, Béthune, J*, and Wieland, F* (2008)
Mutation of a single residue, beta-glutamate-20, alters protein-lipid interactions of light harvesting complex II. Mol Microbiol. 67(1):63-77. Kwa LG, Wegmann D, Brügger B, Wieland FT, Wanner G, Braun P. (2008)
Protein-sphingolipid interactions within cellular membranes. J Lipid Res. 49(1):251-62. Haberkant P, Schmitt O, Contreras FX, Thiele C, Hanada K, Sprong H, Reinhard C, Wieland FT, Brügger B. (2008)
Axonal loss and neuroinflammation caused by peroxisome-deficient oligodendrocytes. Nat Genet. 39(8):969-76.
Kassmann CM, Lappe-Siefke C, Baes M, Brügger B, Mildner A, Werner HB, Natt O, Michaelis T, Prinz M, Frahm J, Nave KA. (2007)
Differential localization of coatomer complex isoforms within the Golgi apparatus. Proc Natl Acad Sci USA 104(11):4425-30.
Moelleken J, Malsam J, Betts MJ, Movafeghi A, Reckmann I, Meissner I, Hellwig A, Russell RB, Söllner T, Brügger B, Wieland FT. (2007)
Human immunodeficiency virus type 1 Nef protein modulates the lipid composition of virions and host cell membrane microdomains. Retrovirology 4:70.
Brügger B, Krautkrämer E, Tibroni N, Munte CE, Rauch S, Leibrecht I, Glass B, Breuer S, Geyer M, Kräusslich HG, Kalbitzer HR, Wieland FT, Fackler OT. (2007)
Multiple and stepwise interactions between coatomer and ADP-ribosylation factor-1 (Arf1)-GTP. Traffic 8(5):582-93.
Sun Z, Anderl F, Fröhlich K, Zhao L, Hanke S, Brügger B, Wieland F, Béthune J. (2007)
The structure of the regulatory domain of the adenylyl cyclase Rv1264 from Mycobacterium tuberculosis with bound oleic acid. J Mol Biol. 369(5):1282-95.
Findeisen F, Linder JU, Schultz A, Schultz JE, Brügger B, Wieland F, Sinning I, Tews I. (2007)
Coatomer, the coat protein of COPI transport vesicles, discriminates endoplasmic reticulum residents from p24 proteins. Mol Cell Biol. 26(21):8011-21.
Béthune J, Kol M, Hoffmann J, Reckmann I, Brügger B, Wieland F. (2006)
Molecular anatomy of a trafficking organelle. Cell 127(4):831-46. Takamori S, Holt M, Stenius K, Lemke EA, Grønborg M, Riedel D, Urlaub H, Schenck S, Brügger B, Ringler P, Müller SA, Rammner B, Gräter F, Hub JS, De Groot BL, Mieskes G, Moriyama Y, Klingauf J, Grubmüller H, Heuser J, Wieland F, Jahn R. (2006)
The HIV lipidome: a raft with an unusual composition. Proc Natl Acad Sci USA 103(8):2641-6.
Brügger B, Glass B, Haberkant P, Leibrecht I, Wieland FT, Kräusslich HG. (2006)
High cholesterol level is essential for myelin membrane growth. Nat Neurosci. 8(4):468-75. Saher G, Brügger B, Lappe-Siefke C, Möbius W, Tozawa R, Wehr MC, Wieland F, Ishibashi S, Nave KA. (2005)
Identification and biophysical characterization of a very-long-chain-fatty-acid-substituted phosphatidylinositol in yeast subcellular membranes. Biochem. J. 381:941-949. R. Schneiter, B. Brügger, C. M. Amann, G. D. Prestwich, R. F. Epand, G. Zellnig, F. T. Wieland, and R. M. Epand. (2004)
Mechanismen der COPI-Vesikelbiogenese. Biospektrum I, 30-33 (Review). B. Brügger and F. T. Wieland (2004)
The membrane domains occupied by glycosylphosphatidylinositol-anchored prion protein and Thy-1 differ in lipid composition. J Biol Chem. 279(9):7530-6. Brügger B, Graham C, Leibrecht I, Mombelli E, Jen A, Wieland F, Morris R. (2004)
Unconventional secretion of fibroblast growth factor 2 is mediated by direct translocation across the plasma membrane of mammalian cells. J Biol Chem. 279(8):6244-51. Schäfer T, Zentgraf H, Zehe C, Brügger B, Bernhagen J, Nickel W. (2004)
Formation and nuclear export of tRNA, rRNA and mRNA is regulated by the ubiquitin ligase Rsp5p. EMBO Rep. 4(12):1156-62. Neumann S, Petfalski E, Brügger B, Grosshans H, Wieland F, Tollervey D, Hurt E. (2003)
Glutamate binding affinity of Drosophila metabotropic glutamate receptor is modulated by association with lipid rafts. Proc. Natl. Acad. Sci. USA 100: 10219-10224. Eroglu, C., Brügger, B., Wieland, F. & Sinning, I. (2003)
Inactivation of ether lipid biosynthesis causes male infertility, defects in eye development and optic nerve hypoplasia in mice. Hum Mol Genet. 12(15):1881-95. Rodemer C, Thai TP, Brügger B, Kaercher T, Werner H, Nave KA, Wieland F, Gorgas K, Just WW. (2003)
Intra-Golgi protein transport depends on a cholesterol balance in the lipid membrane. J Biol Chem. 278(52):53112-22. Stüven E, Porat A, Shimron F, Fass E, Kaloyanova D, Brügger B, Wieland FT, Elazar Z, Helms JB. (2003)
Targeted Disruption Of Ether Lipid Synthesis In Mice. In: Roels F., Baes M., De Bie S. (eds) Peroxisomal Disorders and Regulation of Genes. Advances in Experimental Medicine and Biology, vol 544. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9072-3_46 Rodemer C, Thai TP, Brügger B, Gorgas K, Just W. (2003)
Oligomeric state and stoichiometry of p24 proteins in the early secretory pathway. J Biol Chem. 277(48):46504-11. Jenne N, Frey K, Brügger B, Wieland FT. (2002)
The Sur7p family defines novel cortical domains in Saccharomyces cerevisiae, affects sphingolipid metabolism, and is involved in sporulation. Mol Cell Biol. 22(3):927-34. Young ME, Karpova TS, Brügger B, Moschenross DM, Wang GK, Schneiter R, Wieland FT, Cooper JA. (2002)
Vesicular transport: the core machinery of COPI recruitment and budding. J Cell Sci. 115(Pt 16):3235-40. Review. Nickel W, Brügger B, Wieland FT. (2002)
A t-SNARE of the endocytic pathway must be activated for fusion. J Cell Biol. 155(6):961-8. Paumet F, Brügger B, Parlati F, McNew JA, Söllner TH, Rothman JE. (2001)
Membrane Trafficking: How Transport Vesicles Fuse With Target Membranes in "Protein Modules in Cellular Signalling", eds Heilmeyer L. and Friedrich P. (IOS Press Amsterdam), pp. 257-261 (Review). Walter Nickel, Britta Brügger and Felix T. Wieland (2001)
Molecular Mechanisms of COPI Vesicle Formation in "Protein Modules in Cellular Signalling", eds. Heilmeyer L. and Friedrich P. (IOS Press Amsterdam), pp. 262-267 (Review). Britta Brügger, Walter Nickel, and Felix T. Wieland (2001)
Sphingomyelin-enriched microdomains at the Golgi complex. Mol Biol Cell 12(6):1819-33. Gkantiragas I, Brügger B, Stüven E, Kaloyanova D, Li XY, Löhr K, Lottspeich F, Wieland FT, Helms JB. (2001)
Evidence for segregation of sphingomyelin and cholesterol during formation of COPI-coated vesicles. J Cell Biol. 151(3):507-18. Brügger B, Sandhoff R, Wegehingel S, Gorgas K, Malsam J, Helms JB, Lehmann WD, Nickel W, Wieland FT. (2000)
Megavesicles implicated in the rapid transport of intracisternal aggregates across the Golgi stack. Cell 102(3):335-48.
Volchuk A, Amherdt M, Ravazzola M, Brügger B, Rivera VM, Clackson T, Perrelet A, Söllner TH, Rothman JE, Orci L. (2000)
Putative fusogenic activity of NSF is restricted to a lipid mixture whose coalescence is also triggered by other factors. EMBO J. 19(6):1272-8. Brügger B, Nickel W, Weber T, Parlati F, McNew JA, Rothman JE, Söllner T. (2000)
COPI-Mediated Protein and Lipid Sorting. Protoplasma 207:115-124 (Review). Walter Nickel and Britta Brügger (1999)
Determination of cholesterol at the low picomole level by nano-electrospray ionization tandem mass spectrometry. J Lipid Res. 40(1):126-32. Sandhoff R, Brügger B, Jeckel D, Lehmann WD, Wieland FT. (1999)
Electrospray ionization tandem mass spectrometry (ESI-MS/MS) analysis of the lipid molecular species composition of yeast subcellular membranes reveals acyl chain-based sorting/remodeling of distinct molecular species en route to the plasma membrane. J Cell Biol. 146(4):741-54. Schneiter R, Brügger B, Sandhoff R, Zellnig G, Leber A, Lampl M, Athenstaedt K, Hrastnik C, Eder S, Daum G, Paltauf F, Wieland FT, Kohlwein SD. (1999)
Maturation of the axonal plasma membrane requires upregulation of sphingomyelin synthesis and formation of protein-lipid complexes. EMBO J. 18(7):1761-71. Ledesma MD, Brügger B, Bünning C, Wieland FT, Dotti CG. (1999)
Receptor induced polymerisation of coatomer. Proc. Natl. Acad. Sci U.S.A. 96, 1224-1228. C. Reinhard, C. Harter, M. Bremser, B. Brügger, K. Sohn. B. Helms, and F. Wieland (1999)
A putative heterotrimeric G protein inhibits the fusion of COPI-coated vesicles. Segregation of heterotrimeric G proteins from COPI-coated vesicles. J Biol Chem. 273(24):15203-8. Helms JB, Helms-Brons D, Brügger B, Gkantiragas I, Eberle H, Nickel W, Nürnberg B, Gerdes HH, Wieland FT. (1998)
Intracellular Transport of Glycoproteins and Glycolipids. Trends Glycosci. Glycotechnolog. 10:1-11 (Review). Walter Nickel, Britta Brügger, and Felix T. Wieland (1998)
Protein and lipid sorting between the endoplasmic reticulum and the Golgi complex. Semin Cell Dev Biol. 9(5):493-501. Review. Nickel W, Brügger B, Wieland FT. (1998)
Direct and GTP-dependent interaction of ADP ribosylation factor 1 with coatomer subunit beta. Proc Natl Acad Sci USA 94(9):4418-23. Zhao L, Helms JB, Brügger B, Harter C, Martoglio B, Graf R, Brunner J, Wieland FT. (1997)
Quantitative analysis of biological membrane lipids at the low picomole level by nano-electrospray ionization tandem mass spectrometry. Proc Natl Acad Sci USA 94(6):2339-44. Brügger B, Erben G, Sandhoff R, Wieland FT, Lehmann WD. (1997)
Variable nuclear cytoplasmic distribution of the 11.5-kDa zinc-binding protein (parathymosin-alpha) and identification of a bipartite nuclear localization signal. J Biol Chem. 271(2):1187-93.
Trompeter HI, Blankenburg G, Brügger B, Menne J, Schiermeyer A, Scholz M, Söling HD. (1996)
Collaborations
Collaborations
- Ralf Bartenschlager, Heidelberg, Germany
- Burkhard Bechinger, Strasbourg, France
- Michael Boutros, Heidelberg, Germany
- Oliver Fackler, Heidelberg, Germany
- Christian Freund, Berlin, Germany
- Jacomine Krijnse-Locker, Paris, France
- Hans-Georg Kräusslich, Heidelberg, Germany
- Daniela Mauceri, Heidelberg, Germany
- Klaus-Armin Nave, Göttingen, Germany
- Peter Rehling, Göttinen, Germany
- Carsten Schultz, Portland, USA
- Michael Sereda, Göttingen, Germany
- Christian Thiel, Heidelberg, Germany
- Christoph Thiele, Bonn, Germany
Funding
Funding
- SFB 1129
- SFB 1324
- SFB TRR 83
- SFB TRR 186
- FOR 2509
Open Positions
Contact
Sprechstunde: Mittwochs, 8 - 9 Uhr; Anmeldung mit kurzer Beschreibung des Anliegens über monika.bertram@bzh.uni-heidelberg.de
Heidelberg University
Biochemistry Center (BZH)
Im Neuenheimer Feld 328
69120 Heidelberg
Biochemistry Center (BZH)
Im Neuenheimer Feld 328
69120 Heidelberg
Office:
+49 6221 54-5326 Fax:
+49 6221 54-4486 E-Mail:
britta.bruegger@bzh.uni-heidelberg.deSecretary: Monika Bertram
Office:
+49 6221 54-4152 Fax:
+49 6221 54-4486 E-Mail:
monika.bertram@bzh.uni-heidelberg.de