Research Group Leaders

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Publications

|2026|
Membrane curvature regulates Ups1 dependent phosphatidic acid transfer across lipid bilayers. (2026) Sadeqi, F., Dong, D., Stroh, K., Vache, M., Metz, J., Riedel, D., Janshoff, A., Risselada, H.J., Kolenda, C. And Meinecke , M. eLife https://elifesciences.org/reviewed-preprints/106979
 

|2025|
The Core MICOS Complex Subunit mic60 has Been Substituted by Two Cryptic Mitofilin-containing Proteins in Euglenozoa. (2025) Sheikh, D., Turpin Knotkova, B., Benz, C., Elias, M., Bily, T., Bondar, A., Tesarova, M., Stribrna, E., Heller, J., Meinecke, M. and Hashimi, H. Mol Biol Evol. https://academic.oup.com/mbe/article/42/11/msaf289/8317773?login=true
 
 
|2024|

Drosophila MIC10b can polymerize into cristae-shaping filaments. (2024) Stephan, T., S. Stoldt, M. Barbot, T.D. Carney, F. Lange, M. Bates, P. Bou Dib, K. Inamdar, H.R. Shcherbata, M. Meinecke, D. Riedel, S. Dennerlein, P. Rehling, and S. Jakobs. Life Sci Alli https://www.life-science-alliance.org/content/7/4/e202302177

 
|2023|
Metamorphic proteins at the basis of human autophagy initiation and lipid transfer. (2023) Nguyen A., Lugarini F., David C., Hosnani P., Alagöz C., Friedrich A., Schlütermann D., Knotkova B., Patel A., Parfentev I., Urlaub H., Meinecke M., Stork B., Faesen A. Mol Cell https://www.sciencedirect.com/science/article/pii/S1097276523003210


|2022|
Regulation of mitochondrial proteostasis by the proton gradient. (2022) Patron M., Tarasenko D.,  Nolte H., Kroczek L., Ghosh M., Ohba Y., Lasarzewski Y, Alsadat Ahmadi Z., Cabrera-Orefice A., Eyiama A, Kellermann T., Rugarli EI. , Brandt U., Meinecke M., Langer T. EMBO Journal https://www.embopress.org/doi/full/10.15252/embj.2021110476

Dynamics of the translocation pore of the human peroxisomal protein import machinery. (2022) Ghosh M., Denkert N., Reuter M., Klümper J., Reglinski K., Peschel R., Schliebs W., Erdmann R., Meinecke M. Biological Chemistry doi.org/10.1515/hsz-2022-0170


|2021|
Cooperativity of membrane‑protein and protein–protein interactions control membrane remodeling by epsin 1 and affects clathrin‑mediated endocytosis. (2021) Kroppen B., Teske N., Yambire K.F., Denkert N., Mukherjee I., Tarasenko D., Jaipura G., Zweckstetter M., Milosevic I., Steinem C., Meinecke M. Cellular and Molecular Life Sciences 78(5):2355-2370

MICOS and the mitochondrial inner membrane morphology – when things get out of shape. (2021) Mukherjee I., Ghosh M., Meinecke M. FEBS Letters 595:1159-1183

Protein-dependent membrane remodeling in mitochondrial morphology and clathrin-mediated endocytosis. (2021) Tarasenko D., Meinecke M. European Biophysics Journal https://doi.org/10.1039/C9SM02437A
 
ENTH domain-dependent membrane remodelling. (2021) Steinem C., Meinecke M. Soft Matter 17(2):233-240
 
|2020|
Hrd1 forms the retrotranslocation pore regulated by auto-ubiquitination and binding of misfolded proteins. (2020) Vasic V., Denkert N., Schmidt C., Riedel D., Stein A., Meinecke M. Nature Cell Biology 22(3):274-281

Atg21 organizes Atg8 lipidation at the contact of the vacuole with the phagophore. (2020) Munzel L., Neumann P., Otto F.B., Krick R., Metje-Sprink J., Kroppen B., Karedla N., Enderlein J., Meinecke M., Ficner R., Thumm M. Autophagy https://doi.org/10.1080/15548627.2020.1766332

PI(4,5)P2-dependent regulation of exocytosis by amisyn, the vertebrate-specific competitor of synaptobrevin 2. (2020) Kondratiuk I., Jakhanwal S., Jin J., Sathyanarayanan U., Kroppen B., Pobbati A.V., Krisko A., Ashery U., Meinecke M., Jahn R., Fasshauer D., Milosevic I. PNAS https://doi.org/10.1073/pnas.1908232117
 
|2019|
JASSY - a Chloroplast Outer Membrane Protein Required for Jasmonate Biosynthesis. (2019) Guan L., Denkert N., Eisa A., Lehmann M., Sjuts I., Weiberg A, Soll J., Meinecke M., Schwenkert S. PNAS 116, 10568-10575
 
|2017|
The MICOS component Mic60 displays a conserved membrane-bending activity that is necessary for normal cristae morphology. (2017) Tarasenko D., Barbot M., Jans D.C., Kroppen B., Sadowski B., Heim G., Möbius W., Jakobs S., Meinecke M. Journal of Cell Biology 216, 889-899

Cation selectivity of the presequence translocase channel Tim23 is crucial for efficient protein import. (2017) Denkert N., Schendzielorz A.B., Barbot M., Versemann L., Richter F., Rehling P., Meinecke M. ELife pii: e28324. doi: 10.7554/eLife.28324
 
|2016|
Epsin N-terminal homology domain (ENTH) activity as a function of membrane tension. (2016) Gleisner M., Kroppen B., Fricke C., Kliesch T.T., Janshoff A., Meinecke M.*, Steinem C.* Journal of Biological Chemistry 291, 19953-19961 (*corresponding authors)

Reconstitutions of mitochondrial inner membrane remodeling. (2016) Barbot M., Meinecke M. Journal of Structural Biology 196, 20-28

|2015|
Mic10 oligomerizes to bend mitochondrial inner membranes at cristae junctions. (2015) Barbot M, Jans D, Schulz C, Denkert N, Kroppen B, Hoppert M, Jakobs S, Meinecke M. Cell Metabolism 5, 756-763

Distinct pores for peroxisomal import of PTS1 and PTS2 proteins. (2015) Montilla-Martinez M, Beck S, Meinecke M, Schliebs W, Wagner R, Erdmann R. Cell Reports 13, 2126-2134

Peroxisomal Protein Import Pores. (2015) Meinecke M*, Bartsch P, Wagner R. BBA Molecular Cell Research 1863(5), 821-827 (*corresponding author)

|2014|
Driving a Planar Model System into the 3rd Dimension: Generation and Control of Curved Pore-Spanning Membrane Arrays. (2014) Gleisner M, Mey I, Barbot M, Dreker C, Meinecke M, Steinem C. Soft Matter 10, 6228-6236

|2013|
Cooperative recruitment of Dynamin and BAR domain-containing proteins leads to GTP-dependent membrane scission. (2013) Meinecke M*, Boucrot E, Camdere G, Hon WC, Mittal R, McMahon HT.* Journal of Biological Chemistry 288, 6651-6661 (*corresponding authors)

Preferential targeting of mitotic cells by Salmonella reveals that cell surface cholesterol is maximal during metaphase. (2013) Santos AJM, Meinecke M, Fessler MB, Holden DW, Boucrot E. Journal of Cell Science 126, 2990-2996

|2012|
The channel-forming Sym1 protein is transported by the TIM23 complex in a presequence-independent manner. (2012) Reinhold R, Krüger V, Meinecke M, Schulz C, Schmidt B, Guiard B, Wiedemann N, van der Laan M, Wagner R, Rehling P. Molecular and Cellular Biology 32, 5009-5021

The mitochondrial Oxa1 insertase forms a membrane pore in lipid bilayers. (2012) Krüger V, Deckers M, Hildenbeutel M, van der Laan M, Hellmers M, Dreker C, Preuss M, Herrmann JM, Rehling P, Wagner R, Meinecke M. Journal of Biological Chemistry 287, 33314-33326

Impacts of the osmolality and the luminal ionic strength on osmosensory transporter ProP in proteoliposomes. (2012) Culham DE, Meinecke M, Wood JM. Journal of Biological Chemistry 287, 27813-27822

Helicobacter pylori VacA: A new perspective on an invasive chloride channel. (2012) Rassow J, Meinecke M. Microbes and Infection 14, 1026-1033

|2010|
The Peroxisomal Importomer Constitutes a Large and Highly Dynamic Pore. (2010) Meinecke M, Cizmowski C, Schliebs W, Krüger V, Beck S, Wagner R, Erdmann R. Nature Cell Biology 12, 273 – 277

FCHo proteins are nucleators of clathrin-mediated endocytosis. (2010) Henne WH, Boucrot E, Meinecke M, Evergren E, Vallis Y, Mittal R, McMahon HT. Science 328, 1281-1284

Helicobacter pylori VacA Toxin/Subunit p34: Mitochondrial Targeting of a Proapoptotic Anion Channel. (2010) Domańska G*, Motz C*, Meinecke M*, Harsman A, Papatheodorou P, Reljic B, Dian-Lothrop EA, Galmiche A, Kepp O, Becker L, Günnewig K, Wagner R, Rassow J. PLoS Pathogens 6(4): e1000878. Doi:10.1371/ppat.1000878 (*authors contributed equally to this work)

|2009|
Bacterial Porin Disrupts Mitochondrial Membrane Potential and Sensitizes Host Cells to Apoptosis. (2009) Kozjak-Pavlovic V*, Dian EA.*, Meinecke M*, Kepp O*, Ross K, Rajalingam K, Harsman A, Hauf E, Brinkmann V, Herrmann I, Günther D, Hurwitz R, Rassow J, Wagner R, Rudel T. PLoS Pathogens 5(10): e1000629. doi:10.1371/journal.ppat.1000629 (*authors contributed equally to this work)

|2008|
The Mitochondrial β-Signal and Protein Sorting. (2008) Kutik S, Stojanovski D, Becker T, Stoud DA, Becker L, Meinecke M, Krüger V, Prinz C, Guiard B, Wagner R, Meisinger C, Pfanner N, Wiedemann N. Cell 135, 1159-1160

Dissecting membrane insertion of mitochondrial beta-barrel proteins. (2008) Kutik S, Stojanovski D, Becker L, Becker T, Meinecke M, Krüger V, Prinz C, Meisinger C, Guiard B, Wagner R, Pfanner N, Wiedemann N. Cell 132, 1011-1024

|2007|
Motor-free mitochondrial presequence translocase drives membrane integration of preproteins. (2007) van der Laan M, Meinecke M, Dudek J, Hutu DP, Lind M, Perschil I, Guiard B, Wagner R, Pfanner N, Rehling P. Nature Cell Biology 9, 1155-1159

|2006|
Tim50 Maintains the Permeability Barrier of the Mitochondrial Inner Membrane. (2006) Meinecke M, Wagner R, Kovermann P, Guiard B, Mick DU, Hutu DP, Voos W, Truscott K, Chacinska A, Pfanner N, Rehling P. Science 312, 1523-1526