2020
Upadhyay, A., Marzoll, D., Diernfellner, A., Brunner, M. and Herzel, H. (2020). Multiple random phosphorylations in clock proteins provide long delays and switches. Sci Rep 10, 22224
Diernfellner, A. C. R., and Brunner, M. (2020) Phosphorylation Timers in the Neurospora crassa Circadian Clock. J Mol Biol 432, 3449-3465
2019
Shostak, A., Schermann, G., Diernfellner, A., & Brunner, M. (2019). MXD/MIZ1 complexes activate transcription of MYC-repressed genes. BioRxiv, 842799
Upadhyay, A., Brunner, M., and Herzel, H. (2019) An Inactivation Switch Enables Rhythms in a Neurospora Clock Model. Int J Mol Sci 20
Singh, A., Schermann, G., Reislöhner, S., Kellner,N., Hurt, E., Brunner, M. (2019) Global Transcriptome Characterization and Assembly of Thermophilic Ascomycete Chaetomium thermophilum. doi: https://doi.org/10.1101/826354
Shostak, A., and Brunner, M. (2019) Help from my friends-cooperation of BMAL1 with noncircadian transcription factors. Genes Dev 33, 255-257
Diernfellner, A. C. R., Lauinger, L., Shostak, A., and Brunner, M. (2019) A pathway linking translation stress to checkpoint kinase 2 signaling in Neurospora crassa. Proc Natl Acad Sci U S A 116, 17271-17279
2018
Li, C., Cesbron, F., Oehler, M., Brunner, M., and Hofer, T. (2018) Frequency Modulation of Transcriptional Bursting Enables Sensitive and Rapid Gene Regulation. Cell Syst 6, 409-423 e411
Ananthasubramaniam, B., Diernfellner, A., Brunner, M., and Herzel, H. (2018) Ultradian Rhythms in the Transcriptome of Neurospora crassa. iScience 9, 475-486
Lehmann, R., Herzel, H., Brunner, M., Sancar, G., Sancar, C., Ananthasubramaniam, B. (2018) Morning and Evening Peaking Rhythmic Genes are Regulated by Distinct Transcription Factors in
Neurospora crassa. Martin Bossert (ed.), Information- and communication Theory in Molecular Biology. Springer: 199-210
2017
Shostak, A., Ruppert, B., Diernfellner, A., and Brunner, M. (2017) Correspondence: Reply to 'Oncogenic MYC persistently upregulates the molecular clock component REV-ERBalpha'. Nat Commun 8, 14918
Lauinger, L., Li, J., Shostak, A., Cemel, I. A., Ha, N., Zhang, Y., Merkl, P. E., Obermeyer, S., Stankovic-Valentin, N., Schafmeier, T., Wever, W. J., Bowers, A. A., Carter, K. P., Palmer, A. E., Tschochner, H., Melchior, F., Deshaies, R. J., Brunner, M., and Diernfellner, A. (2017) Thiolutin is a zinc chelator that inhibits the Rpn11 and other JAMM metalloproteases. Nat Chem Biol 13, 709-714
Cemel, I. A., Ha, N., Schermann, G., Yonekawa, S., and Brunner, M. (2017) The coding and noncoding transcriptome of Neurospora crassa. BMC Genomics 18, 978
2016
Shostak, A., Ruppert, B., Ha, N., Bruns, P., Toprak, U. H., Project, I. M.-S., Eils, R., Schlesner, M., Diernfellner, A., and Brunner, M. (2016) MYC/MIZ1-dependent gene repression inversely coordinates the circadian clock with cell cycle and proliferation. Nat Commun 7, 11807
Shostak, A., Diernfellner, A., and Brunner, M. (2016) MYC inhibits the clock and supports proliferation. Cell Cycle 15, 3323-3324
2015
Zhai, Z., Kondo, S., Ha, N., Boquete, J. P., Brunner, M., Ueda, R., and Lemaitre, B. (2015) Accumulation of differentiating intestinal stem cell progenies drives tumorigenesis. Nat Commun 6, 10219
Sancar, C., Sancar, G., Ha, N., Cesbron, F., and Brunner, M. (2015) Dawn- and dusk-phased circadian transcription rhythms coordinate anabolic and catabolic functions in Neurospora. BMC Biol 13, 17
Sancar, C., Ha, N., Yilmaz, R., Tesorero, R., Fisher, T., Brunner, M., and Sancar, G. (2015) Combinatorial control of light induced chromatin remodeling and gene activation in Neurospora. PLoS Genet 11, e1005105
Cesbron, F., Oehler, M., Ha, N., Sancar, G., and Brunner, M. (2015) Transcriptional refractoriness is dependent on core promoter architecture. Nat Commun 6, 6753
2014
Sancar, G., and Brunner, M. (2014) Circadian clocks and energy metabolism. Cell Mol Life Sci 71, 2667-2680
Ruger-Herreros, C., Gil-Sanchez Mdel, M., Sancar, G., Brunner, M., and Corrochano, L. M. (2014) Alteration of light-dependent gene regulation by the absence of the RCO-1/RCM-1 repressor complex in the fungus Neurospora crassa. PLoS One 9, e95069
Lee, C. T., Malzahn, E., Brunner, M., and Mayer, M. P. (2014) Light-induced differences in conformational dynamics of the circadian clock regulator VIVID. J Mol Biol 426, 601-610
Lauinger, L., Diernfellner, A., Falk, S., and Brunner, M. (2014) The RNA helicase FRH is an ATP-dependent regulator of CK1a in the circadian clock of Neurospora crassa. Nat Commun 5, 3598
Hoffmann, J., Symul, L., Shostak, A., Fischer, T., Naef, F., and Brunner, M. (2014) Non-circadian expression masking clock-driven weak transcription rhythms in U2OS cells. PLoS One 9, e102238
2013
Gin, E., Diernfellner, A. C., Brunner, M., and Hofer, T. (2013) The Neurospora photoreceptor VIVID exerts negative and positive control on light sensing to achieve adaptation. Mol Syst Biol 9, 667
Cesbron, F., Brunner, M., and Diernfellner, A. C. (2013) Light-dependent and circadian transcription dynamics in vivo recorded with a destabilized luciferase reporter in Neurospora. PLoS One 8, e83660
2012
Tataroglu, O., Lauinger, L., Sancar, G., Jakob, K., Brunner, M., and Diernfellner, A. C. (2012) Glycogen synthase kinase is a regulator of the circadian clock of Neurospora crassa. J Biol Chem 287, 36936-36943
Sancar, G., Sancar, C., and Brunner, M. (2012) Metabolic compensation of the Neurospora clock by a glucose-dependent feedback of the circadian repressor CSP1 on the core oscillator. Genes Dev 26, 2435-2442
Diernfellner, A. C., and Brunner, M. (2012) O-GlcNAcylation of a circadian clock protein: dPER taking its sweet time. Genes Dev 26, 415-416
2011
Schafmeier, T., and Diernfellner, A. C. (2011) Light input and processing in the circadian clock of Neurospora. FEBS Lett 585, 1467-1473
Sancar, G., Sancar, C., Brugger, B., Ha, N., Sachsenheimer, T., Gin, E., Wdowik, S., Lohmann, I., Wieland, F., Hofer, T., Diernfellner, A., and Brunner, M. (2011) A global circadian repressor controls antiphasic expression of metabolic genes in Neurospora. Mol Cell 44, 687-697
Rey, G., Cesbron, F., Rougemont, J., Reinke, H., Brunner, M., and Naef, F. (2011) Genome-wide and phase-specific DNA-binding rhythms of BMAL1 control circadian output functions in mouse liver. PLoS Biol 9, e1000595
Querfurth, C., Diernfellner, A. C., Gin, E., Malzahn, E., Hofer, T., and Brunner, M. (2011) Circadian conformational change of the Neurospora clock protein FREQUENCY triggered by clustered hyperphosphorylation of a basic domain. Mol Cell 43, 713-722
Merrow, M., and Brunner, M. (2011) Circadian rhythms. FEBS Lett 585, 1383
Diernfellner, A. C., and Schafmeier, T. (2011) Phosphorylations: Making the Neurosporacrassa circadian clock tick. FEBS Lett 585, 1461-1466
2010
Tataroglu, O., and Schafmeier, T. (2010) Of switches and hourglasses: regulation of subcellular traffic in circadian clocks by phosphorylation. EMBO Rep 11, 927-935
Smith, K. M., Sancar, G., Dekhang, R., Sullivan, C. M., Li, S., Tag, A. G., Sancar, C., Bredeweg, E. L., Priest, H. D., McCormick, R. F., Thomas, T. L., Carrington, J. C., Stajich, J. E., Bell-Pedersen, D., Brunner, M., and Freitag, M. (2010) Transcription factors in light and circadian clock signaling networks revealed by genomewide mapping of direct targets for neurospora white collar complex. Eukaryot Cell 9, 1549-1556
Malzahn, E., Ciprianidis, S., Kaldi, K., Schafmeier, T., and Brunner, M. (2010) Photoadaptation in Neurospora by competitive interaction of activating and inhibitory LOV domains. Cell 142, 762-772
2009
Sancar, G., Sancar, C., Brunner, M., and Schafmeier, T. (2009) Activity of the circadian transcription factor White Collar Complex is modulated by phosphorylation of SP-motifs. FEBS Lett 583, 1833-1840
Diernfellner, A. C., Querfurth, C., Salazar, C., Hofer, T., and Brunner, M. (2009) Phosphorylation modulates rapid nucleocytoplasmic shuttling and cytoplasmic accumulation of Neurospora clock protein FRQ on a circadian time scale. Genes Dev 23, 2192-2200
2008
Schafmeier, T., Diernfellner, A., Schafer, A., Dintsis, O., Neiss, A., and Brunner, M. (2008) Circadian activity and abundance rhythms of the Neurospora clock transcription factor WCC associated with rapid nucleo-cytoplasmic shuttling. Genes Dev 22, 3397-3402
Neiss, A., Schafmeier, T., and Brunner, M. (2008) Transcriptional regulation and function of the Neurospora clock gene white collar 2 and its isoforms. EMBO Rep 9, 788-794
Brunner, M., Simons, M. J., and Merrow, M. (2008) Lego clocks: building a clock from parts. Genes Dev 22, 1422-1426
Brunner, M., and Merrow, M. (2008) The green yeast uses its plant-like clock to regulate its animal-like tail. Genes Dev 22, 825-831
Brunner, M., and Kaldi, K. (2008) Interlocked feedback loops of the circadian clock of Neurospora crassa. Mol Microbiol 68, 255-262
2007
Querfurth, C., Diernfellner, A., Heise, F., Lauinger, L., Neiss, A., Tataroglu, O., Brunner, M., and Schafmeier, T. (2007) Posttranslational regulation of Neurospora circadian clock by CK1a-dependent phosphorylation. Cold Spring Harb Symp Quant Biol 72, 177-183
Diernfellner, A., Colot, H. V., Dintsis, O., Loros, J. J., Dunlap, J. C., and Brunner, M. (2007) Long and short isoforms of Neurospora clock protein FRQ support temperature-compensated circadian rhythms. FEBS Lett 581, 5759-5764
2006
Schafmeier, T., Kaldi, K., Diernfellner, A., Mohr, C., and Brunner, M. (2006) Phosphorylation-dependent maturation of Neurospora circadian clock protein from a nuclear repressor toward a cytoplasmic activator. Genes Dev 20, 297-306
Kaldi, K., Gonzalez, B. H., and Brunner, M. (2006) Transcriptional regulation of the Neurospora circadian clock gene wc-1 affects the phase of circadian output. EMBO Rep 7, 199-204
Brunner, M., and Diernfellner, A. (2006) How temperature affects the circadian clock of Neurospora crassa. Chronobiol Int 23, 81-90
2005
Schafmeier, T., Haase, A., Kaldi, K., Scholz, J., Fuchs, M., and Brunner, M. (2005) Transcriptional feedback of Neurospora circadian clock gene by phosphorylation-dependent inactivation of its transcription factor. Cell 122, 235-246
Diernfellner, A. C., Schafmeier, T., Merrow, M. W., and Brunner, M. (2005) Molecular mechanism of temperature sensing by the circadian clock of Neurospora crassa. Genes Dev 19, 1968-1973
2002
Okamoto, K., Brinker, A., Paschen, S. A., Moarefi, I., Hayer-Hartl, M., Neupert, W., and Brunner, M. (2002) The protein import motor of mitochondria: a targeted molecular ratchet driving unfolding and translocation. EMBO J 21, 3659-3671
Moro, F., Okamoto, K., Donzeau, M., Neupert, W., and Brunner, M. (2002) Mitochondrial protein import: molecular basis of the ATP-dependent interaction of MtHsp70 with Tim44. J Biol Chem 277, 6874-6880
2001
Rothbauer, U., Hofmann, S., Muhlenbein, N., Paschen, S. A., Gerbitz, K. D., Neupert, W., Brunner, M., and Bauer, M. F. (2001) Role of the deafness dystonia peptide 1 (DDP1) in import of human Tim23 into the inner membrane of mitochondria. J Biol Chem 276, 37327-37334
Milisav, I., Moro, F., Neupert, W., and Brunner, M. (2001) Modular structure of the TIM23 preprotein translocase of mitochondria. J Biol Chem 276, 25856-25861
Merrow, M., Franchi, L., Dragovic, Z., Gorl, M., Johnson, J., Brunner, M., Macino, G., and Roenneberg, T. (2001) Circadian regulation of the light input pathway in Neurospora crassa. EMBO J 20, 307-315
Gorl, M., Merrow, M., Huttner, B., Johnson, J., Roenneberg, T., and Brunner, M. (2001) A PEST-like element in FREQUENCY determines the length of the circadian period in Neurospora crassa. EMBO J 20, 7074-7084
2000
Paschen, S. A., Rothbauer, U., Kaldi, K., Bauer, M. F., Neupert, W., and Brunner, M. (2000) The role of the TIM8-13 complex in the import of Tim23 into mitochondria. EMBO J 19, 6392-6400
Donzeau, M., Kaldi, K., Adam, A., Paschen, S., Wanner, G., Guiard, B., Bauer, M. F., Neupert, W., and Brunner, M. (2000) Tim23 links the inner and outer mitochondrial membranes. Cell 101, 401-412
Cruciat, C. M., Brunner, S., Baumann, F., Neupert, W., and Stuart, R. A. (2000) The cytochrome bc1 and cytochrome c oxidase complexes associate to form a single supracomplex in yeast mitochondria. J Biol Chem 275, 18093-18098
Bauer, M. F., Hofmann, S., Neupert, W., and Brunner, M. (2000) Protein translocation into mitochondria: the role of TIM complexes. Trends Cell Biol 10, 25-31
Bauer, M.F., Paschen, S.A., Neupert, W. and Brunner, M. (2000) Mechanisms of mitochondrial protein import. Protoplasma 213, 1-10.
1999
Moro, F., Sirrenberg, C., Schneider, H. C., Neupert, W., and Brunner, M. (1999) The TIM17.23 preprotein translocase of mitochondria: composition and function in protein transport into the matrix. EMBO J 18, 3667-3675
Merrow, M., Brunner, M., and Roenneberg, T. (1999) Assignment of circadian function for the Neurospora clock gene frequency. Nature 399, 584-586
Endres, M., Neupert, W., and Brunner, M. (1999) Transport of the ADP/ATP carrier of mitochondria from the TOM complex to the TIM22.54 complex. EMBO J 18, 3214-3221
Bauer, M. F., Rothbauer, U., Muhlenbein, N., Smith, R. J., Gerbitz, K., Neupert, W., Brunner, M., and Hofmann, S. (1999) The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom. FEBS Lett 464, 41-47
Bauer, M. F., Gempel, K., Reichert, A. S., Rappold, G. A., Lichtner, P., Gerbitz, K. D., Neupert, W., Brunner, M., and Hofmann, S. (1999) Genetic and structural characterization of the human mitochondrial inner membrane translocase. J Mol Biol 289, 69-82
Adam, A., Endres, M., Sirrenberg, C., Lottspeich, F., Neupert, W., and Brunner, M. (1999) Tim9, a new component of the TIM22.54 translocase in mitochondria. EMBO J 18, 313-319
1998
Sirrenberg, C., Endres, M., Folsch, H., Stuart, R. A., Neupert, W., and Brunner, M. (1998) Carrier protein import into mitochondria mediated by the intermembrane proteins Tim10/Mrs11 and Tim12/Mrs5. Nature 391, 912-915
Rapaport, D., Brunner, M., Neupert, W., and Westermann, B. (1998) Fzo1p is a mitochondrial outer membrane protein essential for the biogenesis of functional mitochondria in Saccharomyces cerevisiae. J Biol Chem 273, 20150-20155
Kaldi, K., Bauer, M. F., Sirrenberg, C., Neupert, W., and Brunner, M. (1998) Biogenesis of Tim23 and Tim17, integral components of the TIM machinery for matrix-targeted preproteins. EMBO J 17, 1569-1576
Gaume, B., Klaus, C., Ungermann, C., Guiard, B., Neupert, W., and Brunner, M. (1998) Unfolding of preproteins upon import into mitochondria. EMBO J 17, 6497-6507
Folsch, H., Gaume, B., Brunner, M., Neupert, W., and Stuart, R. A. (1998) C- to N-terminal translocation of preproteins into mitochondria. EMBO J 17, 6508-6515
Bauer, M. F., Künkele, K. P., Neupert, W. and Brunner, M. (1998) Proteine auf Reisen. Einsichten 2, 14-17.
1997
Sirrenberg, C., Endres, M., Becker, K., Bauer, M. F., Walther, E., Neupert, W., and Brunner, M. (1997) Functional cooperation and stoichiometry of protein translocases of the outer and inner membranes of mitochondria. J Biol Chem 272, 29963-29966
Arnold, I., Bauer, M. F., Brunner, M., Neupert, W., and Stuart, R. A. (1997) Yeast mitochondrial F1F0-ATPase: the novel subunit e is identical to Tim11. FEBS Lett 411, 195-200
1996
Sirrenberg, C., Bauer, M. F., Guiard, B., Neupert, W., and Brunner, M. (1996) Import of carrier proteins into the mitochondrial inner membrane mediated by Tim22. Nature 384, 582-585
Schneider, H. C., Westermann, B., Neupert, W., and Brunner, M. (1996) The nucleotide exchange factor MGE exerts a key function in the ATP-dependent cycle of mt-Hsp70-Tim44 interaction driving mitochondrial protein import. EMBO J 15, 5796-5803
Klaus, C., Guiard, B., Neupert, W., and Brunner, M. (1996) Determinants in the presequence of cytochrome b2 for import into mitochondria and for proteolytic processing. Eur J Biochem 236, 856-861
Bauer, M. F., Sirrenberg, C., Neupert, W., and Brunner, M. (1996) Role of Tim23 as voltage sensor and presequence receptor in protein import into mitochondria. Cell 87, 33-41
Schneider, H. C., Berthold, J., Bauer, M. F., Klaus, C., Neupert, W. and Brunner, M. (1996) Protein import across the inner mitochondrial membrane. NATO ASI Series H96, 157-165.
1995
Brunner, M., Schneider, H. C., Lill, R., and Neupert, W. (1995) Dissection of protein translocation across the mitochondrial outer and inner membranes. Cold Spring Harb Symp Quant Biol 60, 619-627
Brunner, M., and Neupert, W. (1995) Purification and characterization of mitochondrial processing peptidase of Neurospora crassa. Methods Enzymol 248, 717-728
Berthold, J., Bauer, M. F., Schneider, H. C., Klaus, C., Dietmeier, K., Neupert, W., and Brunner, M. (1995) The MIM complex mediates preprotein translocation across the mitochondrial inner membrane and couples it to the mt-Hsp70/ATP driving system. Cell 81, 1085-1093
1994
Whiteheart, S. W., Rossnagel, K., Buhrow, S. A., Brunner, M., Jaenicke, R., and Rothman, J. E. (1994) N-ethylmaleimide-sensitive fusion protein: a trimeric ATPase whose hydrolysis of ATP is required for membrane fusion. J Cell Biol 126, 945-954
Schneider, H. C., Berthold, J., Bauer, M. F., Dietmeier, K., Guiard, B., Brunner, M., and Neupert, W. (1994) Mitochondrial Hsp70/MIM44 complex facilitates protein import. Nature 371, 768-774
Bassham, D. C., Creighton, A. M., Arretz, M., Brunner, M., and Robinson, C. (1994) Efficient but aberrant cleavage of mitochondrial precursor proteins by the chloroplast stromal processing peptidase. Eur J Biochem 221, 523-528
Arretz, M., Schneider, H., Guiard, B., Brunner, M., and Neupert, W. (1994) Characterization of the mitochondrial processing peptidase of Neurospora crassa. J Biol Chem 269, 4959-4967
Brunner, M., Klaus, C. and Neupert, W. (1994) The mitochondrial processing peptidase. In Heijne, G (ed.) Signal Peptidases, RG Landes Comp, 73-86.
Brunner, M. and Whiteheart, S. W. (1994) Mammalian Proteins involved in membrane traffic in the Golgi and to the cell surface - SNAP. In Rothblatt, J, Novick, P and Stevens, T (eds.) Guidebook to the secretory pathway, Sambrook and Tooze publication at Oxford University press, 180-181.
1993
Whiteheart, S. W., Griff, I. C., Brunner, M., Clary, D. O., Mayer, T., Buhrow, S. A., and Rothman, J. E. (1993) SNAP family of NSF attachment proteins includes a brain-specific isoform. Nature 362, 353-355
Tagaya, M., Wilson, D. W., Brunner, M., Arango, N., and Rothman, J. E. (1993) Domain structure of an N-ethylmaleimide-sensitive fusion protein involved in vesicular transport. J Biol Chem 268, 2662-2666
Söllner, T., Whiteheart, S. W., Brunner, M., Erdjument-Bromage, H., Geromanos, S., Tempst, P., and Rothman, J. E. (1993) SNAP receptors implicated in vesicle targeting and fusion. Nature 362, 318-324
1992
Wilson, D. W., Whiteheart, S. W., Wiedmann, M., Brunner, M., and Rothman, J. E. (1992) A multisubunit particle implicated in membrane fusion. J Cell Biol 117, 531-538
Whiteheart, S. W., Brunner, M., Wilson, D. W., Wiedmann, M., and Rothman, J. E. (1992) Soluble N-ethylmaleimide-sensitive fusion attachment proteins (SNAPs) bind to a multi-SNAP receptor complex in Golgi membranes. J Biol Chem 267, 12239-12243
1991
Serafini, T., Orci, L., Amherdt, M., Brunner, M., Kahn, R. A., and Rothman, J. E. (1991) ADP-ribosylation factor is a subunit of the coat of Golgi-derived COP-coated vesicles: a novel role for a GTP-binding protein. Cell 67, 239-253
1987
Brunner, M., and Bujard, H. (1987) Promoter recognition and promoter strength in the Escherichia coli system. EMBO J 6, 3139-3144