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New Publication from Sinning Group: Insights into splicing quality control: how cells avoid errors in the production of mRNA
Date: January 27, 2025Published: 20 January 2025
The spliceosome is complex molecular machine, which ensures that the genetic information of the DNA - after transcription into a pre-mRNA - is correctly spliced (cut and reassembled) to the mature mRNA required for the production of proteins. The team of Prof. Sinning from the Heidelberg University Biochemistry Center (BZH) succeeded for the first time in depicting a faultily 'blocked' spliceosome at high resolution and reconstructing how it is recognized and eliminated in the cell. These mechanistic studies were carried out in collaboration with colleagues at the Australian National University.
Publication: K. Soni*, A. Horvath, O. Dybkov, M. Schwan, S. Trakansuebkul, D. Flemming, K. Wild, H. Urlaub, T. Fischer* & I. Sinning*: Structures of aberrant spliceosome intermediates on their way to disassembly. Nature Structural & Molecular Biology (20 January 2025) [Abstract]
The spliceosome is complex molecular machine, which ensures that the genetic information of the DNA - after transcription into a pre-mRNA - is correctly spliced (cut and reassembled) to the mature mRNA required for the production of proteins. The team of Prof. Sinning from the Heidelberg University Biochemistry Center (BZH) succeeded for the first time in depicting a faultily 'blocked' spliceosome at high resolution and reconstructing how it is recognized and eliminated in the cell. These mechanistic studies were carried out in collaboration with colleagues at the Australian National University.
Publication: K. Soni*, A. Horvath, O. Dybkov, M. Schwan, S. Trakansuebkul, D. Flemming, K. Wild, H. Urlaub, T. Fischer* & I. Sinning*: Structures of aberrant spliceosome intermediates on their way to disassembly. Nature Structural & Molecular Biology (20 January 2025) [Abstract]
