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BIOCHEMIEZENTRUM HEIDELBERG UNIVERSITY OF HEIDELBERG
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Groupleader: Mandy Jeske

Molecular Functions of Germline Proteins 

Group Leader Mandy Jeske

Mandy Jeske

Molecular Functions of Germline Proteins

  • Research
  • CV
  • Lab Members
  • Publications
  • Collaborations
  • Funding
  • Open Positions
  • Contact
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Research 


   
In the lab, we are using a multidisciplinary approach to investigate proteins and protein complexes with essential functions during germ cell formation and early embryonic development. The research focusses on molecular mechanism such as piRNA-mediated transposon silencing and translation control of mRNAs, which are essential during early animal development.
 
In particular, we are currently focusing ours studies on LOTUS domain-containing proteins and on RNA helicases. To unravel the molecular mechanisms of how these proteins function, we employ a multidisciplinary approach combining RNA/protein biochemistry, X-ray crystallography, cell culture techniques as well as Drosophila genetics.

Twitter @Jeske_Lab

CV 


1998 - 2005  Biochemistry Studies at University Halle-Wittenberg
2005 - 2010  PhD at the University Halle-Wittenberg with Elmar Wahle
2010 - 2017
 
 Postdoc at the EMBL with Anne Ephrussi and Christoph W. Müller
 (EIPOD Developmental/Structural biology)
since 2017  Emmy Noether Group Leader at the Heidelberg University Biochemistry Center (BZH)
   

Lab Members 



Asen Garbelyanski
PhD student

Lab:Room 422 / Phone: +49 6221 54-4739
Mail:asen.garbelyanski@bzh.uni-heidelberg.de

 RoomPhone
LAB 422 +49 6221 54-4739
E-Mail asen.garbelyanski@bzh.uni-heidelberg.de
Jana Kubikova
PhD student

Lab:Room 422 / Phone: +49 6221 54-4739
Mail:jana.kubikova@bzh.uni-heidelberg.de

 RoomPhone
LAB 422 +49 6221 54-4739
E-Mail jana.kubikova@bzh.uni-heidelberg.de
Jutta Metz
TA

Lab:Room 422 / Phone: +49 6221 54-6894
Mail:jutta.metz@bzh.uni-heidelberg.de

 RoomPhone
LAB 422 +49 6221 54-6894
E-Mail jutta.metz@bzh.uni-heidelberg.de
Harpreet Kaur Salgania
PhD student

Lab:Room 422 / Phone: +49 6221 54-6894
Mail:harpreet.salgania@bzh.uni-heidelberg.de

 RoomPhone
LAB 422 +49 6221 54-6894
E-Mail harpreet.salgania@bzh.uni-heidelberg.de

Publications 


ReLo: a simple colocalization assay to identify and characterize physical protein-protein interactions. BioRxiv. doi: https://doi.org/10.1101/2022.03.04.482790
 
Salgania, H.K., Metz, J., and Jeske, M. (2022)

RNA binding proteins Smaug and Cup induce CCR4-NOT-dependent deadenylation of the nanos mRNA in a reconstituted system. BioRxiv. doi:https://doi.org/10.1101/2022.05.11.491288
 
Pekovic, F., Rammelt, C., Kubíková, J., Metz, J., Jeske, M., Wahle, E. (2022)

Molekulare Funktionen von Keimbahn-spezifischen Proteinen. BIOspektrum. 27, 101.
Jeske, M. (2021)

Molecular functions of germline proteins. EU Research. SPR21, 18.
Jeske, M. (2021)

LOTUS-domain proteins - Developmental effectors from a molecular perspective. Biol. Chem. 402, 7–23.
Kubíková, J., Reinig, R., Salgania, H.K., and Jeske, M. (2020)

The LOTUS domain is a conserved DEAD-box RNA helicase regulator essential for the recruitment of Vasa to the germ plasm and nuage. Genes Dev. 31(9), 939-952.
Jeske, M., Müller, C.W., Ephrussi, A. (2017)

The crystal structure of the Drosophila germline-inducer Oskar identifies two domains with distinct Vasa helicase- and RNA-binding activities. Cell Rep. 12(4), 587-98.
Jeske, M., Bordi, M., Glatt, S., Müller, S., Rybin, V., Müller, C.W., Ephrussi, A. (2015)

Assaying mRNA deadenylation in vitro. Methods Mol. Biol. 1125, 297–311.
Jeske, M., Temme, C., Wahle, E. (2014)

Identification of Drosophila and human 7-methyl GMP-specific nucleotidases. J. Biol. Chem. 288(4), 2441-2451.
Buschmann, J., Moritz, B., Jeske, M., Lilie, H., Schierhorn, A., Wahle, E. (2013)

Smaug assembles an ATP-dependent stable complex repressing nanos mRNA translation at multiple levels. EMBO J. 30(1), 90-103.
Jeske, M., Moritz, B., Anders, A., Wahle, E. (2011)

Cell-free deadenylation assays with Drosophila embryo extracts. Meth. Enzymol. 448, 107-118.
Jeske, M., Wahle, E. (2008)

Rapid ATP-dependent deadenylation of nanos mRNA in a cell-free system from Drosophila embryos. J. Biol. Chem. 281(35), 25124-25133.
Jeske, M., Meyer, S., Temme, C., Freudenreich, D., Wahle, E. (2006)

Collaborations 


Funding 


Open Positions 


Interested Trainees and motivated Bachelor and Master students are always welcome to join the lab. Please contact me by mail: jeske@bzh.uni-heidelberg.de

 

Contact



Biochemie-Zentrum
der Universität Heidelberg (BZH)
Im Neuenheimer Feld 328
69120 Heidelberg

Office:
+49 6221 54-4728
Fax:
+49 6221 54-4369
E-Mail:
jeske@bzh.uni-heidelberg.de


LOGO Biochemizentrum Heidelberg Heidelberg University Biochemistry Center (BZH)
Im Neuenheimer Feld 328
69120 Heidelberg
RESEARCH GROUPS
  • Brügger
  • Brunner
  • Höglinger
  • Jeske
  • Meinecke
  • Moser von Filseck
  • Nickel
  • Peschek
  • Russell
  • Schuck
  • Sinning
  • Söllner
  • Former Research Groups »
PAGES
  • Forschungsgruppen
  • Principal Investigators
  • Senior Professors
    • Felix Wieland
    • Ed Hurt
  • Forschungsverbünde
  • Facilities
  • Doktorandenprogramm
  • Lehre am BZH
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